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The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming.

Sardinha-Silva A, Mendonça-Natividade FC, Pinzan CF, Lopes CD, Costa DL, Jacot D, Fernandes FF, Zorzetto-Fernandes ALV, Gay NJ, Sher A, Jankovic D, Soldati-Favre D, Grigg ME, Roque-Barreira MC.

PLoS Pathog. 2019 Jun 21;15(6):e1007871. doi: 10.1371/journal.ppat.1007871. eCollection 2019 Jun.


Whole genome sequencing of experimental hybrids supports meiosis-like sexual recombination in Leishmania.

Inbar E, Shaik J, Iantorno SA, Romano A, Nzelu CO, Owens K, Sanders MJ, Dobson D, Cotton JA, Grigg ME, Beverley SM, Sacks D.

PLoS Genet. 2019 May 15;15(5):e1008042. doi: 10.1371/journal.pgen.1008042. eCollection 2019 May.


Disseminated and Congenital Toxoplasmosis in a Mother and Child With Activated PI3-Kinase δ Syndrome Type 2 (APDS2): Case Report and a Literature Review of Toxoplasma Infections in Primary Immunodeficiencies.

Karanovic D, Michelow IC, Hayward AR, DeRavin SS, Delmonte OM, Grigg ME, Dobbs AK, Niemela JE, Stoddard J, Alhinai Z, Rybak N, Hernandez N, Pittaluga S, Rosenzweig SD, Uzel G, Notarangelo LD.

Front Immunol. 2019 Feb 14;10:77. doi: 10.3389/fimmu.2019.00077. eCollection 2019.


An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats.

Ramakrishnan C, Maier S, Walker RA, Rehrauer H, Joekel DE, Winiger RR, Basso WU, Grigg ME, Hehl AB, Deplazes P, Smith NC.

Sci Rep. 2019 Feb 6;9(1):1474. doi: 10.1038/s41598-018-37671-8.


Design and application of a novel two-amplicon approach for defining eukaryotic microbiota.

Popovic A, Bourdon C, Wang PW, Guttman DS, Voskuijl W, Grigg ME, Bandsma RHJ, Parkinson J.

Microbiome. 2018 Dec 20;6(1):228. doi: 10.1186/s40168-018-0612-3.


High rates of cerebral toxoplasmosis in HIV patients presenting with meningitis in Accra, Ghana.

Opintan JA, Awadzi BK, Biney IJK, Ganu V, Doe R, Kenu E, Adu RF, Osei MM, Akumwena A, Grigg ME, Fahle GA, Newman MJ, Williamson PR, Lartey M.

Trans R Soc Trop Med Hyg. 2017 Oct 1;111(10):464-471. doi: 10.1093/trstmh/trx083.


Genomics and molecular epidemiology of Cryptosporidium species.

Khan A, Shaik JS, Grigg ME.

Acta Trop. 2018 Aug;184:1-14. doi: 10.1016/j.actatropica.2017.10.023. Epub 2017 Oct 27. Review.


Atypical fatal sarcocystosis associated with Sarcocystis neurona in a White-nosed coati (Nasua narica molaris).

Dubey JP, Trupkiewicz JG, Verma SK, Mowery JD, Adedoyin G, Georoff T, Grigg ME.

Vet Parasitol. 2017 Nov 30;247:80-84. doi: 10.1016/j.vetpar.2017.10.003. Epub 2017 Oct 9.


Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage.

Iantorno SA, Durrant C, Khan A, Sanders MJ, Beverley SM, Warren WC, Berriman M, Sacks DL, Cotton JA, Grigg ME.

MBio. 2017 Sep 12;8(5). pii: e01393-17. doi: 10.1128/mBio.01393-17.


Isolation, Culture and Cryopreservation of Sarcocystis species.

Verma SK, Lindsay DS, Grigg ME, Dubey JP.

Curr Protoc Microbiol. 2017 May 16;45:20D.1.1-20D.1.27. doi: 10.1002/cpmc.32.


PopNet: A Markov Clustering Approach to Study Population Genetic Structure.

Zhang J, Khan A, Kennard A, Grigg ME, Parkinson J.

Mol Biol Evol. 2017 Jul 1;34(7):1799-1811. doi: 10.1093/molbev/msx110.


Seroprevalence, isolation and co-infection of multiple Toxoplasma gondii strains in individual bobcats (Lynx rufus) from Mississippi, USA.

Verma SK, Sweeny AR, Lovallo MJ, Calero-Bernal R, Kwok OC, Jiang T, Su C, Grigg ME, Dubey JP.

Int J Parasitol. 2017 Apr;47(5):297-303. doi: 10.1016/j.ijpara.2016.12.007. Epub 2017 Feb 24.


Toxoplasma gondii: Laboratory Maintenance and Growth.

Khan A, Grigg ME.

Curr Protoc Microbiol. 2017 Feb 6;44:20C.1.1-20C.1.17. doi: 10.1002/cpmc.26.


Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramirez JD, Rahman A, Remark R, Mogno I, Ng R, Gnjatic S, Amir ED, Solovyov A, Greenbaum B, Clemente J, Faith J, Belkaid Y, Grigg ME, Merad M.

Cell. 2016 Oct 6;167(2):444-456.e14. doi: 10.1016/j.cell.2016.08.076.


Protozoal-related mortalities in endangered Hawaiian monk seals Neomonachus schauinslandi.

Barbieri MM, Kashinsky L, Rotstein DS, Colegrove KM, Haman KH, Magargal SL, Sweeny AR, Kaufman AC, Grigg ME, Littnan CL.

Dis Aquat Organ. 2016 Sep 26;121(2):85-95.


CD8(+) T cells remove cysts of Toxoplasma gondii from the brain mostly by recognizing epitopes commonly expressed by or cross-reactive between type II and type III strains of the parasite.

Ochiai E, Sa Q, Perkins S, Grigg ME, Suzuki Y.

Microbes Infect. 2016 Jul-Aug;18(7-8):517-22. doi: 10.1016/j.micinf.2016.03.013. Epub 2016 Apr 12.


Elevated Toxoplasma gondii Infection Rates for Retinas from Eye Banks, Southern Brazil.

Commodaro AG, Chiasson M, Sundar N, Rizzo LV, Belfort R Jr, Grigg ME.

Emerg Infect Dis. 2016 Apr;22(4):691-3. doi: 10.3201/eid2204.141819.


Neospora caninum is the leading cause of bovine fetal loss in British Columbia, Canada.

Wilson DJ, Orsel K, Waddington J, Rajeev M, Sweeny AR, Joseph T, Grigg ME, Raverty SA.

Vet Parasitol. 2016 Mar 15;218:46-51. doi: 10.1016/j.vetpar.2016.01.006. Epub 2016 Jan 12.


Local admixture of amplified and diversified secreted pathogenesis determinants shapes mosaic Toxoplasma gondii genomes.

Lorenzi H, Khan A, Behnke MS, Namasivayam S, Swapna LS, Hadjithomas M, Karamycheva S, Pinney D, Brunk BP, Ajioka JW, Ajzenberg D, Boothroyd JC, Boyle JP, Dardé ML, Diaz-Miranda MA, Dubey JP, Fritz HM, Gennari SM, Gregory BD, Kim K, Saeij JP, Su C, White MW, Zhu XQ, Howe DK, Rosenthal BM, Grigg ME, Parkinson J, Liu L, Kissinger JC, Roos DS, Sibley LD.

Nat Commun. 2016 Jan 7;7:10147. doi: 10.1038/ncomms10147.


A Lipolytic Lecithin:Cholesterol Acyltransferase Secreted by Toxoplasma Facilitates Parasite Replication and Egress.

Pszenny V, Ehrenman K, Romano JD, Kennard A, Schultz A, Roos DS, Grigg ME, Carruthers VB, Coppens I.

J Biol Chem. 2016 Feb 19;291(8):3725-46. doi: 10.1074/jbc.M115.671974. Epub 2015 Dec 22.


Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants.

Contopoulos-Ioannidis D, Wheeler KM, Ramirez R, Press C, Mui E, Zhou Y, Van Tubbergen C, Prasad S, Maldonado Y, Withers S, Boyer KM, Noble AG, Rabiah P, Swisher CN, Heydemann P, Wroblewski K, Karrison T, Grigg ME, Montoya JG, McLeod R.

Clin Infect Dis. 2015 Dec 15;61(12):1815-24. doi: 10.1093/cid/civ721. Epub 2015 Sep 24.


Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics.

Hutson SL, Wheeler KM, McLone D, Frim D, Penn R, Swisher CN, Heydemann PT, Boyer KM, Noble AG, Rabiah P, Withers S, Montoya JG, Wroblewski K, Karrison T, Grigg ME, McLeod R.

Clin Infect Dis. 2015 Dec 15;61(12):1831-4. doi: 10.1093/cid/civ720. Epub 2015 Sep 24.


Detection of Sarcocystis spp. infection in bobcats (Lynx rufus).

Verma SK, Calero-Bernal R, Lovallo MJ, Sweeny AR, Grigg ME, Dubey JP.

Vet Parasitol. 2015 Sep 15;212(3-4):422-6. doi: 10.1016/j.vetpar.2015.06.007. Epub 2015 Jun 11.


Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis.

Miller CM, Zakrzewski AM, Robinson DP, Fuller SJ, Walker RA, Ikin RJ, Bao SJ, Grigg ME, Wiley JS, Smith NC.

PLoS One. 2015 Jun 8;10(6):e0129048. doi: 10.1371/journal.pone.0129048. eCollection 2015.


A novel Sarcocystis neurona genotype XIII is associated with severe encephalitis in an unexpectedly broad range of marine mammals from the northeastern Pacific Ocean.

Barbosa L, Johnson CK, Lambourn DM, Gibson AK, Haman KH, Huggins JL, Sweeny AR, Sundar N, Raverty SA, Grigg ME.

Int J Parasitol. 2015 Aug;45(9-10):595-603. doi: 10.1016/j.ijpara.2015.02.013. Epub 2015 May 18.


Ocular toxoplasmosis: lessons from Brazil.

Grigg ME, Dubey JP, Nussenblatt RB.

Am J Ophthalmol. 2015 Jun;159(6):999-1001. doi: 10.1016/j.ajo.2015.04.005. No abstract available.


Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes.

Hehl AB, Basso WU, Lippuner C, Ramakrishnan C, Okoniewski M, Walker RA, Grigg ME, Smith NC, Deplazes P.

BMC Genomics. 2015 Feb 13;16:66. doi: 10.1186/s12864-015-1225-x.


An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM).

Dubey JP, Howe DK, Furr M, Saville WJ, Marsh AE, Reed SM, Grigg ME.

Vet Parasitol. 2015 Apr 15;209(1-2):1-42. doi: 10.1016/j.vetpar.2015.01.026. Epub 2015 Feb 7. Review.


Systems-based analysis of the Sarcocystis neurona genome identifies pathways that contribute to a heteroxenous life cycle.

Blazejewski T, Nursimulu N, Pszenny V, Dangoudoubiyam S, Namasivayam S, Chiasson MA, Chessman K, Tonkin M, Swapna LS, Hung SS, Bridgers J, Ricklefs SM, Boulanger MJ, Dubey JP, Porcella SF, Kissinger JC, Howe DK, Grigg ME, Parkinson J.

MBio. 2015 Feb 10;6(1). pii: e02445-14. doi: 10.1128/mBio.02445-14.


Sarcocystis caninum and Sarcocystis svanai n. spp. (Apicomplexa: Sarcocystidae) Associated with Severe Myositis and Hepatitis in the Domestic Dog (Canis familiaris).

Dubey JP, Sykes JE, Shelton GD, Sharp N, Verma SK, Calero-Bernal R, Viviano J, Sundar N, Khan A, Grigg ME.

J Eukaryot Microbiol. 2015 May-Jun;62(3):307-17. doi: 10.1111/jeu.12182. Epub 2014 Oct 27.


Using molecular epidemiology to track Toxoplasma gondii from terrestrial carnivores to marine hosts: implications for public health and conservation.

VanWormer E, Miller MA, Conrad PA, Grigg ME, Rejmanek D, Carpenter TE, Mazet JA.

PLoS Negl Trop Dis. 2014 May 29;8(5):e2852. doi: 10.1371/journal.pntd.0002852. eCollection 2014.


Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis.

de-la-Torre A, Pfaff AW, Grigg ME, Villard O, Candolfi E, Gomez-Marin JE.

Cytokine. 2014 Jul;68(1):23-31. doi: 10.1016/j.cyto.2014.03.005. Epub 2014 Apr 16.


Inflammasome sensor NLRP1 controls rat macrophage susceptibility to Toxoplasma gondii.

Cirelli KM, Gorfu G, Hassan MA, Printz M, Crown D, Leppla SH, Grigg ME, Saeij JP, Moayeri M.

PLoS Pathog. 2014 Mar 13;10(3):e1003927. doi: 10.1371/journal.ppat.1003927. eCollection 2014 Mar.


Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME.

MBio. 2014 Feb 18;5(1). pii: e01117-13. doi: 10.1128/mBio.01117-13.


Patients with diffuse uveitis and inactive toxoplasmic retinitis lesions test PCR positive for Toxoplasma gondii in their vitreous and blood.

Novais EA, Commodaro AG, Santos F, Muccioli C, Maia A, Nascimento H, Moeller CT, Rizzo LV, Grigg ME, Belfort R Jr.

Br J Ophthalmol. 2014 Jul;98(7):937-40. doi: 10.1136/bjophthalmol-2013-304184. Epub 2014 Feb 11.


Severe South American ocular toxoplasmosis is associated with decreased Ifn-γ/Il-17a and increased Il-6/Il-13 intraocular levels.

de-la-Torre A, Sauer A, Pfaff AW, Bourcier T, Brunet J, Speeg-Schatz C, Ballonzoli L, Villard O, Ajzenberg D, Sundar N, Grigg ME, Gomez-Marin JE, Candolfi E.

PLoS Negl Trop Dis. 2013 Nov 21;7(11):e2541. doi: 10.1371/journal.pntd.0002541. eCollection 2013 Nov.


Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii.

Song C, Chiasson MA, Nursimulu N, Hung SS, Wasmuth J, Grigg ME, Parkinson J.

Mol Syst Biol. 2013 Nov 19;9:708. doi: 10.1038/msb.2013.62.


Toxoplasma serotype is associated with development of ocular toxoplasmosis.

Shobab L, Pleyer U, Johnsen J, Metzner S, James ER, Torun N, Fay MP, Liesenfeld O, Grigg ME.

J Infect Dis. 2013 Nov 1;208(9):1520-8. doi: 10.1093/infdis/jit313. Epub 2013 Jul 21.


Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41.

Tonkin ML, Arredondo SA, Loveless BC, Serpa JJ, Makepeace KA, Sundar N, Petrotchenko EV, Miller LH, Grigg ME, Boulanger MJ.

J Biol Chem. 2013 May 3;288(18):12805-17. doi: 10.1074/jbc.M113.455667. Epub 2013 Mar 19.


Integrated bioinformatic and targeted deletion analyses of the SRS gene superfamily identify SRS29C as a negative regulator of Toxoplasma virulence.

Wasmuth JD, Pszenny V, Haile S, Jansen EM, Gast AT, Sher A, Boyle JP, Boulanger MJ, Parkinson J, Grigg ME.

MBio. 2012 Nov 13;3(6). pii: e00321-12. doi: 10.1128/mBio.00321-12.


Western Australian marsupials are multiply infected with genetically diverse strains of Toxoplasma gondii.

Pan S, Thompson RC, Grigg ME, Sundar N, Smith A, Lymbery AJ.

PLoS One. 2012;7(9):e45147. doi: 10.1371/journal.pone.0045147. Epub 2012 Sep 24.


Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).

McLeod R, Boyer KM, Lee D, Mui E, Wroblewski K, Karrison T, Noble AG, Withers S, Swisher CN, Heydemann PT, Sautter M, Babiarz J, Rabiah P, Meier P, Grigg ME; Toxoplasmosis Study Group.

Clin Infect Dis. 2012 Jun;54(11):1595-605. doi: 10.1093/cid/cis258. Epub 2012 Apr 11.


Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy.

Reid AJ, Vermont SJ, Cotton JA, Harris D, Hill-Cawthorne GA, Könen-Waisman S, Latham SM, Mourier T, Norton R, Quail MA, Sanders M, Shanmugam D, Sohal A, Wasmuth JD, Brunk B, Grigg ME, Howard JC, Parkinson J, Roos DS, Trees AJ, Berriman M, Pain A, Wastling JM.

PLoS Pathog. 2012;8(3):e1002567. doi: 10.1371/journal.ppat.1002567. Epub 2012 Mar 22.


Identification of two novel coccidian species shed by California sea lions (Zalophus californianus).

Carlson-Bremer D, Johnson CK, Miller RH, Gulland FM, Conrad PA, Wasmuth JD, Colegrove KM, Grigg ME.

J Parasitol. 2012 Apr;98(2):347-54. doi: 10.1645/GE-2752.1. Epub 2011 Nov 17.


Population genetics of Toxoplasma gondii: new perspectives from parasite genotypes in wildlife.

Wendte JM, Gibson AK, Grigg ME.

Vet Parasitol. 2011 Nov 24;182(1):96-111. doi: 10.1016/j.vetpar.2011.07.018. Epub 2011 Jul 20. Review.


Polyparasitism is associated with increased disease severity in Toxoplasma gondii-infected marine sentinel species.

Gibson AK, Raverty S, Lambourn DM, Huggins J, Magargal SL, Grigg ME.

PLoS Negl Trop Dis. 2011 May;5(5):e1142. doi: 10.1371/journal.pntd.0001142. Epub 2011 May 24.


Discovery of three novel coccidian parasites infecting California sea lions (Zalophus californianus), with evidence of sexual replication and interspecies pathogenicity.

Colegrove KM, Grigg ME, Carlson-Bremer D, Miller RH, Gulland FM, Ferguson DJ, Rejmanek D, Barr BC, Nordhausen R, Melli AC, Conrad PA.

J Parasitol. 2011 Oct;97(5):868-77. doi: 10.1645/GE-2756.1. Epub 2011 Apr 15.


Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha.

Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, Wohlfert EA, Chou DB, Oldenhove G, Robinson M, Grigg ME, Kastenmayer R, Schwartzberg PL, Belkaid Y.

Immunity. 2011 Mar 25;34(3):435-47. doi: 10.1016/j.immuni.2011.03.003.


Self-mating in the definitive host potentiates clonal outbreaks of the apicomplexan parasites Sarcocystis neurona and Toxoplasma gondii.

Wendte JM, Miller MA, Lambourn DM, Magargal SL, Jessup DA, Grigg ME.

PLoS Genet. 2010 Dec 23;6(12):e1001261. doi: 10.1371/journal.pgen.1001261.


Multi-locus DNA sequencing of Toxoplasma gondii isolated from Brazilian pigs identifies genetically divergent strains.

Frazão-Teixeira E, Sundar N, Dubey JP, Grigg ME, de Oliveira FC.

Vet Parasitol. 2011 Jan 10;175(1-2):33-9. doi: 10.1016/j.vetpar.2010.09.030. Epub 2010 Oct 7.

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