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Items: 1 to 50 of 89

1.

Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study.

Bouchard J, Malhotra R, Shah S, Kao YT, Vaida F, Gupta A, Berg DT, Grinnell BW, Stofan B, Tolwani AJ, Mehta RL.

PLoS One. 2015 Mar 19;10(3):e0120770. doi: 10.1371/journal.pone.0120770. eCollection 2015.

2.

Soluble thrombomodulin reduces inflammation and prevents microalbuminuria induced by chronic endothelial activation in transgenic mice.

Rajashekhar G, Gupta A, Marin A, Friedrich J, Willuweit A, Berg DT, Cramer MS, Sandusky GE, Sutton TA, Basile DP, Grinnell BW, Clauss M.

Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F703-12. doi: 10.1152/ajprenal.00558.2011. Epub 2011 Nov 30.

3.

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.

Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B.

Blood. 2012 Jan 19;119(3):874-83. doi: 10.1182/blood-2011-07-365973. Epub 2011 Nov 23.

4.

Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia.

Schouten M, van 't Veer C, Roelofs JJ, Gerlitz B, Grinnell BW, Levi M, van der Poll T.

Thromb Haemost. 2011 Dec;106(6):1189-96. doi: 10.1160/TH11-06-0438. Epub 2011 Sep 8.

PMID:
21901240
5.

Therapeutic recombinant murine activated protein C attenuates pulmonary coagulopathy and improves survival in murine pneumococcal pneumonia.

Schouten M, van 't Veer C, van den Boogaard FE, Gerlitz B, Grinnell BW, Roelofs JJ, Levi M, van der Poll T.

J Infect Dis. 2010 Nov 15;202(10):1600-7. doi: 10.1086/656787. Epub 2010 Oct 6.

PMID:
20925531
6.

Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study.

Schouten M, Sluijs KF, Gerlitz B, Grinnell BW, Roelofs JJ, Levi MM, van 't Veer C, van der Poll T.

Crit Care. 2010;14(2):R65. doi: 10.1186/cc8964. Epub 2010 Apr 14.

7.

Activated protein C and acute kidney injury: Selective targeting of PAR-1.

Gupta A, Williams MD, Macias WL, Molitoris BA, Grinnell BW.

Curr Drug Targets. 2009 Dec;10(12):1212-26. Review.

PMID:
19715537
8.

Soluble thrombomodulin protects ischemic kidneys.

Sharfuddin AA, Sandoval RM, Berg DT, McDougal GE, Campos SB, Phillips CL, Jones BE, Gupta A, Grinnell BW, Molitoris BA.

J Am Soc Nephrol. 2009 Mar;20(3):524-34. doi: 10.1681/ASN.2008060593. Epub 2009 Jan 28.

9.

Distinct functions of activated protein C differentially attenuate acute kidney injury.

Gupta A, Gerlitz B, Richardson MA, Bull C, Berg DT, Syed S, Galbreath EJ, Swanson BA, Jones BE, Grinnell BW.

J Am Soc Nephrol. 2009 Feb;20(2):267-77. doi: 10.1681/ASN.2008030294. Epub 2008 Dec 17.

10.

Activated protein C modulates chemokine response and tissue injury in experimental sepsis.

Sharma GR, Gerlitz B, Berg DT, Cramer MS, Jakubowski JA, Galbreath EJ, Heuer JG, Grinnell BW.

Adv Exp Med Biol. 2008;614:83-91. doi: 10.1007/978-0-387-74911-2_10.

PMID:
18290317
11.

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L.

Nature. 2008 Feb 28;451(7182):1076-81. doi: 10.1038/nature06559. Epub 2008 Feb 17.

PMID:
18278032
12.

Treatment of sepsis-induced acquired protein C deficiency reverses Angiotensin-converting enzyme-2 inhibition and decreases pulmonary inflammatory response.

Richardson MA, Gupta A, O'Brien LA, Berg DT, Gerlitz B, Syed S, Sharma GR, Cramer MS, Heuer JG, Galbreath EJ, Grinnell BW.

J Pharmacol Exp Ther. 2008 Apr;325(1):17-26. doi: 10.1124/jpet.107.130609. Epub 2008 Jan 8.

PMID:
18182560
13.

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis.

Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP.

Nat Med. 2007 Nov;13(11):1349-58. Epub 2007 Nov 4.

PMID:
17982464
14.

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation.

O'Brien LA, Richardson MA, Mehrbod SF, Berg DT, Gerlitz B, Gupta A, Grinnell BW.

Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2634-41. Epub 2007 Oct 11.

PMID:
17932312
15.

Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.

Berg DT, Gupta A, Richardson MA, O'Brien LA, Calnek D, Grinnell BW.

J Biol Chem. 2007 Dec 21;282(51):36837-44. Epub 2007 Oct 9.

16.

Polymeric coatings that mimic the endothelium: combining nitric oxide release with surface-bound active thrombomodulin and heparin.

Wu B, Gerlitz B, Grinnell BW, Meyerhoff ME.

Biomaterials. 2007 Oct;28(28):4047-55. Epub 2007 Jun 26.

17.

Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension.

Gupta A, Berg DT, Gerlitz B, Richardson MA, Galbreath E, Syed S, Sharma AC, Lowry SF, Grinnell BW.

Shock. 2007 Oct;28(4):468-76.

PMID:
17558353
18.

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.

Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S.

J Clin Invest. 2007 Jul;117(7):1951-60.

19.

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.

Gupta A, Rhodes GJ, Berg DT, Gerlitz B, Molitoris BA, Grinnell BW.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F245-54. Epub 2007 Apr 4.

20.

Role of protein C in renal dysfunction after polymicrobial sepsis.

Gupta A, Berg DT, Gerlitz B, Sharma GR, Syed S, Richardson MA, Sandusky G, Heuer JG, Galbreath EJ, Grinnell BW.

J Am Soc Nephrol. 2007 Mar;18(3):860-7. Epub 2007 Feb 14.

21.

FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis.

Berg DT, Gerlitz B, Sharma GR, Richardson MA, Stephens EJ, Grubbs RL, Holmes KC, Fynboe K, Montani D, Cramer MS, Engle SD, Jakubowski JA, Heuer JG, Grinnell BW.

Clin Vaccine Immunol. 2006 Mar;13(3):426-32.

22.

Activated protein C and sepsis.

O'Brien LA, Gupta A, Grinnell BW.

Front Biosci. 2006 Jan 1;11:676-98. Review.

PMID:
16146761
23.

Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta.

Berg DT, Myers LJ, Richardson MA, Sandusky G, Grinnell BW.

J Biol Chem. 2005 Apr 15;280(15):14943-7. Epub 2005 Feb 16.

24.

The development of drotrecogin alfa (activated) for the treatment of severe sepsis.

Macias WL, Yan SB, Grinnell BW.

Int J Artif Organs. 2004 May;27(5):360-70. Review. No abstract available.

PMID:
15202813
25.

Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway.

Joyce DE, Nelson DR, Grinnell BW.

Crit Care Med. 2004 May;32(5 Suppl):S280-6. Review.

PMID:
15118531
26.

Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by alpha(1)-antitrypsin.

Glasscock LN, Gerlitz B, Cooper ST, Grinnell BW, Church FC.

Biochim Biophys Acta. 2003 Jun 26;1649(1):106-17.

PMID:
12818196
27.

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.

Berg DT, Gerlitz B, Shang J, Smith T, Santa P, Richardson MA, Kurz KD, Grinnell BW, Mace K, Jones BE.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4423-8. Epub 2003 Apr 1.

28.

Modulation of thrombomodulin-dependent activation of human protein C through differential expression of endothelial Smads.

Sandusky G, Berg DT, Richardson MA, Myers L, Grinnell BW.

J Biol Chem. 2002 Dec 20;277(51):49815-9. Epub 2002 Oct 28.

29.
30.

Clinical expert round table discussion (session 3) at the Margaux Conference on Critical Illness: the role of activated protein C in severe sepsis.

Bernard G, Artigas A, Dellinger P, Esmon C, Faist E, Faust SN, Fischer CJ, Fumagalli R, grinnell BW, Sprung C.

Crit Care Med. 2001 Jul;29(7 Suppl):S75-7. Review. No abstract available.

PMID:
11445738
31.

Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis.

Grinnell BW, Joyce D.

Crit Care Med. 2001 Jul;29(7 Suppl):S53-60; discussion S60-1. Review.

PMID:
11445735
32.

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis.

Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW.

J Biol Chem. 2001 Apr 6;276(14):11199-203. Epub 2001 Feb 5.

33.

Unlike thrombin, protein C and activated protein C do not affect vascular tone.

Bhattacharya A, Grinnell BW, Cohen ML.

Peptides. 2000 Aug;21(8):1231-6.

PMID:
11035210
34.

17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway.

Richardson MA, Berg DT, Calnek DS, Ciaccia AV, Joyce DE, Grinnell BW.

Endocrinology. 2000 Oct;141(10):3908-11.

PMID:
11014248
35.

Novel antithrombotics based on modulation of the protein C pathway.

Grinnell BW, Yan SB.

Coron Artery Dis. 1998;9(2-3):89-97. Review. No abstract available.

PMID:
9647409
36.

Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor.

Calnek DS, Grinnell BW.

Exp Cell Res. 1998 Jan 10;238(1):294-8.

PMID:
9457083
37.

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D.

Cell. 1997 Jun 27;89(7):1165-73.

38.

Tipping the balance of blood coagulation.

Grinnell BW.

Nat Biotechnol. 1997 Feb;15(2):124-5. No abstract available.

PMID:
9035131
39.

Antithrombotic efficacy in the guinea pig of a derivative of human protein C with enhanced activation by thrombin.

Kurz KD, Smith T, Wilson A, Gerlitz B, Richardson MA, Grinnell BW.

Blood. 1997 Jan 15;89(2):534-40.

41.

Enhanced protein C activation and inhibition of fibrinogen cleavage by a thrombin modulator.

Berg DT, Wiley MR, Grinnell BW.

Science. 1996 Sep 6;273(5280):1389-91.

PMID:
8703074
42.

Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol.

Richardson MA, Berg DT, Johnston PA, McClure D, Grinnell BW.

J Lipid Res. 1996 May;37(5):1162-6.

43.

Evaluation of activated protein C on canine infarct size in a nonthrombotic model of myocardial reperfusion injury.

Hahn RA, MacDonald BR, Chastain M, Grinnell BW, Simpson PJ.

J Pharmacol Exp Ther. 1996 Mar;276(3):1104-10.

PMID:
8786541
44.

Trans-repressor BEF-1 phosphorylation. A potential control mechanism for human ApoE gene regulation.

Berg DT, Calnek DS, Grinnell BW.

J Biol Chem. 1996 Mar 1;271(9):4589-92.

45.

Surface thrombomodulin modulates thrombin receptor responses on vascular smooth muscle cells.

Grinnell BW, Berg DT.

Am J Physiol. 1996 Feb;270(2 Pt 2):H603-9.

PMID:
8779836
46.
48.

Tyrosine phosphorylation regulates the DNA binding activity of a nuclear factor 1-like repressor protein.

Reifel-Miller AE, Calnek DS, Grinnell BW.

J Biol Chem. 1994 Sep 30;269(39):23861-4.

49.
50.

Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide.

Grinnell BW, Hermann RB, Yan SB.

Glycobiology. 1994 Apr;4(2):221-5.

PMID:
7519910

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