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Items: 33

1.

Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication.

Wang Y, Lee S, Ha Y, Lam W, Chen SR, Dutschman GE, Gullen EA, Grill SP, Cheng Y, F├╝rstner A, Francis S, Baker DC, Yang X, Lee KH, Cheng YC.

Sci Rep. 2017 Aug 30;7(1):10037. doi: 10.1038/s41598-017-08815-z.

2.

Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites.

Paintsil E, Dutschman GE, Hu R, Grill SP, Wang CJ, Lam W, Li FY, Ghebremichael M, Northrup V, Cheng YC.

Antimicrob Agents Chemother. 2011 Feb;55(2):895-903. doi: 10.1128/AAC.01303-10. Epub 2010 Nov 15.

3.

A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro.

Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, Grill SP, Chen AP, Lindenbach BD, Hamilton AD, Cheng YC.

Antimicrob Agents Chemother. 2010 Jan;54(1):197-206. doi: 10.1128/AAC.01206-09. Epub 2009 Nov 9.

4.

Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.

Yang G, Paintsil E, Dutschman GE, Grill SP, Wang CJ, Wang J, Tanaka H, Hamasaki T, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2009 Nov;53(11):4640-6. doi: 10.1128/AAC.00686-09. Epub 2009 Aug 24.

5.

Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture.

Paintsil E, Grill SP, Dutschman GE, Cheng YC.

AIDS Res Ther. 2009 Apr 22;6:5. doi: 10.1186/1742-6405-6-5.

6.

Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog.

Paintsil E, Dutschman GE, Hu R, Grill SP, Lam W, Baba M, Tanaka H, Cheng YC.

Antimicrob Agents Chemother. 2007 Nov;51(11):3870-9. Epub 2007 Aug 27.

7.

Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents.

Gao W, Bussom S, Grill SP, Gullen EA, Hu YC, Huang X, Zhong S, Kaczmarek C, Gutierrez J, Francis S, Baker DC, Yu S, Cheng YC.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4338-42. Epub 2007 May 16.

PMID:
17531481
8.

Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner.

Leung CH, Grill SP, Lam W, Gao W, Sun HD, Cheng YC.

Mol Pharmacol. 2006 Dec;70(6):1946-55. Epub 2006 Aug 29.

PMID:
16940413
9.

Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens.

Leung CH, Grill SP, Lam W, Han QB, Sun HD, Cheng YC.

Mol Pharmacol. 2005 Aug;68(2):286-97. Epub 2005 May 4.

PMID:
15872117
10.

Novel 4'-substituted stavudine analog with improved anti-human immunodeficiency virus activity and decreased cytotoxicity.

Dutschman GE, Grill SP, Gullen EA, Haraguchi K, Takeda S, Tanaka H, Baba M, Cheng YC.

Antimicrob Agents Chemother. 2004 May;48(5):1640-6.

11.

Novel role of 3-phosphoglycerate kinase, a glycolytic enzyme, in the activation of L-nucleoside analogs, a new class of anticancer and antiviral agents.

Krishnan P, Gullen EA, Lam W, Dutschman GE, Grill SP, Cheng YC.

J Biol Chem. 2003 Sep 19;278(38):36726-32. Epub 2003 Jul 16.

12.

Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase.

Kira T, Grill SP, Dutschman GE, Lin JS, Qu F, Choi Y, Chu CK, Cheng YC.

Antimicrob Agents Chemother. 2000 Dec;44(12):3278-84.

13.

Metabolism and mode of inhibition of varicella-zoster virus by L-beta-5-bromovinyl-(2-hydroxymethyl)-(1,3-dioxolanyl)uracil is dependent on viral thymidine kinase.

Li L, Dutschman GE, Gullen EA, Tsujii E, Grill SP, Choi Y, Chu CK, Cheng YC.

Mol Pharmacol. 2000 Nov;58(5):1109-14.

PMID:
11040060
14.

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

Finch RA, Liu M, Grill SP, Rose WC, Loomis R, Vasquez KM, Cheng Y, Sartorelli AC.

Biochem Pharmacol. 2000 Apr 15;59(8):983-91.

PMID:
10692563
15.

Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine.

Yen Y, Grill SP, Dutschman GE, Chang CN, Zhou BS, Cheng YC.

Cancer Res. 1994 Jul 15;54(14):3686-91.

16.

Inhibition of ubiquitin-protein ligase (E3) by mono- and bifunctional phenylarsenoxides. Evidence for essential vicinal thiols and a proximal nucleophile.

Berleth ES, Kasperek EM, Grill SP, Braunscheidel JA, Graziani LA, Pickart CM.

J Biol Chem. 1992 Aug 15;267(23):16403-11.

17.

Anti-herpes simplex virus activity of 5-substituted 2-pyrimidinone nucleosides.

Lewandowski GA, Grill SP, Fisher MH, Dutschman GE, Efange SM, Bardos TJ, Cheng YC.

Antimicrob Agents Chemother. 1989 Mar;33(3):340-4.

19.

Association of Epstein-Barr virus early antigen diffuse component and virus-specified DNA polymerase activity.

Li JS, Zhou BS, Dutschman GE, Grill SP, Tan RS, Cheng YC.

J Virol. 1987 Sep;61(9):2947-9.

20.

Induction of virus enzymes by phorbol esters and n-butyrate in Epstein-Barr virus genome-carrying Raji cells.

Nutter LM, Grill SP, Li JS, Tan RS, Cheng YC.

Cancer Res. 1987 Aug 15;47(16):4407-12.

21.

Demonstration of viral thymidine kinase inhibitor and its effect on deoxynucleotide metabolism in cells infected with herpes simplex virus.

Nutter LM, Grill SP, Dutschman GE, Sharma RA, Bobek M, Cheng YC.

Antimicrob Agents Chemother. 1987 Mar;31(3):368-74.

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25.

Effects of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new antiherpesvirus compound, on synthesis of macromolecules in herpes simplex virus-infected cells.

Cheng YC, Grill SP, Dutschman GE, Frank KB, Chiou JF, Bastow KF, Nakayama K.

Antimicrob Agents Chemother. 1984 Sep;26(3):283-8.

27.

Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells.

Cheng YC, Grill SP, Dutschman GE, Nakayama K, Bastow KF.

J Biol Chem. 1983 Oct 25;258(20):12460-4.

29.

Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.

Cheng YC, Huang ES, Lin JC, Mar EC, Pagano JS, Dutschman GE, Grill SP.

Proc Natl Acad Sci U S A. 1983 May;80(9):2767-70.

30.

Roles of thymidylate synthetase activity in herpes simplex virus-infected HeLa cells.

Cheng YC, Nakayama K, Grill SP.

Biochem Pharmacol. 1983 Apr 15;32(8):1407-10.

PMID:
6222737
31.

Quantitative correlation of homogeneously stained regions on chromosome 10 with dihydrofolate reductase enzyme in human cells.

Wolman SR, Craven ML, Grill SP, Domin BA, Cheng YC.

Proc Natl Acad Sci U S A. 1983 Feb;80(3):807-9.

32.

Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.

Cheng YC, Schinazi RF, Dutschman GE, Tan RS, Grill SP.

J Virol Methods. 1982 Nov;5(3-4):209-17.

PMID:
6296179
33.

Effect of methotrexate on dihydrofolate reductase activity in methotrexate-resistant human KB cells.

Domin BA, Grill SP, Bastow KF, Cheng YC.

Mol Pharmacol. 1982 Mar;21(2):478-82.

PMID:
7099148

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