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Items: 1 to 50 of 150

1.

Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis.

Volpi C, Orabona C, Macchiarulo A, Bianchi R, Puccetti P, Grohmann U.

Expert Opin Drug Discov. 2019 Aug 7:1-14. doi: 10.1080/17460441.2019.1646244. [Epub ahead of print]

PMID:
31389262
2.

Immunoregulatory Interplay Between Arginine and Tryptophan Metabolism in Health and Disease.

Mondanelli G, Iacono A, Allegrucci M, Puccetti P, Grohmann U.

Front Immunol. 2019 Jul 9;10:1565. doi: 10.3389/fimmu.2019.01565. eCollection 2019. No abstract available.

3.

Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives.

Pallotta MT, Tascini G, Crispoldi R, Orabona C, Mondanelli G, Grohmann U, Esposito S.

J Transl Med. 2019 Jul 23;17(1):238. doi: 10.1186/s12967-019-1993-1. Review.

4.

Effects of probiotic administration on immune responses of children and adolescents with type 1 diabetes to a quadrivalent inactivated influenza vaccine.

Bianchini S, Orabona C, Camilloni B, Berioli MG, Argentiero A, Matino D, Alunno A, Albini E, Vacca C, Pallotta MT, Mancini G, Tascini G, Toni G, Mondanelli G, Silvestri E, Grohmann U, Esposito S.

Hum Vaccin Immunother. 2019 Aug 15:1-9. doi: 10.1080/21645515.2019.1633877. [Epub ahead of print]

PMID:
31210557
5.

Amino acid metabolism as drug target in autoimmune diseases.

Mondanelli G, Iacono A, Carvalho A, Orabona C, Volpi C, Pallotta MT, Matino D, Esposito S, Grohmann U.

Autoimmun Rev. 2019 Apr;18(4):334-348. doi: 10.1016/j.autrev.2019.02.004. Epub 2019 Feb 22. Review.

6.

IL-35Ig-expressing dendritic cells induce tolerance via Arginase 1.

Panfili E, Mondanelli G, Orabona C, Bianchi R, Gargaro M, Fallarino F, Puccetti P, Grohmann U, Volpi C, Belladonna ML.

J Cell Mol Med. 2019 May;23(5):3757-3761. doi: 10.1111/jcmm.14215. Epub 2019 Feb 22.

7.

Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.

Fiore A, Ugel S, De Sanctis F, Sandri S, Fracasso G, Trovato R, Sartoris S, Solito S, Mandruzzato S, Vascotto F, Hippen KL, Mondanelli G, Grohmann U, Piro G, Carbone C, Melisi D, Lawlor RT, Scarpa A, Lamolinara A, Iezzi M, Fassan M, Bicciato S, Blazar BR, Sahin U, Murray PJ, Bronte V.

Nat Commun. 2018 Dec 5;9(1):5193. doi: 10.1038/s41467-018-07654-4.

8.

Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.

Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C.

Biochem Pharmacol. 2018 Dec;158:286-297. doi: 10.1016/j.bcp.2018.10.033. Epub 2018 Nov 1.

9.

Is It Time to Use Probiotics to Prevent or Treat Obesity?

Brusaferro A, Cozzali R, Orabona C, Biscarini A, Farinelli E, Cavalli E, Grohmann U, Principi N, Esposito S.

Nutrients. 2018 Nov 1;10(11). pii: E1613. doi: 10.3390/nu10111613. Review.

10.

Immune Checkpoint Molecules, Personalized Immunotherapy, and Autoimmune Diabetes.

Orabona C, Mondanelli G, Puccetti P, Grohmann U.

Trends Mol Med. 2018 Nov;24(11):931-941. doi: 10.1016/j.molmed.2018.08.005. Epub 2018 Sep 17. Review.

PMID:
30236470
11.

Loss of IDO1 Expression From Human Pancreatic β-Cells Precedes Their Destruction During the Development of Type 1 Diabetes.

Anquetil F, Mondanelli G, Gonzalez N, Rodriguez Calvo T, Zapardiel Gonzalo J, Krogvold L, Dahl-Jørgensen K, Van den Eynde B, Orabona C, Grohmann U, von Herrath MG.

Diabetes. 2018 Sep;67(9):1858-1866. doi: 10.2337/db17-1281. Epub 2018 Jun 26.

12.

Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes.

Orabona C, Mondanelli G, Pallotta MT, Carvalho A, Albini E, Fallarino F, Vacca C, Volpi C, Belladonna ML, Berioli MG, Ceccarini G, Esposito SM, Scattoni R, Verrotti A, Ferretti A, De Giorgi G, Toni S, Cappa M, Matteoli MC, Bianchi R, Matino D, Iacono A, Puccetti M, Cunha C, Bicciato S, Antognelli C, Talesa VN, Chatenoud L, Fuchs D, Pilotte L, Van den Eynde B, Lemos MC, Romani L, Puccetti P, Grohmann U.

JCI Insight. 2018 Mar 22;3(6). pii: 96244. doi: 10.1172/jci.insight.96244.

13.

Opportunities and challenges in drug discovery targeting metabotropic glutamate receptor 4.

Volpi C, Fallarino F, Mondanelli G, Macchiarulo A, Grohmann U.

Expert Opin Drug Discov. 2018 May;13(5):411-423. doi: 10.1080/17460441.2018.1443076. Epub 2018 Feb 28. Review.

PMID:
29486616
14.

Fragment-based approach to identify IDO1 inhibitor building blocks.

Coletti A, Camponeschi F, Albini E, Greco FA, Maione V, Custodi C, Ianni F, Grohmann U, Orabona C, Cantini F, Macchiarulo A.

Eur J Med Chem. 2017 Dec 1;141:169-177. doi: 10.1016/j.ejmech.2017.09.044. Epub 2017 Oct 3.

15.

Eating Disorders and Disordered Eating Symptoms in Adolescents with Type 1 Diabetes.

Toni G, Berioli MG, Cerquiglini L, Ceccarini G, Grohmann U, Principi N, Esposito S.

Nutrients. 2017 Aug 19;9(8). pii: E906. doi: 10.3390/nu9080906. Review.

16.

Challenges in the design of reliable immuno-oncology mouse models to inform drug development.

Mondanelli G, Volpi C, Orabona C, Grohmann U.

Future Med Chem. 2017 Aug;9(12):1313-1317. doi: 10.4155/fmc-2017-0027. Epub 2017 Aug 3. No abstract available.

PMID:
28771031
17.

The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO.

Mondanelli G, Ugel S, Grohmann U, Bronte V.

Curr Opin Pharmacol. 2017 Aug;35:30-39. doi: 10.1016/j.coph.2017.05.002. Epub 2017 May 26. Review.

PMID:
28554057
18.

Amino-acid sensing and degrading pathways in immune regulation.

Grohmann U, Mondanelli G, Belladonna ML, Orabona C, Pallotta MT, Iacono A, Puccetti P, Volpi C.

Cytokine Growth Factor Rev. 2017 Jun;35:37-45. doi: 10.1016/j.cytogfr.2017.05.004. Epub 2017 May 18. Review.

19.

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry.

Coletti A, Greco FA, Dolciami D, Camaioni E, Sardella R, Pallotta MT, Volpi C, Orabona C, Grohmann U, Macchiarulo A.

Medchemcomm. 2017 May 16;8(7):1378-1392. doi: 10.1039/c7md00109f. eCollection 2017 Jul 1. Review.

20.

The Proteasome Inhibitor Bortezomib Controls Indoleamine 2,3-Dioxygenase 1 Breakdown and Restores Immune Regulation in Autoimmune Diabetes.

Mondanelli G, Albini E, Pallotta MT, Volpi C, Chatenoud L, Kuhn C, Fallarino F, Matino D, Belladonna ML, Bianchi R, Vacca C, Bicciato S, Boon L, Ricci G, Grohmann U, Puccetti P, Orabona C.

Front Immunol. 2017 Apr 13;8:428. doi: 10.3389/fimmu.2017.00428. eCollection 2017.

21.

A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells.

Mondanelli G, Bianchi R, Pallotta MT, Orabona C, Albini E, Iacono A, Belladonna ML, Vacca C, Fallarino F, Macchiarulo A, Ugel S, Bronte V, Gevi F, Zolla L, Verhaar A, Peppelenbosch M, Mazza EMC, Bicciato S, Laouar Y, Santambrogio L, Puccetti P, Volpi C, Grohmann U.

Immunity. 2017 Feb 21;46(2):233-244. doi: 10.1016/j.immuni.2017.01.005. Epub 2017 Feb 14.

22.

Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1.

Albini E, Rosini V, Gargaro M, Mondanelli G, Belladonna ML, Pallotta MT, Volpi C, Fallarino F, Macchiarulo A, Antognelli C, Bianchi R, Vacca C, Puccetti P, Grohmann U, Orabona C.

J Cell Mol Med. 2017 Jan;21(1):165-176. doi: 10.1111/jcmm.12954. Epub 2016 Sep 30.

23.

IDO1 and TGF-β Mediate Protective Effects of IFN-α in Antigen-Induced Arthritis.

Chalise JP, Pallotta MT, Narendra SC, Carlsson B, Iacono A, Namale J, Boon L, Grohmann U, Magnusson M.

J Immunol. 2016 Oct 15;197(8):3142-3151. Epub 2016 Sep 19.

24.

Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells.

Volpi C, Mondanelli G, Pallotta MT, Vacca C, Iacono A, Gargaro M, Albini E, Bianchi R, Belladonna ML, Celanire S, Mordant C, Heroux M, Royer-Urios I, Schneider M, Vitte PA, Cacquevel M, Galibert L, Poli SM, Solari A, Bicciato S, Calvitti M, Antognelli C, Puccetti P, Orabona C, Fallarino F, Grohmann U.

Neuropharmacology. 2016 Mar;102:59-71. doi: 10.1016/j.neuropharm.2015.10.036. Epub 2015 Oct 30.

25.

IDO1 suppresses inhibitor development in hemophilia A treated with factor VIII.

Matino D, Gargaro M, Santagostino E, Di Minno MN, Castaman G, Morfini M, Rocino A, Mancuso ME, Di Minno G, Coppola A, Talesa VN, Volpi C, Vacca C, Orabona C, Iannitti R, Mazzucconi MG, Santoro C, Tosti A, Chiappalupi S, Sorci G, Tagariello G, Belvini D, Radossi P, Landolfi R, Fuchs D, Boon L, Pirro M, Marchesini E, Grohmann U, Puccetti P, Iorio A, Fallarino F.

J Clin Invest. 2015 Oct 1;125(10):3766-81. doi: 10.1172/JCI81859. Epub 2015 Aug 31.

26.

Islet antigen-pulsed dendritic cells expressing ectopic IL-35Ig protect nonobese diabetic mice from autoimmune diabetes.

Mondanelli G, Volpi C, Bianchi R, Allegrucci M, Talesa VN, Grohmann U, Belladonna ML.

Cytokine. 2015 Oct;75(2):380-8. doi: 10.1016/j.cyto.2015.05.002. Epub 2015 May 21.

PMID:
26003759
27.

Stem cells from human amniotic fluid exert immunoregulatory function via secreted indoleamine 2,3-dioxygenase1.

Romani R, Pirisinu I, Calvitti M, Pallotta MT, Gargaro M, Bistoni G, Vacca C, Di Michele A, Orabona C, Rosati J, Pirro M, Giovagnoli S, Matino D, Prontera P, Rosi G, Grohmann U, Talesa VN, Donti E, Puccetti P, Fallarino F.

J Cell Mol Med. 2015 Jul;19(7):1593-605. doi: 10.1111/jcmm.12534. Epub 2015 Mar 17.

28.

The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals.

Grohmann U, Puccetti P.

Front Immunol. 2015 Feb 12;6:58. doi: 10.3389/fimmu.2015.00058. eCollection 2015. No abstract available.

29.

Ligand binding and functional selectivity of L-tryptophan metabolites at the mouse aryl hydrocarbon receptor (mAhR).

Nuti R, Gargaro M, Matino D, Dolciami D, Grohmann U, Puccetti P, Fallarino F, Macchiarulo A.

J Chem Inf Model. 2014 Dec 22;54(12):3373-83. doi: 10.1021/ci5005459. Epub 2014 Nov 21.

PMID:
25402742
30.

LPS-conditioned dendritic cells confer endotoxin tolerance contingent on tryptophan catabolism.

Fallarino F, Pallotta MT, Matino D, Gargaro M, Orabona C, Vacca C, Mondanelli G, Allegrucci M, Boon L, Romani R, Talesa VN, Puccetti P, Grohmann U.

Immunobiology. 2015 Feb;220(2):315-21. doi: 10.1016/j.imbio.2014.09.017. Epub 2014 Sep 28.

PMID:
25278421
31.

Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes.

Pallotta MT, Orabona C, Bianchi R, Vacca C, Fallarino F, Belladonna ML, Volpi C, Mondanelli G, Gargaro M, Allegrucci M, Talesa VN, Puccetti P, Grohmann U.

J Cell Mol Med. 2014 Oct;18(10):2082-91. doi: 10.1111/jcmm.12360. Epub 2014 Sep 12.

32.

Aryl hydrocarbon receptor control of a disease tolerance defence pathway.

Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P.

Nature. 2014 Jul 10;511(7508):184-90. doi: 10.1038/nature13323.

33.

Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents.

Belladonna ML, Grohmann U.

Biotechnol Genet Eng Rev. 2013;29:149-74. doi: 10.1080/02648725.2013.801228. Epub 2013 Aug 2. Review.

PMID:
24568278
34.

Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival.

Bock F, Rössner S, Onderka J, Lechmann M, Pallotta MT, Fallarino F, Boon L, Nicolette C, DeBenedette MA, Tcherepanova IY, Grohmann U, Steinkasserer A, Cursiefen C, Zinser E.

J Immunol. 2013 Aug 15;191(4):1965-75. doi: 10.4049/jimmunol.1201531. Epub 2013 Jul 12.

35.

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9-TRIF pathway.

Volpi C, Fallarino F, Pallotta MT, Bianchi R, Vacca C, Belladonna ML, Orabona C, De Luca A, Boon L, Romani L, Grohmann U, Puccetti P.

Nat Commun. 2013;4:1852. doi: 10.1038/ncomms2874.

PMID:
23673637
36.

Indoleamine 2,3-dioxygenase: from catalyst to signaling function.

Fallarino F, Grohmann U, Puccetti P.

Eur J Immunol. 2012 Aug;42(8):1932-7. doi: 10.1002/eji.201242572. Review.

37.

A GpC-rich oligonucleotide acts on plasmacytoid dendritic cells to promote immune suppression.

Volpi C, Fallarino F, Bianchi R, Orabona C, De Luca A, Vacca C, Romani L, Gran B, Grohmann U, Puccetti P, Belladonna ML.

J Immunol. 2012 Sep 1;189(5):2283-9. doi: 10.4049/jimmunol.1200497. Epub 2012 Jul 27.

38.

Different partners, opposite outcomes: a new perspective of the immunobiology of indoleamine 2,3-dioxygenase.

Orabona C, Pallotta MT, Grohmann U.

Mol Med. 2012 Jul 18;18:834-42. doi: 10.2119/molmed.2012.00029. Review.

39.

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells.

Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, Servillo G, Brunacci C, Calvitti M, Bicciato S, Mazza EM, Boon L, Grassi F, Fioretti MC, Fallarino F, Puccetti P, Grohmann U.

Nat Immunol. 2011 Jul 31;12(9):870-8. doi: 10.1038/ni.2077.

PMID:
21804557
40.

Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions.

Fallarino F, Grohmann U.

Curr Med Chem. 2011;18(15):2215-21. doi: 0929-8673/11 $58.00+.00. Review.

PMID:
21517758
41.

EMBO workshop on immunology and metabolism.

Staels B, Dombrowicz D, Grohmann U.

EMBO Rep. 2011 May;12(5):386-8. doi: 10.1038/embor.2011.68. Epub 2011 Apr 15.

42.

Xenograft of microencapsulated sertoli cells reverses T1DM in NOD mice by inducing neogenesis of beta-cells.

Luca G, Fallarino F, Calvitti M, Mancuso F, Nastruzzi C, Arato I, Falabella G, Grohmann U, Becchetti E, Puccetti P, Calafiore R.

Transplantation. 2010 Dec 27;90(12):1352-7.

PMID:
21197711
43.

Indoleamine 2,3-dioxygenase and regulatory function: tryptophan starvation and beyond.

Orabona C, Grohmann U.

Methods Mol Biol. 2011;677:269-80. doi: 10.1007/978-1-60761-869-0_19.

PMID:
20941617
44.

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

Fallarino F, Volpi C, Fazio F, Notartomaso S, Vacca C, Busceti C, Bicciato S, Battaglia G, Bruno V, Puccetti P, Fioretti MC, Nicoletti F, Grohmann U, Di Marco R.

Nat Med. 2010 Aug;16(8):897-902. doi: 10.1038/nm.2183. Epub 2010 Jul 25.

PMID:
20657581
45.

Control of immune response by amino acid metabolism.

Grohmann U, Bronte V.

Immunol Rev. 2010 Jul;236:243-64. doi: 10.1111/j.1600-065X.2010.00915.x. Review.

PMID:
20636821
46.

Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8 Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3).

Pallotta MT, Orabona C, Volpi C, Grohmann U, Puccetti P, Fallarino F.

Int J Tryptophan Res. 2010;3:91-7. Epub 2010 Jun 10.

47.

IDO mediates TLR9-driven protection from experimental autoimmune diabetes.

Fallarino F, Volpi C, Zelante T, Vacca C, Calvitti M, Fioretti MC, Puccetti P, Romani L, Grohmann U.

J Immunol. 2009 Nov 15;183(10):6303-12. doi: 10.4049/jimmunol.0901577. Epub 2009 Oct 19. Erratum in: J Immunol. 2010 Jun 15;184(12):7316.

48.

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

Fallarino F, Luca G, Calvitti M, Mancuso F, Nastruzzi C, Fioretti MC, Grohmann U, Becchetti E, Burgevin A, Kratzer R, van Endert P, Boon L, Puccetti P, Calafiore R.

J Exp Med. 2009 Oct 26;206(11):2511-26. doi: 10.1084/jem.20090134. Epub 2009 Oct 12.

49.

TGF-beta and kynurenines as the key to infectious tolerance.

Belladonna ML, Orabona C, Grohmann U, Puccetti P.

Trends Mol Med. 2009 Feb;15(2):41-9. doi: 10.1016/j.molmed.2008.11.006. Epub 2009 Jan 21.

PMID:
19162548
50.

SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.

Orabona C, Pallotta MT, Volpi C, Fallarino F, Vacca C, Bianchi R, Belladonna ML, Fioretti MC, Grohmann U, Puccetti P.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20828-33. doi: 10.1073/pnas.0810278105. Epub 2008 Dec 16.

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