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African Americans With Acute Pancreatitis Present With Worsened Kidney Injury and Have Inadequate Access to Care.

Yazici C, Geary K, Sanchez A, Boulay BR, Papachristou GI, Krett N, Grippo PJ, Jung B.

Pancreas. 2019 Oct;48(9):e66-e68. doi: 10.1097/MPA.0000000000001400. No abstract available.


Knockout of Acinar Enriched microRNAs in Mice Promote Duct Formation But Not Pancreatic Cancer.

Sutaria DS, Jiang J, Azevedo-Pouly AC, Wright L, Bray JA, Fredenburg K, Liu X, Lu J, Torres C, Mancinelli G, Grippo PJ, Coppola V, Schmittgen TD.

Sci Rep. 2019 Jul 31;9(1):11147. doi: 10.1038/s41598-019-47566-x.


p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.

Torres C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, Castellanos K, Grimaldo S, Kumar S, Principe D, Dorman MJ, McKinney R, Hirsch E, Dawson D, Munshi HG, Rana A, Grippo PJ.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14724-14733. doi: 10.1073/pnas.1813012116. Epub 2019 Jul 2.


Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer.

Saloman JL, Albers KM, Cruz-Monserrate Z, Davis BM, Edderkaoui M, Eibl G, Epouhe AY, Gedeon JY, Gorelick FS, Grippo PJ, Groblewski GE, Husain SZ, Lai KKY, Pandol SJ, Uc A, Wen L, Whitcomb DC.

Pancreas. 2019 Jul;48(6):759-779. doi: 10.1097/MPA.0000000000001335.


TM4SF18 is aberrantly expressed in pancreatic cancer and regulates cell growth.

Singhal M, Khatibeghdami M, Principe DR, Mancinelli GE, Schachtschneider KM, Schook LB, Grippo PJ, Grimaldo SR.

PLoS One. 2019 Mar 21;14(3):e0211711. doi: 10.1371/journal.pone.0211711. eCollection 2019.


TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell-Mediated Regression of Pancreatic Cancer.

Principe DR, Park A, Dorman MJ, Kumar S, Viswakarma N, Rubin J, Torres C, McKinney R, Munshi HG, Grippo PJ, Rana A.

Mol Cancer Ther. 2019 Mar;18(3):613-620. doi: 10.1158/1535-7163.MCT-18-0850. Epub 2018 Dec 26.


Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.

Quan S, Principe DR, Dean AE, Park SH, Grippo PJ, Gius D, Horikoshi N.

Sci Rep. 2018 Nov 7;8(1):16501. doi: 10.1038/s41598-018-34792-y.


Omega-3 Fatty Acids Prevent Early Pancreatic Carcinogenesis via Repression of the AKT Pathway.

Ding Y, Mullapudi B, Torres C, Mascariñas E, Mancinelli G, Diaz AM, McKinney R, Barron M, Schultz M, Heiferman M, Wojtanek M, Adrian K, DeCant B, Rao S, Ouellette M, Tsao MS, Bentrem DJ, Grippo PJ.

Nutrients. 2018 Sep 12;10(9). pii: E1289. doi: 10.3390/nu10091289.


Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG.

Sci Rep. 2018 Sep 5;8(1):13225. doi: 10.1038/s41598-018-31658-1.


KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs.

Principe DR, Overgaard NH, Park AJ, Diaz AM, Torres C, McKinney R, Dorman MJ, Castellanos K, Schwind R, Dawson DW, Rana A, Maker A, Munshi HG, Rund LA, Grippo PJ, Schook LB.

Sci Rep. 2018 Aug 22;8(1):12548. doi: 10.1038/s41598-018-30916-6.


Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis.

Michalczyk ER, Chen L, Fine D, Zhao Y, Mascarinas E, Grippo PJ, DiPietro LA.

Sci Rep. 2018 Jul 24;8(1):11142. doi: 10.1038/s41598-018-29465-9.


Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

Overgaard NH, Principe DR, Schachtschneider KM, Jakobsen JT, Rund LA, Grippo PJ, Schook LB, Jungersen G.

Front Immunol. 2018 Jun 7;9:1301. doi: 10.3389/fimmu.2018.01301. eCollection 2018.


Pancreatic cancer subtypes: a roadmap for precision medicine.

Torres C, Grippo PJ.

Ann Med. 2018 Jun;50(4):277-287. doi: 10.1080/07853890.2018.1453168. Epub 2018 Mar 22. Review.


Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer.

Schultz MA, Diaz AM, Smite S, Lay AR, DeCant B, McKinney R, Mascarinas WE, Xia Y, Neumann C, Bentrem D, Dawson DW, Grippo PJ.

Oncotarget. 2017 Oct 4;8(54):92667-92681. doi: 10.18632/oncotarget.21539. eCollection 2017 Nov 3.


Roles of autophagy and metabolism in pancreatic cancer cell adaptation to environmental challenges.

Maertin S, Elperin JM, Lotshaw E, Sendler M, Speakman SD, Takakura K, Reicher BM, Mareninova OA, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G524-G536. doi: 10.1152/ajpgi.00138.2017. Epub 2017 Jul 13.


The Complexity of Omega-3 Fatty Acid Modulation of Signaling Pathways Related to Pancreatic Cancer.

Torres C, Diaz AM, Principe DR, Grippo PJ.

Curr Med Chem. 2018;25(22):2608-2623. doi: 10.2174/0929867324666170616111225. Review.


Canonical and alternative transcript expression of PAX6 and CXCR4 in pancreatic cancer.

Little EC, Kubic JD, Salgia R, Grippo PJ, Lang D.

Oncol Lett. 2017 Jun;13(6):4027-4034. doi: 10.3892/ol.2017.5956. Epub 2017 Mar 29.


TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.

Principe DR, Diaz AM, Torres C, Mangan RJ, DeCant B, McKinney R, Tsao MS, Lowy A, Munshi HG, Jung B, Grippo PJ.

Oncogene. 2017 Jul 27;36(30):4336-4348. doi: 10.1038/onc.2016.500. Epub 2017 Apr 3.


BET inhibitors block pancreatic stellate cell collagen I production and attenuate fibrosis in vivo.

Kumar K, DeCant BT, Grippo PJ, Hwang RF, Bentrem DJ, Ebine K, Munshi HG.

JCI Insight. 2017 Feb 9;2(3):e88032. doi: 10.1172/jci.insight.88032.


Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a Protein-induced Autophagy in Pancreatic Intraepithelial Neoplasms.

Gong J, Belinsky G, Sagheer U, Zhang X, Grippo PJ, Chung C.

J Biol Chem. 2016 Oct 14;291(42):22074-22085. Epub 2016 Aug 24.


miR-216 and miR-217 expression is reduced in transgenic mouse models of pancreatic adenocarcinoma, knockout of miR-216/miR-217 host gene is embryonic lethal.

Azevedo-Pouly AC, Sutaria DS, Jiang J, Elgamal OA, Amari F, Allard D, Grippo PJ, Coppola V, Schmittgen TD.

Funct Integr Genomics. 2017 May;17(2-3):203-212. doi: 10.1007/s10142-016-0512-1. Epub 2016 Aug 19.


Slug inhibits pancreatic cancer initiation by blocking Kras-induced acinar-ductal metaplasia.

Ebine K, Chow CR, DeCant BT, Hattaway HZ, Grippo PJ, Kumar K, Munshi HG.

Sci Rep. 2016 Jul 1;6:29133. doi: 10.1038/srep29133.


Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation.

Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B.

Oncotarget. 2017 Jan 17;8(3):3826-3839. doi: 10.18632/oncotarget.9830.


PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.

Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F.

Oncotarget. 2016 May 10;7(19):28218-34. doi: 10.18632/oncotarget.8587.


TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis.

Principe DR, DeCant B, Mascariñas E, Wayne EA, Diaz AM, Akagi N, Hwang R, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ.

Cancer Res. 2016 May 1;76(9):2525-39. doi: 10.1158/0008-5472.CAN-15-1293. Epub 2016 Mar 15.


HDAC3 mediates smoking-induced pancreatic cancer.

Edderkaoui M, Xu S, Chheda C, Morvaridi S, Hu RW, Grippo PJ, Mascariñas E, Principe DR, Knudsen B, Xue J, Habtezion A, Uyeminami D, Pinkerton KE, Pandol SJ.

Oncotarget. 2016 Feb 16;7(7):7747-60. doi: 10.18632/oncotarget.6820.


Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.

Bauer J, Ozden O, Akagi N, Carroll T, Principe DR, Staudacher JJ, Spehlmann ME, Eckmann L, Grippo PJ, Jung B.

Mol Cancer. 2015 Oct 24;14:182. doi: 10.1186/s12943-015-0456-4.


Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis.

Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M.

Pancreas. 2015 Aug;44(6):882-7. doi: 10.1097/MPA.0000000000000380.


Zileuton, 5-lipoxygenase inhibitor, acts as a chemopreventive agent in intestinal polyposis, by modulating polyp and systemic inflammation.

Gounaris E, Heiferman MJ, Heiferman JR, Shrivastav M, Vitello D, Blatner NR, Knab LM, Phillips JD, Cheon EC, Grippo PJ, Khazaie K, Munshi HG, Bentrem DJ.

PLoS One. 2015 Mar 6;10(3):e0121402. doi: 10.1371/journal.pone.0121402. eCollection 2015.


Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models.

DeCant BT, Principe DR, Guerra C, Pasca di Magliano M, Grippo PJ.

Front Physiol. 2014 Dec 4;5:464. doi: 10.3389/fphys.2014.00464. eCollection 2014. Review.


Ablation of 5-lipoxygenase mitigates pancreatic lesion development.

Knab LM, Schultz M, Principe DR, Mascarinas WE, Gounaris E, Munshi HG, Grippo PJ, Bentrem DJ.

J Surg Res. 2015 Apr;194(2):481-7. doi: 10.1016/j.jss.2014.10.021. Epub 2014 Oct 22.


Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase.

Knab LM, Grippo PJ, Bentrem DJ.

World J Gastroenterol. 2014 Aug 21;20(31):10729-39. doi: 10.3748/wjg.v20.i31.10729. Review.


Snail cooperates with Kras G12D in vivo to increase stem cell factor and enhance mast cell infiltration.

Knab LM, Ebine K, Chow CR, Raza SS, Sahai V, Patel AP, Kumar K, Bentrem DJ, Grippo PJ, Munshi HG.

Mol Cancer Res. 2014 Oct;12(10):1440-8. doi: 10.1158/1541-7786.MCR-14-0111. Epub 2014 Jun 18.


TGF-β: duality of function between tumor prevention and carcinogenesis.

Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L, Pasche B, Lee C, Grippo PJ.

J Natl Cancer Inst. 2014 Feb;106(2):djt369. doi: 10.1093/jnci/djt369. Review.


Snail cooperates with KrasG12D to promote pancreatic fibrosis.

Shields MA, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang RF, Grippo PJ, Munshi HG.

Mol Cancer Res. 2013 Sep;11(9):1078-87. doi: 10.1158/1541-7786.MCR-12-0637. Epub 2013 Jun 12.


Evaluating dietary compounds in pancreatic cancer modeling systems.

Mascariñas E, Eibl G, Grippo PJ.

Methods Mol Biol. 2013;980:225-48. doi: 10.1007/978-1-62703-287-2_12.


Epithelial-mesenchymal transition and pancreatic cancer progression.

Dangi-Garimella S, Krantz SB, Shields MA, Grippo PJ, Munshi HG.

In: Grippo PJ, Munshi HG, editors. Pancreatic Cancer and Tumor Microenvironment. Trivandrum (India): Transworld Research Network; 2012. Chapter 5.


Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.

Grippo PJ, Fitchev PS, Bentrem DJ, Melstrom LG, Dangi-Garimella S, Krantz SB, Heiferman MJ, Chung C, Adrian K, Cornwell ML, Flesche JB, Rao SM, Talamonti MS, Munshi HG, Crawford SE.

Gut. 2012 Oct;61(10):1454-64. doi: 10.1136/gutjnl-2011-300821. Epub 2012 Jan 10.


The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation.

Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, Grippo PJ, Mayerle J, Lerch MM, Gukovskaya AS.

Gastroenterology. 2012 Feb;142(2):377-87.e1-5. doi: 10.1053/j.gastro.2011.10.026. Epub 2011 Oct 29.


Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents.

Grippo PJ, Sandgren EP.

Int J Cancer. 2012 Sep 1;131(5):1243-8. doi: 10.1002/ijc.27322. Epub 2012 Jan 11.


MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.

Krantz SB, Shields MA, Dangi-Garimella S, Cheon EC, Barron MR, Hwang RF, Rao MS, Grippo PJ, Bentrem DJ, Munshi HG.

Mol Cancer Res. 2011 Oct;9(10):1294-304. doi: 10.1158/1541-7786.MCR-11-0023. Epub 2011 Aug 19.


Visualization of mouse pancreas architecture using MR microscopy.

Grippo PJ, Venkatasubramanian PN, Knop RH, Heiferman DM, Iordanescu G, Melstrom LG, Adrian K, Barron MR, Bentrem DJ, Wyrwicz AM.

Am J Pathol. 2011 Aug;179(2):610-8. doi: 10.1016/j.ajpath.2011.04.007. Epub 2011 May 31.


Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells.

Melstrom LG, Salabat MR, Ding XZ, Strouch MJ, Grippo PJ, Mirzoeva S, Pelling JC, Bentrem DJ.

J Surg Res. 2011 May 15;167(2):173-81. doi: 10.1016/j.jss.2010.10.041. Epub 2010 Nov 27.


Mast cell 5-lipoxygenase activity promotes intestinal polyposis in APCDelta468 mice.

Cheon EC, Khazaie K, Khan MW, Strouch MJ, Krantz SB, Phillips J, Blatner NR, Hix LM, Zhang M, Dennis KL, Salabat MR, Heiferman M, Grippo PJ, Munshi HG, Gounaris E, Bentrem DJ.

Cancer Res. 2011 Mar 1;71(5):1627-36. doi: 10.1158/0008-5472.CAN-10-1923. Epub 2011 Jan 7.


Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2.

Dangi-Garimella S, Krantz SB, Barron MR, Shields MA, Heiferman MJ, Grippo PJ, Bentrem DJ, Munshi HG.

Cancer Res. 2011 Feb 1;71(3):1019-28. doi: 10.1158/0008-5472.CAN-10-1855. Epub 2010 Dec 8.


Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression.

Dangi-Garimella S, Strouch MJ, Grippo PJ, Bentrem DJ, Munshi HG.

Oncogene. 2011 Feb 24;30(8):1002-8. doi: 10.1038/onc.2010.485. Epub 2010 Nov 8.


Deploying mouse models of pancreatic cancer for chemoprevention studies.

Grippo PJ, Tuveson DA.

Cancer Prev Res (Phila). 2010 Nov;3(11):1382-7. doi: 10.1158/1940-6207.CAPR-10-0258. Epub 2010 Nov 2. Review.


Alteration of strain background and a high omega-6 fat diet induces earlier onset of pancreatic neoplasia in EL-Kras transgenic mice.

Cheon EC, Strouch MJ, Barron MR, Ding Y, Melstrom LG, Krantz SB, Mullapudi B, Adrian K, Rao S, Adrian TE, Bentrem DJ, Grippo PJ.

Int J Cancer. 2011 Jun 15;128(12):2783-92. doi: 10.1002/ijc.25622. Epub 2010 Oct 26.


Tgfbr1 haploinsufficiency inhibits the development of murine mutant Kras-induced pancreatic precancer.

Adrian K, Strouch MJ, Zeng Q, Barron MR, Cheon EC, Honasoge A, Xu Y, Phukan S, Sadim M, Bentrem DJ, Pasche B, Grippo PJ.

Cancer Res. 2009 Dec 15;69(24):9169-74. doi: 10.1158/0008-5472.CAN-09-1705.


A high omega-3 fatty acid diet mitigates murine pancreatic precancer development.

Strouch MJ, Ding Y, Salabat MR, Melstrom LG, Adrian K, Quinn C, Pelham C, Rao S, Adrian TE, Bentrem DJ, Grippo PJ.

J Surg Res. 2011 Jan;165(1):75-81. doi: 10.1016/j.jss.2009.04.022. Epub 2009 May 15.

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