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In memoriam James L. German, a pioneer in early human genetic research.

Groden J, Passarge E.

Am J Med Genet A. 2018 Dec;176(12):2543-2544. doi: 10.1002/ajmg.a.40513. Epub 2018 Oct 5. No abstract available.


Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1.

Hankey W, Chen Z, Bergman MJ, Fernandez MO, Hancioglu B, Lan X, Jegga AG, Zhang J, Jin VX, Aronow BJ, Wang Q, Groden J.

Oncotarget. 2018 Jul 27;9(58):31214-31230. doi: 10.18632/oncotarget.25781. eCollection 2018 Jul 27.


A tri-serine cluster within the topoisomerase II╬▒-interaction domain of the BLM helicase is required for regulating chromosome breakage in human cells.

Behnfeldt JH, Acharya S, Tangeman L, Gocha AS, Keirsey J, Groden J.

Hum Mol Genet. 2018 Apr 1;27(7):1241-1251. doi: 10.1093/hmg/ddy038.


Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.

Hankey W, Frankel WL, Groden J.

Cancer Metastasis Rev. 2018 Mar;37(1):159-172. doi: 10.1007/s10555-017-9725-6. Review.


Mutational Mechanisms That Activate Wnt Signaling and Predict Outcomes in Colorectal Cancer Patients.

Hankey W, McIlhatton MA, Ebede K, Kennedy B, Hancioglu B, Zhang J, Brock GN, Huang K, Groden J.

Cancer Res. 2018 Feb 1;78(3):617-630. doi: 10.1158/0008-5472.CAN-17-1357. Epub 2017 Dec 6.


Differential requirements for DNA repair proteins in immortalized cell lines using alternative lengthening of telomere mechanisms.

Martinez AR, Kaul Z, Parvin JD, Groden J.

Genes Chromosomes Cancer. 2017 Aug;56(8):617-631. doi: 10.1002/gcc.22465. Epub 2017 May 31.


Identification of endometrial cancer methylation features using combined methylation analysis methods.

Trimarchi MP, Yan P, Groden J, Bundschuh R, Goodfellow PJ.

PLoS One. 2017 Mar 9;12(3):e0173242. doi: 10.1371/journal.pone.0173242. eCollection 2017.


Regulation of BLM Nucleolar Localization.

Tangeman L, McIlhatton MA, Grierson P, Groden J, Acharya S.

Genes (Basel). 2016 Sep 21;7(9). pii: E69. doi: 10.3390/genes7090069.


Loss-of-function screening to identify miRNAs involved in senescence: tumor suppressor activity of miRNA-335 and its new target CARF.

Yu Y, Gao R, Kaul Z, Li L, Kato Y, Zhang Z, Groden J, Kaul SC, Wadhwa R.

Sci Rep. 2016 Jul 26;6:30185. doi: 10.1038/srep30185.


Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.

Mcilhatton MA, Boivin GP, Groden J.

Biomed Res Int. 2016;2016:1414383. doi: 10.1155/2016/1414383. Epub 2016 Jun 20. Review.


Catheter failure rates and time course with epidural versus combined spinal-epidural analgesia in labor.

Groden J, Gonzalez-Fiol A, Aaronson J, Sachs A, Smiley R.

Int J Obstet Anesth. 2016 May;26:4-7. doi: 10.1016/j.ijoa.2016.01.004. Epub 2016 Jan 14.


Genetic Manipulation of Homologous Recombination In Vivo Attenuates Intestinal Tumorigenesis.

McIlhatton MA, Murnan K, Carson D, Boivin GP, Croce CM, Groden J.

Cancer Prev Res (Phila). 2015 Jul;8(7):650-6. doi: 10.1158/1940-6207.CAPR-15-0001-T. Epub 2015 Apr 23.


Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells.

Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden J.

PLoS One. 2014 Aug 1;9(8):e103819. doi: 10.1371/journal.pone.0103819. eCollection 2014.


MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.

Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Cascione L, Sumani KM, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CM.

Cancer Cell. 2014 Apr 14;25(4):469-83. doi: 10.1016/j.ccr.2014.03.006.


WRN loss induces switching of telomerase-independent mechanisms of telomere elongation.

Gocha AR, Acharya S, Groden J.

PLoS One. 2014 Apr 7;9(4):e93991. doi: 10.1371/journal.pone.0093991. eCollection 2014.


The HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament.

Amunugama R, Groden J, Fishel R.

DNA Repair (Amst). 2013 Sep;12(9):723-32. doi: 10.1016/j.dnarep.2013.05.005. Epub 2013 Jun 28.


Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription.

Grierson PM, Acharya S, Groden J.

Mutat Res. 2013 Mar-Apr;743-744:89-96. doi: 10.1016/j.mrfmmm.2012.12.002. Epub 2012 Dec 19.


Human sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.

Gocha AR, Nuovo G, Iwenofu OH, Groden J.

Am J Pathol. 2013 Jan;182(1):41-8. doi: 10.1016/j.ajpath.2012.10.001.


Alternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression.

Gocha AR, Harris J, Groden J.

Mutat Res. 2013 Mar-Apr;743-744:142-50. doi: 10.1016/j.mrfmmm.2012.11.006. Epub 2012 Dec 3. Review.


Genotypes and phenotypes: animal models of familial adenomatous polyposis coli.

Groden J, Burt R.

Gastroenterology. 2012 Nov;143(5):1133-1135. doi: 10.1053/j.gastro.2012.09.023. Epub 2012 Sep 23. No abstract available.


BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.

Grierson PM, Lillard K, Behbehani GK, Combs KA, Bhattacharyya S, Acharya S, Groden J.

Hum Mol Genet. 2012 Mar 1;21(5):1172-83. doi: 10.1093/hmg/ddr545. Epub 2011 Nov 21.


Chromosome breakage is regulated by the interaction of the BLM helicase and topoisomerase IIalpha.

Russell B, Bhattacharyya S, Keirsey J, Sandy A, Grierson P, Perchiniak E, Kavecansky J, Acharya S, Groden J.

Cancer Res. 2011 Jan 15;71(2):561-71. doi: 10.1158/0008-5472.CAN-10-1727. Epub 2011 Jan 11.


Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.

Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ.

J Biol Chem. 2010 Dec 31;285(53):41337-47. doi: 10.1074/jbc.M110.170704. Epub 2010 Nov 3.


Discussion: 'Scheduling the first prenatal visit' by Nettleman et al.

Shanks A, Carbone J, Goetzinger K, Reed J, Groden J.

Am J Obstet Gynecol. 2010 Sep;203(3):e1-4. doi: 10.1016/j.ajog.2010.06.059.


Unwinding protein complexes in ALTernative telomere maintenance.

Bhattacharyya S, Sandy A, Groden J.

J Cell Biochem. 2010 Jan 1;109(1):7-15. doi: 10.1002/jcb.22388. Review.


The mitochondrial protein hTID-1 partners with the caspase-cleaved adenomatous polyposis cell tumor suppressor to facilitate apoptosis.

Qian J, Perchiniak EM, Sun K, Groden J.

Gastroenterology. 2010 Apr;138(4):1418-28. doi: 10.1053/j.gastro.2009.10.044. Epub 2009 Nov 6.


Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates.

Bhattacharyya S, Keirsey J, Russell B, Kavecansky J, Lillard-Wetherell K, Tahmaseb K, Turchi JJ, Groden J.

J Biol Chem. 2009 May 29;284(22):14966-77. doi: 10.1074/jbc.M900195200. Epub 2009 Mar 27.


The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus.

Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy AM, Groden J.

Gastroenterology. 2008 Jul;135(1):152-62. doi: 10.1053/j.gastro.2008.03.074. Epub 2008 Apr 4.


Harnessing mismatch repair to model sporadic cancers.

Fishel R, Groden J.

Nat Methods. 2008 Mar;5(3):225-6. doi: 10.1038/nmeth0308-225. No abstract available.


Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer.

Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ Jr, Aronow BJ.

Genome Biol. 2007;8(7):R131.


The basic necessities.

Groden J.

Rehab Manag. 2007 Mar;20(2):28, 30-1. No abstract available.


Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis.

Qian J, Steigerwald K, Combs KA, Barton MC, Groden J.

Oncogene. 2007 Jul 19;26(33):4872-6. Epub 2007 Feb 5.


A placebo double-blind pilot study of dextromethorphan for problematic behaviors in children with autism.

Woodard C, Groden J, Goodwin M, Bodfish J.

Autism. 2007 Jan;11(1):29-41.


The Werner and Bloom syndrome proteins catalyze regression of a model replication fork.

Machwe A, Xiao L, Groden J, Orren DK.

Biochemistry. 2006 Nov 28;45(47):13939-46.


beta-Catenin/Wnt signaling regulates expression of the membrane type 3 matrix metalloproteinase in gastric cancer.

Lowy AM, Clements WM, Bishop J, Kong L, Bonney T, Sisco K, Aronow B, Fenoglio-Preiser C, Groden J.

Cancer Res. 2006 May 1;66(9):4734-41.


The treatment of the behavioral sequelae of autism with dextromethorphan: a case report.

Woodard C, Groden J, Goodwin M, Shanower C, Bianco J.

J Autism Dev Disord. 2005 Aug;35(4):515-8.


BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast.

Lillard-Wetherell K, Combs KA, Groden J.

Cancer Res. 2005 Jul 1;65(13):5520-2.


RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange.

Machwe A, Xiao L, Groden J, Matson SW, Orren DK.

J Biol Chem. 2005 Jun 17;280(24):23397-407. Epub 2005 Apr 20.


The APC tumor suppressor promotes transcription-independent apoptosis in vitro.

Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J.

Mol Cancer Res. 2005 Feb;3(2):78-89.


BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin.

Slupianek A, Gurdek E, Koptyra M, Nowicki MO, Siddiqui KM, Groden J, Skorski T.

Oncogene. 2005 Jun 2;24(24):3914-22.


Transcriptional profiles of intestinal tumors in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumors.

Reichling T, Goss KH, Carson DJ, Holdcraft RW, Ley-Ebert C, Witte D, Aronow BJ, Groden J.

Cancer Res. 2005 Jan 1;65(1):166-76.


Crosslinks and crosstalk: human cancer syndromes and DNA repair defects.

Risinger MA, Groden J.

Cancer Cell. 2004 Dec;6(6):539-45. Review.


Strain-specific of alachlor on murine olfactory mucosal responses.

Genter MB, Goss KH, Groden J.

Toxicol Pathol. 2004 Nov-Dec;32(6):719-25.


Mouse Models of Intestinal Cancer.

Boivin GP, Groden J.

Comp Med. 2004 Feb;54(1):15-8. Review. No abstract available.


Isoforms of the APC tumor suppressor and their ability to inhibit cell growth and tumorigenicity.

Carson DJ, Santoro IM, Groden J.

Oncogene. 2004 Sep 16;23(42):7144-8.


Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2.

Lillard-Wetherell K, Machwe A, Langland GT, Combs KA, Behbehani GK, Schonberg SA, German J, Turchi JJ, Orren DK, Groden J.

Hum Mol Genet. 2004 Sep 1;13(17):1919-32. Epub 2004 Jun 30.


Alternative splicing of the APC gene in the neural retina and retinal pigment epithelium.

Liou GI, Samuel S, Matragoon S, Goss KH, Santoro I, Groden J, Hunt RC, Wang F, Miller SS, Caldwell RB, Rustgi AK, Singh H, Marcus DM.

Mol Vis. 2004 Jun 14;10:383-91.


Adenomatous polyposis coli/beta-catenin interaction and downstream targets: altered gene expression in gastrointestinal tumors.

Clements WM, Lowy AM, Groden J.

Clin Colorectal Cancer. 2003 Aug;3(2):113-20. Review.


Dysregulation of beta-catenin expression correlates with tumor differentiation in pancreatic duct adenocarcinoma.

Lowy AM, Fenoglio-Preiser C, Kim OJ, Kordich J, Gomez A, Knight J, James L, Groden J.

Ann Surg Oncol. 2003 Apr;10(3):284-90.


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