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Items: 16


Left-right asymmetric heart jogging increases the robustness of dextral heart looping in zebrafish.

Grimes DT, Patterson VL, Luna-Arvizu G, Schottenfeld-Roames J, Irons ZH, Burdine RD.

Dev Biol. 2019 Nov 20. pii: S0012-1606(19)30254-4. doi: 10.1016/j.ydbio.2019.11.012. [Epub ahead of print]


Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model.

Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM, Norris DP.

Nat Commun. 2019 Sep 6;10(1):4072. doi: 10.1038/s41467-019-12067-y.


Making and breaking symmetry in development, growth and disease.

Grimes DT.

Development. 2019 Aug 15;146(16). pii: dev170985. doi: 10.1242/dev.170985. Review.


Developmental Biology: Go with the Flow to Keep the Body Straight.

Grimes DT.

Curr Biol. 2019 Feb 4;29(3):R101-R103. doi: 10.1016/j.cub.2018.12.011.


ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.

Harris A, Siggers P, Corrochano S, Warr N, Sagar D, Grimes DT, Suzuki M, Burdine RD, Cong F, Koo BK, Clevers H, Stévant I, Nef S, Wells S, Brauner R, Ben Rhouma B, Belguith N, Eozenou C, Bignon-Topalovic J, Bashamboo A, McElreavey K, Greenfield A.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5474-5479. doi: 10.1073/pnas.1801223115. Epub 2018 May 7.


Left-Right Patterning: Breaking Symmetry to Asymmetric Morphogenesis.

Grimes DT, Burdine RD.

Trends Genet. 2017 Sep;33(9):616-628. doi: 10.1016/j.tig.2017.06.004. Epub 2017 Jul 15. Review.


Modeling Syndromic Congenital Heart Defects in Zebrafish.

Grant MG, Patterson VL, Grimes DT, Burdine RD.

Curr Top Dev Biol. 2017;124:1-40. doi: 10.1016/bs.ctdb.2016.11.010. Epub 2017 Jan 24. Review.


Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature.

Grimes DT, Boswell CW, Morante NF, Henkelman RM, Burdine RD, Ciruna B.

Science. 2016 Jun 10;352(6291):1341-4. doi: 10.1126/science.aaf6419.


Genetic Analysis Reveals a Hierarchy of Interactions between Polycystin-Encoding Genes and Genes Controlling Cilia Function during Left-Right Determination.

Grimes DT, Keynton JL, Buenavista MT, Jin X, Patel SH, Kyosuke S, Vibert J, Williams DJ, Hamada H, Hussain R, Nauli SM, Norris DP.

PLoS Genet. 2016 Jun 6;12(6):e1006070. doi: 10.1371/journal.pgen.1006070. eCollection 2016 Jun.


c21orf59/kurly Controls Both Cilia Motility and Polarization.

Jaffe KM, Grimes DT, Schottenfeld-Roames J, Werner ME, Ku TS, Kim SK, Pelliccia JL, Morante NF, Mitchell BJ, Burdine RD.

Cell Rep. 2016 Mar 1;14(8):1841-9. doi: 10.1016/j.celrep.2016.01.069. Epub 2016 Feb 18.


ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.

Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP.

Development. 2014 Oct;141(20):3966-77. doi: 10.1242/dev.107755.


Developmental biology. Cilia discern left from right.

Norris DP, Grimes DT.

Science. 2012 Oct 12;338(6104):206-7. doi: 10.1126/science.1230401. No abstract available.


Mouse models of ciliopathies: the state of the art.

Norris DP, Grimes DT.

Dis Model Mech. 2012 May;5(3):299-312. doi: 10.1242/dmm.009340. Review.


Pkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.

Field S, Riley KL, Grimes DT, Hilton H, Simon M, Powles-Glover N, Siggers P, Bogani D, Greenfield A, Norris DP.

Development. 2011 Mar;138(6):1131-42. doi: 10.1242/dev.058149. Epub 2011 Feb 9.


Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway.

Patterson VL, Damrau C, Paudyal A, Reeve B, Grimes DT, Stewart ME, Williams DJ, Siggers P, Greenfield A, Murdoch JN.

Hum Mol Genet. 2009 May 15;18(10):1719-39. doi: 10.1093/hmg/ddp075. Epub 2009 Feb 17.

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