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Items: 5


Evaluation of human dermal fibroblasts directly reprogrammed to adipocyte-like cells as a metabolic disease model.

Chen JH, Goh KJ, Rocha N, Groeneveld MP, Minic M, Barrett TG, Savage D, Semple RK.

Dis Model Mech. 2017 Dec 19;10(12):1411-1420. doi: 10.1242/dmm.030981.


Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.

Minic M, Rocha N, Harris J, Groeneveld MP, Leiter S, Wareham N, Sleigh A, De Lonlay P, Hussain K, O'Rahilly S, Semple RK.

J Clin Endocrinol Metab. 2017 Aug 1;102(8):2914-2921. doi: 10.1210/jc.2017-00768.


Acute knockdown of the insulin receptor or its substrates Irs1 and 2 in 3T3-L1 adipocytes suppresses adiponectin production.

Groeneveld MP, Brierley GV, Rocha NM, Siddle K, Semple RK.

Sci Rep. 2016 Feb 18;6:21105. doi: 10.1038/srep21105.


Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.

Lindhurst MJ, Parker VE, Payne F, Sapp JC, Rudge S, Harris J, Witkowski AM, Zhang Q, Groeneveld MP, Scott CE, Daly A, Huson SM, Tosi LL, Cunningham ML, Darling TN, Geer J, Gucev Z, Sutton VR, Tziotzios C, Dixon AK, Helliwell T, O'Rahilly S, Savage DB, Wakelam MJ, Barroso I, Biesecker LG, Semple RK.

Nat Genet. 2012 Jun 24;44(8):928-33. doi: 10.1038/ng.2332.


Adiponectin and leptin in human severe insulin resistance - diagnostic utility and biological insights.

Groeneveld MP, Huang-Doran I, Semple RK.

Biochimie. 2012 Oct;94(10):2172-9. doi: 10.1016/j.biochi.2012.01.021. Epub 2012 Feb 4. Review.


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