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Items: 1 to 50 of 105


In situ Structure of Rotavirus VP1 RNA-Dependent RNA Polymerase.

Jenni S, Salgado EN, Herrmann T, Li Z, Grant T, Grigorieff N, Trapani S, Estrozi LF, Harrison SC.

J Mol Biol. 2019 Aug 9;431(17):3124-3138. doi: 10.1016/j.jmb.2019.06.016. Epub 2019 Jun 21.


High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations.

Jung J, Grant T, Thomas DR, Diehnelt CW, Grigorieff N, Joshua-Tor L.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12828-12832. doi: 10.1073/pnas.1903562116. Epub 2019 Jun 10.


Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids.

Liberta F, Loerch S, Rennegarbe M, Schierhorn A, Westermark P, Westermark GT, Hazenberg BPC, Grigorieff N, Fändrich M, Schmidt M.

Nat Commun. 2019 Mar 7;10(1):1104. doi: 10.1038/s41467-019-09033-z.


Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification.

Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D.

Ultramicroscopy. 2019 Aug;203:170-180. doi: 10.1016/j.ultramic.2018.11.016. Epub 2018 Nov 29.


Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation.

Vemu A, Szczesna E, Zehr EA, Spector JO, Grigorieff N, Deaconescu AM, Roll-Mecak A.

Science. 2018 Aug 24;361(6404). pii: eaau1504. doi: 10.1126/science.aau1504.


Atomic Resolution Cryo-EM Structure of β-Galactosidase.

Bartesaghi A, Aguerrebere C, Falconieri V, Banerjee S, Earl LA, Zhu X, Grigorieff N, Milne JLS, Sapiro G, Wu X, Subramaniam S.

Structure. 2018 Jun 5;26(6):848-856.e3. doi: 10.1016/j.str.2018.04.004. Epub 2018 May 10.


Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors.

Regan MC, Grant T, McDaniel MJ, Karakas E, Zhang J, Traynelis SF, Grigorieff N, Furukawa H.

Neuron. 2018 May 2;98(3):521-529.e3. doi: 10.1016/j.neuron.2018.03.034. Epub 2018 Apr 12.


cisTEM, user-friendly software for single-particle image processing.

Grant T, Rohou A, Grigorieff N.

Elife. 2018 Mar 7;7. pii: e35383. doi: 10.7554/eLife.35383.


Physical basis of amyloid fibril polymorphism.

Close W, Neumann M, Schmidt A, Hora M, Annamalai K, Schmidt M, Reif B, Schmidt V, Grigorieff N, Fändrich M.

Nat Commun. 2018 Feb 16;9(1):699. doi: 10.1038/s41467-018-03164-5.


Structure of RNA polymerase bound to ribosomal 30S subunit.

Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA.

Elife. 2017 Oct 13;6. pii: e28560. doi: 10.7554/eLife.28560.


Expression, purification, and contaminant detection for structural studies of Ralstonia metallidurance ClC protein rm1.

Abeyrathne PD, Grigorieff N.

PLoS One. 2017 Jul 10;12(7):e0180163. doi: 10.1371/journal.pone.0180163. eCollection 2017.


Ensemble cryo-EM elucidates the mechanism of translation fidelity.

Loveland AB, Demo G, Grigorieff N, Korostelev AA.

Nature. 2017 Jun 1;546(7656):113-117. doi: 10.1038/nature22397. Epub 2017 May 24.


CryoEM Structure of an Influenza Virus Receptor-Binding Site Antibody-Antigen Interface.

Liu Y, Pan J, Jenni S, Raymond DD, Caradonna T, Do KT, Schmidt AG, Harrison SC, Grigorieff N.

J Mol Biol. 2017 Jun 16;429(12):1829-1839. doi: 10.1016/j.jmb.2017.05.011. Epub 2017 May 12.


Single-protein detection in crowded molecular environments in cryo-EM images.

Rickgauer JP, Grigorieff N, Denk W.

Elife. 2017 May 3;6. pii: e25648. doi: 10.7554/eLife.25648.


Mechanism of ribosome rescue by ArfA and RF2.

Demo G, Svidritskiy E, Madireddy R, Diaz-Avalos R, Grant T, Grigorieff N, Sousa D, Korostelev AA.

Elife. 2017 Mar 16;6. pii: e23687. doi: 10.7554/eLife.23687.


Conformational States of a Soluble, Uncleaved HIV-1 Envelope Trimer.

Liu Y, Pan J, Cai Y, Grigorieff N, Harrison SC, Chen B.

J Virol. 2017 Apr 28;91(10). pii: e00175-17. doi: 10.1128/JVI.00175-17. Print 2017 May 15.


Structure of the transporter associated with antigen processing trapped by herpes simplex virus.

Oldham ML, Grigorieff N, Chen J.

Elife. 2016 Dec 9;5. pii: e21829. doi: 10.7554/eLife.21829.


Frealign: An Exploratory Tool for Single-Particle Cryo-EM.

Grigorieff N.

Methods Enzymol. 2016;579:191-226. doi: 10.1016/bs.mie.2016.04.013. Epub 2016 Jun 7. Review.


Ribosome•RelA structures reveal the mechanism of stringent response activation.

Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA.

Elife. 2016 Jul 19;5. pii: e17029. doi: 10.7554/eLife.17029.


Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction.

Laxmikanthan G, Xu C, Brilot AF, Warren D, Steele L, Seah N, Tong W, Grigorieff N, Landy A, Van Duyne GD.

Elife. 2016 May 25;5. pii: e14313. doi: 10.7554/eLife.14313.


Cryo-EM reveals the steric zipper structure of a light chain-derived amyloid fibril.

Schmidt A, Annamalai K, Schmidt M, Grigorieff N, Fändrich M.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6200-5. doi: 10.1073/pnas.1522282113. Epub 2016 May 16.


Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.

Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA.

Elife. 2016 May 9;5. pii: e14874. doi: 10.7554/eLife.14874.


Activation of NMDA receptors and the mechanism of inhibition by ifenprodil.

Tajima N, Karakas E, Grant T, Simorowski N, Diaz-Avalos R, Grigorieff N, Furukawa H.

Nature. 2016 Jun 2;534(7605):63-8. doi: 10.1038/nature17679. Epub 2016 May 2.


Structure and conformational states of the bovine mitochondrial ATP synthase by cryo-EM.

Zhou A, Rohou A, Schep DG, Bason JV, Montgomery MG, Walker JE, Grigorieff N, Rubinstein JL.

Elife. 2015 Oct 6;4:e10180. doi: 10.7554/eLife.10180.


Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, Fändrich M, Grigorieff N.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11858-63. doi: 10.1073/pnas.1503455112. Epub 2015 Sep 8.


Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0.

Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T.

J Struct Biol. 2015 Nov;192(2):163-73. doi: 10.1016/j.jsb.2015.08.015. Epub 2015 Aug 28.


CTFFIND4: Fast and accurate defocus estimation from electron micrographs.

Rohou A, Grigorieff N.

J Struct Biol. 2015 Nov;192(2):216-21. doi: 10.1016/j.jsb.2015.08.008. Epub 2015 Aug 13.


Automatic estimation and correction of anisotropic magnification distortion in electron microscopes.

Grant T, Grigorieff N.

J Struct Biol. 2015 Nov;192(2):204-8. doi: 10.1016/j.jsb.2015.08.006. Epub 2015 Aug 13.


Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.

Liang B, Li Z, Jenni S, Rahmeh AA, Morin BM, Grant T, Grigorieff N, Harrison SC, Whelan SPJ.

Cell. 2015 Jul 16;162(2):314-327. doi: 10.1016/j.cell.2015.06.018. Epub 2015 Jul 2.


Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6.

Grant T, Grigorieff N.

Elife. 2015 May 29;4:e06980. doi: 10.7554/eLife.06980.


A primer to single-particle cryo-electron microscopy.

Cheng Y, Grigorieff N, Penczek PA, Walz T.

Cell. 2015 Apr 23;161(3):438-449. doi: 10.1016/j.cell.2015.03.050. Review.


Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.

Svidritskiy E, Brilot AF, Koh CS, Grigorieff N, Korostelev AA.

Structure. 2014 Aug 5;22(8):1210-1218. doi: 10.1016/j.str.2014.06.003. Epub 2014 Jul 17.


Taura syndrome virus IRES initiates translation by binding its tRNA-mRNA-like structural element in the ribosomal decoding center.

Koh CS, Brilot AF, Grigorieff N, Korostelev AA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9139-44. doi: 10.1073/pnas.1406335111. Epub 2014 Jun 9.


Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

Szyk A, Deaconescu AM, Spector J, Goodman B, Valenstein ML, Ziolkowska NE, Kormendi V, Grigorieff N, Roll-Mecak A.

Cell. 2014 Jun 5;157(6):1405-15. doi: 10.1016/j.cell.2014.03.061.


Frealix: model-based refinement of helical filament structures from electron micrographs.

Rohou A, Grigorieff N.

J Struct Biol. 2014 May;186(2):234-44. doi: 10.1016/j.jsb.2014.03.012. Epub 2014 Mar 20.


Structure of the ribosome with elongation factor G trapped in the pretranslocation state.

Brilot AF, Korostelev AA, Ermolenko DN, Grigorieff N.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20994-9. doi: 10.1073/pnas.1311423110. Epub 2013 Dec 9.


Quantitative characterization of electron detectors for transmission electron microscopy.

Ruskin RS, Yu Z, Grigorieff N.

J Struct Biol. 2013 Dec;184(3):385-93. doi: 10.1016/j.jsb.2013.10.016. Epub 2013 Nov 1.


Likelihood-based classification of cryo-EM images using FREALIGN.

Lyumkis D, Brilot AF, Theobald DL, Grigorieff N.

J Struct Biol. 2013 Sep;183(3):377-388. doi: 10.1016/j.jsb.2013.07.005. Epub 2013 Jul 17.


Direct detection pays off for electron cryo-microscopy.

Grigorieff N.

Elife. 2013 Feb 19;2:e00573. doi: 10.7554/eLife.00573.


Location of the dsRNA-dependent polymerase, VP1, in rotavirus particles.

Estrozi LF, Settembre EC, Goret G, McClain B, Zhang X, Chen JZ, Grigorieff N, Harrison SC.

J Mol Biol. 2013 Jan 9;425(1):124-32. doi: 10.1016/j.jmb.2012.10.011. Epub 2012 Oct 23.


Interplay of DNA repair with transcription: from structures to mechanisms.

Deaconescu AM, Artsimovitch I, Grigorieff N.

Trends Biochem Sci. 2012 Dec;37(12):543-52. doi: 10.1016/j.tibs.2012.09.002. Epub 2012 Oct 17. Review.


Movies of ice-embedded particles enhance resolution in electron cryo-microscopy.

Campbell MG, Cheng A, Brilot AF, Moeller A, Lyumkis D, Veesler D, Pan J, Harrison SC, Potter CS, Carragher B, Grigorieff N.

Structure. 2012 Nov 7;20(11):1823-8. doi: 10.1016/j.str.2012.08.026. Epub 2012 Sep 27.


Maturation in action: CryoEM study of a viral capsid caught during expansion.

Veesler D, Quispe J, Grigorieff N, Potter CS, Carragher B, Johnson JE.

Structure. 2012 Aug 8;20(8):1384-90. doi: 10.1016/j.str.2012.05.011. Epub 2012 Jun 28.


Optimal noise reduction in 3D reconstructions of single particles using a volume-normalized filter.

Sindelar CV, Grigorieff N.

J Struct Biol. 2012 Oct;180(1):26-38. doi: 10.1016/j.jsb.2012.05.005. Epub 2012 May 18.


Beam-induced motion of vitrified specimen on holey carbon film.

Brilot AF, Chen JZ, Cheng A, Pan J, Harrison SC, Potter CS, Carragher B, Henderson R, Grigorieff N.

J Struct Biol. 2012 Mar;177(3):630-7. doi: 10.1016/j.jsb.2012.02.003. Epub 2012 Feb 16.


Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface.

Deaconescu AM, Sevostyanova A, Artsimovitch I, Grigorieff N.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3353-8. doi: 10.1073/pnas.1115105109. Epub 2012 Feb 13.


Outcome of the first electron microscopy validation task force meeting.

Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL.

Structure. 2012 Feb 8;20(2):205-14. doi: 10.1016/j.str.2011.12.014.


Tilt-pair analysis of images from a range of different specimens in single-particle electron cryomicroscopy.

Henderson R, Chen S, Chen JZ, Grigorieff N, Passmore LA, Ciccarelli L, Rubinstein JL, Crowther RA, Stewart PL, Rosenthal PB.

J Mol Biol. 2011 Nov 11;413(5):1028-46. doi: 10.1016/j.jmb.2011.09.008. Epub 2011 Sep 12.


Structural complexity of a composite amyloid fibril.

Lewandowski JR, van der Wel PC, Rigney M, Grigorieff N, Griffin RG.

J Am Chem Soc. 2011 Sep 21;133(37):14686-98. doi: 10.1021/ja203736z. Epub 2011 Aug 23.


An adaptation of the Wiener filter suitable for analyzing images of isolated single particles.

Sindelar CV, Grigorieff N.

J Struct Biol. 2011 Oct;176(1):60-74. doi: 10.1016/j.jsb.2011.06.010. Epub 2011 Jul 2.

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