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Items: 1 to 50 of 103

1.

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia.

Adelman ER, Huang HT, Roisman A, Olsson A, Colaprico A, Qin T, Lindsley RC, Bejar R, Salomonis N, Grimes HL, Figueroa ME.

Cancer Discov. 2019 Aug;9(8):1080-1101. doi: 10.1158/2159-8290.CD-18-1474. Epub 2019 May 13.

PMID:
31085557
2.

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.

Duy C, Teater M, Garrett-Bakelman FE, Lee TC, Meydan C, Glass JL, Li M, Hellmuth JC, Mohammad HP, Smitheman KN, Shih AH, Abdel-Wahab O, Tallman MS, Guzman ML, Muench D, Grimes HL, Roboz GJ, Kruger RG, Creasy CL, Paietta EM, Levine RL, Carroll M, Melnick AM.

Cancer Discov. 2019 Jul;9(7):872-889. doi: 10.1158/2159-8290.CD-19-0106. Epub 2019 May 10.

PMID:
31076479
3.

Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation.

Park DS, Akuffo AA, Muench DE, Grimes HL, Epling-Burnette PK, Maini PK, Anderson ARA, Bonsall MB.

PLoS Comput Biol. 2019 Apr 26;15(4):e1006913. doi: 10.1371/journal.pcbi.1006913. eCollection 2019 Apr.

4.

Author Correction: Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.

Olsson A, Venkatasubramanian M, Chaudhri VK, Aronow BJ, Salomonis N, Singh H, Grimes HL.

Nature. 2019 May;569(7755):E3. doi: 10.1038/s41586-019-1107-5.

PMID:
31019298
5.

Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors.

Dwivedi P, Muench DE, Wagner M, Azam M, Grimes HL, Greis KD.

Sci Data. 2019 Apr 9;6(1):21. doi: 10.1038/s41597-019-0015-8.

6.

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma.

Lee C, Rudneva VA, Erkek S, Zapatka M, Chau LQ, Tacheva-Grigorova SK, Garancher A, Rusert JM, Aksoy O, Lea R, Mohammad HP, Wang J, Weiss WA, Grimes HL, Pfister SM, Northcott PA, Wechsler-Reya RJ.

Nat Commun. 2019 Jan 18;10(1):332. doi: 10.1038/s41467-018-08269-5.

7.

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification.

Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS.

Cell Rep. 2018 Dec 11;25(11):3229. doi: 10.1016/j.celrep.2018.11.075. No abstract available.

8.

The Molecular Signature of Megakaryocyte-Erythroid Progenitors Reveals a Role for the Cell Cycle in Fate Specification.

Lu YC, Sanada C, Xavier-Ferrucio J, Wang L, Zhang PX, Grimes HL, Venkatasubramanian M, Chetal K, Aronow B, Salomonis N, Krause DS.

Cell Rep. 2018 Nov 20;25(8):2083-2093.e4. doi: 10.1016/j.celrep.2018.10.084. Erratum in: Cell Rep. 2018 Dec 11;25(11):3229.

9.

SKI controls MDS-associated chronic TGF-β signaling, aberrant splicing, and stem cell fitness.

Muench DE, Ferchen K, Velu CS, Pradhan K, Chetal K, Chen X, Weirauch MT, Colmenares C, Verma A, Salomonis N, Grimes HL.

Blood. 2018 Nov 22;132(21):e24-e34. doi: 10.1182/blood-2018-06-860890. Epub 2018 Sep 24.

10.

The Human Cell Atlas bone marrow single-cell interactive web portal.

Hay SB, Ferchen K, Chetal K, Grimes HL, Salomonis N.

Exp Hematol. 2018 Dec;68:51-61. doi: 10.1016/j.exphem.2018.09.004. Epub 2018 Sep 21.

11.

Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes.

Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, Li B, Sashida G, Peng Y, Xu Z, Huang R, Zhang L, Freudiger GM, Wang J, Dong Y, Zhou Y, Wang J, Wu L, Bu J, Chen A, Zhao X, Sun X, Chetal K, Olsson A, Watanabe M, Romick-Rosendale LE, Harada H, Shih LY, Tse W, Bridges JP, Caligiuri MA, Huang T, Zheng Y, Witte DP, Wang QF, Qu CK, Salomonis N, Grimes HL, Nimer SD, Xiao Z, Huang G.

Cancer Discov. 2018 Nov;8(11):1438-1457. doi: 10.1158/2159-8290.CD-17-1203. Epub 2018 Aug 23.

PMID:
30139811
12.

KLF5 controls glutathione metabolism to suppress p190-BCR-ABL+ B-cell lymphoblastic leukemia.

Zhang C, D'Alessandro A, Wellendorf AM, Mohmoud F, Serrano-Lopez J, Perentesis JP, Komurov K, Alexe G, Stegmaier K, Whitsett JA, Grimes HL, Cancelas JA.

Oncotarget. 2018 Jul 3;9(51):29665-29679. doi: 10.18632/oncotarget.25667. eCollection 2018 Jul 3.

13.

miR-196b target screen reveals mechanisms maintaining leukemia stemness with therapeutic potential.

Meyer SE, Muench DE, Rogers AM, Newkold TJ, Orr E, O'Brien E, Perentesis JP, Doench JG, Lal A, Morris PJ, Thomas CJ, Lieberman J, McGlinn E, Aronow BJ, Salomonis N, Grimes HL.

J Exp Med. 2018 Aug 6;215(8):2115-2136. doi: 10.1084/jem.20171312. Epub 2018 Jul 11.

14.

Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors.

Dwivedi P, Muench DE, Wagner M, Azam M, Grimes HL, Greis KD.

Leukemia. 2019 Jan;33(1):75-87. doi: 10.1038/s41375-018-0188-8. Epub 2018 Jul 5.

15.

Setd2 regulates quiescence and differentiation of adult hematopoietic stem cells by restricting RNA polymerase II elongation.

Zhou Y, Yan X, Feng X, Bu J, Dong Y, Lin P, Hayashi Y, Huang R, Olsson A, Andreassen PR, Grimes HL, Wang QF, Cheng T, Xiao Z, Jin J, Huang G.

Haematologica. 2018 Jul;103(7):1110-1123. doi: 10.3324/haematol.2018.187708. Epub 2018 Apr 12.

16.

A guide to choosing fluorescent protein combinations for flow cytometric analysis based on spectral overlap.

Kleeman B, Olsson A, Newkold T, Kofron M, DeLay M, Hildeman D, Grimes HL.

Cytometry A. 2018 May;93(5):556-562. doi: 10.1002/cyto.a.23360. Epub 2018 Mar 13.

17.

Obesity alters the long-term fitness of the hematopoietic stem cell compartment through modulation of Gfi1 expression.

Lee JM, Govindarajah V, Goddard B, Hinge A, Muench DE, Filippi MD, Aronow B, Cancelas JA, Salomonis N, Grimes HL, Reynaud D.

J Exp Med. 2018 Feb 5;215(2):627-644. doi: 10.1084/jem.20170690. Epub 2017 Dec 27.

18.

SETD2-mediated crosstalk between H3K36me3 and H3K79me2 in MLL-rearranged leukemia.

Bu J, Chen A, Yan X, He F, Dong Y, Zhou Y, He J, Zhan D, Lin P, Hayashi Y, Sun Y, Zhang Y, Xiao Z, Grimes HL, Wang QF, Huang G.

Leukemia. 2018 Apr;32(4):890-899. doi: 10.1038/leu.2017.339. Epub 2017 Nov 29.

19.

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes.

Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS.

Immunity. 2017 Nov 21;47(5):890-902.e4. doi: 10.1016/j.immuni.2017.10.021.

20.

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.

Mizukawa B, O'Brien E, Moreira DC, Wunderlich M, Hochstetler CL, Duan X, Liu W, Orr E, Grimes HL, Mulloy JC, Zheng Y.

Blood. 2017 Sep 14;130(11):1336-1346. doi: 10.1182/blood-2016-12-758458. Epub 2017 Aug 4.

21.

Counting the cost of lineage decisions.

Yáñez A, Goodridge HS, Grimes HL.

Nat Immunol. 2017 Jul 19;18(8):872-873. doi: 10.1038/ni.3794. No abstract available.

PMID:
28722717
22.

The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis.

Kurkewich JL, Hansen J, Klopfenstein N, Zhang H, Wood C, Boucher A, Hickman J, Muench DE, Grimes HL, Dahl R.

PLoS Genet. 2017 Jul 13;13(7):e1006887. doi: 10.1371/journal.pgen.1006887. eCollection 2017 Jul.

23.

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT.

Leukemia. 2017 Jul;31(7):1659. doi: 10.1038/leu.2017.95. Epub 2017 Apr 7.

24.

Targeting c-FOS and DUSP1 abrogates intrinsic resistance to tyrosine-kinase inhibitor therapy in BCR-ABL-induced leukemia.

Kesarwani M, Kincaid Z, Gomaa A, Huber E, Rohrabaugh S, Siddiqui Z, Bouso MF, Latif T, Xu M, Komurov K, Mulloy JC, Cancelas JA, Grimes HL, Azam M.

Nat Med. 2017 Apr;23(4):472-482. doi: 10.1038/nm.4310. Epub 2017 Mar 20.

25.

Enhanced MAPK signaling is essential for CSF3R-induced leukemia.

Rohrabaugh S, Kesarwani M, Kincaid Z, Huber E, Leddonne J, Siddiqui Z, Khalifa Y, Komurov K, Grimes HL, Azam M.

Leukemia. 2017 Aug;31(8):1770-1778. doi: 10.1038/leu.2016.376. Epub 2016 Dec 27.

26.

Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire.

Li KP, Fähnrich A, Roy E, Cuda CM, Grimes HL, Perlman HR, Kalies K, Hildeman DA.

J Immunol. 2017 Jan 1;198(1):257-269. Epub 2016 Nov 16.

27.

Epistasis between TIFAB and miR-146a: neighboring genes in del(5q) myelodysplastic syndrome.

Varney ME, Choi K, Bolanos L, Christie S, Fang J, Grimes HL, Maciejewski JP, Inoue JI, Starczynowski DT.

Leukemia. 2017 Feb;31(2):491-495. doi: 10.1038/leu.2016.276. Epub 2016 Oct 3. No abstract available. Erratum in: Leukemia. 2017 Jul;31(7):1659.

28.

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.

Olsson A, Venkatasubramanian M, Chaudhri VK, Aronow BJ, Salomonis N, Singh H, Grimes HL.

Nature. 2016 Sep 29;537(7622):698-702. doi: 10.1038/nature19348. Epub 2016 Aug 31. Erratum in: Nature. 2019 May;569(7755):E3.

29.

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes.

Fang J, Liu X, Bolanos L, Barker B, Rigolino C, Cortelezzi A, Oliva EN, Cuzzola M, Grimes HL, Fontanillo C, Komurov K, MacBeth K, Starczynowski DT.

Nat Med. 2016 Jul;22(7):727-34. doi: 10.1038/nm.4127. Epub 2016 Jun 13.

30.

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia.

Meyer SE, Qin T, Muench DE, Masuda K, Venkatasubramanian M, Orr E, Suarez L, Gore SD, Delwel R, Paietta E, Tallman MS, Fernandez H, Melnick A, Le Beau MM, Kogan S, Salomonis N, Figueroa ME, Grimes HL.

Cancer Discov. 2016 May;6(5):501-15. doi: 10.1158/2159-8290.CD-16-0008. Epub 2016 Mar 25.

31.

Transcriptional Control of Stem and Progenitor Potential.

Muench DE, Grimes HL.

Curr Stem Cell Rep. 2015 Sep;1(3):139-150. Epub 2015 Jun 26.

32.

Nutrient database improvement project: Separable components and proximate composition of raw and cooked retail cuts from the beef loin and round.

Acheson RJ, Woerner DR, Martin JN, Belk KE, Engle TE, Brown TR, Brooks JC, Luna AM, Thompson LD, Grimes HL, Arnold AN, Savell JW, Gehring KB, Douglass LW, Howe JC, Patterson KY, Roseland JM, Williams JR, Cifelli A, Leheska JM, McNeill SH.

Meat Sci. 2015 Dec;110:236-44. doi: 10.1016/j.meatsci.2015.06.001. Epub 2015 Jun 3.

PMID:
26280470
33.

Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells.

Nayak RC, Trump LR, Aronow BJ, Myers K, Mehta P, Kalfa T, Wellendorf AM, Valencia CA, Paddison PJ, Horwitz MS, Grimes HL, Lutzko C, Cancelas JA.

J Clin Invest. 2015 Aug 3;125(8):3103-16. doi: 10.1172/JCI80924. Epub 2015 Jul 20.

34.

A 2-way miRror of red blood cells and leukemia.

Grimes HL, Meyer SE.

Blood. 2015 Feb 19;125(8):1202-3. doi: 10.1182/blood-2015-01-618975.

35.

Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.

Cumaraswamy AA, Lewis AM, Geletu M, Todic A, Diaz DB, Cheng XR, Brown CE, Laister RC, Muench D, Kerman K, Grimes HL, Minden MD, Gunning PT.

ACS Med Chem Lett. 2014 Sep 19;5(11):1202-1206. eCollection 2014 Nov 13.

36.

Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network.

Fang J, Barker B, Bolanos L, Liu X, Jerez A, Makishima H, Christie S, Chen X, Rao DS, Grimes HL, Komurov K, Weirauch MT, Cancelas JA, Maciejewski JP, Starczynowski DT.

Cell Rep. 2014 Sep 11;8(5):1328-38. doi: 10.1016/j.celrep.2014.07.062. Epub 2014 Sep 4.

37.

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

Northcott PA, Lee C, Zichner T, Stütz AM, Erkek S, Kawauchi D, Shih DJ, Hovestadt V, Zapatka M, Sturm D, Jones DT, Kool M, Remke M, Cavalli FM, Zuyderduyn S, Bader GD, VandenBerg S, Esparza LA, Ryzhova M, Wang W, Wittmann A, Stark S, Sieber L, Seker-Cin H, Linke L, Kratochwil F, Jäger N, Buchhalter I, Imbusch CD, Zipprich G, Raeder B, Schmidt S, Diessl N, Wolf S, Wiemann S, Brors B, Lawerenz C, Eils J, Warnatz HJ, Risch T, Yaspo ML, Weber UD, Bartholomae CC, von Kalle C, Turányi E, Hauser P, Sanden E, Darabi A, Siesjö P, Sterba J, Zitterbart K, Sumerauer D, van Sluis P, Versteeg R, Volckmann R, Koster J, Schuhmann MU, Ebinger M, Grimes HL, Robinson GW, Gajjar A, Mynarek M, von Hoff K, Rutkowski S, Pietsch T, Scheurlen W, Felsberg J, Reifenberger G, Kulozik AE, von Deimling A, Witt O, Eils R, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Korbel JO, Wechsler-Reya RJ, Pfister SM.

Nature. 2014 Jul 24;511(7510):428-34. doi: 10.1038/nature13379. Epub 2014 Jun 22.

38.

ATF3 is a novel regulator of mouse neutrophil migration.

Boespflug ND, Kumar S, McAlees JW, Phelan JD, Grimes HL, Hoebe K, Hai T, Filippi MD, Karp CL.

Blood. 2014 Mar 27;123(13):2084-93. doi: 10.1182/blood-2013-06-510909. Epub 2014 Jan 27.

39.

Therapeutic antagonists of microRNAs deplete leukemia-initiating cell activity.

Velu CS, Chaubey A, Phelan JD, Horman SR, Wunderlich M, Guzman ML, Jegga AG, Zeleznik-Le NJ, Chen J, Mulloy JC, Cancelas JA, Jordan CT, Aronow BJ, Marcucci G, Bhat B, Gebelein B, Grimes HL.

J Clin Invest. 2014 Jan;124(1):222-36. doi: 10.1172/JCI66005. Epub 2013 Dec 16.

40.

Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.

Tidwell T, Wechsler J, Nayak RC, Trump L, Salipante SJ, Cheng JC, Donadieu J, Glaubach T, Corey SJ, Grimes HL, Lutzko C, Cancelas JA, Horwitz MS.

Blood. 2014 Jan 23;123(4):562-9. doi: 10.1182/blood-2013-07-513242. Epub 2013 Nov 1.

41.

Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors.

Phelan JD, Saba I, Zeng H, Kosan C, Messer MS, Olsson HA, Fraszczak J, Hildeman DA, Aronow BJ, Möröy T, Grimes HL.

PLoS Genet. 2013;9(9):e1003713. doi: 10.1371/journal.pgen.1003713. Epub 2013 Sep 12.

42.

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells.

Goyama S, Schibler J, Cunningham L, Zhang Y, Rao Y, Nishimoto N, Nakagawa M, Olsson A, Wunderlich M, Link KA, Mizukawa B, Grimes HL, Kurokawa M, Liu PP, Huang G, Mulloy JC.

J Clin Invest. 2013 Sep;123(9):3876-88. doi: 10.1172/JCI68557. Epub 2013 Aug 27. Erratum in: J Clin Invest. 2013 Nov 1;123(11):4979.

43.

mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression.

Guo F, Li J, Zhang S, Du W, Amarachintha S, Sipple J, Phelan J, Grimes HL, Zheng Y, Pang Q.

Leukemia. 2014 Jan;28(1):203-6. doi: 10.1038/leu.2013.215. Epub 2013 Jul 15. No abstract available.

44.

Recombineering-based dissection of flanking and paralogous Hox gene functions in mouse reproductive tracts.

Raines AM, Adam M, Magella B, Meyer SE, Grimes HL, Dey SK, Potter SS.

Development. 2013 Jul;140(14):2942-52. doi: 10.1242/dev.092569. Epub 2013 Jun 12.

45.

Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking.

Taniguchi Ishikawa E, Chang KH, Nayak R, Olsson HA, Ficker AM, Dunn SK, Madhu MN, Sengupta A, Whitsett JA, Grimes HL, Cancelas JA.

Nat Commun. 2013;4:1660. doi: 10.1038/ncomms2645.

46.

Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia.

Khandanpour C, Phelan JD, Vassen L, Schütte J, Chen R, Horman SR, Gaudreau MC, Krongold J, Zhu J, Paul WE, Dührsen U, Göttgens B, Grimes HL, Möröy T.

Cancer Cell. 2013 Feb 11;23(2):200-14. doi: 10.1016/j.ccr.2013.01.011.

47.

ELANE mutations in cyclic and severe congenital neutropenia: genetics and pathophysiology.

Horwitz MS, Corey SJ, Grimes HL, Tidwell T.

Hematol Oncol Clin North Am. 2013 Feb;27(1):19-41, vii. doi: 10.1016/j.hoc.2012.10.004. Epub 2012 Nov 7. Review.

48.

Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress.

Unnisa Z, Clark JP, Roychoudhury J, Thomas E, Tessarollo L, Copeland NG, Jenkins NA, Grimes HL, Kumar AR.

Blood. 2012 Dec 13;120(25):4973-81. doi: 10.1182/blood-2012-06-435800. Epub 2012 Oct 22.

49.

Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells.

Velu CS, Grimes HL.

Methods Mol Biol. 2012;928:185-95. doi: 10.1007/978-1-62703-008-3_15.

50.

The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.

Khandanpour C, Krongold J, Schütte J, Bouwman F, Vassen L, Gaudreau MC, Chen R, Calero-Nieto FJ, Diamanti E, Hannah R, Meyer SE, Grimes HL, van der Reijden BA, Jansen JH, Patel CV, Peeters JK, Löwenberg B, Dührsen U, Göttgens B, Möröy T.

Blood. 2012 Nov 8;120(19):4006-17. doi: 10.1182/blood-2011-02-334722. Epub 2012 Aug 28.

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