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Items: 29

1.

The unfolded protein response regulator ATF6 promotes mesodermal differentiation.

Kroeger H, Grimsey N, Paxman R, Chiang WC, Plate L, Jones Y, Shaw PX, Trejo J, Tsang SH, Powers E, Kelly JW, Wiseman RL, Lin JH.

Sci Signal. 2018 Feb 13;11(517). pii: eaan5785. doi: 10.1126/scisignal.aan5785.

2.

Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling.

Hunter MR, Finlay DB, Macdonald CE, Cawston EE, Grimsey NL, Glass M.

Methods Enzymol. 2017;593:43-59. doi: 10.1016/bs.mie.2017.05.001. Epub 2017 Jun 27.

PMID:
28750814
3.

s signalling of the CB1 receptor and the influence of receptor number.

Finlay DB, Cawston EE, Grimsey NL, Hunter MR, Korde A, Vemuri VK, Makriyannis A, Glass M.

Br J Pharmacol. 2017 Aug;174(15):2545-2562. doi: 10.1111/bph.13866. Epub 2017 Jun 19.

4.

ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPX3L Motif.

Dores MR, Grimsey NJ, Mendez F, Trejo J.

PLoS One. 2016 Jun 14;11(6):e0157587. doi: 10.1371/journal.pone.0157587. eCollection 2016.

5.

Sulfation of the FLAG epitope is affected by co-expression of G protein-coupled receptors in a mammalian cell model.

Hunter MR, Grimsey NL, Glass M.

Sci Rep. 2016 Jun 7;6:27316. doi: 10.1038/srep27316.

6.

GPR18 undergoes a high degree of constitutive trafficking but is unresponsive to N-Arachidonoyl Glycine.

Finlay DB, Joseph WR, Grimsey NL, Glass M.

PeerJ. 2016 Mar 21;4:e1835. doi: 10.7717/peerj.1835. eCollection 2016.

7.

Integration of endothelial protease-activated receptor-1 inflammatory signaling by ubiquitin.

Grimsey NJ, Trejo J.

Curr Opin Hematol. 2016 May;23(3):274-9. doi: 10.1097/MOH.0000000000000232. Review.

8.

Recycling and Endosomal Sorting of Protease-activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins.

Grimsey NJ, Coronel LJ, Cordova IC, Trejo J.

J Biol Chem. 2016 Jan 29;291(5):2223-36. doi: 10.1074/jbc.M115.702993. Epub 2015 Dec 3.

9.

Identification of N-arachidonoyl dopamine as a highly biased ligand at cannabinoid CB1 receptors.

Redmond WJ, Cawston EE, Grimsey NL, Stuart J, Edington AR, Glass M, Connor M.

Br J Pharmacol. 2016 Jan;173(1):115-27. doi: 10.1111/bph.13341. Epub 2015 Nov 17.

10.

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes.

Grimsey NJ, Aguilar B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V, Trejo J.

J Cell Biol. 2015 Sep 28;210(7):1117-31. doi: 10.1083/jcb.201504007. Epub 2015 Sep 21.

11.

Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington's disease brain.

Dowie MJ, Grimsey NL, Hoffman T, Faull RL, Glass M.

J Chem Neuroanat. 2014 Sep;59-60:62-71. doi: 10.1016/j.jchemneu.2014.06.004. Epub 2014 Jun 27.

PMID:
24978314
12.

A general method for site specific fluorescent labeling of recombinant chemokines.

Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM.

PLoS One. 2014 Jan 28;9(1):e81454. doi: 10.1371/journal.pone.0081454. eCollection 2014.

13.

Endosomal signaling by protease-activated receptors.

Grimsey N, Lin H, Trejo J.

Methods Enzymol. 2014;535:389-401. doi: 10.1016/B978-0-12-397925-4.00022-5. Review.

14.

Distinct roles of the phosphatidate phosphatases lipin 1 and 2 during adipogenesis and lipid droplet biogenesis in 3T3-L1 cells.

Sembongi H, Miranda M, Han GS, Fakas S, Grimsey N, Vendrell J, Carman GM, Siniossoglou S.

J Biol Chem. 2013 Nov 29;288(48):34502-13. doi: 10.1074/jbc.M113.488445. Epub 2013 Oct 16.

15.

Real-time characterization of cannabinoid receptor 1 (CB1 ) allosteric modulators reveals novel mechanism of action.

Cawston EE, Redmond WJ, Breen CM, Grimsey NL, Connor M, Glass M.

Br J Pharmacol. 2013 Oct;170(4):893-907. doi: 10.1111/bph.12329.

16.

Sensitive and accurate quantification of human leukocyte migration using high-content Discovery-1 imaging system and ATPlite assay.

Grimsey NL, Moodley KS, Glass M, Graham ES.

J Biomol Screen. 2012 Mar;17(3):386-93. doi: 10.1177/1087057111428985. Epub 2011 Dec 1.

PMID:
22140120
17.

Adaptor protein complex-2 (AP-2) and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals.

Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J.

J Biol Chem. 2011 Nov 25;286(47):40760-70. doi: 10.1074/jbc.M111.299776. Epub 2011 Sep 30.

18.

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection.

Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, Floto RA.

J Clin Invest. 2011 Sep;121(9):3554-63. doi: 10.1172/JCI46095. Epub 2011 Aug 1.

19.

Cannabinoid receptor 2 undergoes Rab5-mediated internalization and recycles via a Rab11-dependent pathway.

Grimsey NL, Goodfellow CE, Dragunow M, Glass M.

Biochim Biophys Acta. 2011 Aug;1813(8):1554-60. doi: 10.1016/j.bbamcr.2011.05.010. Epub 2011 May 26.

20.

Regulation of protease-activated receptor signaling by post-translational modifications.

Grimsey N, Soto AG, Trejo J.

IUBMB Life. 2011 Jun;63(6):403-11. doi: 10.1002/iub.442. Epub 2011 Mar 24. Review.

21.

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics.

Grimsey NL, Graham ES, Dragunow M, Glass M.

Biochem Pharmacol. 2010 Oct 1;80(7):1050-62. doi: 10.1016/j.bcp.2010.06.007. Epub 2010 Jun 23.

PMID:
20599795
22.

Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.

Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S.

J Biol Chem. 2008 Oct 24;283(43):29166-74. doi: 10.1074/jbc.M804278200. Epub 2008 Aug 11.

23.

Evaluating the role of LPIN1 variation in insulin resistance, body weight, and human lipodystrophy in U.K. Populations.

Fawcett KA, Grimsey N, Loos RJ, Wheeler E, Daly A, Soos M, Semple R, Syddall H, Cooper C, Siniossoglou S, O'Rahilly S, Wareham NJ, Barroso I.

Diabetes. 2008 Sep;57(9):2527-33. doi: 10.2337/db08-0422. Epub 2008 Jun 30.

24.

A novel high-throughput assay for the quantitative assessment of receptor trafficking.

Grimsey NL, Narayan PJ, Dragunow M, Glass M.

Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1377-82. doi: 10.1111/j.1440-1681.2008.04991.x. Epub 2008 Jun 18.

PMID:
18565191
25.

The human lipodystrophy gene BSCL2/seipin may be essential for normal adipocyte differentiation.

Payne VA, Grimsey N, Tuthill A, Virtue S, Gray SL, Dalla Nora E, Semple RK, O'Rahilly S, Rochford JJ.

Diabetes. 2008 Aug;57(8):2055-60. doi: 10.2337/db08-0184. Epub 2008 May 5.

26.

Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!

Grimsey NL, Goodfellow CE, Scotter EL, Dowie MJ, Glass M, Graham ES.

J Neurosci Methods. 2008 Jun 15;171(1):78-86. doi: 10.1016/j.jneumeth.2008.02.014. Epub 2008 Mar 2.

PMID:
18406468
27.

Two human ARFGAPs associated with COP-I-coated vesicles.

Frigerio G, Grimsey N, Dale M, Majoul I, Duden R.

Traffic. 2007 Nov;8(11):1644-55. Epub 2007 Sep 29.

28.

Control of phospholipid synthesis by phosphorylation of the yeast lipin Pah1p/Smp2p Mg2+-dependent phosphatidate phosphatase.

O'Hara L, Han GS, Peak-Chew S, Grimsey N, Carman GM, Siniossoglou S.

J Biol Chem. 2006 Nov 10;281(45):34537-48. Epub 2006 Sep 12.

29.

The yeast lipin Smp2 couples phospholipid biosynthesis to nuclear membrane growth.

Santos-Rosa H, Leung J, Grimsey N, Peak-Chew S, Siniossoglou S.

EMBO J. 2005 Jun 1;24(11):1931-41. Epub 2005 May 5.

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