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Items: 45


Unraveling the multiplex folding of nucleosome chains in higher order chromatin.

Grigoryev SA, Schubert M.

Essays Biochem. 2019 Apr 23;63(1):109-121. doi: 10.1042/EBC20180066. Print 2019 Apr 23. Review.


Nucleosome spacing periodically modulates nucleosome chain folding and DNA topology in circular nucleosome arrays.

Bass MV, Nikitina T, Norouzi D, Zhurkin VB, Grigoryev SA.

J Biol Chem. 2019 Mar 15;294(11):4233-4246. doi: 10.1074/jbc.RA118.006412. Epub 2019 Jan 10.


Chromatin Higher-Order Folding: A Perspective with Linker DNA Angles.

Grigoryev SA.

Biophys J. 2018 May 22;114(10):2290-2297. doi: 10.1016/j.bpj.2018.03.009. Epub 2018 Apr 6. Review.


DNA topology in chromatin is defined by nucleosome spacing.

Nikitina T, Norouzi D, Grigoryev SA, Zhurkin VB.

Sci Adv. 2017 Oct 27;3(10):e1700957. doi: 10.1126/sciadv.1700957. eCollection 2017 Oct.


Regulation of chromatin folding by conformational variations of nucleosome linker DNA.

Buckwalter JM, Norouzi D, Harutyunyan A, Zhurkin VB, Grigoryev SA.

Nucleic Acids Res. 2017 Sep 19;45(16):9372-9387. doi: 10.1093/nar/gkx562.


Genome-wide mapping of histone H3K9me2 in acute myeloid leukemia reveals large chromosomal domains associated with massive gene silencing and sites of genome instability.

Salzberg AC, Harris-Becker A, Popova EY, Keasey N, Loughran TP, Claxton DF, Grigoryev SA.

PLoS One. 2017 Mar 16;12(3):e0173723. doi: 10.1371/journal.pone.0173723. eCollection 2017.


Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair.

Adkins NL, Swygert SG, Kaur P, Niu H, Grigoryev SA, Sung P, Wang H, Peterson CL.

J Biol Chem. 2017 Mar 31;292(13):5271-5281. doi: 10.1074/jbc.M117.776369. Epub 2017 Feb 15.


Hierarchical looping of zigzag nucleosome chains in metaphase chromosomes.

Grigoryev SA, Bascom G, Buckwalter JM, Schubert MB, Woodcock CL, Schlick T.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1238-43. doi: 10.1073/pnas.1518280113. Epub 2016 Jan 19.


A role for stefin B (cystatin B) in inflammation and endotoxemia.

Maher K, Jerič Kokelj B, Butinar M, Mikhaylov G, Manček-Keber M, Stoka V, Vasiljeva O, Turk B, Grigoryev SA, Kopitar-Jerala N.

J Biol Chem. 2014 Nov 14;289(46):31736-50. doi: 10.1074/jbc.M114.609396. Epub 2014 Oct 6.


Nucleosome-positioning sequence repeats impact chromatin silencing in yeast minichromosomes.

Chakraborty SA, Kazi AA, Khan TM, Grigoryev SA.

Genetics. 2014 Nov;198(3):1015-29. doi: 10.1534/genetics.114.169508. Epub 2014 Sep 3.


Developmentally regulated linker histone H1c promotes heterochromatin condensation and mediates structural integrity of rod photoreceptors in mouse retina.

Popova EY, Grigoryev SA, Fan Y, Skoultchi AI, Zhang SS, Barnstable CJ.

J Biol Chem. 2013 Jun 14;288(24):17895-907. doi: 10.1074/jbc.M113.452144. Epub 2013 May 3.


Combined micrococcal nuclease and exonuclease III digestion reveals precise positions of the nucleosome core/linker junctions: implications for high-resolution nucleosome mapping.

Nikitina T, Wang D, Gomberg M, Grigoryev SA, Zhurkin VB.

J Mol Biol. 2013 Jun 12;425(11):1946-1960. doi: 10.1016/j.jmb.2013.02.026. Epub 2013 Feb 28.


Nucleosome spacing and chromatin higher-order folding.

Grigoryev SA.

Nucleus. 2012 Nov-Dec;3(6):493-9. doi: 10.4161/nucl.22168. Epub 2012 Sep 18.


Short nucleosome repeats impose rotational modulations on chromatin fibre folding.

Correll SJ, Schubert MH, Grigoryev SA.

EMBO J. 2012 May 16;31(10):2416-26. doi: 10.1038/emboj.2012.80. Epub 2012 Mar 30.


Chromatin organization - the 30 nm fiber.

Grigoryev SA, Woodcock CL.

Exp Cell Res. 2012 Jul 15;318(12):1448-55. doi: 10.1016/j.yexcr.2012.02.014. Epub 2012 Feb 24. Review.


A single heterochromatin boundary element imposes position-independent antisilencing activity in Saccharomyces cerevisiae minichromosomes.

Chakraborty SA, Simpson RT, Grigoryev SA.

PLoS One. 2011;6(9):e24835. doi: 10.1371/journal.pone.0024835. Epub 2011 Sep 16.


A structural perspective on the where, how, why, and what of nucleosome positioning.

Arya G, Maitra A, Grigoryev SA.

J Biomol Struct Dyn. 2010 Jun;27(6):803-20. Review.


Rearrangement of upstream sequences of the hTERT gene during cellular immortalization.

Zhao Y, Wang S, Popova EY, Grigoryev SA, Zhu J.

Genes Chromosomes Cancer. 2009 Nov;48(11):963-74. doi: 10.1002/gcc.20698.


Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions.

Grigoryev SA, Arya G, Correll S, Woodcock CL, Schlick T.

Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13317-22. doi: 10.1073/pnas.0903280106. Epub 2009 Jul 27.


Conformational change in the chromatin remodelling protein MENT.

Ong PC, Golding SJ, Pearce MC, Irving JA, Grigoryev SA, Pike D, Langendorf CG, Bashtannyk-Puhalovich TA, Bottomley SP, Whisstock JC, Pike RN, McGowan S.

PLoS One. 2009;4(3):e4727. doi: 10.1371/journal.pone.0004727. Epub 2009 Mar 6.


Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation.

Popova EY, Krauss SW, Short SA, Lee G, Villalobos J, Etzell J, Koury MJ, Ney PA, Chasis JA, Grigoryev SA.

Chromosome Res. 2009;17(1):47-64. doi: 10.1007/s10577-008-9005-y. Epub 2009 Jan 27.


Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, Hayama R, Leonelli L, Han H, Grigoryev SA, Allis CD, Coonrod SA.

J Cell Biol. 2009 Jan 26;184(2):205-13. doi: 10.1083/jcb.200806072. Epub 2009 Jan 19.


DNA accelerates the inhibition of human cathepsin V by serpins.

Ong PC, McGowan S, Pearce MC, Irving JA, Kan WT, Grigoryev SA, Turk B, Silverman GA, Brix K, Bottomley SP, Whisstock JC, Pike RN.

J Biol Chem. 2007 Dec 21;282(51):36980-6. Epub 2007 Oct 8.


MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome.

Nikitina T, Ghosh RP, Horowitz-Scherer RA, Hansen JC, Grigoryev SA, Woodcock CL.

J Biol Chem. 2007 Sep 21;282(38):28237-45. Epub 2007 Jul 27.


X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation.

McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC.

EMBO J. 2006 Jul 12;25(13):3144-55. Epub 2006 Jun 29.


Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin.

Bulynko YA, Hsing LC, Mason RW, Tremethick DJ, Grigoryev SA.

Mol Cell Biol. 2006 Jun;26(11):4172-84.


The end adjusts the means: heterochromatin remodelling during terminal cell differentiation.

Grigoryev SA, Bulynko YA, Popova EY.

Chromosome Res. 2006;14(1):53-69. Review.


Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT.

Istomina NE, Shushanov SS, Springhetti EM, Karpov VL, Krasheninnikov IA, Stevens K, Zaret KS, Singh PB, Grigoryev SA.

Mol Cell Biol. 2003 Sep;23(18):6455-68.


Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT.

Springhetti EM, Istomina NE, Whisstock JC, Nikitina T, Woodcock CL, Grigoryev SA.

J Biol Chem. 2003 Oct 31;278(44):43384-93. Epub 2003 Aug 19.


Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.

Irving JA, Shushanov SS, Pike RN, Popova EY, Brömme D, Coetzer TH, Bottomley SP, Boulynko IA, Grigoryev SA, Whisstock JC.

J Biol Chem. 2002 Apr 12;277(15):13192-201. Epub 2002 Jan 30.


Higher-order folding of heterochromatin: protein bridges span the nucleosome arrays.

Grigoryev SA.

Biochem Cell Biol. 2001;79(3):227-41. Review.


The nature of the nucleosomal barrier to transcription: direct observation of paused intermediates by electron cryomicroscopy.

Bednar J, Studitsky VM, Grigoryev SA, Felsenfeld G, Woodcock CL.

Mol Cell. 1999 Sep;4(3):377-86.


MENT, a heterochromatin protein that mediates higher order chromatin folding, is a new serpin family member.

Grigoryev SA, Bednar J, Woodcock CL.

J Biol Chem. 1999 Feb 26;274(9):5626-36.


Nucleosomes, linker DNA, and linker histone form a unique structural motif that directs the higher-order folding and compaction of chromatin.

Bednar J, Horowitz RA, Grigoryev SA, Carruthers LM, Hansen JC, Koster AJ, Woodcock CL.

Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14173-8.


A chromatin folding model that incorporates linker variability generates fibers resembling the native structures.

Woodcock CL, Grigoryev SA, Horowitz RA, Whitaker N.

Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9021-5.


A novel nonhistone protein (MENT) promotes nuclear collapse at the terminal stage of avian erythropoiesis.

Grigoryev SA, Solovieva VO, Spirin KS, Krasheninnikov IA.

Exp Cell Res. 1992 Feb;198(2):268-75.


Loosened nucleosome linker folding in transcriptionally active chromatin of chicken embryo erythrocyte nuclei.

Grigoryev SA, Spirin KS, Krasheninnikov IA.

Nucleic Acids Res. 1990 Dec 25;18(24):7397-406.


A topological model for chromatin transcription and a role for nucleosome linkers.

Grigoryev SA, Krasheninnikov IA.

FEBS Lett. 1983 Oct 3;162(1):1-4.


Transient unfolding of trypsin-digested chromatin core particles.

Grigoryev SA, Krasheninnikov IA.

Eur J Biochem. 1982 Dec;129(1):119-25.


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