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Dexamethasone: chondroprotective corticosteroid or catabolic killer?

Black R, Grodzinsky AJ.

Eur Cell Mater. 2019 Nov 22;38:246-263. doi: 10.22203/eCM.v038a17.


Lose-Dose Administration of Dexamethasone Is Beneficial in Preventing Secondary Tendon Damage in a Stress-Deprived Joint Injury Explant Model.

Connizzo BK, Grodzinsky AJ.

J Orthop Res. 2020 Jan;38(1):139-149. doi: 10.1002/jor.24451. Epub 2019 Sep 6.


Age-associated changes in the response of tendon explants to stress deprivation is sex-dependent.

Connizzo BK, Piet JM, Shefelbine SJ, Grodzinsky AJ.

Connect Tissue Res. 2020 Jan;61(1):48-62. doi: 10.1080/03008207.2019.1648444. Epub 2019 Aug 14.


Physical inactivity and knee osteoarthritis in guinea pigs.

Wallace IJ, Bendele AM, Riew G, Frank EH, Hung HH, Holowka NB, Bolze AS, Venable EM, Yegian AK, Dingwall HL, Carmody RN, Grodzinsky AJ, Lieberman DE.

Osteoarthritis Cartilage. 2019 Nov;27(11):1721-1728. doi: 10.1016/j.joca.2019.07.005. Epub 2019 Jul 11.


Enzyme Pretreatment plus Locally Delivered HB-IGF-1 Stimulate Integrative Cartilage Repair In Vitro.

Liebesny PH, Mroszczyk K, Zlotnick H, Hung HH, Frank E, Kurz B, Zanotto G, Frisbie D, Grodzinsky AJ.

Tissue Eng Part A. 2019 Sep;25(17-18):1191-1201. doi: 10.1089/ten.TEA.2019.0013. Epub 2019 Sep 3.


Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium.

Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK.

Nat Biomed Eng. 2019 Mar;3(3):230-245. doi: 10.1038/s41551-018-0334-7. Epub 2019 Jan 7.


Nanoscale Poroelasticity of the Tectorial Membrane Determines Hair Bundle Deflections.

Sellon JB, Azadi M, Oftadeh R, Nia HT, Ghaffari R, Grodzinsky AJ, Freeman DM.

Phys Rev Lett. 2019 Jan 18;122(2):028101. doi: 10.1103/PhysRevLett.122.028101.


Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis.

Geiger BC, Wang S, Padera RF Jr, Grodzinsky AJ, Hammond PT.

Sci Transl Med. 2018 Nov 28;10(469). pii: eaat8800. doi: 10.1126/scitranslmed.aat8800.


A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage.

Orozco GA, Tanska P, Florea C, Grodzinsky AJ, Korhonen RK.

Sci Rep. 2018 Oct 22;8(1):15599. doi: 10.1038/s41598-018-33759-3.


Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.

Krishnan Y, Rees HA, Rossitto CP, Kim SE, Hung HK, Frank EH, Olsen BD, Liu DR, Hammond PT, Grodzinsky AJ.

Biomaterials. 2018 Nov;183:218-233. doi: 10.1016/j.biomaterials.2018.08.050. Epub 2018 Aug 25.


Cartilage diseases.

Krishnan Y, Grodzinsky AJ.

Matrix Biol. 2018 Oct;71-72:51-69. doi: 10.1016/j.matbio.2018.05.005. Epub 2018 May 24. Review.


Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis.

Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR.

J Biol Chem. 2018 Jul 20;293(29):11459-11469. doi: 10.1074/jbc.M117.818542. Epub 2018 May 23.


Quantitative analysis of T2 relaxation times of the patellofemoral joint cartilage 3 years after anterior cruciate ligament reconstruction.

Kim CW, Hosseini A, Lin L, Wang Y, Torriani M, Gill T, Grodzinsky AJ, Li G.

J Orthop Translat. 2017 Jul 2;12:85-92. doi: 10.1016/ eCollection 2018 Jan.


Release of pro-inflammatory cytokines from muscle and bone causes tenocyte death in a novel rotator cuff in vitro explant culture model.

Connizzo BK, Grodzinsky AJ.

Connect Tissue Res. 2018 Sep;59(5):423-436. doi: 10.1080/03008207.2018.1439486. Epub 2018 Jun 6. Erratum in: Connect Tissue Res. 2019 Jul;60(4):418.


Biological connective tissues exhibit viscoelastic and poroelastic behavior at different frequency regimes: Application to tendon and skin biophysics.

Oftadeh R, Connizzo BK, Nia HT, Ortiz C, Grodzinsky AJ.

Acta Biomater. 2018 Apr 1;70:249-259. doi: 10.1016/j.actbio.2018.01.041. Epub 2018 Feb 7.


Multiscale Poroviscoelastic Compressive Properties of Mouse Supraspinatus Tendons Are Altered in Young and Aged Mice.

Connizzo BK, Grodzinsky AJ.

J Biomech Eng. 2018 May 1;140(5). doi: 10.1115/1.4038745.


Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis.

Bajpayee AG, De la Vega RE, Scheu M, Varady NH, Yannatos IA, Brown LA, Krishnan Y, Fitzsimons TJ, Bhattacharya P, Frank EH, Grodzinsky AJ, Porter RM.

Eur Cell Mater. 2017 Dec 5;34:341-364. doi: 10.22203/eCM.v034a21.


Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts.

Behrendt P, Feldheim M, Preusse-Prange A, Weitkamp JT, Haake M, Eglin D, Rolauffs B, Fay J, Seekamp A, Grodzinsky AJ, Kurz B.

Osteoarthritis Cartilage. 2018 Feb;26(2):264-275. doi: 10.1016/j.joca.2017.11.007. Epub 2017 Nov 21.


AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering.

Han B, Nia HT, Wang C, Chandrasekaran P, Li Q, Chery DR, Li H, Grodzinsky AJ, Han L.

ACS Biomater Sci Eng. 2017 Sep 11;3(9):2033-2049. doi: 10.1021/acsbiomaterials.7b00307. Epub 2017 Jul 11.


Size- and speed-dependent mechanical behavior in living mammalian cytoplasm.

Hu J, Jafari S, Han Y, Grodzinsky AJ, Cai S, Guo M.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9529-9534. doi: 10.1073/pnas.1702488114. Epub 2017 Aug 21.


Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair?

Rothdiener M, Uynuk-Ool T, Südkamp N, Aurich M, Grodzinsky AJ, Kurz B, Rolauffs B.

J Tissue Eng Regen Med. 2018 Feb;12(2):e1206-e1220. doi: 10.1002/term.2516. Epub 2017 Nov 8.


Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity.

Swärd P, Wang Y, Hansson M, Lohmander LS, Grodzinsky AJ, Struglics A.

Arthritis Res Ther. 2017 Jul 5;19(1):157. doi: 10.1186/s13075-017-1318-9.


Synthetic nanoscale electrostatic particles as growth factor carriers for cartilage repair.

Shah NJ, Geiger BC, Quadir MA, Hyder MN, Krishnan Y, Grodzinsky AJ, Hammond PT.

Bioeng Transl Med. 2016 Sep;1(3):347-356. doi: 10.1002/btm2.10043. Epub 2016 Nov 18.


Impact of a daily exercise dose on knee joint cartilage - a systematic review and meta-analysis of randomized controlled trials in healthy animals.

Bricca A, Juhl CB, Grodzinsky AJ, Roos EM.

Osteoarthritis Cartilage. 2017 Aug;25(8):1223-1237. doi: 10.1016/j.joca.2017.03.009. Epub 2017 Mar 18. Review.


Tendon exhibits complex poroelastic behavior at the nanoscale as revealed by high-frequency AFM-based rheology.

Connizzo BK, Grodzinsky AJ.

J Biomech. 2017 Mar 21;54:11-18. doi: 10.1016/j.jbiomech.2017.01.029. Epub 2017 Jan 30.


Cartilage-targeting drug delivery: can electrostatic interactions help?

Bajpayee AG, Grodzinsky AJ.

Nat Rev Rheumatol. 2017 Mar;13(3):183-193. doi: 10.1038/nrrheum.2016.210. Epub 2017 Feb 9. Review.


Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment.

Wang Y, Li Y, Khabut A, Chubinskaya S, Grodzinsky AJ, Önnerfjord P.

Matrix Biol. 2017 Nov;63:11-22. doi: 10.1016/j.matbio.2016.12.004. Epub 2016 Dec 15.


Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation.

Kar S, Smith DW, Gardiner BS, Grodzinsky AJ.

PLoS One. 2016 Dec 15;11(12):e0168047. doi: 10.1371/journal.pone.0168047. eCollection 2016.


Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds.

Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK.

Sci Rep. 2016 Dec 1;6:37949. doi: 10.1038/srep37949.


IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage.

Behrendt P, Preusse-Prange A, Klüter T, Haake M, Rolauffs B, Grodzinsky AJ, Lippross S, Kurz B.

Osteoarthritis Cartilage. 2016 Nov;24(11):1981-1988. doi: 10.1016/j.joca.2016.06.016. Epub 2016 Jun 24.


Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases.

Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D.

Sci Transl Med. 2016 Oct 12;8(360):360ra135.


Growth Factor-Mediated Migration of Bone Marrow Progenitor Cells for Accelerated Scaffold Recruitment.

Liebesny PH, Byun S, Hung HH, Pancoast JR, Mroszczyk KA, Young WT, Lee RT, Frisbie DD, Kisiday JD, Grodzinsky AJ.

Tissue Eng Part A. 2016 Jul;22(13-14):917-27. doi: 10.1089/ten.TEA.2015.0524. Epub 2016 Jun 28.


Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis.

Grodzinsky AJ, Wang Y, Kakar S, Vrahas MS, Evans CH.

J Orthop Res. 2017 Mar;35(3):406-411. doi: 10.1002/jor.23295. Epub 2017 Mar 2. Review.


Wide bandwidth nanomechanical assessment of murine cartilage reveals protection of aggrecan knock-in mice from joint-overuse.

Azadi M, Nia HT, Gauci SJ, Ortiz C, Fosang AJ, Grodzinsky AJ.

J Biomech. 2016 Jun 14;49(9):1634-1640. doi: 10.1016/j.jbiomech.2016.03.055. Epub 2016 Apr 3.


Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology.

Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B.

Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9. doi: 10.1016/j.joca.2016.02.001. Epub 2016 Feb 12.


Modeling IL-1 induced degradation of articular cartilage.

Kar S, Smith DW, Gardiner BS, Li Y, Wang Y, Grodzinsky AJ.

Arch Biochem Biophys. 2016 Mar 15;594:37-53. doi: 10.1016/ Epub 2016 Feb 10.


Solid stress and elastic energy as measures of tumour mechanopathology.

Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK.

Nat Biomed Eng. 2016;1. pii: 0004. doi: 10.1038/s41551-016-0004. Epub 2016 Nov 28.


Osteoarthritis year in review 2015: mechanics.

Varady NH, Grodzinsky AJ.

Osteoarthritis Cartilage. 2016 Jan;24(1):27-35. doi: 10.1016/j.joca.2015.08.018. Review.


Noncontact three-dimensional mapping of intracellular hydromechanical properties by Brillouin microscopy.

Scarcelli G, Polacheck WJ, Nia HT, Patel K, Grodzinsky AJ, Kamm RD, Yun SH.

Nat Methods. 2015 Dec;12(12):1132-4. doi: 10.1038/nmeth.3616. Epub 2015 Oct 5.


Charge based intra-cartilage delivery of single dose dexamethasone using Avidin nano-carriers suppresses cytokine-induced catabolism long term.

Bajpayee AG, Quadir MA, Hammond PT, Grodzinsky AJ.

Osteoarthritis Cartilage. 2016 Jan;24(1):71-81. doi: 10.1016/j.joca.2015.07.010. Epub 2015 Jul 26.


Predicting Knee Osteoarthritis.

Gardiner BS, Woodhouse FG, Besier TF, Grodzinsky AJ, Lloyd DG, Zhang L, Smith DW.

Ann Biomed Eng. 2016 Jan;44(1):222-33. doi: 10.1007/s10439-015-1393-5. Epub 2015 Jul 24. Review.


Articular cartilage of the knee 3 years after ACL reconstruction. A quantitative T2 relaxometry analysis of 10 knees.

Bae JH, Hosseini A, Wang Y, Torriani M, Gill TJ, Grodzinsky AJ, Li G.

Acta Orthop. 2015;86(5):605-10. doi: 10.3109/17453674.2015.1039426.


Biomechanical properties of murine meniscus surface via AFM-based nanoindentation.

Li Q, Doyran B, Gamer LW, Lu XL, Qin L, Ortiz C, Grodzinsky AJ, Rosen V, Han L.

J Biomech. 2015 Jun 1;48(8):1364-70. doi: 10.1016/j.jbiomech.2015.02.064. Epub 2015 Mar 11.


Aggrecan nanoscale solid-fluid interactions are a primary determinant of cartilage dynamic mechanical properties.

Nia HT, Han L, Bozchalooi IS, Roughley P, Youcef-Toumi K, Grodzinsky AJ, Ortiz C.

ACS Nano. 2015 Mar 24;9(3):2614-25. doi: 10.1021/nn5062707. Epub 2015 Mar 13.


A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage.

Bajpayee AG, Scheu M, Grodzinsky AJ, Porter RM.

J Orthop Res. 2015 May;33(5):660-7. doi: 10.1002/jor.22841. Epub 2015 Mar 18.


Dynamic nanomechanics of individual bone marrow stromal cells and cell-matrix composites during chondrogenic differentiation.

Lee B, Han L, Frank EH, Grodzinsky AJ, Ortiz C.

J Biomech. 2015 Jan 2;48(1):171-5. doi: 10.1016/j.jbiomech.2014.11.005. Epub 2014 Nov 12.


Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis.

Li Y, Wang Y, Chubinskaya S, Schoeberl B, Florine E, Kopesky P, Grodzinsky AJ.

Osteoarthritis Cartilage. 2015 Feb;23(2):266-74. doi: 10.1016/j.joca.2014.11.006. Epub 2014 Nov 11.


High-bandwidth AFM-based rheology is a sensitive indicator of early cartilage aggrecan degradation relevant to mouse models of osteoarthritis.

Nia HT, Gauci SJ, Azadi M, Hung HH, Frank E, Fosang AJ, Ortiz C, Grodzinsky AJ.

J Biomech. 2015 Jan 2;48(1):162-5. doi: 10.1016/j.jbiomech.2014.11.012. Epub 2014 Nov 18.


Time evolution of deformation in a human cartilage under cyclic loading.

Zhang L, Miramini S, Smith DW, Gardiner BS, Grodzinsky AJ.

Ann Biomed Eng. 2015 May;43(5):1166-77. doi: 10.1007/s10439-014-1164-8. Epub 2014 Oct 21.


Effects of the combination of microfracture and self-assembling Peptide filling on the repair of a clinically relevant trochlear defect in an equine model.

Miller RE, Grodzinsky AJ, Barrett MF, Hung HH, Frank EH, Werpy NM, McIlwraith CW, Frisbie DD.

J Bone Joint Surg Am. 2014 Oct 1;96(19):1601-9. doi: 10.2106/JBJS.M.01408.

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