Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 107


Pillars Article: Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. 1999. 285: 727-729.

Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T.

J Immunol. 2018 Apr 1;200(7):2231-2233. No abstract available.


Soluble MICB in Plasma and Urine Explains Population Expansions of NKG2D+CD4 T Cells Inpatients with Juvenile-Onset Systemic Lupus Erythematosus.

Hamada S, Caballero-Benitez A, Duran KL, Stevens AM, Spies T, Groh V.

Open J Immunol. 2017 Mar;7(1):1-17. doi: 10.4236/oji.2017.71001. Epub 2017 Mar 29.


MICA-Expressing Monocytes Enhance Natural Killer Cell Fc Receptor-Mediated Antitumor Functions.

Campbell AR, Duggan MC, Suarez-Kelly LP, Bhave N, Opheim KS, McMichael EL, Trikha P, Parihar R, Luedke E, Lewis A, Yung B, Lee R, Raulet D, Tridandapani S, Groh V, Yu L, Yildiz V, Byrd JC, Caligiuri MA, Carson WE 3rd.

Cancer Immunol Res. 2017 Sep;5(9):778-789. doi: 10.1158/2326-6066.CIR-16-0005. Epub 2017 Jul 19.


Control of Tumor Initiation by NKG2D Naturally Expressed on Ovarian Cancer Cells.

Cai X, Caballero-Benitez A, Gewe MM, Jenkins IC, Drescher CW, Strong RK, Spies T, Groh V.

Neoplasia. 2017 Jun;19(6):471-482. doi: 10.1016/j.neo.2017.03.005. Epub 2017 May 9.


Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts.

Vasu S, He S, Cheney C, Gopalakrishnan B, Mani R, Lozanski G, Mo X, Groh V, Whitman SP, Konopitzky R, Kössl C, Bucci D, Lucas DM, Yu J, Caligiuri MA, Blum W, Adam PJ, Borges E, Rueter B, Heider KH, Marcucci G, Muthusamy N.

Blood. 2016 Jun 9;127(23):2879-89. doi: 10.1182/blood-2015-11-680546. Epub 2016 Mar 24.


Autonomous stimulation of cancer cell plasticity by the human NKG2D lymphocyte receptor coexpressed with its ligands on cancer cells.

Cai X, Dai Z, Reeves RS, Caballero-Benitez A, Duran KL, Delrow JJ, Porter PL, Spies T, Groh V.

PLoS One. 2014 Oct 7;9(10):e108942. doi: 10.1371/journal.pone.0108942. eCollection 2014.


Soluble major histocompatibility complex class I-related chain B molecules are increased and correlate with clinical outcomes during rhinovirus infection in healthy subjects.

Telcian AG, Zdrenghea MT, Caramori G, Laza-Stanca V, Message SD, Kebadze T, Kon OM, Groh V, Papi A, Johnston SL, Mallia P, Stanciu LA.

Chest. 2014 Jul;146(1):32-40. doi: 10.1378/chest.13-2247.


Effects on tumor development and metastatic dissemination by the NKG2D lymphocyte receptor expressed on cancer cells.

El-Gazzar A, Cai X, Reeves RS, Dai Z, Caballero-Benitez A, McDonald DL, Vazquez J, Gooley TA, Sale GE, Spies T, Groh V.

Oncogene. 2014 Oct 9;33(41):4932-40. doi: 10.1038/onc.2013.435. Epub 2013 Oct 21.


Interleukin 15 primes natural killer cells to kill via NKG2D and cPLA2 and this pathway is active in psoriatic arthritis.

Tang F, Sally B, Ciszewski C, Abadie V, Curran SA, Groh V, Fitzgerald O, Winchester RJ, Jabri B.

PLoS One. 2013 Sep 25;8(9):e76292. doi: 10.1371/journal.pone.0076292. eCollection 2013.


Immunobiology and conflicting roles of the human NKG2D lymphocyte receptor and its ligands in cancer.

El-Gazzar A, Groh V, Spies T.

J Immunol. 2013 Aug 15;191(4):1509-15. doi: 10.4049/jimmunol.1301071. Review.


Expression of ERp5 and GRP78 on the membrane of chronic lymphocytic leukemia cells: association with soluble MICA shedding.

Huergo-Zapico L, Gonzalez-Rodriguez AP, Contesti J, Gonzalez E, López-Soto A, Fernandez-Guizan A, Acebes-Huerta A, de Los Toyos JR, Lopez-Larrea C, Groh V, Spies T, Gonzalez S.

Cancer Immunol Immunother. 2012 Aug;61(8):1201-10. doi: 10.1007/s00262-011-1195-z. Epub 2012 Jan 4.


RSV infection modulates IL-15 production and MICA levels in respiratory epithelial cells.

Zdrenghea MT, Telcian AG, Laza-Stanca V, Bellettato CM, Edwards MR, Nikonova A, Khaitov MR, Azimi N, Groh V, Mallia P, Johnston SL, Stanciu LA.

Eur Respir J. 2012 Mar;39(3):712-20. doi: 10.1183/09031936.00099811. Epub 2011 Aug 18.


Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells.

Benitez AC, Dai Z, Mann HH, Reeves RS, Margineantu DH, Gooley TA, Groh V, Spies T.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4081-6. doi: 10.1073/pnas.1018603108. Epub 2011 Feb 14.


Crystal structure of a gammadelta T-cell receptor specific for the human MHC class I homolog MICA.

Xu B, Pizarro JC, Holmes MA, McBeth C, Groh V, Spies T, Strong RK.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2414-9. doi: 10.1073/pnas.1015433108. Epub 2011 Jan 24.


NKG2D initiates caspase-mediated CD3zeta degradation and lymphocyte receptor impairments associated with human cancer and autoimmune disease.

Hanaoka N, Jabri B, Dai Z, Ciszewski C, Stevens AM, Yee C, Nakakuma H, Spies T, Groh V.

J Immunol. 2010 Nov 15;185(10):5732-42. doi: 10.4049/jimmunol.1002092. Epub 2010 Oct 6.


Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins.

Sester M, Koebernick K, Owen D, Ao M, Bromberg Y, May E, Stock E, Andrews L, Groh V, Spies T, Steinle A, Menz B, Burgert HG.

J Immunol. 2010 Jan 1;184(1):255-67. doi: 10.4049/jimmunol.0902343. Epub 2009 Nov 30.


NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo.

Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya A, Carbone E, Colucci F.

J Clin Invest. 2009 May;119(5):1251-63. doi: 10.1172/JCI36022. Epub 2009 Apr 6.


Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus.

Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V.

J Exp Med. 2009 Apr 13;206(4):793-805. doi: 10.1084/jem.20081648. Epub 2009 Mar 16.


Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15.

Tang F, Chen Z, Ciszewski C, Setty M, Solus J, Tretiakova M, Ebert E, Han J, Lin A, Guandalini S, Groh V, Spies T, Green P, Jabri B.

J Exp Med. 2009 Mar 16;206(3):707-19. doi: 10.1084/jem.20071887. Epub 2009 Feb 23.


Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.

McSharry BP, Burgert HG, Owen DP, Stanton RJ, Prod'homme V, Sester M, Koebernick K, Groh V, Spies T, Cox S, Little AM, Wang EC, Tomasec P, Wilkinson GW.

J Virol. 2008 May;82(9):4585-94. doi: 10.1128/JVI.02251-07. Epub 2008 Feb 20.


Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands.

Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, Strong RK, Groh V, Spies T.

Nature. 2007 May 24;447(7143):482-6. Epub 2007 May 9.


Adenovirus vector delivery stimulates natural killer cell recognition.

Tomasec P, Wang EC, Groh V, Spies T, McSharry BP, Aicheler RJ, Stanton RJ, Wilkinson GW.

J Gen Virol. 2007 Apr;88(Pt 4):1103-8.


Expression of nonclassical class I molecules by intestinal epithelial cells.

Perera L, Shao L, Patel A, Evans K, Meresse B, Blumberg R, Geraghty D, Groh V, Spies T, Jabri B, Mayer L.

Inflamm Bowel Dis. 2007 Mar;13(3):298-307.


Fas-ligand-mediated paracrine T cell regulation by the receptor NKG2D in tumor immunity.

Groh V, Smythe K, Dai Z, Spies T.

Nat Immunol. 2006 Jul;7(7):755-62. Epub 2006 May 28. Erratum in: Nat Immunol. 2006 Sep;7(9):1004.


Natural cytotoxicity receptors: influenza virus in the spotlight.

Spies T, Groh V.

Nat Immunol. 2006 May;7(5):443-4. No abstract available.


Clinicopathological significance of major histocompatibility complex class I-related chain a and B expression in thyroid cancer.

Xu X, Rao G, Gaffud MJ, Ding HG, Maki G, Klingemann HG, Groh V, Spies T, Caillat-Zucman S, Gattuso P, Plate J, Prinz RA.

J Clin Endocrinol Metab. 2006 Jul;91(7):2704-12. Epub 2006 Apr 18.


Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.

Azimi N, Jacobson S, Tanaka Y, Corey L, Groh V, Spies T.

Immunogenetics. 2006 May;58(4):252-8. Epub 2006 Mar 28.


Immunobiology of human NKG2D and its ligands.

González S, Groh V, Spies T.

Curr Top Microbiol Immunol. 2006;298:121-38. Review.


MICA expressed by multiple myeloma and monoclonal gammopathy of undetermined significance plasma cells Costimulates pamidronate-activated gammadelta lymphocytes.

Girlanda S, Fortis C, Belloni D, Ferrero E, Ticozzi P, Sciorati C, Tresoldi M, Vicari A, Spies T, Groh V, Caligaris-Cappio F, Ferrarini M.

Cancer Res. 2005 Aug 15;65(16):7502-8.


Efficient cross-priming of tumor antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells.

Groh V, Li YQ, Cioca D, Hunder NN, Wang W, Riddell SR, Yee C, Spies T.

Proc Natl Acad Sci U S A. 2005 May 3;102(18):6461-6. Epub 2005 Apr 11.


Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

Meresse B, Chen Z, Ciszewski C, Tretiakova M, Bhagat G, Krausz TN, Raulet DH, Lanier LL, Groh V, Spies T, Ebert EC, Green PH, Jabri B.

Immunity. 2004 Sep;21(3):357-66.


HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells.

Carbone E, Neri P, Mesuraca M, Fulciniti MT, Otsuki T, Pende D, Groh V, Spies T, Pollio G, Cosman D, Catalano L, Tassone P, Rotoli B, Venuta S.

Blood. 2005 Jan 1;105(1):251-8. Epub 2004 Aug 24.


Autocrine/paracrine IL-15 that is required for type I IFN-mediated dendritic cell expression of MHC class I-related chain A and B is impaired in hepatitis C virus infection.

Jinushi M, Takehara T, Tatsumi T, Kanto T, Groh V, Spies T, Suzuki T, Miyagi T, Hayashi N.

J Immunol. 2003 Nov 15;171(10):5423-9.


Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium.

Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki J, Kiyono H.

J Immunol. 2003 Oct 15;171(8):4131-9.


Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.

Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9452-7. Epub 2003 Jul 23.


Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.

Jinushi M, Takehara T, Tatsumi T, Kanto T, Groh V, Spies T, Kimura R, Miyagi T, Mochizuki K, Sasaki Y, Hayashi N.

Int J Cancer. 2003 Apr 10;104(3):354-61.


Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.

Jinushi M, Takehara T, Kanto T, Tatsumi T, Groh V, Spies T, Miyagi T, Suzuki T, Sasaki Y, Hayashi N.

J Immunol. 2003 Feb 1;170(3):1249-56.


Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.

Groh V, Wu J, Yee C, Spies T.

Nature. 2002 Oct 17;419(6908):734-8.


Expression of stress-induced MHC class I related chain molecules on human melanoma.

Vetter CS, Groh V, thor Straten P, Spies T, Bröcker EB, Becker JC.

J Invest Dermatol. 2002 Apr;118(4):600-5.


MIC expression in renal and pancreatic allografts.

Hankey KG, Drachenberg CB, Papadimitriou JC, Klassen DK, Philosophe B, Bartlett ST, Groh V, Spies T, Mann DL.

Transplantation. 2002 Jan 27;73(2):304-6.


NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment.

Roberts AI, Lee L, Schwarz E, Groh V, Spies T, Ebert EC, Jabri B.

J Immunol. 2001 Nov 15;167(10):5527-30.


Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.

Steinle A, Li P, Morris DL, Groh V, Lanier LL, Strong RK, Spies T.

Immunogenetics. 2001 May-Jun;53(4):279-87.


MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function.

Das H, Groh V, Kuijl C, Sugita M, Morita CT, Spies T, Bukowski JF.

Immunity. 2001 Jul;15(1):83-93.


Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC induced on virus-infected cells.

Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T.

Nat Immunol. 2001 Mar;2(3):255-60.


A single amino acid substitution causes loss of expression of a MICA allele.

Li Z, Groh V, Strong RK, Spies T.

Immunogenetics. 2000 Mar;51(3):246-8. No abstract available.


Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA.

Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T.

Science. 1999 Jul 30;285(5428):727-9.

Supplemental Content

Support Center