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Reevaluating Benefits in the Moral Justification of Animal Research: A Comment on "Necessary Conditions for Morally Responsible Animal Research".

Eggel M, Neuhaus CP, Grimm H.

Camb Q Healthc Ethics. 2020 Jan;29(1):131-143. doi: 10.1017/S0963180119000860.


An Alternative to the Orthodoxy in Animal Ethics? Limits and Merits of the Wittgensteinian Critique of Moral Individualism.

Monsó S, Grimm H.

Animals (Basel). 2019 Dec 1;9(12). pii: E1057. doi: 10.3390/ani9121057.


Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells.

Janitschke D, Nelke C, Lauer AA, Regner L, Winkler J, Thiel A, Grimm HS, Hartmann T, Grimm MOW.

Biomolecules. 2019 Nov 2;9(11). pii: E689. doi: 10.3390/biom9110689.


PKPD Assessment of the Anti-CD20 Antibody Obinutuzumab in Cynomolgus Monkey is Feasible Despite Marked Anti-Drug Antibody Response in This Species.

Grimm HP, Schick E, Hainzl D, Justies N, Yu L, Klein C, Husar E, Richter WF.

J Pharm Sci. 2019 Nov;108(11):3729-3736. doi: 10.1016/j.xphs.2019.07.013. Epub 2019 Jul 25.


"Patients' interests first, but … "⁻Austrian Veterinarians' Attitudes to Moral Challenges in Modern Small Animal Practice.

Springer S, Sandøe P, Bøker Lund T, Grimm H.

Animals (Basel). 2019 May 15;9(5). pii: E241. doi: 10.3390/ani9050241.


Profiling of Alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis.

Grimm MOW, Lauer AA, Grösgen S, Thiel A, Lehmann J, Winkler J, Janitschke D, Herr C, Beisswenger C, Bals R, Grimm HS, Hartmann T.

J Nutr Biochem. 2019 May;67:123-137. doi: 10.1016/j.jnutbio.2019.01.015. Epub 2019 Feb 11.


Austrian Veterinarians' Attitudes to Euthanasia in Equine Practice.

Springer S, Jenner F, Tichy A, Grimm H.

Animals (Basel). 2019 Jan 30;9(2). pii: E44. doi: 10.3390/ani9020044.


Harm-benefit analysis - what is the added value? A review of alternative strategies for weighing harms and benefits as part of the assessment of animal research.

Grimm H, Olsson IAS, Sandøe P.

Lab Anim. 2019 Feb;53(1):17-27. doi: 10.1177/0023677218783004. Epub 2018 Jul 3. Review.


The Effects of Exercise, Aspirin, and Celecoxib in an Atherogenic Environment.

Grimm H, Kretzschmar J, Cook MD, Brown MD.

Med Sci Sports Exerc. 2018 Oct;50(10):2033-2039. doi: 10.1249/MSS.0000000000001657.


Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC.

MAbs. 2018 Jul;10(5):803-813. doi: 10.1080/19420862.2018.1458808. Epub 2018 May 9.


Drawing the line in clinical treatment of companion animals: recommendations from an ethics working party.

Grimm H, Bergadano A, Musk GC, Otto K, Taylor PM, Duncan JC.

Vet Rec. 2018 Jun 9;182(23):664. doi: 10.1136/vr.104559. Epub 2018 Mar 30.


Prediction of the Optimal Dosing Regimen Using a Mathematical Model of Tumor Uptake for Immunocytokine-Based Cancer Immunotherapy.

Ribba B, Boetsch C, Nayak T, Grimm HP, Charo J, Evers S, Klein C, Tessier J, Charoin JE, Phipps A, Pisa P, Teichgräber V.

Clin Cancer Res. 2018 Jul 15;24(14):3325-3333. doi: 10.1158/1078-0432.CCR-17-2953. Epub 2018 Feb 20.


Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation.

Grimm MOW, Thiel A, Lauer AA, Winkler J, Lehmann J, Regner L, Nelke C, Janitschke D, Benoist C, Streidenberger O, Stötzel H, Endres K, Herr C, Beisswenger C, Grimm HS, Bals R, Lammert F, Hartmann T.

Int J Mol Sci. 2017 Dec 19;18(12). pii: E2764. doi: 10.3390/ijms18122764.


Interplay among Sequence, Folding Propensity, and Bio-Piezoelectric Response in Short Peptides and Peptoids.

Marvin CW, Grimm HM, Miller NC, Horne WS, Hutchison GR.

J Phys Chem B. 2017 Nov 9;121(44):10269-10275. doi: 10.1021/acs.jpcb.7b10085. Epub 2017 Oct 30.


The Road to Hell Is Paved with Good Intentions: Why Harm-Benefit Analysis and Its Emphasis on Practical Benefit Jeopardizes the Credibility of Research.

Grimm H, Eggel M, Deplazes-Zemp A, Biller-Andorno N.

Animals (Basel). 2017 Sep 11;7(9). pii: E70. doi: 10.3390/ani7090070.


Differential Response to Exercise in African Americans with High Levels of Inflammation.

Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins-Ball AM, Williamson ST, Ling C, Grimm H, Brown MD.

Ethn Dis. 2017 Jul 20;27(3):233-240. doi: 10.18865/ed.27.3.233. eCollection 2017 Summer.


Quantification of IgG monoclonal antibody clearance in tissues.

Eigenmann MJ, Fronton L, Grimm HP, Otteneder MB, Krippendorff BF.

MAbs. 2017 Aug/Sep;9(6):1007-1015. doi: 10.1080/19420862.2017.1337619. Epub 2017 Jun 14.


White paper and colourful language: Toward a realistic view of animal research.

Grimm H, Eggel M.

Altern Lab Anim. 2017 May;45(2):101-103. No abstract available.


Methodologies for Quantitative Systems Pharmacology (QSP) Models: Design and Estimation.

Ribba B, Grimm HP, Agoram B, Davies MR, Gadkar K, Niederer S, van Riel N, Timmis J, van der Graaf PH.

CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):496-498. doi: 10.1002/psp4.12206. Epub 2017 Jul 11.


APP Function and Lipids: A Bidirectional Link.

Grimm MO, Mett J, Grimm HS, Hartmann T.

Front Mol Neurosci. 2017 Mar 10;10:63. doi: 10.3389/fnmol.2017.00063. eCollection 2017. Review.


Eicosapentaenoic acid and docosahexaenoic acid increase the degradation of amyloid-β by affecting insulin-degrading enzyme.

Grimm MO, Mett J, Stahlmann CP, Haupenthal VJ, Blümel T, Stötzel H, Grimm HS, Hartmann T.

Biochem Cell Biol. 2016 Dec;94(6):534-542. Epub 2016 Apr 4.


Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.

Grimm MO, Regner L, Mett J, Stahlmann CP, Schorr P, Nelke C, Streidenberger O, Stoetzel H, Winkler J, Zaidan SR, Thiel A, Endres K, Grimm HS, Volmer DA, Hartmann T.

Int J Mol Sci. 2016 Oct 29;17(11). pii: E1809.


In Vivo Fluorescence Imaging of the Activity of CEA TCB, a Novel T-Cell Bispecific Antibody, Reveals Highly Specific Tumor Targeting and Fast Induction of T-Cell-Mediated Tumor Killing.

Lehmann S, Perera R, Grimm HP, Sam J, Colombetti S, Fauti T, Fahrni L, Schaller T, Freimoser-Grundschober A, Zielonka J, Stoma S, Rudin M, Klein C, Umana P, Gerdes C, Bacac M.

Clin Cancer Res. 2016 Sep 1;22(17):4417-27. doi: 10.1158/1078-0432.CCR-15-2622. Epub 2016 Apr 26.


Attitudes of Austrian veterinarians towards euthanasia in small animal practice: impacts of age and gender on views on euthanasia.

Hartnack S, Springer S, Pittavino M, Grimm H.

BMC Vet Res. 2016 Feb 4;12:26. doi: 10.1186/s12917-016-0649-0.


Development of a Unified Dissolution and Precipitation Model and Its Use for the Prediction of Oral Drug Absorption.

Jakubiak P, Wagner B, Grimm HP, Petrig-Schaffland J, Schuler F, Alvarez-Sánchez R.

Mol Pharm. 2016 Feb 1;13(2):586-98. doi: 10.1021/acs.molpharmaceut.5b00808. Epub 2016 Jan 5.


Oxidized Docosahexaenoic Acid Species and Lipid Peroxidation Products Increase Amyloidogenic Amyloid Precursor Protein Processing.

Grimm MO, Haupenthal VJ, Mett J, Stahlmann CP, Blümel T, Mylonas NT, Endres K, Grimm HS, Hartmann T.

Neurodegener Dis. 2016;16(1-2):44-54.


Professionalism and ethics in animal research.

Biller-Andorno N, Grimm H, Walker RL.

Nat Biotechnol. 2015 Oct;33(10):1027-8. doi: 10.1038/nbt.3363. No abstract available.


APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression.

Grimm MO, Mett J, Stahlmann CP, Grösgen S, Haupenthal VJ, Blümel T, Hundsdörfer B, Zimmer VC, Mylonas NT, Tanila H, Müller U, Grimm HS, Hartmann T.

Front Aging Neurosci. 2015 May 19;7:77. doi: 10.3389/fnagi.2015.00077. eCollection 2015.


Vitamin E: Curse or Benefit in Alzheimer's Disease? A Systematic Investigation of the Impact of α-, γ- and δ-Tocopherol on Aß Generation and Degradation in Neuroblastoma Cells.

Grimm MO, Stahlmann CP, Mett J, Haupenthal VJ, Zimmer VC, Lehmann J, Hundsdörfer B, Endres K, Grimm HS, Hartmann T.

J Nutr Health Aging. 2015 Jun;19(6):646-56. doi: 10.1007/s12603-015-0506-z.


Turning apples into oranges? The harm-benefit analysis and how to take ethical considerations into account.

Grimm H.

Altern Lab Anim. 2015 May;43(2):P22-4. No abstract available.


Chronic aerobic exercise improves blood pressure dipping status in African American nondippers.

Ling C, Diaz KM, Kretzschmar J, Feairheller DL, Sturgeon KM, Perkins A, Veerabhadrappa P, Williamson ST, Lee H, Grimm H, Babbitt DM, Brown MD.

Blood Press Monit. 2014 Dec;19(6):353-8. doi: 10.1097/MBP.0000000000000075.


PS dependent APP cleavage regulates glucosylceramide synthase and is affected in Alzheimer's disease.

Grimm MO, Hundsdörfer B, Grösgen S, Mett J, Zimmer VC, Stahlmann CP, Haupenthal VJ, Rothhaar TL, Lehmann J, Pätzold A, Zinser EG, Tanila H, Shen J, Müller U, Grimm HS, Hartmann T.

Cell Physiol Biochem. 2014;34(1):92-110. doi: 10.1159/000362987. Epub 2014 Jun 16.


Pharmacokinetics of paracetamol in Göttingen minipigs: in vivo studies and modeling to elucidate physiological determinants of absorption.

Suenderhauf C, Tuffin G, Lorentsen H, Grimm HP, Flament C, Parrott N.

Pharm Res. 2014 Oct;31(10):2696-707. doi: 10.1007/s11095-014-1367-6. Epub 2014 May 3.


Effects of moderate aerobic exercise training on vascular health and blood pressure in African Americans.

Feairheller DL, Diaz KM, Kashem MA, Thakkar SR, Veerabhadrappa P, Sturgeon KM, Ling C, Williamson ST, Kretzschmar J, Lee H, Grimm H, Babbitt DM, Vin C, Fan X, Crabbe DL, Brown MD.

J Clin Hypertens (Greenwich). 2014 Jul;16(7):504-10. doi: 10.1111/jch.12328. Epub 2014 Apr 29.


The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease.

Grimm MO, Zimmer VC, Lehmann J, Grimm HS, Hartmann T.

Biomed Res Int. 2013;2013:814390. doi: 10.1155/2013/814390. Epub 2014 Feb 19. Review.


[Animal protection without limits? Human-animal relations in between anthropomorphism and objectification].

Grimm H, Hartnack S.

Berl Munch Tierarztl Wochenschr. 2013 Sep-Oct;126(9-10):370-7. German.


A standardized exercise intervention differentially affects premenopausal and postmenopausal African-American women.

Kretzschmar J, Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD.

Menopause. 2014 Jun;21(6):579-84. doi: 10.1097/GME.0000000000000133.


Impact of Vitamin D on amyloid precursor protein processing and amyloid-β peptide degradation in Alzheimer's disease.

Grimm MO, Lehmann J, Mett J, Zimmer VC, Grösgen S, Stahlmann CP, Hundsdörfer B, Haupenthal VJ, Rothhaar TL, Herr C, Bals R, Grimm HS, Hartmann T.

Neurodegener Dis. 2014;13(2-3):75-81. doi: 10.1159/000355462. Epub 2013 Oct 30.


Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study.

Burg VK, Grimm HS, Rothhaar TL, Grösgen S, Hundsdörfer B, Haupenthal VJ, Zimmer VC, Mett J, Weingärtner O, Laufs U, Broersen LM, Tanila H, Vanmierlo T, Lütjohann D, Hartmann T, Grimm MO.

J Neurosci. 2013 Oct 9;33(41):16072-87. doi: 10.1523/JNEUROSCI.1506-13.2013.


Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys.

Vexler V, Yu L, Pamulapati C, Garrido R, Grimm HP, Sriraman P, Bohini S, Schraeml M, Singh U, Brandt M, Ries S, Ma H, Klumpp K, Ji C.

MAbs. 2013 Sep-Oct;5(5):776-86. doi: 10.4161/mabs.25642. Epub 2013 Jul 8.


Endothelial activation microparticles and inflammation status improve with exercise training in african americans.

Babbitt DM, Diaz KM, Feairheller DL, Sturgeon KM, Perkins AM, Veerabhadrappa P, Williamson ST, Kretzschmar J, Ling C, Lee H, Grimm H, Thakkar SR, Crabbe DL, Kashem MA, Brown MD.

Int J Hypertens. 2013;2013:538017. doi: 10.1155/2013/538017. Epub 2013 Apr 18.


Visit-to-visit and 24-h blood pressure variability: association with endothelial and smooth muscle function in African Americans.

Diaz KM, Veerabhadrappa P, Kashem MA, Thakkar SR, Feairheller DL, Sturgeon KM, Ling C, Williamson ST, Kretzschmar J, Lee H, Grimm H, Babbitt DM, Vin C, Fan X, Crabbe DL, Brown MD.

J Hum Hypertens. 2013 Nov;27(11):671-7. doi: 10.1038/jhh.2013.33. Epub 2013 Apr 25.


The effects of interleukin-6 signal blockade on immune system, reproductive and skeletal development in juvenile mice.

Sakurai T, Takai R, Bürgin H, Shioda A, Sakamoto Y, Amano J, Grimm HP, Richter WF, Higuchi Y, Chiba S, Kawamura A, Suzuki M, Müller L.

Birth Defects Res B Dev Reprod Toxicol. 2013 Apr;98(2):170-82. doi: 10.1002/bdrb.21053. Epub 2013 Mar 25.


Effect of Different Phospholipids on α-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer's Disease.

Grimm MO, Haupenthal VJ, Rothhaar TL, Zimmer VC, Grösgen S, Hundsdörfer B, Lehmann J, Grimm HS, Hartmann T.

Int J Mol Sci. 2013 Mar 13;14(3):5879-98. doi: 10.3390/ijms14035879.


The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS).

Tluczkiewicz I, Batke M, Kroese D, Buist H, Aldenberg T, Pauné E, Grimm H, Kühne R, Schüürmann G, Mangelsdorf I, Escher SE.

Regul Toxicol Pharmacol. 2013 Nov;67(2):157-69. doi: 10.1016/j.yrtph.2013.02.004. Epub 2013 Feb 21.


Plasmalogens inhibit APP processing by directly affecting γ-secretase activity in Alzheimer's disease.

Rothhaar TL, Grösgen S, Haupenthal VJ, Burg VK, Hundsdörfer B, Mett J, Riemenschneider M, Grimm HS, Hartmann T, Grimm MO.

ScientificWorldJournal. 2012;2012:141240. doi: 10.1100/2012/141240. Epub 2012 Apr 1.


The dynamics of Aβ distribution after γ-secretase inhibitor treatment, as determined by experimental and modelling approaches in a wild type rat.

Tai LM, Jacobsen H, Ozmen L, Flohr A, Jakob-Roetne R, Caruso A, Grimm HP.

J Pharmacokinet Pharmacodyn. 2012 Jun;39(3):227-37. doi: 10.1007/s10928-012-9246-4. Epub 2012 Apr 6.


Amyloid precursor protein (APP) mediated regulation of ganglioside homeostasis linking Alzheimer's disease pathology with ganglioside metabolism.

Grimm MO, Zinser EG, Grösgen S, Hundsdörfer B, Rothhaar TL, Burg VK, Kaestner L, Bayer TA, Lipp P, Müller U, Grimm HS, Hartmann T.

PLoS One. 2012;7(3):e34095. doi: 10.1371/journal.pone.0034095. Epub 2012 Mar 28.


Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.

Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, Li J, McVay S, O'Mahony J, Otteneder M, Pantze M, Putnam WS, Qiu ZJ, Ruppel J, Singer T, Stauch O, Theil FP, Visich J, Yang J, Ying Y, Khawli LA, Richter WF.

MAbs. 2012 Mar-Apr;4(2):243-55. doi: 10.4161/mabs.4.2.19387. Epub 2012 Mar 1.

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