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Items: 1 to 50 of 55

1.

A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155.

Husain B, Ramani SR, Chiang E, Lehoux I, Paduchuri S, Arena TA, Patel A, Wilson B, Chan P, Franke Y, Wong AW, Lill JR, Turley SJ, Gonzalez LC, Grogan JL, Martinez-Martin N.

Mol Cell Proteomics. 2019 Jul 15. pii: mcp.TIR119.001433. doi: 10.1074/mcp.TIR119.001433. [Epub ahead of print]

2.

Regulation of Tumor-Associated Myeloid Cell Activity by CBP/EP300 Bromodomain Modulation of H3K27 Acetylation.

de Almeida Nagata DE, Chiang EY, Jhunjhunwala S, Caplazi P, Arumugam V, Modrusan Z, Chan E, Merchant M, Jin L, Arnott D, Romero FA, Magnuson S, Gascoigne KE, Grogan JL.

Cell Rep. 2019 Apr 2;27(1):269-281.e4. doi: 10.1016/j.celrep.2019.03.008.

3.

CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1.

Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu TD, Harden Bowles K, Arumugam V, Schartner J, Cubas R, Mittman S, Javinal V, Anderson KR, Warming S, Grogan JL, Chiang EY.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11731-E11740. doi: 10.1073/pnas.1814052115. Epub 2018 Nov 30.

4.

Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer.

Wu P, Sneeringer CJ, Pitts KE, Day ES, Chan BK, Wei B, Lehoux I, Mortara K, Li H, Wu J, Franke Y, Moffat JG, Grogan JL, Heffron TP, Wang W.

Structure. 2019 Jan 2;27(1):125-133.e4. doi: 10.1016/j.str.2018.10.025. Epub 2018 Nov 29.

PMID:
30503777
5.

The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function.

Hernandez S, Qing J, Thibodeau RH, Du X, Park S, Lee HM, Xu M, Oh S, Navarro A, Roose-Girma M, Newman RJ, Warming S, Nannini M, Sampath D, Kim JM, Grogan JL, Mellman I.

Cell Rep. 2018 Oct 2;25(1):80-94. doi: 10.1016/j.celrep.2018.09.012.

6.

Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing.

Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R.

JCI Insight. 2018 Jul 12;3(13). pii: 120546. doi: 10.1172/jci.insight.120546.

7.

GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).

Romero FA, Murray J, Lai KW, Tsui V, Albrecht BK, An L, Beresini MH, de Leon Boenig G, Bronner SM, Chan EW, Chen KX, Chen Z, Choo EF, Clagg K, Clark K, Crawford TD, Cyr P, de Almeida Nagata D, Gascoigne KE, Grogan JL, Hatzivassiliou G, Huang W, Hunsaker TL, Kaufman S, Koenig SG, Li R, Li Y, Liang X, Liao J, Liu W, Ly J, Maher J, Masui C, Merchant M, Ran Y, Taylor AM, Wai J, Wang F, Wei X, Yu D, Zhu BY, Zhu X, Magnuson S.

J Med Chem. 2017 Nov 22;60(22):9162-9183. doi: 10.1021/acs.jmedchem.7b00796. Epub 2017 Sep 21.

PMID:
28892380
8.

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE.

Li T, Lu G, Chiang EY, Chernov-Rogan T, Grogan JL, Chen J.

PLoS One. 2017 Jul 6;12(7):e0180154. doi: 10.1371/journal.pone.0180154. eCollection 2017.

9.

New Cancer Immunotherapy Agents in Development: a report from an associated program of the 31stAnnual Meeting of the Society for Immunotherapy of Cancer, 2016.

Adusumilli PS, Cha E, Cornfeld M, Davis T, Diab A, Dubensky TW Jr, Evans E, Grogan JL, Irving BA, Leidner RS, Olwill SA, Soon-Shiong P, Triebel F, Tuck D, Bot A, Dansey RD, Drake CG, Freeman GJ, Ibrahim R, Patel S, Chen DS.

J Immunother Cancer. 2017 Jun 20;5:50. doi: 10.1186/s40425-017-0253-2. eCollection 2017. Review.

10.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.

Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL.

Nat Commun. 2017 Mar 1;8:14644. doi: 10.1038/ncomms14644.

11.

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle.

Manieri NA, Chiang EY, Grogan JL.

Trends Immunol. 2017 Jan;38(1):20-28. doi: 10.1016/j.it.2016.10.002. Epub 2016 Oct 25. Review.

PMID:
27793572
12.

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.

Ghosh S, Taylor A, Chin M, Huang HR, Conery AR, Mertz JA, Salmeron A, Dakle PJ, Mele D, Cote A, Jayaram H, Setser JW, Poy F, Hatzivassiliou G, DeAlmeida-Nagata D, Sandy P, Hatton C, Romero FA, Chiang E, Reimer T, Crawford T, Pardo E, Watson VG, Tsui V, Cochran AG, Zawadzke L, Harmange JC, Audia JE, Bryant BM, Cummings RT, Magnuson SR, Grogan JL, Bellon SF, Albrecht BK, Sims RJ 3rd, Lora JM.

J Biol Chem. 2016 Jun 17;291(25):13014-27. doi: 10.1074/jbc.M115.708560. Epub 2016 Apr 7.

13.

TIGIT Enhances Antigen-Specific Th2 Recall Responses and Allergic Disease.

Kourepini E, Paschalidis N, Simoes DC, Aggelakopoulou M, Grogan JL, Panoutsakopoulou V.

J Immunol. 2016 May 1;196(9):3570-80. doi: 10.4049/jimmunol.1501591. Epub 2016 Mar 25.

14.

Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics.

Bumbaca Yadav D, Sharma VK, Boswell CA, Hotzel I, Tesar D, Shang Y, Ying Y, Fischer SK, Grogan JL, Chiang EY, Urban K, Ulufatu S, Khawli LA, Prabhu S, Joseph S, Kelley RF.

J Biol Chem. 2015 Dec 11;290(50):29732-41. doi: 10.1074/jbc.M115.692434. Epub 2015 Oct 21.

15.

The checkpoint inhibitor TIGIT limits antitumor and antiviral CD8+ T cell responses.

Johnston RJ, Yu X, Grogan JL.

Oncoimmunology. 2015 May 27;4(9):e1036214. eCollection 2015 Sep.

16.

The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function.

Johnston RJ, Comps-Agrar L, Hackney J, Yu X, Huseni M, Yang Y, Park S, Javinal V, Chiu H, Irving B, Eaton DL, Grogan JL.

Cancer Cell. 2014 Dec 8;26(6):923-937. doi: 10.1016/j.ccell.2014.10.018. Epub 2014 Nov 26.

17.

Efficacy and safety of pateclizumab (anti-lymphotoxin-α) compared to adalimumab in rheumatoid arthritis: a head-to-head phase 2 randomized controlled study (The ALTARA Study).

Kennedy WP, Simon JA, Offutt C, Horn P, Herman A, Townsend MJ, Tang MT, Grogan JL, Hsieh F, Davis JC.

Arthritis Res Ther. 2014 Oct 30;16(5):467. doi: 10.1186/s13075-014-0467-3.

18.

EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells.

Chiang EY, Johnston RJ, Grogan JL.

PLoS One. 2013 Dec 26;8(12):e83457. doi: 10.1371/journal.pone.0083457. eCollection 2013.

19.

Dimerization of LTβR by LTα1β2 is necessary and sufficient for signal transduction.

Sudhamsu J, Yin J, Chiang EY, Starovasnik MA, Grogan JL, Hymowitz SG.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19896-901. doi: 10.1073/pnas.1310838110. Epub 2013 Nov 18.

20.

TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.

Yu X, Pappu R, Ramirez-Carrozzi V, Ota N, Caplazi P, Zhang J, Yan D, Xu M, Lee WP, Grogan JL.

Mucosal Immunol. 2014 May;7(3):730-40. doi: 10.1038/mi.2013.92. Epub 2013 Nov 13.

21.

Controlling herpetic stromal keratitis by modulating lymphotoxin-alpha-mediated inflammatory pathways.

Veiga-Parga T, Giménez F, Mulik S, Chiang EY, Grogan JL, Rouse BT.

Microbes Infect. 2013 Sep-Oct;15(10-11):677-87. doi: 10.1016/j.micinf.2013.07.001. Epub 2013 Jul 10.

22.

A role for Th17 cells in the regulation of tertiary lymphoid follicles.

Grogan JL, Ouyang W.

Eur J Immunol. 2012 Sep;42(9):2255-62. doi: 10.1002/eji.201242656. Review.

23.

In vivo depletion of lymphotoxin-alpha expressing lymphocytes inhibits xenogeneic graft-versus-host-disease.

Chiang EY, Kolumam G, McCutcheon KM, Young J, Lin Z, Balazs M, Grogan JL.

PLoS One. 2012;7(3):e33106. doi: 10.1371/journal.pone.0033106. Epub 2012 Mar 12.

24.

Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.

Stengel KF, Harden-Bowles K, Yu X, Rouge L, Yin J, Comps-Agrar L, Wiesmann C, Bazan JF, Eaton DL, Grogan JL.

Proc Natl Acad Sci U S A. 2012 Apr 3;109(14):5399-404. doi: 10.1073/pnas.1120606109. Epub 2012 Mar 15.

25.

Safety, pharmacokinetics, and biologic activity of pateclizumab, a novel monoclonal antibody targeting lymphotoxin α: results of a phase I randomized, placebo-controlled trial.

Emu B, Luca D, Offutt C, Grogan JL, Rojkovich B, Williams MB, Tang MT, Xiao J, Lee JH, Davis JC.

Arthritis Res Ther. 2012 Jan 8;14(1):R6. doi: 10.1186/ar3554.

26.

Tube feeding therapy in paediatric Crohn's disease.

Terry A, Grogan JL, Casson DH, Dalzell AM, El-Matary W.

Aliment Pharmacol Ther. 2011 Jul;34(2):260-1; author reply 261. doi: 10.1111/j.1365-2036.2011.04720.x. No abstract available.

27.

Enteral feeding therapy for newly diagnosed pediatric Crohn's disease: a double-blind randomized controlled trial with two years follow-up.

Grogan JL, Casson DH, Terry A, Burdge GC, El-Matary W, Dalzell AM.

Inflamm Bowel Dis. 2012 Feb;18(2):246-53. doi: 10.1002/ibd.21690. Epub 2011 Mar 18.

PMID:
21425210
28.

Resurrection of a clinical antibody: template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody.

Castellana NE, McCutcheon K, Pham VC, Harden K, Nguyen A, Young J, Adams C, Schroeder K, Arnott D, Bafna V, Grogan JL, Lill JR.

Proteomics. 2011 Feb;11(3):395-405. doi: 10.1002/pmic.201000487. Epub 2011 Jan 5.

29.
30.

Lymphotoxin-alphabeta heterotrimers are cleaved by metalloproteinases and contribute to synovitis in rheumatoid arthritis.

Young J, Yu X, Wolslegel K, Nguyen A, Kung C, Chiang E, Kolumam G, Wei N, Wong WL, DeForge L, Townsend MJ, Grogan JL.

Cytokine. 2010 Jul;51(1):78-86. doi: 10.1016/j.cyto.2010.03.003. Epub 2010 Mar 31.

PMID:
20356761
31.

Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease.

Chiang EY, Kolumam GA, Yu X, Francesco M, Ivelja S, Peng I, Gribling P, Shu J, Lee WP, Refino CJ, Balazs M, Paler-Martinez A, Nguyen A, Young J, Barck KH, Carano RA, Ferrando R, Diehl L, Chatterjea D, Grogan JL.

Nat Med. 2009 Jul;15(7):766-73. doi: 10.1038/nm.1984. Epub 2009 Jun 28.

PMID:
19561618
32.

Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells.

Cupedo T, Crellin NK, Papazian N, Rombouts EJ, Weijer K, Grogan JL, Fibbe WE, Cornelissen JJ, Spits H.

Nat Immunol. 2009 Jan;10(1):66-74. doi: 10.1038/ni.1668. Epub 2008 Nov 23.

PMID:
19029905
33.

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H, Eaton D, Grogan JL.

Nat Immunol. 2009 Jan;10(1):48-57. doi: 10.1038/ni.1674. Epub 2008 Nov 16.

PMID:
19011627
34.

Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

Fitzsimmons CM, Stewart TJ, Hoffmann KF, Grogan JL, Yazdanbakhsh M, Dunne DW.

Parasite Immunol. 2004 Aug-Sep;26(8-9):371-6.

35.

Th2 cells: orchestrating barrier immunity.

Stetson DB, Voehringer D, Grogan JL, Xu M, Reinhardt RL, Scheu S, Kelly BL, Locksley RM.

Adv Immunol. 2004;83:163-89. Review. No abstract available.

PMID:
15135631
36.

Basal chromatin modification at the IL-4 gene in helper T cells.

Grogan JL, Wang ZE, Stanley S, Harmon B, Loots GG, Rubin EM, Locksley RM.

J Immunol. 2003 Dec 15;171(12):6672-9.

37.

Diesel particulate matter exposure to railroad train crews.

Liukonen LR, Grogan JL, Myers W.

AIHA J (Fairfax, Va). 2002 Sep-Oct;63(5):610-6.

PMID:
12529916
38.

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment.

Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA.

Nat Immunol. 2003 Feb;4(2):182-8. Epub 2003 Jan 13.

PMID:
12524538
39.

T helper cell differentiation: on again, off again.

Grogan JL, Locksley RM.

Curr Opin Immunol. 2002 Jun;14(3):366-72. Review.

PMID:
11973136
40.

Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes.

Davies SJ, Grogan JL, Blank RB, Lim KC, Locksley RM, McKerrow JH.

Science. 2001 Nov 9;294(5545):1358-61.

41.

Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM.

Immunity. 2001 Mar;14(3):205-15.

42.

Effect of localized cytokine dysregulation: accelerated rejection of IL-2-expressing skin grafts.

Blackburn C, Grogan JL, Augustine CL, Miller JF, Varigos G, Morahan G.

Immunol Cell Biol. 2001 Apr;79(2):128-31.

PMID:
11264705
43.

Chronic schistosomiasis: dendritic cells generated from patients can overcome antigen-specific T cell hyporesponsiveness.

van Den Biggelaar AH, Grogan JL, Filié Y, Jordens R, Kremsner PG, Koning F, Yazdanbakhsh M.

J Infect Dis. 2000 Jul;182(1):260-5. Epub 2000 Jun 29.

PMID:
10882605
44.

Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice.

Grogan JL, Kramer A, Nogai A, Dong L, Ohde M, Schneider-Mergener J, Kamradt T.

J Immunol. 1999 Oct 1;163(7):3764-70.

45.

T1/ST2 expression is enhanced on CD4+ T cells from schistosome egg-induced granulomas: analysis of Th cell cytokine coexpression ex vivo.

Löhning M, Grogan JL, Coyle AJ, Yazdanbakhsh M, Meisel C, Gutierrez-Ramos JC, Radbruch A, Kamradt T.

J Immunol. 1999 Apr 1;162(7):3882-9.

46.

The effect of anti-IL-10 on proliferation and cytokine production in human schistosomiasis: fresh versus cryopreserved cells.

Grogan JL, Kremsner PG, Deelder AM, Yazdanbakhsh M.

Parasite Immunol. 1998 Jul;20(7):345-9.

47.

T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function.

Löhning M, Stroehmann A, Coyle AJ, Grogan JL, Lin S, Gutierrez-Ramos JC, Levinson D, Radbruch A, Kamradt T.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6930-5.

48.
49.

Anti-schistosome IgG4 and IgE at 2 years after chemotherapy: infected versus uninfected individuals.

Grogan JL, Kremsner PG, van Dam GJ, Deelder AM, Yazdanbakhsh M.

J Infect Dis. 1997 Nov;176(5):1344-50.

PMID:
9359737
50.

Elevated proliferation and interleukin-4 release from CD4+ cells after chemotherapy in human Schistosoma haematobium infection.

Grogan JL, Kremsner PG, Deelder AM, Yazdanbakhsh M.

Eur J Immunol. 1996 Jun;26(6):1365-70.

PMID:
8647218

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