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Items: 33

1.

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.

Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF.

J Clin Invest. 2019 May 14;130:2745-2759. doi: 10.1172/JCI124738.

2.

Piperazine-Derivative MMV665917: An Effective Drug in the Diarrheic Piglet Model of Cryptosporidium hominis.

Lee S, Ginese M, Girouard D, Beamer G, Huston CD, Osbourn D, Griggs DW, Tzipori S.

J Infect Dis. 2019 Jun 19;220(2):285-293. doi: 10.1093/infdis/jiz105.

PMID:
30893435
3.

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

Minutti CM, Modak RV, Macdonald F, Li F, Smyth DJ, Dorward DA, Blair N, Husovsky C, Muir A, Giampazolias E, Dobie R, Maizels RM, Kendall TJ, Griggs DW, Kopf M, Henderson NC, Zaiss DM.

Immunity. 2019 Mar 19;50(3):645-654.e6. doi: 10.1016/j.immuni.2019.01.008. Epub 2019 Feb 12.

4.

An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis.

Ulmasov B, Noritake H, Carmichael P, Oshima K, Griggs DW, Neuschwander-Tetri BA.

Hepatol Commun. 2018 Dec 27;3(2):246-261. doi: 10.1002/hep4.1298. eCollection 2019 Feb.

5.

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model.

Stebbins E, Jumani RS, Klopfer C, Barlow J, Miller P, Campbell MA, Meyers MJ, Griggs DW, Huston CD.

PLoS Negl Trop Dis. 2018 Jan 8;12(1):e0006183. doi: 10.1371/journal.pntd.0006183. eCollection 2018 Jan.

6.

αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis.

Murray IR, Gonzalez ZN, Baily J, Dobie R, Wallace RJ, Mackinnon AC, Smith JR, Greenhalgh SN, Thompson AI, Conroy KP, Griggs DW, Ruminski PG, Gray GA, Singh M, Campbell MA, Kendall TJ, Dai J, Li Y, Iredale JP, Simpson H, Huard J, Péault B, Henderson NC.

Nat Commun. 2017 Oct 24;8(1):1118. doi: 10.1038/s41467-017-01097-z.

7.

Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.

Ulmasov B, Neuschwander-Tetri BA, Lai J, Monastyrskiy V, Bhat T, Yates MP, Oliva J, Prinsen MJ, Ruminski PG, Griggs DW.

Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518. doi: 10.1016/j.jcmgh.2016.03.004. eCollection 2016 Jul.

8.

Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.

Griggs DW, Prinsen MJ, Oliva J, Campbell MA, Arnett SD, Tajfirouz D, Ruminski PG, Yu Y, Bond BR, Ji Y, Neckermann G, Choy RK, de Hostos E, Meyers MJ.

J Pharmacol Exp Ther. 2016 May;357(2):423-31. doi: 10.1124/jpet.115.231167. Epub 2016 Feb 23.

9.

Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.

Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L, Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ, Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD, Sverdrup FM, Chen X.

Bioorg Med Chem. 2015 Aug 15;23(16):5144-50. doi: 10.1016/j.bmc.2015.02.050. Epub 2015 Mar 4.

10.

Evaluation of aminohydantoins as a novel class of antimalarial agents.

Meyers MJ, Tortorella MD, Xu J, Qin L, He Z, Lang X, Zeng W, Xu W, Qin L, Prinsen MJ, Sverdrup FM, Eickhoff CS, Griggs DW, Oliva J, Ruminski PG, Jacobsen EJ, Campbell MA, Wood DC, Goldberg DE, Liu X, Lu Y, Lu X, Tu Z, Lu X, Ding K, Chen X.

ACS Med Chem Lett. 2013 Dec 6;5(1):89-93. doi: 10.1021/ml400412x. eCollection 2014 Jan 9.

11.

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.

Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.

12.

Alphav and beta1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways.

Chai DH, Arner EC, Griggs DW, Grodzinsky AJ.

Osteoarthritis Cartilage. 2010 Feb;18(2):249-56. doi: 10.1016/j.joca.2009.09.002. Epub 2009 Sep 22.

13.

ADAM-8 isolated from human osteoarthritic chondrocytes cleaves fibronectin at Ala(271).

Zack MD, Malfait AM, Skepner AP, Yates MP, Griggs DW, Hall T, Hills RL, Alston JT, Nemirovskiy OV, Radabaugh MR, Leone JW, Arner EC, Tortorella MD.

Arthritis Rheum. 2009 Sep;60(9):2704-13. doi: 10.1002/art.24753.

14.

Autoactivation of human ADAM8: a novel pre-processing step is required for catalytic activity.

Hall T, Leone JW, Wiese JF, Griggs DW, Pegg LE, Pauley AM, Tomasselli AG, Zack MD.

Biosci Rep. 2009 Aug;29(4):217-28. doi: 10.1042/BSR20080145.

PMID:
18811590
15.

Proprotein convertase activation of aggrecanases in cartilage in situ.

Malfait AM, Arner EC, Song RH, Alston JT, Markosyan S, Staten N, Yang Z, Griggs DW, Tortorella MD.

Arch Biochem Biophys. 2008 Oct 1;478(1):43-51. doi: 10.1016/j.abb.2008.07.012. Epub 2008 Jul 19.

PMID:
18671934
16.

R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors.

Nagarajan SR, Devadas B, Malecha JW, Lu HF, Ruminski PG, Rico JG, Rogers TE, Marrufo LD, Collins JT, Kleine HP, Lantz MK, Zhu J, Green NF, Russell MA, Landis BH, Miller LM, Meyer DM, Duffin TD, Engleman VW, Finn MB, Freeman SK, Griggs DW, Williams ML, Nickols MA, Pegg JA, Shannon KE, Steininger C, Westlin MM, Nickols GA, Keene JL.

Bioorg Med Chem. 2007 Jun 1;15(11):3783-800. Epub 2007 Mar 15.

PMID:
17399986
17.

Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

Song RH, Tortorella MD, Malfait AM, Alston JT, Yang Z, Arner EC, Griggs DW.

Arthritis Rheum. 2007 Feb;56(2):575-85.

18.

VCC-1, a novel chemokine, promotes tumor growth.

Weinstein EJ, Head R, Griggs DW, Sun D, Evans RJ, Swearingen ML, Westlin MM, Mazzarella R.

Biochem Biophys Res Commun. 2006 Nov 10;350(1):74-81. Epub 2006 Sep 12.

PMID:
16989774
19.

Discovery of diphenylmethanepropionic and dihydrostilbeneacetic acids as antagonists of the integrin alphavbeta3.

Nagarajan SR, Meyer JM, Miyashiro JM, Engleman VW, Freeman SK, Griggs DW, Klover JA, Nickols GA.

Chem Biol Drug Des. 2006 Feb;67(2):177-81.

PMID:
16492166
20.

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy.

Abdollahi A, Griggs DW, Zieher H, Roth A, Lipson KE, Saffrich R, Gröne HJ, Hallahan DE, Reisfeld RA, Debus J, Niethammer AG, Huber PE.

Clin Cancer Res. 2005 Sep 1;11(17):6270-9.

21.
22.

Anti-metastatic properties of RGD-peptidomimetic agents S137 and S247.

Shannon KE, Keene JL, Settle SL, Duffin TD, Nickols MA, Westlin M, Schroeter S, Ruminski PG, Griggs DW.

Clin Exp Metastasis. 2004;21(2):129-38.

PMID:
15168730
23.

A small molecule antagonist of the alpha(v)beta3 integrin suppresses MDA-MB-435 skeletal metastasis.

Harms JF, Welch DR, Samant RS, Shevde LA, Miele ME, Babu GR, Goldberg SF, Gilman VR, Sosnowski DM, Campo DA, Gay CV, Budgeon LR, Mercer R, Jewell J, Mastro AM, Donahue HJ, Erin N, Debies MT, Meehan WJ, Jones AL, Mbalaviele G, Nickols A, Christensen ND, Melly R, Beck LN, Kent J, Rader RK, Kotyk JJ, Pagel MD, Westlin WF, Griggs DW.

Clin Exp Metastasis. 2004;21(2):119-28.

PMID:
15168729
24.

The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives.

Menéndez JA, Mehmi I, Griggs DW, Lupu R.

Endocr Relat Cancer. 2003 Jun;10(2):141-52. Review.

PMID:
12790776
25.

Adenovirus inhibition by peptidomimetic integrin antagonists.

Hippenmeyer PJ, Ruminski PG, Rico JG, Lu HS, Griggs DW.

Antiviral Res. 2002 Jul;55(1):169-78.

PMID:
12076761
26.

Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry.

Schmidt CM, Settle SL, Keene JL, Westlin WF, Nickols GA, Griggs DW.

Clin Exp Metastasis. 1999;17(6):537-44.

PMID:
10763921
27.
28.

A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivo.

Engleman VW, Nickols GA, Ross FP, Horton MA, Griggs DW, Settle SL, Ruminski PG, Teitelbaum SL.

J Clin Invest. 1997 May 1;99(9):2284-92.

29.
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33.

Cloning and promoter identification of the iron-regulated cir gene of Escherichia coli.

Griggs DW, Tharp BB, Konisky J.

J Bacteriol. 1987 Dec;169(12):5343-52.

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