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Immune genes are primed for robust transcription by proximal long noncoding RNAs located in nuclear compartments.

Fanucchi S, Fok ET, Dalla E, Shibayama Y, Börner K, Chang EY, Stoychev S, Imakaev M, Grimm D, Wang KC, Li G, Sung WK, Mhlanga MM.

Nat Genet. 2018 Dec 10. doi: 10.1038/s41588-018-0298-2. [Epub ahead of print]


Evaluating Sociotechnical Dynamics in a Simulated Remotely-Piloted Aircraft System: A Layered Dynamics Approach.

Gorman JC, Demir M, Cooke NJ, Grimm DA.

Ergonomics. 2018 Dec 8:1-44. doi: 10.1080/00140139.2018.1557750. [Epub ahead of print]


A robust and all-inclusive pipeline for shuffling of Adeno-associated viruses (AAV).

Herrmann AK, Bender C, Kienle E, Grosse S, El Andari J, Botta J, Schürmann N, Wiedtke E, Niopek D, Grimm D.

ACS Synth Biol. 2018 Dec 4. doi: 10.1021/acssynbio.8b00373. [Epub ahead of print]


Current knowledge about the impact of microgravity on the proteome.

Strauch SM, Grimm D, Corydon TJ, Krüger M, Bauer J, Lebert M, Wise P, Infanger M, Richter P.

Expert Rev Proteomics. 2018 Nov 19:1-12. doi: 10.1080/14789450.2019.1550362. [Epub ahead of print]


Methods and Tools in Genome-wide Association Studies.

Gumpinger AC, Roqueiro D, Grimm DG, Borgwardt KM.

Methods Mol Biol. 2018;1819:93-136. doi: 10.1007/978-1-4939-8618-7_5.


U.S. labs using a record number of monkeys.

Grimm D.

Science. 2018 Nov 9;362(6415):630. doi: 10.1126/science.362.6415.630. No abstract available.


Diet-dependent function of the extracellular matrix proteoglycan Lumican in obesity and glucose homeostasis.

Wolff G, Taranko AE, Meln I, Weinmann J, Sijmonsma T, Lerch S, Heide D, Billeter AT, Tews D, Krunic D, Fischer-Posovszky P, Müller-Stich BP, Herzig S, Grimm D, Heikenwälder M, Kao WW, Vegiopoulos A.

Mol Metab. 2018 Oct 23. pii: S2212-8778(18)30837-8. doi: 10.1016/j.molmet.2018.10.007. [Epub ahead of print]


Pupillometry Trends in the Setting of Increased Intracranial Pressure.

McNett M, Moran C, Grimm D, Gianakis A.

J Neurosci Nurs. 2018 Dec;50(6):357-361. doi: 10.1097/JNN.0000000000000401.


Preparative enrichment of human tissue cells capable to change a site of growth in vitro or in vivo - Recent developments.

Bauer J, Cohly HHP, Sahana J, Grimm D.

Prep Biochem Biotechnol. 2018 Nov 5:1-7. doi: 10.1080/10826068.2018.1525567. [Epub ahead of print]


Sexual activity and quality of life in patients after treatment for breast and ovarian cancer.

Mayer S, Iborra S, Grimm D, Steinsiek L, Mahner S, Bossart M, Woelber L, Voss PJ, Gitsch G, Hasenburg A.

Arch Gynecol Obstet. 2018 Nov 1. doi: 10.1007/s00404-018-4922-2. [Epub ahead of print]


Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9.

Bubeck F, Hoffmann MD, Harteveld Z, Aschenbrenner S, Bietz A, Waldhauer MC, Börner K, Fakhiri J, Schmelas C, Dietz L, Grimm D, Correia BE, Eils R, Niopek D.

Nat Methods. 2018 Nov;15(11):924-927. doi: 10.1038/s41592-018-0178-9. Epub 2018 Oct 30.


Pazopanib, Cabozantinib, and Vandetanib in the Treatment of Progressive Medullary Thyroid Cancer with a Special Focus on the Adverse Effects on Hypertension.

Milling RV, Grimm D, Krüger M, Grosse J, Kopp S, Bauer J, Infanger M, Wehland M.

Int J Mol Sci. 2018 Oct 20;19(10). pii: E3258. doi: 10.3390/ijms19103258. Review.


Airlines fight effort to force them to carry lab animals.

Grimm D.

Science. 2018 Oct 5;362(6410):15. doi: 10.1126/science.362.6410.15. No abstract available.


Participation of elderly gynecological cancer patients in clinical trials.

Prieske K, Trillsch F, Oskay-Özcelik G, Chekerov R, Bleich C, Oliveira-Ferrer L, Grimm D, Kuerti S, Mueller V, Suling A, Schmalfeldt B, Sehouli J, Mahner S, Woelber L.

Arch Gynecol Obstet. 2018 Oct;298(4):797-804. doi: 10.1007/s00404-018-4886-2. Epub 2018 Aug 30.


Semantic Analysis of Posttranslational Modification of Proteins Accumulated in Thyroid Cancer Cells Exposed to Simulated Microgravity.

Bauer J, Wehland M, Infanger M, Grimm D, Gombocz E.

Int J Mol Sci. 2018 Aug 1;19(8). pii: E2257. doi: 10.3390/ijms19082257.


Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A, Brinkmann K, Emenegger J, Grimm DG, Castellanos-Rizaldos E, Goldman JW, Sequist LV, Soria JC, Camidge DR, Gadgeel SM, Wakelee HA, Raponi M, Noerholm M, Skog J.

Ann Oncol. 2018 Oct 1;29(10):2143. doi: 10.1093/annonc/mdy261. No abstract available.


Mushroom cultivation in the circular economy.

Grimm D, Wösten HAB.

Appl Microbiol Biotechnol. 2018 Sep;102(18):7795-7803. doi: 10.1007/s00253-018-9226-8. Epub 2018 Jul 19. Review.


Thyroid cancer cells in space during the TEXUS-53 sounding rocket mission - The THYROID Project.

Kopp S, Krüger M, Feldmann S, Oltmann H, Schütte A, Schmitz B, Bauer J, Schulz H, Saar K, Huebner N, Wehland M, Nassef MZ, Melnik D, Meltendorf S, Infanger M, Grimm D.

Sci Rep. 2018 Jul 9;8(1):10355. doi: 10.1038/s41598-018-28695-1.


AAVvector-mediated in vivo reprogramming into pluripotency.

Senís E, Mosteiro L, Wilkening S, Wiedtke E, Nowrouzi A, Afzal S, Fronza R, Landerer H, Abad M, Niopek D, Schmidt M, Serrano M, Grimm D.

Nat Commun. 2018 Jul 9;9(1):2651. doi: 10.1038/s41467-018-05059-x.


Impact of the assembly-activating protein (AAP) on molecular evolution of synthetic Adeno-associated virus (AAV) capsids.

Herrmann AK, Grosse S, Börner K, Krämer C, Wiedtke E, Gunkel M, Grimm D.

Hum Gene Ther. 2018 Jul 6. doi: 10.1089/hum.2018.085. [Epub ahead of print]


Opening the lab door.

Grimm D.

Science. 2018 Jun 29;360(6396):1392-1395. doi: 10.1126/science.360.6396.1392. No abstract available.


Pathway Analysis Hints Towards Beneficial Effects of Long-Term Vibration on Human Chondrocytes.

Lützenberg R, Solano K, Buken C, Sahana J, Riwaldt S, Kopp S, Krüger M, Schulz H, Saar K, Huebner N, Hemmersbach R, Bauer J, Infanger M, Grimm D, Wehland M.

Cell Physiol Biochem. 2018;47(4):1729-1741. doi: 10.1159/000491006. Epub 2018 Jun 27.


A randomized controlled trial of MoodSwings 2.0: An internet-based self-management program for bipolar disorder.

Gliddon E, Cosgrove V, Berk L, Lauder S, Mohebbi M, Grimm D, Dodd S, Coulson C, Raju K, Suppes T, Berk M.

Bipolar Disord. 2018 Jun 21. doi: 10.1111/bdi.12669. [Epub ahead of print]


Correlation of Isotope Count With Sentinel Node Positivity in Vulvar Cancer.

Woelber L, Joosse SA, Grimm D, Mathey S, Mahner S, Burandt E, Klutmann S, Schmalfeldt B, Prieske K.

Int J Gynecol Cancer. 2018 Sep;28(7):1403-1409. doi: 10.1097/IGC.0000000000001298.


MAP3K7 is recurrently deleted in pediatric T-lymphoblastic leukemia and affects cell proliferation independently of NF-κB.

Cordas Dos Santos DM, Eilers J, Sosa Vizcaino A, Orlova E, Zimmermann M, Stanulla M, Schrappe M, Börner K, Grimm D, Muckenthaler MU, Kulozik AE, Kunz JB.

BMC Cancer. 2018 Jun 18;18(1):663. doi: 10.1186/s12885-018-4525-0.


Current and Future Treatments for Persistent Pulmonary Hypertension in the Newborn.

Pedersen J, Hedegaard ER, Simonsen U, Krüger M, Infanger M, Grimm D.

Basic Clin Pharmacol Toxicol. 2018 Oct;123(4):392-406. doi: 10.1111/bcpt.13051. Epub 2018 Jul 19. Review.


Decreased E-Cadherin in MCF7 Human Breast Cancer Cells Forming Multicellular Spheroids Exposed to Simulated Microgravity.

Sahana J, Nassef MZ, Wehland M, Kopp S, Krüger M, Corydon TJ, Infanger M, Bauer J, Grimm D.

Proteomics. 2018 Jul;18(13):e1800015. doi: 10.1002/pmic.201800015. Epub 2018 Jun 19.


High-Throughput Dissection of AAV-Host Interactions: The Fast and the Curious.

Herrmann AK, Grimm D.

J Mol Biol. 2018 Aug 17;430(17):2626-2640. doi: 10.1016/j.jmb.2018.05.022. Epub 2018 May 19. Review.


Compliance: An Ounce of Prevention Is Worth a Pound of Cure.

Grimm DA.

Front Health Serv Manage. 2018 Summer;34(4):32-41. doi: 10.1097/HAP.0000000000000035. No abstract available.


Linking Genomic and Metabolomic Natural Variation Uncovers Nematode Pheromone Biosynthesis.

Falcke JM, Bose N, Artyukhin AB, Rödelsperger C, Markov GV, Yim JJ, Grimm D, Claassen MH, Panda O, Baccile JA, Zhang YK, Le HH, Jolic D, Schroeder FC, Sommer RJ.

Cell Chem Biol. 2018 Jun 21;25(6):787-796.e12. doi: 10.1016/j.chembiol.2018.04.004. Epub 2018 May 17.


A Focus on Macitentan in the Treatment of Pulmonary Arterial Hypertension.

Bedan M, Grimm D, Wehland M, Simonsen U, Infanger M, Krüger M.

Basic Clin Pharmacol Toxicol. 2018 Aug;123(2):103-113. doi: 10.1111/bcpt.13033. Epub 2018 Jun 5. Review.


Tissue Engineering Under Microgravity Conditions-Use of Stem Cells and Specialized Cells.

Grimm D, Egli M, Krüger M, Riwaldt S, Corydon TJ, Kopp S, Wehland M, Wise P, Infanger M, Mann V, Sundaresan A.

Stem Cells Dev. 2018 Jun 15;27(12):787-804. doi: 10.1089/scd.2017.0242. Epub 2018 Mar 29.


Exosome-Based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients.

Castellanos-Rizaldos E, Grimm DG, Tadigotla V, Hurley J, Healy J, Neal PL, Sher M, Venkatesan R, Karlovich C, Raponi M, Krug A, Noerholm M, Tannous J, Tannous BA, Raez LE, Skog JK.

Clin Cancer Res. 2018 Jun 15;24(12):2944-2950. doi: 10.1158/1078-0432.CCR-17-3369. Epub 2018 Mar 13.


Late manifestation of alloantibody-associated injury and clinical pulmonary antibody-mediated rejection: Evidence from cell-free DNA analysis.

Agbor-Enoh S, Jackson AM, Tunc I, Berry GJ, Cochrane A, Grimm D, Davis A, Shah P, Brown AW, Wang Y, Timofte I, Shah P, Gorham S, Wylie J, Goodwin N, Jang MK, Marishta A, Bhatti K, Fideli U, Yang Y, Luikart H, Cao Z, Pirooznia M, Zhu J, Marboe C, Iacono A, Nathan SD, Orens J, Valantine HA, Khush K.

J Heart Lung Transplant. 2018 Jul;37(7):925-932. doi: 10.1016/j.healun.2018.01.1305. Epub 2018 Jan 31.


The happiness project.

Grimm D.

Science. 2018 Feb 9;359(6376):624-627. doi: 10.1126/science.359.6376.624. No abstract available.


The rate and potential relevance of new mutations in a colonizing plant lineage.

Exposito-Alonso M, Becker C, Schuenemann VJ, Reiter E, Setzer C, Slovak R, Brachi B, Hagmann J, Grimm DG, Chen J, Busch W, Bergelson J, Ness RW, Krause J, Burbano HA, Weigel D.

PLoS Genet. 2018 Feb 12;14(2):e1007155. doi: 10.1371/journal.pgen.1007155. eCollection 2018 Feb.


Key Proteins Involved in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity.

Dittrich A, Grimm D, Sahana J, Bauer J, Krüger M, Infanger M, Magnusson NE.

Cell Physiol Biochem. 2018;45(2):429-445. doi: 10.1159/000486920. Epub 2018 Jan 24.


The Impact of Vitamin D in the Treatment of Essential Hypertension.

Legarth C, Grimm D, Wehland M, Bauer J, Krüger M.

Int J Mol Sci. 2018 Feb 3;19(2). pii: E455. doi: 10.3390/ijms19020455. Review.


Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis.

Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU, Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA, Baumgart J, Galle PR, Zimmermann T.

Oncotarget. 2017 Dec 18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29.


Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.

Lou WP, Mateos A, Koch M, Klussman S, Yang C, Lu N, Kumar S, Limpert S, Göpferich M, Zschaetzsch M, Sliwinski C, Kenzelmann M, Seedorf M, Maillo C, Senis E, Grimm D, Puttagunta R, Mendez R, Liu K, Hassan BA, Martin-Villalba A.

Front Mol Neurosci. 2018 Jan 12;10:445. doi: 10.3389/fnmol.2017.00445. eCollection 2017.


The role of NFκB in spheroid formation of human breast cancer cells cultured on the Random Positioning Machine.

Kopp S, Sahana J, Islam T, Petersen AG, Bauer J, Corydon TJ, Schulz H, Saar K, Huebner N, Slumstrup L, Riwaldt S, Wehland M, Infanger M, Luetzenberg R, Grimm D.

Sci Rep. 2018 Jan 17;8(1):921. doi: 10.1038/s41598-017-18556-8.


Split Cas9, Not Hairs - Advancing the Therapeutic Index of CRISPR Technology.

Schmelas C, Grimm D.

Biotechnol J. 2018 Sep;13(9):e1700432. doi: 10.1002/biot.201700432. Epub 2018 Feb 2. Review.


The Effects of Palate Features and Glossectomy Surgery on /s/ Production.

Grimm DL, Stone M, Woo J, Lee J, Hwang JH, Bedrosian GE, Prince JL.

J Speech Lang Hear Res. 2017 Dec 20;60(12):3417-3425. doi: 10.1044/2017_JSLHR-S-16-0425.


Improved EGFR mutation detection using combined exosomal RNA and circulating tumor DNA in NSCLC patient plasma.

Krug AK, Enderle D, Karlovich C, Priewasser T, Bentink S, Spiel A, Brinkmann K, Emenegger J, Grimm DG, Castellanos-Rizaldos E, Goldman JW, Sequist LV, Soria JC, Camidge DR, Gadgeel SM, Wakelee HA, Raponi M, Noerholm M, Skog J.

Ann Oncol. 2018 Mar 1;29(3):700-706. doi: 10.1093/annonc/mdx765.


Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models.

Riwaldt S, Monici M, Graver Petersen A, Birk Jensen U, Evert K, Pantalone D, Utpatel K, Evert M, Wehland M, Krüger M, Kopp S, Frandsen S, Corydon T, Sahana J, Bauer J, Lützenberg R, Infanger M, Grimm D.

Int J Mol Sci. 2017 Dec 3;18(12). pii: E2604. doi: 10.3390/ijms18122604.


Single-cut genome editing restores dystrophin expression in a new mouse model of muscular dystrophy.

Amoasii L, Long C, Li H, Mireault AA, Shelton JM, Sanchez-Ortiz E, McAnally JR, Bhattacharyya S, Schmidt F, Grimm D, Hauschka SD, Bassel-Duby R, Olson EN.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaan8081. doi: 10.1126/scitranslmed.aan8081. Erratum in: Sci Transl Med. 2018 Jan 24;10 (425):.


Oldest images of dogs show hunting, leashes.

Grimm D.

Science. 2017 Nov 17;358(6365):854. doi: 10.1126/science.358.6365.854. No abstract available.


Loss of BRCA1 promotor hypermethylation in recurrent high-grade ovarian cancer.

Prieske K, Prieske S, Joosse SA, Trillsch F, Grimm D, Burandt E, Mahner S, Schmalfeldt B, Milde-Langosch K, Oliveira-Ferrer L, Woelber L.

Oncotarget. 2017 Sep 15;8(47):83063-83074. doi: 10.18632/oncotarget.20945. eCollection 2017 Oct 10.


Synthetic AAV/CRISPR vectors for blocking HIV-1 expression in persistently infected astrocytes.

Kunze C, Börner K, Kienle E, Orschmann T, Rusha E, Schneider M, Radivojkov-Blagojevic M, Drukker M, Desbordes S, Grimm D, Brack-Werner R.

Glia. 2018 Feb;66(2):413-427. doi: 10.1002/glia.23254. Epub 2017 Nov 9.


The AraGWAS Catalog: a curated and standardized Arabidopsis thaliana GWAS catalog.

Togninalli M, Seren Ü, Meng D, Fitz J, Nordborg M, Weigel D, Borgwardt K, Korte A, Grimm DG.

Nucleic Acids Res. 2018 Jan 4;46(D1):D1150-D1156. doi: 10.1093/nar/gkx954.

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