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Items: 1 to 50 of 106

1.

Crossover-site sequence and DNA torsional stress control strand interchanges by the Bxb1 site-specific serine recombinase.

Keenholtz RA, Grindley ND, Hatfull GF, Marko JF.

Nucleic Acids Res. 2016 Oct 14;44(18):8921-8932. Epub 2016 Aug 22.

2.

Prechemistry nucleotide selection checkpoints in the reaction pathway of DNA polymerase I and roles of glu710 and tyr766.

Bermek O, Grindley ND, Joyce CM.

Biochemistry. 2013 Sep 10;52(36):6258-74. doi: 10.1021/bi400837k. Epub 2013 Aug 27.

3.

Conformational landscapes of DNA polymerase I and mutator derivatives establish fidelity checkpoints for nucleotide insertion.

Hohlbein J, Aigrain L, Craggs TD, Bermek O, Potapova O, Shoolizadeh P, Grindley ND, Joyce CM, Kapanidis AN.

Nat Commun. 2013;4:2131. doi: 10.1038/ncomms3131.

4.

Remote control of DNA-acting enzymes by varying the Brownian dynamics of a distant DNA end.

Bai H, Kath JE, Zörgiebel FM, Sun M, Ghosh P, Hatfull GF, Grindley ND, Marko JF.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16546-51. doi: 10.1073/pnas.1203118109. Epub 2012 Sep 24.

5.

Single-molecule analysis reveals the molecular bearing mechanism of DNA strand exchange by a serine recombinase.

Bai H, Sun M, Ghosh P, Hatfull GF, Grindley ND, Marko JF.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7419-24. doi: 10.1073/pnas.1018436108. Epub 2011 Apr 18.

6.

Distinct roles of the active-site Mg2+ ligands, Asp882 and Asp705, of DNA polymerase I (Klenow fragment) during the prechemistry conformational transitions.

Bermek O, Grindley ND, Joyce CM.

J Biol Chem. 2011 Feb 4;286(5):3755-66. doi: 10.1074/jbc.M110.167593. Epub 2010 Nov 16.

7.

Conformational transitions in DNA polymerase I revealed by single-molecule FRET.

Santoso Y, Joyce CM, Potapova O, Le Reste L, Hohlbein J, Torella JP, Grindley ND, Kapanidis AN.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):715-20. doi: 10.1073/pnas.0910909107. Epub 2009 Dec 18.

8.

Chemical shift mapping of gammadelta resolvase dimer and activated tetramer: mechanistic implications for DNA strand exchange.

Gehman JD, Cocco MJ, Grindley ND.

Biochim Biophys Acta. 2008 Dec;1784(12):2086-92. doi: 10.1016/j.bbapap.2008.08.023. Epub 2008 Sep 17.

PMID:
18840551
9.

Fingers-closing and other rapid conformational changes in DNA polymerase I (Klenow fragment) and their role in nucleotide selectivity.

Joyce CM, Potapova O, Delucia AM, Huang X, Basu VP, Grindley ND.

Biochemistry. 2008 Jun 10;47(23):6103-16. doi: 10.1021/bi7021848. Epub 2008 May 13.

PMID:
18473481
10.

Conformational changes during normal and error-prone incorporation of nucleotides by a Y-family DNA polymerase detected by 2-aminopurine fluorescence.

DeLucia AM, Grindley ND, Joyce CM.

Biochemistry. 2007 Sep 25;46(38):10790-803. Epub 2007 Aug 29.

PMID:
17725324
11.

The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases.

DeLucia AM, Chaudhuri S, Potapova O, Grindley ND, Joyce CM.

J Biol Chem. 2006 Sep 15;281(37):27286-91. Epub 2006 Jul 10.

12.

Implications of structures of synaptic tetramers of gamma delta resolvase for the mechanism of recombination.

Kamtekar S, Ho RS, Cocco MJ, Li W, Wenwieser SV, Boocock MR, Grindley ND, Steitz TA.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10642-7. Epub 2006 Jun 28.

13.

Mechanisms of site-specific recombination.

Grindley ND, Whiteson KL, Rice PA.

Annu Rev Biochem. 2006;75:567-605. Review.

PMID:
16756503
14.

DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics.

Potapova O, Chan C, DeLucia AM, Helquist SA, Kool ET, Grindley ND, Joyce CM.

Biochemistry. 2006 Jan 24;45(3):890-8.

15.

Structure of a synaptic gammadelta resolvase tetramer covalently linked to two cleaved DNAs.

Li W, Kamtekar S, Xiong Y, Sarkis GJ, Grindley ND, Steitz TA.

Science. 2005 Aug 19;309(5738):1210-5. Epub 2005 Jun 30.

16.

An open letter to Elias Zerhouni.

Altman S, Bassler BL, Beckwith J, Belfort M, Berg HC, Bloom B, Brenchley JE, Campbell A, Collier RJ, Connell N, Cozzarelli NR, Craig NL, Darst S, Ebright RH, Elledge SJ, Falkow S, Galan JE, Gottesman M, Gourse R, Grindley ND, Gross CA, Grossman A, Hochschild A, Howe M, Hurwitz J, Isberg RR, Kaplan S, Kornberg A, Kustu SG, Landick RC, Landy A, Levy SB, Losick R, Long SR, Maloy SR, Mekalanos JJ, Neidhardt FC, Pace NR, Ptashne M, Roberts JW, Roth JR, Rothman-Denes LB, Salyers A, Schaechter M, Shapiro L, Silhavy TJ, Simon MI, Walker G, Yanofsky C, Zinder N.

Science. 2005 Mar 4;307(5714):1409-10. No abstract available.

PMID:
15746409
17.
19.
21.

Interaction of DNA polymerase I (Klenow fragment) with the single-stranded template beyond the site of synthesis.

Turner RM Jr, Grindley ND, Joyce CM.

Biochemistry. 2003 Mar 4;42(8):2373-85.

PMID:
12600204
22.

The mutational specificity of the Dbh lesion bypass polymerase and its implications.

Potapova O, Grindley ND, Joyce CM.

J Biol Chem. 2002 Aug 2;277(31):28157-66. Epub 2002 May 21.

23.

Cryptic plasmids of Mycobacterium avium: Tn552 to the rescue.

Kirby C, Waring A, Griffin TJ, Falkinham JO 3rd, Grindley ND, Derbyshire KM.

Mol Microbiol. 2002 Jan;43(1):173-86.

24.

Discrimination against purine-pyrimidine mispairs in the polymerase active site of DNA polymerase I: a structural explanation.

Minnick DT, Liu L, Grindley ND, Kunkel TA, Joyce CM.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1194-9.

25.

The basis of asymmetry in IS2 transposition.

Lewis LA, Gadura N, Greene M, Saby R, Grindley ND.

Mol Microbiol. 2001 Nov;42(4):887-901.

26.

A model for the gamma delta resolvase synaptic complex.

Sarkis GJ, Murley LL, Leschziner AE, Boocock MR, Stark WM, Grindley ND.

Mol Cell. 2001 Sep;8(3):623-31.

27.

Contacts between the 5' nuclease of DNA polymerase I and its DNA substrate.

Xu Y, Potapova O, Leschziner AE, Grindley ND, Joyce CM.

J Biol Chem. 2001 Aug 10;276(32):30167-77. Epub 2001 May 10.

28.

In vitro transposition system for efficient generation of random mutants of Campylobacter jejuni.

Colegio OR, Griffin TJ 4th, Grindley ND, Galán JE.

J Bacteriol. 2001 Apr;183(7):2384-8.

29.
30.

Identification of genes encoding exported Mycobacterium tuberculosis proteins using a Tn552'phoA in vitro transposition system.

Braunstein M, Griffin TJ IV, Kriakov JI, Friedman ST, Grindley ND, Jacobs WR Jr.

J Bacteriol. 2000 May;182(10):2732-40.

31.

In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis.

Griffin TJ 4th, Parsons L, Leschziner AE, DeVost J, Derbyshire KM, Grindley ND.

Nucleic Acids Res. 1999 Oct 1;27(19):3859-65.

32.

Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity.

Arnold PH, Blake DG, Grindley ND, Boocock MR, Stark WM.

EMBO J. 1999 Mar 1;18(5):1407-14.

34.

Tn552 transposase catalyzes concerted strand transfer in vitro.

Leschziner AE, Griffin TJ 4th, Grindley ND.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7345-50.

35.

How E. coli DNA polymerase I (Klenow fragment) distinguishes between deoxy- and dideoxynucleotides.

Astatke M, Grindley ND, Joyce CM.

J Mol Biol. 1998 Apr 24;278(1):147-65.

PMID:
9571040
36.

A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides.

Astatke M, Ng K, Grindley ND, Joyce CM.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3402-7.

37.

Site-specific recombination: synapsis and strand exchange revealed.

Grindley ND.

Curr Biol. 1997 Oct 1;7(10):R608-12. Review.

39.

Biochemical and mutational studies of the 5'-3' exonuclease of DNA polymerase I of Escherichia coli.

Xu Y, Derbyshire V, Ng K, Sun XC, Grindley ND, Joyce CM.

J Mol Biol. 1997 May 2;268(2):284-302.

PMID:
9159471
40.
41.

DNA transposition: from a black box to a color monitor.

Grindley ND, Leschziner AE.

Cell. 1995 Dec 29;83(7):1063-6. Review. No abstract available.

42.

Catalytic residues of gamma delta resolvase act in cis.

Boocock MR, Zhu X, Grindley ND.

EMBO J. 1995 Oct 16;14(20):5129-40.

43.

A functional analysis of the inverted repeat of the gamma delta transposable element.

May EW, Grindley ND.

J Mol Biol. 1995 Apr 7;247(4):578-87.

PMID:
7723015
44.

The tyrosine-6 hydroxyl of gamma delta resolvase is not required for the DNA cleavage and rejoining reactions.

Leschziner AE, Boocock MR, Grindley ND.

Mol Microbiol. 1995 Mar;15(5):865-70.

PMID:
7596288
46.

Analysis of a nucleoprotein complex: the synaptosome of gamma delta resolvase.

Grindley ND.

Science. 1993 Oct 29;262(5134):738-40.

PMID:
8235593
47.
48.

Mapping interactions between the catalytic domain of resolvase and its DNA substrate using cysteine-coupled EDTA-iron.

Mazzarelli JM, Ermácora MR, Fox RO, Grindley ND.

Biochemistry. 1993 Mar 30;32(12):2979-86.

PMID:
8384484
49.
50.

Binding of the IS903 transposase to its inverted repeat in vitro.

Derbyshire KM, Grindley ND.

EMBO J. 1992 Sep;11(9):3449-55.

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