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Items: 1 to 50 of 78

1.

Characterization of the σ-Pore in Mutant hKv1.3 Potassium Channels.

Tyutyaev P, Grissmer S.

Cell Physiol Biochem. 2018;46(3):1112-1121. doi: 10.1159/000488840. Epub 2018 Apr 13.

2.

Kinetic Aspects of Verapamil Binding (On-Rate) on Wild-Type and Six hKv1.3 Mutant Channels.

Diesch AK, Grissmer S.

Cell Physiol Biochem. 2017;44(1):172-184. doi: 10.1159/000484625. Epub 2017 Nov 6.

3.

Observation of σ-pore currents in mutant hKv1.2_V370C potassium channels.

Tyutyaev P, Grissmer S.

PLoS One. 2017 Apr 20;12(4):e0176078. doi: 10.1371/journal.pone.0176078. eCollection 2017.

4.

International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.

Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H.

Pharmacol Rev. 2017 Jan;69(1):1-11. doi: 10.1124/pr.116.012864. Epub 2016 Nov 15. Review.

PMID:
28267675
5.

Evidence for the interaction of endophilin a3 with endogenous Kca2.3 channels in PC12 cells.

Janbein M, Quader MA, Hoppner AC, Grüner I, Wanker E, Wälter S, Küppers E, Grissmer S, Jäger H.

Cell Physiol Biochem. 2014;34(2):474-90. doi: 10.1159/000363016. Epub 2014 Jul 30.

6.

Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels.

Nikouee A, Janbein M, Grissmer S.

Br J Pharmacol. 2012 Nov;167(6):1378-88. doi: 10.1111/j.1476-5381.2012.02092.x.

7.

Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: an experimental and computational comparison.

Nikouee A, Khabiri M, Grissmer S, Ettrich R.

J Phys Chem B. 2012 May 3;116(17):5132-40. doi: 10.1021/jp2102463. Epub 2012 Apr 19.

PMID:
22490327
8.

Charybdotoxin unbinding from the mKv1.3 potassium channel: a combined computational and experimental study.

Khabiri M, Nikouee A, Cwiklik L, Grissmer S, Ettrich R.

J Phys Chem B. 2011 Oct 6;115(39):11490-500. doi: 10.1021/jp2061909. Epub 2011 Sep 13.

PMID:
21877740
9.

A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel.

Prütting S, Grissmer S.

J Biol Chem. 2011 Jun 3;286(22):20031-42. doi: 10.1074/jbc.M110.185405. Epub 2011 Apr 15.

10.
11.

Why does the inner-helix mutation A413C double the stoichiometry of Kv1.3 channel block by emopamil but not by verapamil?

Rossokhin A, Dreker T, Grissmer S, Zhorov BS.

Mol Pharmacol. 2011 Apr;79(4):681-91. doi: 10.1124/mol.110.068031. Epub 2011 Jan 10.

PMID:
21220411
12.

cAMP-dependent chloride conductance evokes ammonia-induced blebbing in the microglial cell line, BV-2.

Svoboda N, Pruetting S, Grissmer S, Kerschbaum HH.

Cell Physiol Biochem. 2009;24(1-2):53-64. doi: 10.1159/000227813. Epub 2009 Jul 1.

13.

Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K+ channel, hKv1.3: implications for a second open state?

Kuras Z, Grissmer S.

Br J Pharmacol. 2009 Jul;157(5):757-68. doi: 10.1111/j.1476-5381.2009.00202.x. Epub 2009 Apr 9.

14.

Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.

Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, Feurle J, Tasler S, Prütting S, Kuras Z, Visan V, Grissmer S.

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2299-304. doi: 10.1016/j.bmcl.2009.02.077. Epub 2009 Feb 25. Erratum in: Bioorg Med Chem Lett. 2011 Sep 15;21(18):5647-8.

PMID:
19282171
15.

AQP4 expression in striatal primary cultures is regulated by dopamine--implications for proliferation of astrocytes.

Küppers E, Gleiser C, Brito V, Wachter B, Pauly T, Hirt B, Grissmer S.

Eur J Neurosci. 2008 Dec;28(11):2173-82. doi: 10.1111/j.1460-9568.2008.06531.x.

PMID:
19046364
16.

Identification and characterization of a novel, shorter isoform of the small conductance Ca2+ -activated K+ channel SK2.

Murthy SR, Teodorescu G, Nijholt IM, Dolga AM, Grissmer S, Spiess J, Blank T.

J Neurochem. 2008 Sep;106(6):2312-21. doi: 10.1111/j.1471-4159.2008.05557.x. Epub 2008 Jul 9.

17.

Chloride influx provokes lamellipodium formation in microglial cells.

Zierler S, Frei E, Grissmer S, Kerschbaum HH.

Cell Physiol Biochem. 2008;21(1-3):55-62. doi: 10.1159/000113747. Epub 2008 Jan 16. Erratum in: Cell Physiol Biochem. 2009;24(5-6):635.

18.

Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins.

Pimentel C, M'Barek S, Visan V, Grissmer S, Sampieri F, Sabatier JM, Darbon H, Fajloun Z.

Protein Sci. 2008 Jan;17(1):107-18. Epub 2007 Nov 27.

19.

Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.

Liebau S, Vaida B, Proepper C, Grissmer S, Storch A, Boeckers TM, Dietl P, Wittekindt OH.

J Neurochem. 2007 Jun;101(5):1338-1350.

20.

Interactions of N-terminal and C-terminal parts of the small conductance Ca2+ activated K+ channel, hSK3.

Frei E, Spindler I, Grissmer S, Jäger H.

Cell Physiol Biochem. 2006;18(4-5):165-76.

21.

Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation.

Liebau S, Pröpper C, Böckers T, Lehmann-Horn F, Storch A, Grissmer S, Wittekindt OH.

J Neurochem. 2006 Oct;99(2):426-37.

22.

Interaction of d-tubocurarine with potassium channels: molecular modeling and ligand binding.

Rossokhin A, Teodorescu G, Grissmer S, Zhorov BS.

Mol Pharmacol. 2006 Apr;69(4):1356-65. Epub 2006 Jan 3.

PMID:
16391240
23.

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.

Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Wang X.

Pharmacol Rev. 2005 Dec;57(4):473-508. Review. No abstract available.

PMID:
16382104
24.

International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.

Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H.

Pharmacol Rev. 2005 Dec;57(4):463-72. Review. No abstract available.

PMID:
16382103
25.

The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine.

Wittekindt OH, Schmitz A, Lehmann-Horn F, Hänsel W, Grissmer S.

Neuropharmacology. 2006 Mar;50(4):458-67. Epub 2005 Nov 28.

PMID:
16310228
26.

Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain.

Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM.

Mol Pharmacol. 2006 Jan;69(1):354-62. Epub 2005 Oct 18.

PMID:
16234482
27.

Investigation of the phenylalkylamine binding site in hKv1.3 (H399T), a mutant with a reduced C-type inactivated state.

Dreker T, Grissmer S.

Mol Pharmacol. 2005 Oct;68(4):966-73. Epub 2005 Jul 6.

PMID:
16000530
28.

Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.

M'Barek S, Chagot B, Andreotti N, Visan V, Mansuelle P, Grissmer S, Marrakchi M, El Ayeb M, Sampieri F, Darbon H, Fajloun Z, De Waard M, Sabatier JM.

Proteins. 2005 Aug 15;60(3):401-11.

PMID:
15971207
29.

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.

Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM.

Biochem J. 2005 Jan 1;385(Pt 1):95-104.

30.

Mapping of maurotoxin binding sites on hKv1.2, hKv1.3, and hIKCa1 channels.

Visan V, Fajloun Z, Sabatier JM, Grissmer S.

Mol Pharmacol. 2004 Nov;66(5):1103-12. Epub 2004 Jul 30.

PMID:
15286210
31.
32.
33.

Toxins and potassium channels.

Grissmer S, Tytgat J.

Toxicon. 2004 Jun 15;43(8):863. No abstract available.

PMID:
15208018
34.

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators.

Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG.

Mol Pharmacol. 2004 Jun;65(6):1364-74.

PMID:
15155830
35.

An apamin- and scyllatoxin-insensitive isoform of the human SK3 channel.

Wittekindt OH, Visan V, Tomita H, Imtiaz F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl DJ.

Mol Pharmacol. 2004 Mar;65(3):788-801.

PMID:
14978258
36.

Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro.

Jäger H, Dreker T, Buck A, Giehl K, Gress T, Grissmer S.

Mol Pharmacol. 2004 Mar;65(3):630-8.

PMID:
14978241
37.

A novel non-neuronal hSK3 isoform with a dominant-negative effect on hSK3 currents.

Wittekindt OH, Dreker T, Morris-Rosendahl DJ, Lehmann-Horn F, Grissmer S.

Cell Physiol Biochem. 2004;14(1-2):23-30.

38.

International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of Pharmacology.

Pharmacol Rev. 2003 Dec;55(4):583-6.

PMID:
14657415
39.

Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels.

Jouirou B, Mosbah A, Visan V, Grissmer S, M'Barek S, Fajloun Z, Van Rietschoten J, Devaux C, Rochat H, Lippens G, El Ayeb M, De Waard M, Mabrouk K, Sabatier JM.

Biochem J. 2004 Jan 1;377(Pt 1):37-49.

40.

The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.

Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM.

Biochem J. 2004 Jan 1;377(Pt 1):25-36.

41.

A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.

M'Barek S, Lopez-Gonzalez I, Andreotti N, di Luccio E, Visan V, Grissmer S, Judge S, El Ayeb M, Darbon H, Rochat H, Sampieri F, Béraud E, Fajloun Z, De Waard M, Sabatier JM.

J Biol Chem. 2003 Aug 15;278(33):31095-104. Epub 2003 Jun 3.

42.

Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.

Bräuer M, Frei E, Claes L, Grissmer S, Jäger H.

Am J Physiol Cell Physiol. 2003 Jul;285(1):C22-30. Epub 2003 Mar 12.

43.

Structure of the BgK-Kv1.1 complex based on distance restraints identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers.

Gilquin B, Racapé J, Wrisch A, Visan V, Lecoq A, Grissmer S, Ménez A, Gasparini S.

J Biol Chem. 2002 Oct 4;277(40):37406-13. Epub 2002 Jul 19.

44.

A Shaker homologue encodes an A-type current in Xenopus laevis.

Kerschbaum HH, Grissmer S, Engel E, Richter K, Lehner C, Jäger H.

Brain Res. 2002 Feb 8;927(1):55-68.

PMID:
11814432
45.
48.

Structural differences of bacterial and mammalian K+ channels.

Wrisch A, Grissmer S.

J Biol Chem. 2000 Dec 15;275(50):39345-53.

49.

Design of a potent and selective inhibitor of the intermediate-conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.

Wulff H, Miller MJ, Hansel W, Grissmer S, Cahalan MD, Chandy KG.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8151-6.

50.

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