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Items: 1 to 50 of 152

1.

Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity.

Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M.

EMBO Rep. 2018 Oct 2. pii: e46512. doi: 10.15252/embr.201846512. [Epub ahead of print]

PMID:
30279279
2.

On the role of the immunoproteasome in transplant rejection.

Basler M, Li J, Groettrup M.

Immunogenetics. 2018 Sep 15. doi: 10.1007/s00251-018-1084-0. [Epub ahead of print] Review.

PMID:
30220008
3.

The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.

Aichem A, Anders S, Catone N, Rößler P, Stotz S, Berg A, Schwab R, Scheuermann S, Bialas J, Schütz-Stoffregen MC, Schmidtke G, Peter C, Groettrup M, Wiesner S.

Nat Commun. 2018 Aug 20;9(1):3321. doi: 10.1038/s41467-018-05776-3.

4.

Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.

Treise I, Huber EM, Klein-Rodewald T, Heinemeyer W, Grassmann SA, Basler M, Adler T, Rathkolb B, Helming L, Andres C, Klaften M, Landbrecht C, Wieland T, Strom TM, McCoy KD, Macpherson AJ, Wolf E, Groettrup M, Ollert M, Neff F, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Groll M, Busch DH.

Sci Rep. 2018 Apr 13;8(1):5975. doi: 10.1038/s41598-018-24199-0.

5.

The expression profile of the ubiquitin-like modifier FAT10 in immune cells suggests cell type-specific functions.

Schregle R, Mah MM, Mueller S, Aichem A, Basler M, Groettrup M.

Immunogenetics. 2018 Jul;70(7):429-438. doi: 10.1007/s00251-018-1055-5. Epub 2018 Mar 5.

PMID:
29508036
6.

Immunoproteasome inhibition prevents chronic antibody-mediated allograft rejection in renal transplantation.

Li J, Basler M, Alvarez G, Brunner T, Kirk CJ, Groettrup M.

Kidney Int. 2018 Mar;93(3):670-680. doi: 10.1016/j.kint.2017.09.023. Epub 2017 Dec 8.

PMID:
29229189
7.

The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10.

Schmidtke G, Schregle R, Alvarez G, Huber EM, Groettrup M.

Mol Immunol. 2017 Dec 2. pii: S0161-5890(17)30593-X. doi: 10.1016/j.molimm.2017.11.030. [Epub ahead of print]

PMID:
29208314
8.

The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T cell repertoire.

Basler M, Mundt S, Groettrup M.

Eur J Immunol. 2018 Mar;48(3):419-429. doi: 10.1002/eji.201747282. Epub 2017 Nov 10.

PMID:
29067678
9.

Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome.

Basler M, Maurits E, de Bruin G, Koerner J, Overkleeft HS, Groettrup M.

Br J Pharmacol. 2018 Jan;175(1):38-52. doi: 10.1111/bph.14069. Epub 2017 Nov 29.

PMID:
29034459
10.

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice.

Koerner J, Brunner T, Groettrup M.

Oncotarget. 2017 Feb 7;8(31):50873-50888. doi: 10.18632/oncotarget.15141. eCollection 2017 Aug 1.

11.

No prolongation of skin allograft survival by immunoproteasome inhibition in mice.

Mundt S, Basler M, Sawitzki B, Groettrup M.

Mol Immunol. 2017 Aug;88:32-37. doi: 10.1016/j.molimm.2017.05.022. Epub 2017 Jun 2.

PMID:
28582644
12.

Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma.

Sommershof A, Scheuermann L, Koerner J, Groettrup M.

Brain Behav Immun. 2017 Oct;65:140-149. doi: 10.1016/j.bbi.2017.04.021. Epub 2017 Apr 27.

PMID:
28457810
13.

Immunoproteasome subunit deficiency has no influence on the canonical pathway of NF-κB activation.

Bitzer A, Basler M, Krappmann D, Groettrup M.

Mol Immunol. 2017 Mar;83:147-153. doi: 10.1016/j.molimm.2017.01.019. Epub 2017 Jan 31.

PMID:
28157553
14.

Newly translated proteins are substrates for ubiquitin, ISG15, and FAT10.

Spinnenhirn V, Bitzer A, Aichem A, Groettrup M.

FEBS Lett. 2017 Jan;591(1):186-195. doi: 10.1002/1873-3468.12512. Epub 2016 Dec 20.

15.

Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells.

Rank L, Veith S, Gwosch EC, Demgenski J, Ganz M, Jongmans MC, Vogel C, Fischbach A, Buerger S, Fischer JM, Zubel T, Stier A, Renner C, Schmalz M, Beneke S, Groettrup M, Kuiper RP, Bürkle A, Ferrando-May E, Mangerich A.

Nucleic Acids Res. 2016 Dec 1;44(21):10386-10405. Epub 2016 Sep 29.

16.

The ubiquitin-like modifier FAT10 in cancer development.

Aichem A, Groettrup M.

Int J Biochem Cell Biol. 2016 Oct;79:451-461. doi: 10.1016/j.biocel.2016.07.001. Epub 2016 Jul 5. Review.

PMID:
27393295
17.

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H.

Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16.

18.

Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.

Mundt S, Basler M, Buerger S, Engler H, Groettrup M.

Sci Rep. 2016 Jan 18;6:19434. doi: 10.1038/srep19434.

19.

The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carcinoma.

Herrmann VL, Wieland DE, Legler DF, Wittmann V, Groettrup M.

Prostate. 2016 Apr;76(5):456-68. doi: 10.1002/pros.23136. Epub 2015 Dec 30.

PMID:
26715028
20.

Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation.

Bitzer A, Basler M, Groettrup M.

Mol Immunol. 2016 Jan;69:99-105. doi: 10.1016/j.molimm.2015.11.004. Epub 2015 Nov 17.

PMID:
26598275
21.

Inhibition and deficiency of the immunoproteasome subunit LMP7 attenuates LCMV-induced meningitis.

Mundt S, Engelhardt B, Kirk CJ, Groettrup M, Basler M.

Eur J Immunol. 2016 Jan;46(1):104-13. doi: 10.1002/eji.201545578. Epub 2015 Nov 2.

22.

The immunoproteasome: a novel drug target for autoimmune diseases.

Basler M, Mundt S, Bitzer A, Schmidt C, Groettrup M.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S74-9. Epub 2015 Oct 12. Review.

PMID:
26458097
23.

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.

Buerger S, Herrmann VL, Mundt S, Trautwein N, Groettrup M, Basler M.

J Immunol. 2015 Nov 1;195(9):4106-16. doi: 10.4049/jimmunol.1500592. Epub 2015 Sep 23.

24.

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.

Herrmann VL, Hartmayer C, Planz O, Groettrup M.

J Control Release. 2015 Oct 28;216:121-31. doi: 10.1016/j.jconrel.2015.08.019. Epub 2015 Aug 12.

PMID:
26276509
25.

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.

Dufner A, Kisser A, Niendorf S, Basters A, Reissig S, Schönle A, Aichem A, Kurz T, Schlosser A, Yablonski D, Groettrup M, Buch T, Waisman A, Schamel WW, Prinz M, Knobeloch KP.

Nat Immunol. 2015 Sep;16(9):950-60. doi: 10.1038/ni.3230. Epub 2015 Jul 27.

PMID:
26214742
26.

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.

Basler M, Buerger S, Groettrup M.

Mol Immunol. 2015 Dec;68(2 Pt A):129-32. doi: 10.1016/j.molimm.2015.04.012. Epub 2015 May 14. Review.

PMID:
25983082
27.

Analgesia in mice with experimental meningitis reduces pain without altering immune parameters.

Mundt S, Groettrup M, Basler M.

ALTEX. 2015;32(3):183-9. doi: 10.14573/altex.1502021. Epub 2015 Mar 24.

28.

Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.

Bialas J, Groettrup M, Aichem A.

PLoS One. 2015 Mar 13;10(3):e0120329. doi: 10.1371/journal.pone.0120329. eCollection 2015.

29.

Editorial overview: Molecular immunology: targeting the immune system.

Groettrup M, Ovaa H.

Curr Opin Chem Biol. 2014 Dec;23:v-vii. No abstract available.

PMID:
25467126
30.

No evidence for immunoproteasomes in chicken lymphoid organs and activated lymphocytes.

Erath S, Groettrup M.

Immunogenetics. 2015 Jan;67(1):51-60. doi: 10.1007/s00251-014-0814-1. Epub 2014 Nov 19.

PMID:
25403261
31.

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice.

Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M.

J Cell Sci. 2014 Nov 15;127(Pt 22):4883-93. doi: 10.1242/jcs.152371. Epub 2014 Sep 30.

32.

Subunit specific inhibitors of proteasomes and their potential for immunomodulation.

Kisselev AF, Groettrup M.

Curr Opin Chem Biol. 2014 Dec;23:16-22. doi: 10.1016/j.cbpa.2014.08.012. Epub 2014 Sep 15. Review.

33.

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial.

Morath J, Gola H, Sommershof A, Hamuni G, Kolassa S, Catani C, Adenauer H, Ruf-Leuschner M, Schauer M, Elbert T, Groettrup M, Kolassa IT.

J Psychiatr Res. 2014 Jul;54:1-10. doi: 10.1016/j.jpsychires.2014.03.016. Epub 2014 Mar 27.

PMID:
24726027
34.

Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.

Aichem A, Catone N, Groettrup M.

FEBS J. 2014 Apr;281(7):1848-59. doi: 10.1111/febs.12745. Epub 2014 Mar 3.

35.

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

Basler M, Mundt S, Muchamuel T, Moll C, Jiang J, Groettrup M, Kirk CJ.

EMBO Mol Med. 2014 Feb;6(2):226-38. doi: 10.1002/emmm.201303543. Epub 2014 Jan 16.

36.

The unique functions of tissue-specific proteasomes.

Kniepert A, Groettrup M.

Trends Biochem Sci. 2014 Jan;39(1):17-24. doi: 10.1016/j.tibs.2013.10.004. Epub 2013 Nov 26. Review.

PMID:
24286712
37.

Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins.

Nathan JA, Spinnenhirn V, Schmidtke G, Basler M, Groettrup M, Goldberg AL.

Cell. 2013 Feb 28;152(5):1184-94. doi: 10.1016/j.cell.2013.01.037.

38.

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells.

Gola H, Engler H, Sommershof A, Adenauer H, Kolassa S, Schedlowski M, Groettrup M, Elbert T, Kolassa IT.

BMC Psychiatry. 2013 Jan 29;13:40. doi: 10.1186/1471-244X-13-40.

39.

FAT10ylation as a signal for proteasomal degradation.

Schmidtke G, Aichem A, Groettrup M.

Biochim Biophys Acta. 2014 Jan;1843(1):97-102. doi: 10.1016/j.bbamcr.2013.01.009. Epub 2013 Jan 18. Review.

40.

Using protease inhibitors in antigen presentation assays.

Basler M, Groettrup M.

Methods Mol Biol. 2013;960:31-39. doi: 10.1007/978-1-62703-218-6_3.

PMID:
23329476
41.

The immunoproteasome in antigen processing and other immunological functions.

Basler M, Kirk CJ, Groettrup M.

Curr Opin Immunol. 2013 Feb;25(1):74-80. doi: 10.1016/j.coi.2012.11.004. Epub 2012 Dec 6. Review.

PMID:
23219269
42.

Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens.

Mahmutefendić H, Zagorac GB, Tomaš MI, Groettrup M, Momburg F, Lučin P.

Mol Immunol. 2013 Sep;55(2):149-52. doi: 10.1016/j.molimm.2012.10.008. Epub 2012 Nov 27. Review.

PMID:
23200229
43.

Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation.

Kalim KW, Basler M, Kirk CJ, Groettrup M.

J Immunol. 2012 Oct 15;189(8):4182-93. doi: 10.4049/jimmunol.1201183. Epub 2012 Sep 14.

44.

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit.

Kalim KW, Groettrup M.

Mol Immunol. 2013 Mar;53(3):274-82. doi: 10.1016/j.molimm.2012.08.014. Epub 2012 Sep 14.

PMID:
22982753
45.

NUB1 modulation of GSK3β reduces tau aggregation.

Richet E, Pooler AM, Rodriguez T, Novoselov SS, Schmidtke G, Groettrup M, Hanger DP, Cheetham ME, van der Spuy J.

Hum Mol Genet. 2012 Dec 15;21(24):5254-67. doi: 10.1093/hmg/dds376. Epub 2012 Sep 10.

PMID:
22965877
46.

The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.

Aichem A, Kalveram B, Spinnenhirn V, Kluge K, Catone N, Johansen T, Groettrup M.

J Cell Sci. 2012 Oct 1;125(Pt 19):4576-85. doi: 10.1242/jcs.107789. Epub 2012 Jul 13.

47.

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration.

Schaeuble K, Hauser MA, Rippl AV, Bruderer R, Otero C, Groettrup M, Legler DF.

J Cell Sci. 2012 Oct 1;125(Pt 19):4463-74. doi: 10.1242/jcs.097519. Epub 2012 Jul 13.

48.

Why the structure but not the activity of the immunoproteasome subunit low molecular mass polypeptide 2 rescues antigen presentation.

Basler M, Lauer C, Moebius J, Weber R, Przybylski M, Kisselev AF, Tsu C, Groettrup M.

J Immunol. 2012 Aug 15;189(4):1868-77. doi: 10.4049/jimmunol.1103592. Epub 2012 Jul 6.

49.

Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo.

Schliehe C, Bitzer A, van den Broek M, Groettrup M.

J Virol. 2012 Sep;86(18):9782-93. doi: 10.1128/JVI.00694-12. Epub 2012 Jul 3.

50.

Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice.

Mueller M, Reichardt W, Koerner J, Groettrup M.

J Control Release. 2012 Aug 20;162(1):159-66. doi: 10.1016/j.jconrel.2012.06.015. Epub 2012 Jun 15.

PMID:
22709589

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