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Items: 1 to 50 of 277

1.

Atomic resolution structures of tetrahydrofolate methylation in the desulfitobacterial glycine betaine metabolism.

Badmann T, Groll M.

Chembiochem. 2019 Sep 13. doi: 10.1002/cbic.201900515. [Epub ahead of print]

PMID:
31518049
2.

On the importance of the innervation of the human cervical longitudinal ligaments at vertebral level.

Stegmann T, Steinke H, Pieroh P, Dehghani F, Völker A, Groll MJ, Wolfskämpf T, Werner M, Kollan J, Hinz A, Leimert M.

Surg Radiol Anat. 2019 Sep 6. doi: 10.1007/s00276-019-02316-6. [Epub ahead of print]

PMID:
31493007
3.

Engineering a Polyspecific Pyrrolysyl-tRNA Synthetase by a High Throughput FACS Screen.

Hohl A, Karan R, Akal A, Renn D, Liu X, Ghorpade S, Groll M, Rueping M, Eppinger J.

Sci Rep. 2019 Aug 19;9(1):11971. doi: 10.1038/s41598-019-48357-0.

4.

Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens.

Zhou Q, Bräuer A, Adihou H, Schmalhofer M, Saura P, Grammbitter GLC, Kaila VRI, Groll M, Bode HB.

Chem Sci. 2019 May 14;10(25):6341-6349. doi: 10.1039/c9sc00749k. eCollection 2019 Jul 7.

5.

Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.

Evangelou P, Groll M, Oppermann H, Gaunitz F, Eisenlöffel C, Müller W, Eschrich K, Schänzer A, Nestler U.

Med Mol Morphol. 2019 Apr 20. doi: 10.1007/s00795-019-00223-8. [Epub ahead of print]

PMID:
31006040
6.

An Uncommon Type II PKS Catalyzes Biosynthesis of Aryl Polyene Pigments.

Grammbitter GLC, Schmalhofer M, Karimi K, Shi YM, Schöner TA, Tobias NJ, Morgner N, Groll M, Bode HB.

J Am Chem Soc. 2019 Apr 3. doi: 10.1021/jacs.8b10776. [Epub ahead of print]

PMID:
30908039
7.

Genetically Encoded Biotin Analogues: Incorporation and Application in Bacterial and Mammalian Cells.

Hohl A, Mideksa YG, Karan R, Akal A, Vogler M, Groll M, Rueping M, Lang K, Feige MJ, Eppinger J.

Chembiochem. 2019 Jul 15;20(14):1795-1798. doi: 10.1002/cbic.201900015. Epub 2019 Jun 26.

PMID:
30900320
8.

The Co-chaperone Cns1 and the Recruiter Protein Hgh1 Link Hsp90 to Translation Elongation via Chaperoning Elongation Factor 2.

Schopf FH, Huber EM, Dodt C, Lopez A, Biebl MM, Rutz DA, Mühlhofer M, Richter G, Madl T, Sattler M, Groll M, Buchner J.

Mol Cell. 2019 Apr 4;74(1):73-87.e8. doi: 10.1016/j.molcel.2019.02.011. Epub 2019 Mar 12.

PMID:
30876805
9.

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits.

Xin BT, Huber EM, de Bruin G, Heinemeyer W, Maurits E, Espinal C, Du Y, Janssens M, Weyburne ES, Kisselev AF, Florea BI, Driessen C, van der Marel GA, Groll M, Overkleeft HS.

J Med Chem. 2019 Feb 14;62(3):1626-1642. doi: 10.1021/acs.jmedchem.8b01884. Epub 2019 Feb 5.

10.

Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.

Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, Borkhardt A, Kurz T, Christianson DW, Hauer J, Hansen FK.

J Med Chem. 2018 Nov 21;61(22):10299-10309. doi: 10.1021/acs.jmedchem.8b01487. Epub 2018 Nov 8.

PMID:
30365892
11.

Design, synthesis, and evaluation of cystargolide-based β-lactones as potent proteasome inhibitors.

Niroula D, Hallada LP, Le Chapelain C, Ganegamage SK, Dotson D, Rogelj S, Groll M, Tello-Aburto R.

Eur J Med Chem. 2018 Sep 5;157:962-977. doi: 10.1016/j.ejmech.2018.08.052. Epub 2018 Aug 20.

12.

Structural and Mechanistic Features of ClyA-Like α-Pore-Forming Toxins.

Bräuning B, Groll M.

Toxins (Basel). 2018 Aug 23;10(9). pii: E343. doi: 10.3390/toxins10090343. Review.

13.

Iron Scavenging in Aspergillus Species: Structural and Biochemical Insights into Fungal Siderophore Esterases.

Ecker F, Haas H, Groll M, Huber EM.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14624-14629. doi: 10.1002/anie.201807093. Epub 2018 Aug 27.

PMID:
30070018
14.

(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.

Groll M, Nguyen H, Vellalath S, Romo D.

Mar Drugs. 2018 Jul 19;16(7). pii: E240. doi: 10.3390/md16070240.

15.

Impacts of dam draining on the mobility of heavy metals and arsenic in water and basin bottom sediments of three studied dams in Germany.

Hahn J, Opp C, Evgrafova A, Groll M, Zitzer N, Laufenberg G.

Sci Total Environ. 2018 Nov 1;640-641:1072-1081. doi: 10.1016/j.scitotenv.2018.05.295. Epub 2018 Jun 6.

PMID:
30021272
16.

Osteomyelitis: A Context for Wound Management.

Groll ME, Woods T, Salcido R.

Adv Skin Wound Care. 2018 Jun;31(6):253-262. doi: 10.1097/01.ASW.0000532737.64628.2a.

PMID:
29782414
17.

Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB.

Bräuning B, Bertosin E, Praetorius F, Ihling C, Schatt A, Adler A, Richter K, Sinz A, Dietz H, Groll M.

Nat Commun. 2018 May 4;9(1):1806. doi: 10.1038/s41467-018-04139-2.

18.

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Treise I, Huber EM, Klein-Rodewald T, Heinemeyer W, Grassmann SA, Basler M, Adler T, Rathkolb B, Helming L, Andres C, Klaften M, Landbrecht C, Wieland T, Strom TM, McCoy KD, Macpherson AJ, Wolf E, Groettrup M, Ollert M, Neff F, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Groll M, Busch DH.

Sci Rep. 2018 Apr 13;8(1):5975. doi: 10.1038/s41598-018-24199-0.

19.

Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ.

Mader SL, Bräuer A, Groll M, Kaila VRI.

Nat Commun. 2018 Mar 21;9(1):1168. doi: 10.1038/s41467-018-03442-2.

20.

A Predictive Approach for the Optical Control of Carbonic Anhydrase II Activity.

DuBay KH, Iwan K, Osorio-Planes L, Geissler PL, Groll M, Trauner D, Broichhagen J.

ACS Chem Biol. 2018 Mar 16;13(3):793-800. doi: 10.1021/acschembio.7b00862. Epub 2018 Feb 9.

PMID:
29357237
21.

On the Trails of the Proteasome Fold: Structural and Functional Analysis of the Ancestral β-Subunit Protein Anbu.

Vielberg MT, Bauer VC, Groll M.

J Mol Biol. 2018 Mar 2;430(5):628-640. doi: 10.1016/j.jmb.2018.01.004.

PMID:
29355501
22.

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases.

Wachtel R, Bräuning B, Mader SL, Ecker F, Kaila VRI, Groll M, Itzen A.

Nat Commun. 2018 Jan 3;9(1):44. doi: 10.1038/s41467-017-02110-1.

23.

The Y. bercovieri Anbu crystal structure sheds light on the evolution of highly (pseudo)symmetric multimers.

Piasecka A, Czapinska H, Vielberg MT, Szczepanowski RH, Kiefersauer R, Reed S, Groll M, Bochtler M.

J Mol Biol. 2018 Mar 2;430(5):611-627. doi: 10.1016/j.jmb.2017.11.016. Epub 2017 Dec 16.

24.

Comparison of a target-equalization-cancellation approach and a localization approach to source separation.

Mi J, Groll M, Colburn HS.

J Acoust Soc Am. 2017 Nov;142(5):2933. doi: 10.1121/1.5009763.

25.

Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes.

Grötzinger SW, Karan R, Strillinger E, Bader S, Frank A, Al Rowaihi IS, Akal A, Wackerow W, Archer JA, Rueping M, Weuster-Botz D, Groll M, Eppinger J, Arold ST.

ACS Chem Biol. 2018 Jan 19;13(1):161-170. doi: 10.1021/acschembio.7b00792. Epub 2017 Dec 18.

PMID:
29188989
26.

The Mammalian Proteasome Activator PA28 Forms an Asymmetric α4β3 Complex.

Huber EM, Groll M.

Structure. 2017 Oct 3;25(10):1473-1480.e3. doi: 10.1016/j.str.2017.07.013. Epub 2017 Aug 31.

27.

Mechanism of Allosteric Inhibition of the Enzyme IspD by Three Different Classes of Ligands.

Schwab A, Illarionov B, Frank A, Kunfermann A, Seet M, Bacher A, Witschel MC, Fischer M, Groll M, Diederich F.

ACS Chem Biol. 2017 Aug 18;12(8):2132-2138. doi: 10.1021/acschembio.7b00004. Epub 2017 Jul 7.

PMID:
28686408
28.

Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.

Kugel S, Baunach M, Baer P, Ishida-Ito M, Sundaram S, Xu Z, Groll M, Hertweck C.

Nat Commun. 2017 Jun 15;8:15804. doi: 10.1038/ncomms15804.

29.

Common Fibril Structures Imply Systemically Conserved Protein Misfolding Pathways In Vivo.

Annamalai K, Liberta F, Vielberg MT, Close W, Lilie H, Gührs KH, Schierhorn A, Koehler R, Schmidt A, Haupt C, Hegenbart U, Schönland S, Schmidt M, Groll M, Fändrich M.

Angew Chem Int Ed Engl. 2017 Jun 19;56(26):7510-7514. doi: 10.1002/anie.201701761. Epub 2017 May 23.

PMID:
28544119
30.

Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.

Marion A, Groll M, Scharf DH, Scherlach K, Glaser M, Sievers H, Schuster M, Hertweck C, Brakhage AA, Antes I, Huber EM.

ACS Chem Biol. 2017 Jul 21;12(7):1874-1882. doi: 10.1021/acschembio.6b00847. Epub 2017 Jun 6.

PMID:
28525266
31.

Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome.

Cui H, Baur R, Le Chapelain C, Dubiella C, Heinemeyer W, Huber EM, Groll M.

Chembiochem. 2017 Mar 16;18(6):523-526. doi: 10.1002/cbic.201700021. Epub 2017 Feb 22.

PMID:
28098422
32.

The Methylerythritol Phosphate Pathway to Isoprenoids.

Frank A, Groll M.

Chem Rev. 2017 Apr 26;117(8):5675-5703. doi: 10.1021/acs.chemrev.6b00537. Epub 2016 Dec 20. Review.

PMID:
27995802
33.

The CCAAT-binding complex (CBC) in Aspergillus species.

Hortschansky P, Haas H, Huber EM, Groll M, Brakhage AA.

Biochim Biophys Acta Gene Regul Mech. 2017 May;1860(5):560-570. doi: 10.1016/j.bbagrm.2016.11.008. Epub 2016 Dec 8. Review.

PMID:
27939757
34.

Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.

Stingele J, Bellelli R, Alte F, Hewitt G, Sarek G, Maslen SL, Tsutakawa SE, Borg A, Kjær S, Tainer JA, Skehel JM, Groll M, Boulton SJ.

Mol Cell. 2016 Nov 17;64(4):688-703. doi: 10.1016/j.molcel.2016.09.031. Epub 2016 Oct 27.

35.

Characterization of a Cyanobacterial Haloperoxidase and Evaluation of its Biocatalytic Halogenation Potential.

Frank A, Seel CJ, Groll M, Gulder T.

Chembiochem. 2016 Nov 3;17(21):2028-2032. doi: 10.1002/cbic.201600417. Epub 2016 Sep 22.

PMID:
27542168
36.

A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i.

Huber EM, Heinemeyer W, de Bruin G, Overkleeft HS, Groll M.

EMBO J. 2016 Dec 1;35(23):2602-2613. Epub 2016 Oct 27.

37.

Tunable Probes with Direct Fluorescence Signals for the Constitutive and Immunoproteasome.

Dubiella C, Cui H, Groll M.

Angew Chem Int Ed Engl. 2016 Oct 10;55(42):13330-13334. doi: 10.1002/anie.201605753.

PMID:
27709817
38.

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.

Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS.

J Med Chem. 2016 Aug 11;59(15):7177-87. doi: 10.1021/acs.jmedchem.6b00705. Epub 2016 Aug 1.

PMID:
27438186
39.

Rational Design of Proteasome Inhibitors as Antimalarial Drugs.

Le Chapelain C, Groll M.

Angew Chem Int Ed Engl. 2016 May 23;55(22):6370-2. doi: 10.1002/anie.201602519. Epub 2016 Apr 15.

PMID:
27079849
40.

A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.

Huber EM, Heinemeyer W, Li X, Arendt CS, Hochstrasser M, Groll M.

Nat Commun. 2016 Mar 11;7:10900. doi: 10.1038/ncomms10900.

41.

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA.

Duell ER, Glaser M, Le Chapelain C, Antes I, Groll M, Huber EM.

ACS Chem Biol. 2016 Apr 15;11(4):1082-9. doi: 10.1021/acschembio.5b00905. Epub 2016 Feb 9.

PMID:
26808594
42.

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.

Pahl A, Lakemeyer M, Vielberg MT, Hackl MW, Vomacka J, Korotkov VS, Stein ML, Fetzer C, Lorenz-Baath K, Richter K, Waldmann H, Groll M, Sieber SA.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15892-6. doi: 10.1002/anie.201507266. Epub 2015 Nov 13.

PMID:
26566002
43.

Selective Inhibition of the Immunoproteasome by Structure-Based Targeting of a Non-catalytic Cysteine.

Dubiella C, Baur R, Cui H, Huber EM, Groll M.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15888-91. doi: 10.1002/anie.201506631. Epub 2015 Nov 13.

PMID:
26563572
44.

Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis.

Bräuer A, Beck P, Hintermann L, Groll M.

Angew Chem Int Ed Engl. 2016 Jan 4;55(1):422-6. doi: 10.1002/anie.201507835. Epub 2015 Nov 10.

PMID:
26553478
45.

Targeted Delivery of Proteasome Inhibitors to Somatostatin-Receptor-Expressing Cancer Cells by Octreotide Conjugation.

Beck P, Cui H, Hegemann JD, Marahiel MA, Krüger A, Groll M.

ChemMedChem. 2015 Dec;10(12):1969-73. doi: 10.1002/cmdc.201500449. Epub 2015 Oct 16.

PMID:
26471124
46.

Rule-based Cervical Spine Defect Classification Using Medical Narratives.

Deng Y, Groll MJ, Denecke K.

Stud Health Technol Inform. 2015;216:1038.

PMID:
26262337
47.

Identification of a β1/β2-specific sulfonamide proteasome ligand by crystallographic screening.

Beck P, Reboud-Ravaux M, Groll M.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11275-8. doi: 10.1002/anie.201505054. Epub 2015 Aug 4.

PMID:
26242779
48.

Azobenzene-based inhibitors of human carbonic anhydrase II.

Runtsch LS, Barber DM, Mayer P, Groll M, Trauner D, Broichhagen J.

Beilstein J Org Chem. 2015 Jul 7;11:1129-35. doi: 10.3762/bjoc.11.127. eCollection 2015.

49.

Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.

Haslbeck V, Drazic A, Eckl JM, Alte F, Helmuth M, Popowicz G, Schmidt W, Braun F, Weiwad M, Fischer G, Gemmecker G, Sattler M, Striggow F, Groll M, Richter K.

Biosci Rep. 2015 Apr 20;35(3). pii: e00210. doi: 10.1042/BSR20150042.

50.

Macyranones: Structure, Biosynthesis, and Binding Mode of an Unprecedented Epoxyketone that Targets the 20S Proteasome.

Keller L, Plaza A, Dubiella C, Groll M, Kaiser M, Müller R.

J Am Chem Soc. 2015 Jul 1;137(25):8121-30. doi: 10.1021/jacs.5b03833. Epub 2015 Jun 17.

PMID:
26050527

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