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Items: 1 to 50 of 163


The expanded specificity and physiological role of a widespread N-degron recognin.

Gao X, Yeom J, Groisman EA.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18629-18637. doi: 10.1073/pnas.1821060116. Epub 2019 Aug 26.


Activator of one protease transforms into inhibitor of another in response to nutritional signals.

Yeom J, Groisman EA.

Genes Dev. 2019 Sep 1;33(17-18):1280-1292. doi: 10.1101/gad.325241.119. Epub 2019 Aug 1.


Slow growth determines nonheritable antibiotic resistance in Salmonella enterica.

Pontes MH, Groisman EA.

Sci Signal. 2019 Jul 30;12(592). pii: eaax3938. doi: 10.1126/scisignal.aax3938.


Dietary sugar silences a colonization factor in a mammalian gut symbiont.

Townsend GE 2nd, Han W, Schwalm ND 3rd, Raghavan V, Barry NA, Goodman AL, Groisman EA.

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):233-238. doi: 10.1073/pnas.1813780115. Epub 2018 Dec 17. Erratum in: Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5831.


A protein that controls the onset of a Salmonella virulence program.

Yeom J, Pontes MH, Choi J, Groisman EA.

EMBO J. 2018 Jul 13;37(14). pii: e96977. doi: 10.15252/embj.201796977. Epub 2018 Jun 1.


Gene expression kinetics governs stimulus-specific decoration of the Salmonella outer membrane.

Hong X, Chen HD, Groisman EA.

Sci Signal. 2018 May 8;11(529). pii: eaar7921. doi: 10.1126/scisignal.aar7921.


Reduction in adaptor amounts establishes degradation hierarchy among protease substrates.

Yeom J, Gao X, Groisman EA.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4483-E4492. doi: 10.1073/pnas.1722246115. Epub 2018 Apr 23.


Protein synthesis controls phosphate homeostasis.

Pontes MH, Groisman EA.

Genes Dev. 2018 Jan 1;32(1):79-92. doi: 10.1101/gad.309245.117. Epub 2018 Feb 1.


Activation of master virulence regulator PhoP in acidic pH requires the Salmonella-specific protein UgtL.

Choi J, Groisman EA.

Sci Signal. 2017 Aug 29;10(494). pii: eaan6284. doi: 10.1126/scisignal.aan6284.


Navigating the Gut Buffet: Control of Polysaccharide Utilization in Bacteroides spp.

Schwalm ND 3rd, Groisman EA.

Trends Microbiol. 2017 Dec;25(12):1005-1015. doi: 10.1016/j.tim.2017.06.009. Epub 2017 Jul 18. Review.


Sequestration from Protease Adaptor Confers Differential Stability to Protease Substrate.

Yeom J, Wayne KJ, Groisman EA.

Mol Cell. 2017 Apr 20;66(2):234-246.e5. doi: 10.1016/j.molcel.2017.03.009.


RNA secondary structures regulate three steps of Rho-dependent transcription termination within a bacterial mRNA leader.

Kriner MA, Groisman EA.

Nucleic Acids Res. 2017 Jan 25;45(2):631-642. doi: 10.1093/nar/gkw889. Epub 2016 Oct 5.


Prioritization of polysaccharide utilization and control of regulator activation in Bacteroides thetaiotaomicron.

Schwalm ND 3rd, Townsend GE 2nd, Groisman EA.

Mol Microbiol. 2017 Apr;104(1):32-45. doi: 10.1111/mmi.13609. Epub 2017 Feb 3.


Reducing Ribosome Biosynthesis Promotes Translation during Low Mg2+ Stress.

Pontes MH, Yeom J, Groisman EA.

Mol Cell. 2016 Nov 3;64(3):480-492. doi: 10.1016/j.molcel.2016.05.008. Epub 2016 Oct 13.


Multiple Signals Govern Utilization of a Polysaccharide in the Gut Bacterium Bacteroides thetaiotaomicron.

Schwalm ND 3rd, Townsend GE 2nd, Groisman EA.

mBio. 2016 Oct 11;7(5). pii: e01342-16. doi: 10.1128/mBio.01342-16.


Feedback Control of Two-Component Regulatory Systems.

Groisman EA.

Annu Rev Microbiol. 2016 Sep 8;70:103-24. doi: 10.1146/annurev-micro-102215-095331. Review.


Learning from the Leaders: Gene Regulation by the Transcription Termination Factor Rho.

Kriner MA, Sevostyanova A, Groisman EA.

Trends Biochem Sci. 2016 Aug;41(8):690-699. doi: 10.1016/j.tibs.2016.05.012. Epub 2016 Jun 17. Review.


Acidic pH sensing in the bacterial cytoplasm is required for Salmonella virulence.

Choi J, Groisman EA.

Mol Microbiol. 2016 Sep;101(6):1024-38. doi: 10.1111/mmi.13439. Epub 2016 Jul 8.


An RNA motif advances transcription by preventing Rho-dependent termination.

Sevostyanova A, Groisman EA.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6835-43. doi: 10.1073/pnas.1515383112. Epub 2015 Nov 16.


The Bacterial Transcription Termination Factor Rho Coordinates Mg(2+) Homeostasis with Translational Signals.

Kriner MA, Groisman EA.

J Mol Biol. 2015 Dec 4;427(24):3834-49. doi: 10.1016/j.jmb.2015.10.020. Epub 2015 Oct 30.


When Too Much ATP Is Bad for Protein Synthesis.

Pontes MH, Sevostyanova A, Groisman EA.

J Mol Biol. 2015 Aug 14;427(16):2586-2594. doi: 10.1016/j.jmb.2015.06.021. Epub 2015 Jul 4. Review.


Salmonella promotes virulence by repressing cellulose production.

Pontes MH, Lee EJ, Choi J, Groisman EA.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5183-8. doi: 10.1073/pnas.1500989112. Epub 2015 Apr 6.


Species-specific dynamic responses of gut bacteria to a mammalian glycan.

Raghavan V, Groisman EA.

J Bacteriol. 2015 May;197(9):1538-48. doi: 10.1128/JB.00010-15. Epub 2015 Feb 17.


Flagella-independent surface motility in Salmonella enterica serovar Typhimurium.

Park SY, Pontes MH, Groisman EA.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1850-5. doi: 10.1073/pnas.1422938112. Epub 2015 Jan 26.


Bacterial nucleoid-associated protein uncouples transcription levels from transcription timing.

Zwir I, Yeo WS, Shin D, Latifi T, Huang H, Groisman EA.

mBio. 2014 Oct 7;5(5):e01485-14. doi: 10.1128/mBio.01485-14.


Tuning transcription of nutrient utilization genes to catabolic rate promotes growth in a gut bacterium.

Raghavan V, Lowe EC, Townsend GE 2nd, Bolam DN, Groisman EA.

Mol Microbiol. 2014 Sep;93(5):1010-25. doi: 10.1111/mmi.12714. Epub 2014 Aug 12.


Unusually long-lived pause required for regulation of a Rho-dependent transcription terminator.

Hollands K, Sevostiyanova A, Groisman EA.

Proc Natl Acad Sci U S A. 2014 May 13;111(19):E1999-2007. doi: 10.1073/pnas.1319193111. Epub 2014 Apr 28.


Control of a Salmonella virulence operon by proline-charged tRNA(Pro).

Lee EJ, Choi J, Groisman EA.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3140-5. doi: 10.1073/pnas.1316209111. Epub 2014 Feb 10.


Signal-specific temporal response by the Salmonella PhoP/PhoQ regulatory system.

Park SY, Groisman EA.

Mol Microbiol. 2014 Jan;91(1):135-44. doi: 10.1111/mmi.12449. Epub 2013 Nov 20.


Bacterial Mg2+ homeostasis, transport, and virulence.

Groisman EA, Hollands K, Kriner MA, Lee EJ, Park SY, Pontes MH.

Annu Rev Genet. 2013;47:625-46. doi: 10.1146/annurev-genet-051313-051025. Epub 2013 Sep 20. Review.


A bacterial virulence protein promotes pathogenicity by inhibiting the bacterium's own F1Fo ATP synthase.

Lee EJ, Pontes MH, Groisman EA.

Cell. 2013 Jul 3;154(1):146-56. doi: 10.1016/j.cell.2013.06.004.


The biology of the PmrA/PmrB two-component system: the major regulator of lipopolysaccharide modifications.

Chen HD, Groisman EA.

Annu Rev Microbiol. 2013;67:83-112. doi: 10.1146/annurev-micro-092412-155751. Epub 2013 Jun 17. Review.


The lipopolysaccharide modification regulator PmrA limits Salmonella virulence by repressing the type three-secretion system Spi/Ssa.

Choi J, Groisman EA.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9499-504. doi: 10.1073/pnas.1303420110. Epub 2013 May 20.


Conflicting roles for a cell surface modification in Salmonella.

May JF, Groisman EA.

Mol Microbiol. 2013 Jun;88(5):970-83. doi: 10.1111/mmi.12236. Epub 2013 May 5.


An allele of an ancestral transcription factor dependent on a horizontally acquired gene product.

Chen HD, Jewett MW, Groisman EA.

PLoS Genet. 2012;8(12):e1003060. doi: 10.1371/journal.pgen.1003060. Epub 2012 Dec 27.


Intramolecular arrangement of sensor and regulator overcomes relaxed specificity in hybrid two-component systems.

Townsend GE 2nd, Raghavan V, Zwir I, Groisman EA.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E161-9. doi: 10.1073/pnas.1212102110. Epub 2012 Dec 19.


Expression of STM4467-encoded arginine deiminase controlled by the STM4463 regulator contributes to Salmonella enterica serovar Typhimurium virulence.

Choi Y, Choi J, Groisman EA, Kang DH, Shin D, Ryu S.

Infect Immun. 2012 Dec;80(12):4291-7. doi: 10.1128/IAI.00880-12. Epub 2012 Sep 24.


Reciprocal control between a bacterium's regulatory system and the modification status of its lipopolysaccharide.

Kato A, Chen HD, Latifi T, Groisman EA.

Mol Cell. 2012 Sep 28;47(6):897-908. doi: 10.1016/j.molcel.2012.07.017. Epub 2012 Aug 23.


Tandem attenuators control expression of the Salmonella mgtCBR virulence operon.

Lee EJ, Groisman EA.

Mol Microbiol. 2012 Oct;86(1):212-24. doi: 10.1111/j.1365-2958.2012.08188.x. Epub 2012 Aug 26.


Control of a Salmonella virulence locus by an ATP-sensing leader messenger RNA.

Lee EJ, Groisman EA.

Nature. 2012 Jun 13;486(7402):271-5. doi: 10.1038/nature11090.


The promoter architectural landscape of the Salmonella PhoP regulon.

Zwir I, Latifi T, Perez JC, Huang H, Groisman EA.

Mol Microbiol. 2012 May;84(3):463-85. doi: 10.1111/j.1365-2958.2012.08036.x. Epub 2012 Mar 27.


Riboswitch control of Rho-dependent transcription termination.

Hollands K, Proshkin S, Sklyarova S, Epshtein V, Mironov A, Nudler E, Groisman EA.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5376-81. doi: 10.1073/pnas.1112211109. Epub 2012 Mar 19.


Inhibition of bacterial virulence: drug-like molecules targeting the Salmonella enterica PhoP response regulator.

Tang YT, Gao R, Havranek JJ, Groisman EA, Stock AM, Marshall GR.

Chem Biol Drug Des. 2012 Jun;79(6):1007-17. doi: 10.1111/j.1747-0285.2012.01362.x. Epub 2012 Mar 21.


Intrinsic negative feedback governs activation surge in two-component regulatory systems.

Yeo WS, Zwir I, Huang HV, Shin D, Kato A, Groisman EA.

Mol Cell. 2012 Feb 10;45(3):409-21. doi: 10.1016/j.molcel.2011.12.027. Erratum in: Mol Cell. 2012 Mar 30;45(6):844.


Ancestral genes can control the ability of horizontally acquired loci to confer new traits.

Chen HD, Jewett MW, Groisman EA.

PLoS Genet. 2011 Jul;7(7):e1002184. doi: 10.1371/journal.pgen.1002184. Epub 2011 Jul 21.


Genome-wide detection of novel regulatory RNAs in E. coli.

Raghavan R, Groisman EA, Ochman H.

Genome Res. 2011 Sep;21(9):1487-97. doi: 10.1101/gr.119370.110. Epub 2011 Jun 10.


A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.

Park SY, Cromie MJ, Lee EJ, Groisman EA.

Cell. 2010 Sep 3;142(5):737-48. doi: 10.1016/j.cell.2010.07.046.


Defining the plasticity of transcription factor binding sites by Deconstructing DNA consensus sequences: the PhoP-binding sites among gamma/enterobacteria.

Harari O, Park SY, Huang H, Groisman EA, Zwir I.

PLoS Comput Biol. 2010 Jul 22;6(7):e1000862. doi: 10.1371/journal.pcbi.1000862.


Positive autoregulation shapes response timing and intensity in two-component signal transduction systems.

Mitrophanov AY, Hadley TJ, Groisman EA.

J Mol Biol. 2010 Aug 27;401(4):671-80. doi: 10.1016/j.jmb.2010.06.051. Epub 2010 Jun 30.


An antisense RNA that governs the expression kinetics of a multifunctional virulence gene.

Lee EJ, Groisman EA.

Mol Microbiol. 2010 May;76(4):1020-33. doi: 10.1111/j.1365-2958.2010.07161.x. Epub 2010 Apr 14.

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