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Items: 38


NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity.

Gharagozloo M, Mahmoud S, Simard C, Yamamoto K, Bobbala D, Ilangumaran S, Smith MD, Lamontagne A, Jarjoura S, Denault JB, Blais V, Gendron L, Vilariño-Güell C, Sadovnick AD, Ting JP, Calabresi PA, Amrani A, Gris D.

PLoS Biol. 2019 Sep 16;17(9):e3000451. doi: 10.1371/journal.pbio.3000451. eCollection 2019 Sep.


Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1.

Desbiens L, Lapointe C, Gendron L, Gharagozloo M, Vincent L, Pejler G, Gris D, D'Orléans-Juste P.

J Pharmacol Exp Ther. 2019 Sep;370(3):437-446. doi: 10.1124/jpet.118.256016. Epub 2019 Jun 27.


Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease.

Vilariño-Güell C, Zimprich A, Martinelli-Boneschi F, Herculano B, Wang Z, Matesanz F, Urcelay E, Vandenbroeck K, Leyva L, Gris D, Massaad C, Quandt JA, Traboulsee AL, Encarnacion M, Bernales CQ, Follett J, Yee IM, Criscuoli MG, Deutschländer A, Reinthaler EM, Zrzavy T, Mascia E, Zauli A, Esposito F, Alcina A, Izquierdo G, Espino-Paisán L, Mena J, Antigüedad A, Urbaneja-Romero P, Ortega-Pinazo J, Song W, Sadovnick AD.

PLoS Genet. 2019 Jun 6;15(6):e1008180. doi: 10.1371/journal.pgen.1008180. eCollection 2019 Jun.


NLRX1 Enhances Glutamate Uptake and Inhibits Glutamate Release by Astrocytes.

Mahmoud S, Gharagozloo M, Simard C, Amrani A, Gris D.

Cells. 2019 Apr 30;8(5). pii: E400. doi: 10.3390/cells8050400.


Astrocytes Maintain Glutamate Homeostasis in the CNS by Controlling the Balance between Glutamate Uptake and Release.

Mahmoud S, Gharagozloo M, Simard C, Gris D.

Cells. 2019 Feb 20;8(2). pii: E184. doi: 10.3390/cells8020184. Review.


Role of the p38 MAPK/C/EBPβ Pathway in the Regulation of Phenotype and IL-10 and IL-12 Production by Tolerogenic Bone Marrow-Derived Dendritic Cells.

Guindi C, Cloutier A, Gaudreau S, Zerif E, McDonald PP, Tatsiy O, Asselin C, Dupuis G, Gris D, Amrani AA.

Cells. 2018 Dec 7;7(12). pii: E256. doi: 10.3390/cells7120256.


Exhaustive Multi-Parametric Assessment of the Behavioral Array of Daily Activities of Mice Using Cluster and Factor Analysis.

Yamamoto K, Gris KV, Sotelo Fonseca JE, Gharagozloo M, Mahmoud S, Simard C, Houle-Martel D, Cloutier T, Gris P, Gris D.

Front Behav Neurosci. 2018 Aug 30;12:187. doi: 10.3389/fnbeh.2018.00187. eCollection 2018.


The Dual Immunoregulatory function of Nlrp12 in T Cell-Mediated Immune Response: Lessons from Experimental Autoimmune Encephalomyelitis.

Gharagozloo M, Mahmoud S, Simard C, Mahvelati TM, Amrani A, Gris D.

Cells. 2018 Aug 27;7(9). pii: E119. doi: 10.3390/cells7090119.


NLR-Dependent Regulation of Inflammation in Multiple Sclerosis.

Gharagozloo M, Gris KV, Mahvelati T, Amrani A, Lukens JR, Gris D.

Front Immunol. 2018 Jan 18;8:2012. doi: 10.3389/fimmu.2017.02012. eCollection 2017. Review. Erratum in: Front Immunol. 2018 Feb 28;9:404.


The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide.

Lanchec E, Désilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, Gris D, Leduc R, Lavoie C.

J Biol Chem. 2017 Dec 15;292(50):20669-20682. doi: 10.1074/jbc.M117.792911. Epub 2017 Oct 20.


Loss of NLRX1 Exacerbates Neural Tissue Damage and NF-κB Signaling following Brain Injury.

Theus MH, Brickler T, Meza AL, Coutermarsh-Ott S, Hazy A, Gris D, Allen IC.

J Immunol. 2017 Nov 15;199(10):3547-3558. doi: 10.4049/jimmunol.1700251. Epub 2017 Oct 9.


Supervised and Unsupervised Learning Technology in the Study of Rodent Behavior.

Gris KV, Coutu JP, Gris D.

Front Behav Neurosci. 2017 Jul 28;11:141. doi: 10.3389/fnbeh.2017.00141. eCollection 2017. Review.


Constitutively active Stat5b signaling confers tolerogenic functions to dendritic cells of NOD mice and halts diabetes progression.

Zerif E, Maalem A, Gaudreau S, Guindi C, Ramzan M, Véroneau S, Gris D, Stankova J, Rola-Pleszczynski M, Mourad W, Dupuis G, Amrani A.

J Autoimmun. 2017 Jan;76:63-74. doi: 10.1016/j.jaut.2016.09.001. Epub 2016 Sep 12.


Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis.

Desbiens L, Lapointe C, Gharagozloo M, Mahmoud S, Pejler G, Gris D, D'Orléans-Juste P.

Mediators Inflamm. 2016;2016:9797021. doi: 10.1155/2016/9797021. Epub 2016 Aug 17.


Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: Potential implications for neurodegenerative diseases.

Takser L, Benachour N, Husk B, Cabana H, Gris D.

Toxicol Rep. 2016 Jan 15;3:180-189. doi: 10.1016/j.toxrep.2015.12.008. eCollection 2016.


The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis.

Gharagozloo M, Mahvelati TM, Imbeault E, Gris P, Zerif E, Bobbala D, Ilangumaran S, Amrani A, Gris D.

J Neuroinflammation. 2015 Oct 31;12:198. doi: 10.1186/s12974-015-0414-5.


Struggling for breath in Sherbrooke - 1st Symposium on "One mitochondrion, many diseases" in Sherbrooke, Québec, Canada, March 11th, 2015.

Braun RJ, Dumit VI, Monpays C, Roucou X, Serrano D, St-Pierre J, Waters PJ, Bates I, Gris D.

Microb Cell. 2015 May 20;2(6):208-213. doi: 10.15698/mic2015.06.207. No abstract available.


Nlrx1 regulates neuronal cell death.

Imbeault E, Mahvelati TM, Braun R, Gris P, Gris D.

Mol Brain. 2014 Dec 24;7:90. doi: 10.1186/s13041-014-0090-x.


The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/microglia-induced inflammation.

Eitas TK, Chou WC, Wen H, Gris D, Robbins GR, Brickey J, Oyama Y, Ting JP.

J Biol Chem. 2014 Feb 14;289(7):4173-9. doi: 10.1074/jbc.M113.533034. Epub 2013 Dec 23.


Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy.

Savard A, Lavoie K, Brochu ME, Grbic D, Lepage M, Gris D, Sebire G.

J Neuroinflammation. 2013 Sep 5;10:110. doi: 10.1186/1742-2094-10-110.


Assessment of oxidative metabolism.

Imbeault E, Gris D.

Methods Mol Biol. 2013;1031:51-7. doi: 10.1007/978-1-62703-481-4_6.


NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

Allen IC, Moore CB, Schneider M, Lei Y, Davis BK, Scull MA, Gris D, Roney KE, Zimmermann AG, Bowzard JB, Ranjan P, Monroe KM, Pickles RJ, Sambhara S, Ting JP.

Immunity. 2011 Jun 24;34(6):854-65. doi: 10.1016/j.immuni.2011.03.026.


Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures.

Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G, Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, Schlossmacher MG.

J Neural Transm (Vienna). 2011 May;118(5):795-808. doi: 10.1007/s00702-011-0653-2. Epub 2011 May 7.


The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.

Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP.

J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12.


Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP.

Nat Immunol. 2011 May;12(5):408-15. doi: 10.1038/ni.2022. Epub 2011 Apr 10.


The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.

Jha S, Srivastava SY, Brickey WJ, Iocca H, Toews A, Morrison JP, Chen VS, Gris D, Matsushima GK, Ting JP.

J Neurosci. 2010 Nov 24;30(47):15811-20. doi: 10.1523/JNEUROSCI.4088-10.2010.


Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis.

Huang MT, Mortensen BL, Taxman DJ, Craven RR, Taft-Benz S, Kijek TM, Fuller JR, Davis BK, Allen IC, Brickey WJ, Gris D, Wen H, Kawula TH, Ting JP.

J Immunol. 2010 Nov 1;185(9):5476-85. doi: 10.4049/jimmunol.1002154. Epub 2010 Oct 4.


Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.

Arthur JC, Lich JD, Ye Z, Allen IC, Gris D, Wilson JE, Schneider M, Roney KE, O'Connor BP, Moore CB, Morrison A, Sutterwala FS, Bertin J, Koller BH, Liu Z, Ting JP.

J Immunol. 2010 Oct 15;185(8):4515-9. doi: 10.4049/jimmunol.1002227. Epub 2010 Sep 22.


NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses.

Gris D, Ye Z, Iocca HA, Wen H, Craven RR, Gris P, Huang M, Schneider M, Miller SD, Ting JP.

J Immunol. 2010 Jul 15;185(2):974-81. doi: 10.4049/jimmunol.0904145. Epub 2010 Jun 23.


A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism.

Gris P, Gauthier J, Cheng P, Gibson DG, Gris D, Laur O, Pierson J, Wentworth S, Nackley AG, Maixner W, Diatchenko L.

Mol Pain. 2010 Jun 2;6:33. doi: 10.1186/1744-8069-6-33.


Staphylococcus aureus alpha-hemolysin activates the NLRP3-inflammasome in human and mouse monocytic cells.

Craven RR, Gao X, Allen IC, Gris D, Bubeck Wardenburg J, McElvania-Tekippe E, Ting JP, Duncan JA.

PLoS One. 2009 Oct 14;4(10):e7446. doi: 10.1371/journal.pone.0007446.


The systemic inflammatory response after spinal cord injury damages lungs and kidneys.

Gris D, Hamilton EF, Weaver LC.

Exp Neurol. 2008 May;211(1):259-70. doi: 10.1016/j.expneurol.2008.01.033. Epub 2008 Mar 4.


Methylprednisolone causes minimal improvement after spinal cord injury in rats, contrasting with benefits of an anti-integrin treatment.

Weaver LC, Gris D, Saville LR, Oatway MA, Chen Y, Marsh DR, Hamilton EF, Dekaban GA.

J Neurotrauma. 2005 Dec;22(12):1375-87.


Autonomic dysreflexia after spinal cord injury: central mechanisms and strategies for prevention.

Weaver LC, Marsh DR, Gris D, Brown A, Dekaban GA.

Prog Brain Res. 2006;152:245-63. Review.


Transient blockade of the CD11d/CD18 integrin reduces secondary damage after spinal cord injury, improving sensory, autonomic, and motor function.

Gris D, Marsh DR, Oatway MA, Chen Y, Hamilton EF, Dekaban GA, Weaver LC.

J Neurosci. 2004 Apr 21;24(16):4043-51.


Central mechanisms for autonomic dysreflexia after spinal cord injury.

Weaver LC, Marsh DR, Gris D, Meakin SO, Dekaban GA.

Prog Brain Res. 2002;137:83-95. Review. No abstract available.


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