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Items: 38

1.

Structure of the archaeal chemotaxis protein CheY in a domain-swapped dimeric conformation.

Paithankar KS, Enderle M, Wirthensohn DC, Miller A, Schlesner M, Pfeiffer F, Rittner A, Grininger M, Oesterhelt D.

Acta Crystallogr F Struct Biol Commun. 2019 Sep 1;75(Pt 9):576-585. doi: 10.1107/S2053230X19010896. Epub 2019 Aug 30.

2.

Comparative biochemical and structural analysis of the flavin-binding dodecins from Streptomyces davaonensis and Streptomyces coelicolor reveals striking differences with regard to multimerization.

Bourdeaux F, Ludwig P, Paithankar K, Sander B, Essen LO, Grininger M, Mack M.

Microbiology. 2019 Oct;165(10):1095-1106. doi: 10.1099/mic.0.000835.

PMID:
31339487
3.

Protein denaturation at the air-water interface and how to prevent it.

D'Imprima E, Floris D, Joppe M, Sánchez R, Grininger M, Kühlbrandt W.

Elife. 2019 Apr 1;8. pii: e42747. doi: 10.7554/eLife.42747.

4.

Fatty Acid Biosynthesis: Chain-Length Regulation and Control.

Heil CS, Wehrheim SS, Paithankar KS, Grininger M.

Chembiochem. 2019 Sep 16;20(18):2298-2321. doi: 10.1002/cbic.201800809. Epub 2019 Jun 27. Review.

PMID:
30908841
5.

Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains.

Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M.

ACS Chem Biol. 2019 Mar 15;14(3):426-433. doi: 10.1021/acschembio.8b01060. Epub 2019 Feb 11.

PMID:
30682239
6.

Probing the modularity of megasynthases by rational engineering of a fatty acid synthase Type I.

Rittner A, Paithankar KS, Drexler DJ, Himmler A, Grininger M.

Protein Sci. 2019 Feb;28(2):414-428. doi: 10.1002/pro.3550. Epub 2018 Dec 20.

PMID:
30394635
7.

Site-Specific Labelling of Multidomain Proteins by Amber Codon Suppression.

Heil CS, Rittner A, Goebel B, Beyer D, Grininger M.

Sci Rep. 2018 Oct 5;8(1):14864. doi: 10.1038/s41598-018-33115-5.

8.

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).

Rossini E, Gajewski J, Klaus M, Hummer G, Grininger M.

Chem Commun (Camb). 2018 Oct 11;54(82):11606-11609. doi: 10.1039/c8cc06838k.

PMID:
30264077
9.

Engineering strategies for rational polyketide synthase design.

Klaus M, Grininger M.

Nat Prod Rep. 2018 Oct 17;35(10):1070-1081. doi: 10.1039/c8np00030a. Review.

PMID:
29938731
10.

An engineered fatty acid synthase combined with a carboxylic acid reductase enables de novo production of 1-octanol in Saccharomyces cerevisiae.

Henritzi S, Fischer M, Grininger M, Oreb M, Boles E.

Biotechnol Biofuels. 2018 Jun 1;11:150. doi: 10.1186/s13068-018-1149-1. eCollection 2018.

11.

Characterization of the small flavin-binding dodecin in the roseoflavin producer Streptomyces davawensis.

Ludwig P, Sévin DC, Busche T, Kalinowski J, Bourdeaux F, Grininger M, Mack M.

Microbiology. 2018 Jun;164(6):908-919. doi: 10.1099/mic.0.000662.

PMID:
29856311
12.

Flavin Storage and Sequestration by Mycobacterium tuberculosis Dodecin.

Bourdeaux F, Hammer CA, Vogt S, Schweighöfer F, Nöll G, Wachtveitl J, Grininger M.

ACS Infect Dis. 2018 Jul 13;4(7):1082-1092. doi: 10.1021/acsinfecdis.7b00237. Epub 2018 Apr 9.

PMID:
29608272
13.

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering.

Rittner A, Paithankar KS, Huu KV, Grininger M.

ACS Chem Biol. 2018 Mar 16;13(3):723-732. doi: 10.1021/acschembio.7b00718. Epub 2018 Feb 1.

PMID:
29328619
14.

Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins.

Fischer M, Grininger M.

Beilstein J Org Chem. 2017 Jun 21;13:1204-1211. doi: 10.3762/bjoc.13.119. eCollection 2017. Review.

15.

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production.

Gajewski J, Pavlovic R, Fischer M, Boles E, Grininger M.

Nat Commun. 2017 Mar 10;8:14650. doi: 10.1038/ncomms14650.

16.

Engineering fatty acid synthases for directed polyketide production.

Gajewski J, Buelens F, Serdjukow S, Janßen M, Cortina N, Grubmüller H, Grininger M.

Nat Chem Biol. 2017 Apr;13(4):363-365. doi: 10.1038/nchembio.2314. Epub 2017 Feb 20.

PMID:
28218912
17.

Expanding the product portfolio of fungal type I fatty acid synthases.

Zhu Z, Zhou YJ, Krivoruchko A, Grininger M, Zhao ZK, Nielsen J.

Nat Chem Biol. 2017 Apr;13(4):360-362. doi: 10.1038/nchembio.2301. Epub 2017 Feb 20.

PMID:
28218911
18.

Crystallization and X-ray diffraction studies of a complete bacterial fatty-acid synthase type I.

Enderle M, McCarthy A, Paithankar KS, Grininger M.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1401-7. doi: 10.1107/S2053230X15018336. Epub 2015 Oct 23.

19.

Cryo-EM structure of fatty acid synthase (FAS) from Rhodosporidium toruloides provides insights into the evolutionary development of fungal FAS.

Fischer M, Rhinow D, Zhu Z, Mills DJ, Zhao ZK, Vonck J, Grininger M.

Protein Sci. 2015 Jun;24(6):987-95. doi: 10.1002/pro.2678. Epub 2015 Apr 2.

20.

Multi-Ligand-Binding Flavoprotein Dodecin as a Key Element for Reversible Surface Modification in Nano-biotechnology.

Gutiérrez Sánchez C, Su Q, Schönherr H, Grininger M, Nöll G.

ACS Nano. 2015;9(4):3491-500. doi: 10.1021/nn506993s. Epub 2015 Mar 13.

PMID:
25738566
21.

Modular polyketide synthases (PKSs): a new model fits all?

Rittner A, Grininger M.

Chembiochem. 2014 Nov 24;15(17):2489-93. doi: 10.1002/cbic.201402432. Epub 2014 Oct 16.

PMID:
25318851
22.

Perspectives on the evolution, assembly and conformational dynamics of fatty acid synthase type I (FAS I) systems.

Grininger M.

Curr Opin Struct Biol. 2014 Apr;25:49-56. doi: 10.1016/j.sbi.2013.12.004. Epub 2014 Jan 21. Review.

PMID:
24457260
23.

Directed manipulation of a flavoprotein photocycle.

Staudt H, Hoesl MG, Dreuw A, Serdjukow S, Oesterhelt D, Budisa N, Wachtveitl J, Grininger M.

Angew Chem Int Ed Engl. 2013 Aug 5;52(32):8463-6. doi: 10.1002/anie.201302334. Epub 2013 Jul 1. No abstract available.

PMID:
23818044
24.

Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.

Ciccarelli L, Connell SR, Enderle M, Mills DJ, Vonck J, Grininger M.

Structure. 2013 Jul 2;21(7):1251-7. doi: 10.1016/j.str.2013.04.023. Epub 2013 Jun 6.

25.

The flavoprotein dodecin as a redox probe for electron transfer through DNA.

Yu Y, Heidel B, Parapugna TL, Wenderhold-Reeb S, Song B, Schönherr H, Grininger M, Nöll G.

Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4950-3. doi: 10.1002/anie.201208987. Epub 2013 Mar 26. No abstract available.

26.

Ultrafast excited-state deactivation of flavins bound to dodecin.

Staudt H, Oesterhelt D, Grininger M, Wachtveitl J.

J Biol Chem. 2012 May 18;287(21):17637-44. doi: 10.1074/jbc.M111.331652. Epub 2012 Mar 26.

27.

Mechanism of substrate shuttling by the acyl-carrier protein within the fatty acid mega-synthase.

Anselmi C, Grininger M, Gipson P, Faraldo-Gómez JD.

J Am Chem Soc. 2010 Sep 8;132(35):12357-64. doi: 10.1021/ja103354w.

PMID:
20704262
28.

Structural and biochemical characterization of a halophilic archaeal alkaline phosphatase.

Wende A, Johansson P, Vollrath R, Dyall-Smith M, Oesterhelt D, Grininger M.

J Mol Biol. 2010 Jul 2;400(1):52-62. doi: 10.1016/j.jmb.2010.04.057. Epub 2010 May 11.

PMID:
20438737
29.

Direct structural insight into the substrate-shuttling mechanism of yeast fatty acid synthase by electron cryomicroscopy.

Gipson P, Mills DJ, Wouts R, Grininger M, Vonck J, Kühlbrandt W.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9164-9. doi: 10.1073/pnas.0913547107. Epub 2010 Mar 15.

30.

Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.

Johansson P, Mulinacci B, Koestler C, Vollrath R, Oesterhelt D, Grininger M.

Structure. 2009 Aug 12;17(8):1063-74. doi: 10.1016/j.str.2009.06.014.

31.

Blue-light-triggered photorelease of active chemicals captured by the flavoprotein dodecin.

Nöll G, Trawöger S, von Sanden-Flohe M, Dick B, Grininger M.

Chembiochem. 2009 Mar 23;10(5):834-7. doi: 10.1002/cbic.200900014. No abstract available.

PMID:
19253924
32.

Dodecin is the key player in flavin homeostasis of archaea.

Grininger M, Staudt H, Johansson P, Wachtveitl J, Oesterhelt D.

J Biol Chem. 2009 May 8;284(19):13068-76. doi: 10.1074/jbc.M808063200. Epub 2009 Feb 17.

33.

Electrochemical switching of the flavoprotein dodecin at gold surfaces modified by flavin-DNA hybrid linkers.

Grininger M, Nöll G, Trawöger S, Sinner EK, Oesterhelt D.

Biointerphases. 2008 Sep;3(3):51-8. doi: 10.1116/1.2965134.

PMID:
20408700
34.

Inhibition of the fungal fatty acid synthase type I multienzyme complex.

Johansson P, Wiltschi B, Kumari P, Kessler B, Vonrhein C, Vonck J, Oesterhelt D, Grininger M.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12803-8. doi: 10.1073/pnas.0805827105. Epub 2008 Aug 25.

35.

Dodecin sequesters FAD in closed conformation from the aqueous solution.

Grininger M, Seiler F, Zeth K, Oesterhelt D.

J Mol Biol. 2006 Dec 8;364(4):561-6. Epub 2006 Sep 5.

PMID:
17027852
36.

Dodecins: a family of lumichrome binding proteins.

Grininger M, Zeth K, Oesterhelt D.

J Mol Biol. 2006 Mar 31;357(3):842-57. Epub 2006 Jan 18.

PMID:
16460756
37.

Parameters affecting the X-ray dose absorbed by macromolecular crystals.

Murray JW, Rudiño-Piñera E, Owen RL, Grininger M, Ravelli RB, Garman EF.

J Synchrotron Radiat. 2005 May;12(Pt 3):268-75. Epub 2005 Apr 14.

PMID:
15840910
38.

Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm.

Grininger M, Ravelli RB, Heider U, Zeth K.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1429-31. Epub 2004 Jul 21.

PMID:
15272167

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