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Participation of elderly gynecological cancer patients in clinical trials.

Prieske K, Trillsch F, Oskay-Özcelik G, Chekerov R, Bleich C, Oliveira-Ferrer L, Grimm D, Kuerti S, Mueller V, Suling A, Schmalfeldt B, Sehouli J, Mahner S, Woelber L.

Arch Gynecol Obstet. 2018 Oct;298(4):797-804. doi: 10.1007/s00404-018-4886-2. Epub 2018 Aug 30.


Semantic Analysis of Posttranslational Modification of Proteins Accumulated in Thyroid Cancer Cells Exposed to Simulated Microgravity.

Bauer J, Wehland M, Infanger M, Grimm D, Gombocz E.

Int J Mol Sci. 2018 Aug 1;19(8). pii: E2257. doi: 10.3390/ijms19082257.


Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A, Brinkmann K, Emenegger J, Grimm DG, Castellanos-Rizaldos E, Goldman JW, Sequist LV, Soria JC, Camidge DR, Gadgeel SM, Wakelee HA, Raponi M, Noerholm M, Skog J.

Ann Oncol. 2018 Jul 28. doi: 10.1093/annonc/mdy261. [Epub ahead of print] No abstract available.


Mushroom cultivation in the circular economy.

Grimm D, Wösten HAB.

Appl Microbiol Biotechnol. 2018 Sep;102(18):7795-7803. doi: 10.1007/s00253-018-9226-8. Epub 2018 Jul 19. Review.


Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission - The THYROID Project.

Kopp S, Krüger M, Feldmann S, Oltmann H, Schütte A, Schmitz B, Bauer J, Schulz H, Saar K, Huebner N, Wehland M, Nassef MZ, Melnik D, Meltendorf S, Infanger M, Grimm D.

Sci Rep. 2018 Jul 9;8(1):10355. doi: 10.1038/s41598-018-28695-1.


AAVvector-mediated in vivo reprogramming into pluripotency.

Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D.

Nat Commun. 2018 Jul 9;9(1):2651. doi: 10.1038/s41467-018-05059-x.


Impact of the assembly-activating protein (AAP) on molecular evolution of synthetic Adeno-associated virus (AAV) capsids.

Herrmann AK, Grosse S, Börner K, Krämer C, Wiedtke E, Gunkel M, Grimm D.

Hum Gene Ther. 2018 Jul 6. doi: 10.1089/hum.2018.085. [Epub ahead of print]


Opening the lab door.

Grimm D.

Science. 2018 Jun 29;360(6396):1392-1395. doi: 10.1126/science.360.6396.1392. No abstract available.


Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes.

Lützenberg R, Solano K, Buken C, Sahana J, Riwaldt S, Kopp S, Krüger M, Schulz H, Saar K, Huebner N, Hemmersbach R, Bauer J, Infanger M, Grimm D, Wehland M.

Cell Physiol Biochem. 2018;47(4):1729-1741. doi: 10.1159/000491006. Epub 2018 Jun 27.


A randomized controlled trial of MoodSwings 2.0: An internet-based self-management program for bipolar disorder.

Gliddon E, Cosgrove V, Berk L, Lauder S, Mohebbi M, Grimm D, Dodd S, Coulson C, Raju K, Suppes T, Berk M.

Bipolar Disord. 2018 Jun 21. doi: 10.1111/bdi.12669. [Epub ahead of print]


Correlation of Isotope Count With Sentinel Node Positivity in Vulvar Cancer.

Woelber L, Joosse SA, Grimm D, Mathey S, Mahner S, Burandt E, Klutmann S, Schmalfeldt B, Prieske K.

Int J Gynecol Cancer. 2018 Sep;28(7):1403-1409. doi: 10.1097/IGC.0000000000001298.


MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, Börner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB.

BMC Cancer. 2018 Jun 18;18(1):663. doi: 10.1186/s12885-018-4525-0.


Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn.

Pedersen J, Hedegaard ER, Simonsen U, Krüger M, Infanger M, Grimm D.

Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):392-406. doi: 10.1111/bcpt.13051. Epub 2018 Jul 19. Review.


Decreased E-Cadherin in MCF7 Human Breast Cancer Cells Forming Multicellular Spheroids Exposed to Simulated Microgravity.

Sahana J, Nassef MZ, Wehland M, Kopp S, Krüger M, Corydon TJ, Infanger M, Bauer J, Grimm D.

Proteomics. 2018 Jul;18(13):e1800015. doi: 10.1002/pmic.201800015. Epub 2018 Jun 19.


High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

Herrmann AK, Grimm D.

J Mol Biol. 2018 Aug 17;430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Epub 2018 May 19. Review.


Compliance: An Ounce of Prevention Is Worth a Pound of Cure.

Grimm DA.

Front Health Serv Manage. 2018 Summer;34(4):32-41. doi: 10.1097/HAP.0000000000000035. No abstract available.


Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis.

Falcke JM, Bose N, Artyukhin AB, Rödelsperger C, Markov GV, Yim JJ, Grimm D, Claassen MH, Panda O, Baccile JA, Zhang YK, Le HH, Jolic D, Schroeder FC, Sommer RJ.

Cell Chem Biol. 2018 Jun 21;25(6):787-796.e12. doi: 10.1016/j.chembiol.2018.04.004. Epub 2018 May 17.


A Focus on Macitentan in the Treatment of Pulmonary Arterial Hypertension.

Bedan M, Grimm D, Wehland M, Simonsen U, Infanger M, Krüger M.

Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):103-113. doi: 10.1111/bcpt.13033. Epub 2018 Jun 5. Review.


Tissue Engineering Under Microgravity Conditions-Use of Stem Cells and Specialized Cells.

Grimm D, Egli M, Krüger M, Riwaldt S, Corydon TJ, Kopp S, Wehland M, Wise P, Infanger M, Mann V, Sundaresan A.

Stem Cells Dev. 2018 Jun 15;27(12):787-804. doi: 10.1089/scd.2017.0242. Epub 2018 Mar 29.


Exosome-Based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients.

Castellanos-Rizaldos E, Grimm DG, Tadigotla V, Hurley J, Healy J, Neal PL, Sher M, Venkatesan R, Karlovich C, Raponi M, Krug A, Noerholm M, Tannous J, Tannous BA, Raez LE, Skog JK.

Clin Cancer Res. 2018 Jun 15;24(12):2944-2950. doi: 10.1158/1078-0432.CCR-17-3369. Epub 2018 Mar 13.


Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: Evidence from cell-free DNA analysis.

Agbor-Enoh S, Jackson AM, Tunc I, Berry GJ, Cochrane A, Grimm D, Davis A, Shah P, Brown AW, Wang Y, Timofte I, Shah P, Gorham S, Wylie J, Goodwin N, Jang MK, Marishta A, Bhatti K, Fideli U, Yang Y, Luikart H, Cao Z, Pirooznia M, Zhu J, Marboe C, Iacono A, Nathan SD, Orens J, Valantine HA, Khush K.

J Heart Lung Transplant. 2018 Jul;37(7):925-932. doi: 10.1016/j.healun.2018.01.1305. Epub 2018 Jan 31.


The happiness project.

Grimm D.

Science. 2018 Feb 9;359(6376):624-627. doi: 10.1126/science.359.6376.624. No abstract available.


The rate and potential relevance of new mutations in a colonizing plant lineage.

Exposito-Alonso M, Becker C, Schuenemann VJ, Reiter E, Setzer C, Slovak R, Brachi B, Hagmann J, Grimm DG, Chen J, Busch W, Bergelson J, Ness RW, Krause J, Burbano HA, Weigel D.

PLoS Genet. 2018 Feb 12;14(2):e1007155. doi: 10.1371/journal.pgen.1007155. eCollection 2018 Feb.


Key Proteins Involved in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity.

Dittrich A, Grimm D, Sahana J, Bauer J, Krüger M, Infanger M, Magnusson NE.

Cell Physiol Biochem. 2018;45(2):429-445. doi: 10.1159/000486920. Epub 2018 Jan 24.


The Impact of Vitamin D in the Treatment of Essential Hypertension.

Legarth C, Grimm D, Wehland M, Bauer J, Krüger M.

Int J Mol Sci. 2018 Feb 3;19(2). pii: E455. doi: 10.3390/ijms19020455. Review.


Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU, Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA, Baumgart J, Galle PR, Zimmermann T.

Oncotarget. 2017 Dec 18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29.


Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

Lou WP, Mateos A, Koch M, Klussman S, Yang C, Lu N, Kumar S, Limpert S, Göpferich M, Zschaetzsch M, Sliwinski C, Kenzelmann M, Seedorf M, Maillo C, Senis E, Grimm D, Puttagunta R, Mendez R, Liu K, Hassan BA, Martin-Villalba A.

Front Mol Neurosci. 2018 Jan 12;10:445. doi: 10.3389/fnmol.2017.00445. eCollection 2017.


The role of NFκB in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine.

Kopp S, Sahana J, Islam T, Petersen AG, Bauer J, Corydon TJ, Schulz H, Saar K, Huebner N, Slumstrup L, Riwaldt S, Wehland M, Infanger M, Luetzenberg R, Grimm D.

Sci Rep. 2018 Jan 17;8(1):921. doi: 10.1038/s41598-017-18556-8.


Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology.

Schmelas C, Grimm D.

Biotechnol J. 2018 Sep;13(9):e1700432. doi: 10.1002/biot.201700432. Epub 2018 Feb 2. Review.


The Effects of Palate Features and Glossectomy Surgery on /s/ Production.

Grimm DL, Stone M, Woo J, Lee J, Hwang JH, Bedrosian GE, Prince JL.

J Speech Lang Hear Res. 2017 Dec 20;60(12):3417-3425. doi: 10.1044/2017_JSLHR-S-16-0425.


Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A, Brinkmann K, Emenegger J, Grimm DG, Castellanos-Rizaldos E, Goldman JW, Sequist LV, Soria JC, Camidge DR, Gadgeel SM, Wakelee HA, Raponi M, Noerholm M, Skog J.

Ann Oncol. 2018 Mar 1;29(3):700-706. doi: 10.1093/annonc/mdx765.


Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models.

Riwaldt S, Monici M, Graver Petersen A, Birk Jensen U, Evert K, Pantalone D, Utpatel K, Evert M, Wehland M, Krüger M, Kopp S, Frandsen S, Corydon T, Sahana J, Bauer J, Lützenberg R, Infanger M, Grimm D.

Int J Mol Sci. 2017 Dec 3;18(12). pii: E2604. doi: 10.3390/ijms18122604.


Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaan8081. doi: 10.1126/scitranslmed.aan8081. Erratum in: Sci Transl Med. 2018 Jan 24;10 (425):.


Oldest images of dogs show hunting, leashes.

Grimm D.

Science. 2017 Nov 17;358(6365):854. doi: 10.1126/science.358.6365.854. No abstract available.


Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer.

Prieske K, Prieske S, Joosse SA, Trillsch F, Grimm D, Burandt E, Mahner S, Schmalfeldt B, Milde-Langosch K, Oliveira-Ferrer L, Woelber L.

Oncotarget. 2017 Sep 15;8(47):83063-83074. doi: 10.18632/oncotarget.20945. eCollection 2017 Oct 10.


Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.

Kunze C, Börner K, Kienle E, Orschmann T, Rusha E, Schneider M, Radivojkov-Blagojevic M, Drukker M, Desbordes S, Grimm D, Brack-Werner R.

Glia. 2018 Feb;66(2):413-427. doi: 10.1002/glia.23254. Epub 2017 Nov 9.


The AraGWAS Catalog: a curated and standardized Arabidopsis thaliana GWAS catalog.

Togninalli M, Seren Ü, Meng D, Fitz J, Nordborg M, Weigel D, Borgwardt K, Korte A, Grimm DG.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1150-D1156. doi: 10.1093/nar/gkx954.


Semantic analysis of thyroid cancer cell proteins obtained from rare research opportunities.

Bauer J, Grimm D, Gombocz E.

J Biomed Inform. 2017 Dec;76:138-153. doi: 10.1016/j.jbi.2017.10.011. Epub 2017 Oct 18.


Mapping the global potential for marine aquaculture.

Gentry RR, Froehlich HE, Grimm D, Kareiva P, Parke M, Rust M, Gaines SD, Halpern BS.

Nat Ecol Evol. 2017 Sep;1(9):1317-1324. doi: 10.1038/s41559-017-0257-9. Epub 2017 Aug 14.


The Combination of Valsartan and Sacubitril in the Treatment of Hypertension and Heart Failure - an Update.

Nielsen PM, Grimm D, Wehland M, Simonsen U, Krüger M.

Basic Clin Pharmacol Toxicol. 2018 Jan;122(1):9-18. doi: 10.1111/bcpt.12912. Epub 2017 Oct 11. Review.


PETA targets early-career wildlife researcher.

Grimm D.

Science. 2017 Sep 15;357(6356):1087. doi: 10.1126/science.357.6356.1087. No abstract available.


Deposition of exchange-coupled dinickel complexes on gold substrates utilizing ambidentate mercapto-carboxylato ligands.

Börner M, Blömer L, Kischel M, Richter P, Salvan G, Zahn DRT, Siles PF, Fuentes MEN, Bufon CCB, Grimm D, Schmidt OG, Breite D, Abel B, Kersting B.

Beilstein J Nanotechnol. 2017 Jul 5;8:1375-1387. doi: 10.3762/bjnano.8.139. eCollection 2017.


A Special Focus on Selexipag - Treatment of Pulmonary Arterial Hypertension.

Sorensen LM, Wehland M, Kruger M, Simonsen U, Nassef MZ, Infanger M, Grimm D.

Curr Pharm Des. 2017;23(34):5191-5199. doi: 10.2174/1381612823666170908114227.


Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine.

Warnke E, Pietsch J, Kopp S, Bauer J, Sahana J, Wehland M, Krüger M, Hemmersbach R, Infanger M, Lützenberg R, Grimm D.

Cell Physiol Biochem. 2017;43(1):257-270. doi: 10.1159/000480368. Epub 2017 Aug 30.


Small But Increasingly Mighty: Latest Advances in AAV Vector Research, Design, and Evolution.

Grimm D, Büning H.

Hum Gene Ther. 2017 Nov;28(11):1075-1086. doi: 10.1089/hum.2017.172. Epub 2017 Aug 23. Review.


Hypertension Caused by Lenvatinib and Everolimus in the Treatment of Metastatic Renal Cell Carcinoma.

Bendtsen MAF, Grimm D, Bauer J, Wehland M, Wise P, Magnusson NE, Infanger M, Krüger M.

Int J Mol Sci. 2017 Aug 10;18(8). pii: E1736. doi: 10.3390/ijms18081736. Review.


Modulation of cellular energetics by galactose and pioglitazone.

Grimm D, Altamirano L, Paudel S, Welker L, Konkle ME, Chakraborty N, Menze MA.

Cell Tissue Res. 2017 Sep;369(3):641-646. doi: 10.1007/s00441-017-2657-1. Epub 2017 Aug 3.


Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

Grosse S, Penaud-Budloo M, Herrmann AK, Börner K, Fakhiri J, Laketa V, Krämer C, Wiedtke E, Gunkel M, Ménard L, Ayuso E, Grimm D.

J Virol. 2017 Sep 27;91(20). pii: e01198-17. doi: 10.1128/JVI.01198-17. Print 2017 Oct 15.


Next-generation AAV vectors for clinical use: an ever-accelerating race.

Weinmann J, Grimm D.

Virus Genes. 2017 Oct;53(5):707-713. doi: 10.1007/s11262-017-1502-7. Epub 2017 Jul 31. Review.


Understanding and Modeling Teams As Dynamical Systems.

Gorman JC, Dunbar TA, Grimm D, Gipson CL.

Front Psychol. 2017 Jul 11;8:1053. doi: 10.3389/fpsyg.2017.01053. eCollection 2017. Review.

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