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Items: 1 to 50 of 258

1.

Oxysterols as lipid mediators: Their biosynthetic genes, enzymes and metabolites.

Griffiths WJ, Wang Y.

Prostaglandins Other Lipid Mediat. 2019 Nov 4;147:106381. doi: 10.1016/j.prostaglandins.2019.106381. [Epub ahead of print] Review.

2.

Formation and metabolism of oxysterols and cholestenoic acids found in the mouse circulation: Lessons learnt from deuterium-enrichment experiments and the CYP46A1 transgenic mouse.

Crick PJ, Yutuc E, Abdel-Khalik J, Saeed A, Betsholtz C, Genove G, Björkhem I, Wang Y, Griffiths WJ.

J Steroid Biochem Mol Biol. 2019 Dec;195:105475. doi: 10.1016/j.jsbmb.2019.105475. Epub 2019 Sep 18.

3.

Reply.

Azzu V, Fonseca M, Kennard L, Duckworth A, Moini N, Qurashi M, Brais R, Davies S, Manson A, Staples E, Kumararatne DS, Griffiths WJH.

J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2508-2509. doi: 10.1016/j.jaip.2019.06.015. No abstract available.

PMID:
31495439
4.

An unusual cause of cholangiopathy.

Aslam SP, Cacciottolo TM, Bowden D, Griffiths WJH, Godfrey EM.

Gastrointest Endosc. 2019 Nov;90(5):850-851. doi: 10.1016/j.gie.2019.06.020. Epub 2019 Jun 22. No abstract available.

PMID:
31238057
5.

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation.

Hamesch K, Mandorfer M, Pereira VM, Moeller LS, Pons M, Dolman GE, Reichert MC, Schneider CV, Woditsch V, Voss J, Lindhauer C, Fromme M, Spivak I, Guldiken N, Zhou B, Arslanow A, Schaefer B, Zoller H, Aigner E, Reiberger T, Wetzel M, Siegmund B, Simões C, Gaspar R, Maia L, Costa D, Bento-Miranda M, van Helden J, Yagmur E, Bzdok D, Stolk J, Gleiber W, Knipel V, Windisch W, Mahadeva R, Bals R, Koczulla R, Barrecheguren M, Miravitlles M, Janciauskiene S, Stickel F, Lammert F, Liberal R, Genesca J, Griffiths WJ, Trauner M, Krag A, Trautwein C, Strnad P; European Alpha1-Liver Study Group.

Gastroenterology. 2019 Sep;157(3):705-719.e18. doi: 10.1053/j.gastro.2019.05.013. Epub 2019 May 20.

PMID:
31121167
6.

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.

Raselli T, Hearn T, Wyss A, Atrott K, Peter A, Frey-Wagner I, Spalinger MR, Maggio EM, Sailer AW, Schmitt J, Schreiner P, Moncsek A, Mertens J, Scharl M, Griffiths WJ, Bueter M, Geier A, Rogler G, Wang Y, Misselwitz B.

J Lipid Res. 2019 Jul;60(7):1270-1283. doi: 10.1194/jlr.M093229. Epub 2019 May 21.

7.

Liver disease is common in patients with common variable immunodeficiency and predicts mortality in the presence of cirrhosis or portal hypertension.

Azzu V, Fonseca M, Duckworth A, Kennard L, Moini N, Qurashi M, Brais R, Davies S, Manson A, Staples E, Kumararatne DS, Griffiths WJH.

J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2484-2486.e3. doi: 10.1016/j.jaip.2019.04.016. Epub 2019 Apr 24. No abstract available.

PMID:
31026542
8.

Mining for Oxysterols in Cyp7b1-/- Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5.

Meljon A, Crick PJ, Yutuc E, Yau JL, Seckl JR, Theofilopoulos S, Arenas E, Wang Y, Griffiths WJ.

Biomolecules. 2019 Apr 13;9(4). pii: E149. doi: 10.3390/biom9040149.

9.

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders.

Griffiths WJ, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Hoi-Yee Wu T, Goenka A, Ghosh A, Jones SA, Covey DF, Ory DS, Wang Y.

Free Radic Biol Med. 2019 Nov 20;144:124-133. doi: 10.1016/j.freeradbiomed.2019.04.020. Epub 2019 Apr 19.

10.

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

J Steroid Biochem Mol Biol. 2019 Jun;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025. Epub 2019 Mar 30.

11.

Oxysterol research: a brief review.

Griffiths WJ, Wang Y.

Biochem Soc Trans. 2019 Apr 30;47(2):517-526. doi: 10.1042/BST20180135. Epub 2019 Apr 1. Review.

12.

Developing an Enzyme-Assisted Derivatization Method for Analysis of C27 Bile Alcohols and Acids by Electrospray Ionization-Mass Spectrometry.

Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y, Griffiths WJ.

Molecules. 2019 Feb 7;24(3). pii: E597. doi: 10.3390/molecules24030597.

13.

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo.

Theofilopoulos S, Abreu de Oliveira WA, Yang S, Yutuc E, Saeed A, Abdel-Khalik J, Ullgren A, Cedazo-Minguez A, Björkhem I, Wang Y, Griffiths WJ, Arenas E.

J Biol Chem. 2019 Mar 15;294(11):4169-4176. doi: 10.1074/jbc.RA118.005639. Epub 2019 Jan 17.

14.

Concentrations of bile acid precursors in cerebrospinal fluid of Alzheimer's disease patients.

Griffiths WJ, Abdel-Khalik J, Yutuc E, Roman G, Warner M, Gustafsson JÅ, Wang Y.

Free Radic Biol Med. 2019 Apr;134:42-52. doi: 10.1016/j.freeradbiomed.2018.12.020. Epub 2018 Dec 19.

15.

Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.

Griffiths WJ, Crick PJ, Meljon A, Theofilopoulos S, Abdel-Khalik J, Yutuc E, Parker JE, Kelly DE, Kelly SL, Arenas E, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Feb;1864(2):191-211. doi: 10.1016/j.bbalip.2018.11.006. Epub 2018 Nov 22.

16.

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods.

Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Geilenkeuser WJ, Lövgren-Sandblom A, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Bretillon L, Browne RW, Caccia C, Cenarro A, Crick PJ, Fauler G, García-Llatas G, Griffiths WJ, Iuliano L, Lagarda MJ, Leoni V, Lottenberg AM, Matysik S, McDonald J, Rideout TC, Schmitz G, Nunes VS, Wang Y, Zerbinati C, Diczfalusy U, Schött HF.

Biochimie. 2018 Oct;153:26-32. doi: 10.1016/j.biochi.2018.07.016. Epub 2018 Jul 29.

PMID:
30063945
17.

Identification of 7α,24-dihydroxy-3-oxocholest-4-en-26-oic and 7α,25-dihydroxy-3-oxocholest-4-en-26-oic acids in human cerebrospinal fluid and plasma.

Abdel-Khalik J, Crick PJ, Yutuc E, DeBarber AE, Duell PB, Steiner RD, Laina I, Wang Y, Griffiths WJ.

Biochimie. 2018 Oct;153:86-98. doi: 10.1016/j.biochi.2018.06.020. Epub 2018 Jun 28.

18.

Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications.

Kaliyaperumal K, Grove JI, Delahay RM, Griffiths WJH, Duckworth A, Aithal GP.

J Hepatol. 2018 Oct;69(4):948-957. doi: 10.1016/j.jhep.2018.05.013. Epub 2018 May 21. Review.

PMID:
29792895
19.

Investigation and management of a raised serum ferritin.

Cullis JO, Fitzsimons EJ, Griffiths WJ, Tsochatzis E, Thomas DW; British Society for Haematology.

Br J Haematol. 2018 May;181(3):331-340. doi: 10.1111/bjh.15166. Epub 2018 Apr 19. Review.

PMID:
29672840
20.

Diagnosis and therapy of genetic haemochromatosis (review and 2017 update).

Fitzsimons EJ, Cullis JO, Thomas DW, Tsochatzis E, Griffiths WJH; British Society for Haematology.

Br J Haematol. 2018 May;181(3):293-303. doi: 10.1111/bjh.15164. Epub 2018 Apr 16. No abstract available.

PMID:
29663319
21.

Identification of unusual oxysterols and bile acids with 7-oxo or 3β,5α,6β-trihydroxy functions in human plasma by charge-tagging mass spectrometry with multistage fragmentation.

Griffiths WJ, Gilmore I, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Wu TH, Goenka A, Ghosh A, Jones SA, Wang Y.

J Lipid Res. 2018 Jun;59(6):1058-1070. doi: 10.1194/jlr.D083246. Epub 2018 Apr 6.

22.

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0).

Bezine M, Maatoug S, Ben Khalifa R, Debbabi M, Zarrouk A, Wang Y, Griffiths WJ, Nury T, Samadi M, Vejux A, de Sèze J, Moreau T, Kharrat R, El Ayeb M, Lizard G.

Biochimie. 2018 Oct;153:56-69. doi: 10.1016/j.biochi.2018.02.008. Epub 2018 Feb 17.

PMID:
29462682
23.

An update on oxysterol biochemistry: New discoveries in lipidomics.

Griffiths WJ, Wang Y.

Biochem Biophys Res Commun. 2018 Oct 7;504(3):617-622. doi: 10.1016/j.bbrc.2018.02.019. Epub 2018 Feb 5. Review.

24.

Unravelling new pathways of sterol metabolism: lessons learned from in-born errors and cancer.

Wang Y, Griffiths WJ.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):90-96. doi: 10.1097/MCO.0000000000000442. Review.

25.

Liver transplantation in adults with liver disease due to common variable immunodeficiency leads to early recurrent disease and poor outcome.

Azzu V, Elias JE, Duckworth A, Davies S, Brais R, Kumararatne DS, Gimson AES, Griffiths WJH.

Liver Transpl. 2018 Feb;24(2):171-181. doi: 10.1002/lt.24979.

26.

Comparison of the composition of bile acids in bile of patients with adenocarcinoma of the pancreas and benign disease.

Rees DO, Crick PJ, Jenkins GJ, Wang Y, Griffiths WJ, Brown TH, Al-Sarireh B.

J Steroid Biochem Mol Biol. 2017 Nov;174:290-295. doi: 10.1016/j.jsbmb.2017.10.011. Epub 2017 Oct 12.

27.

Liver disease predicts mortality in patients with X-linked immunodeficiency with hyper-IgM but can be prevented by early hematopoietic stem cell transplantation.

Azzu V, Kennard L, Morillo-Gutierrez B, Slatter M, Edgar JDM, Kumararatne DS, Griffiths WJH.

J Allergy Clin Immunol. 2018 Jan;141(1):405-408.e7. doi: 10.1016/j.jaci.2017.06.036. Epub 2017 Jul 26. No abstract available.

PMID:
28756297
28.

Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers.

Griffiths WJ, Hearn T, Crick PJ, Abdel-Khalik J, Dickson A, Yutuc E, Wang Y.

Chem Phys Lipids. 2017 Oct;207(Pt B):69-80. doi: 10.1016/j.chemphyslip.2017.04.004. Epub 2017 Apr 12.

29.

Sterolomics: State of the art, developments, limitations and challenges.

Griffiths WJ, Wang Y.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Aug;1862(8):771-773. doi: 10.1016/j.bbalip.2017.03.001. Epub 2017 Mar 14. Review.

30.

Cholesterolomics: An update.

Griffiths WJ, Abdel-Khalik J, Yutuc E, Morgan AH, Gilmore I, Hearn T, Wang Y.

Anal Biochem. 2017 May 1;524:56-67. doi: 10.1016/j.ab.2017.01.009. Epub 2017 Jan 10. Review.

31.

Reduced Plasma Levels of 25-Hydroxycholesterol and Increased Cerebrospinal Fluid Levels of Bile Acid Precursors in Multiple Sclerosis Patients.

Crick PJ, Griffiths WJ, Zhang J, Beibel M, Abdel-Khalik J, Kuhle J, Sailer AW, Wang Y.

Mol Neurobiol. 2017 Dec;54(10):8009-8020. doi: 10.1007/s12035-016-0281-9. Epub 2016 Nov 23.

32.

Defective cholesterol metabolism in amyotrophic lateral sclerosis.

Abdel-Khalik J, Yutuc E, Crick PJ, Gustafsson JÅ, Warner M, Roman G, Talbot K, Gray E, Griffiths WJ, Turner MR, Wang Y.

J Lipid Res. 2017 Jan;58(1):267-278. doi: 10.1194/jlr.P071639. Epub 2016 Nov 3.

33.

The role of microRNA-155/liver X receptor pathway in experimental and idiopathic pulmonary fibrosis.

Kurowska-Stolarska M, Hasoo MK, Welsh DJ, Stewart L, McIntyre D, Morton BE, Johnstone S, Miller AM, Asquith DL, Millar NL, Millar AB, Feghali-Bostwick CA, Hirani N, Crick PJ, Wang Y, Griffiths WJ, McInnes IB, McSharry C.

J Allergy Clin Immunol. 2017 Jun;139(6):1946-1956. doi: 10.1016/j.jaci.2016.09.021. Epub 2016 Oct 14.

34.

Current trends in oxysterol research.

Griffiths WJ, Abdel-Khalik J, Hearn T, Yutuc E, Morgan AH, Wang Y.

Biochem Soc Trans. 2016 Apr 15;44(2):652-8. doi: 10.1042/BST20150255. Review.

35.

Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients.

Griffiths WJ, Abdel-Khalik J, Crick PJ, Ogundare M, Shackleton CH, Tuschl K, Kwok MK, Bigger BW, Morris AA, Honda A, Xu L, Porter NA, Björkhem I, Clayton PT, Wang Y.

J Steroid Biochem Mol Biol. 2017 May;169:77-87. doi: 10.1016/j.jsbmb.2016.03.018. Epub 2016 Mar 11.

36.

An Interferon Regulated MicroRNA Provides Broad Cell-Intrinsic Antiviral Immunity through Multihit Host-Directed Targeting of the Sterol Pathway.

Robertson KA, Hsieh WY, Forster T, Blanc M, Lu H, Crick PJ, Yutuc E, Watterson S, Martin K, Griffiths SJ, Enright AJ, Yamamoto M, Pradeepa MM, Lennox KA, Behlke MA, Talbot S, Haas J, Dölken L, Griffiths WJ, Wang Y, Angulo A, Ghazal P.

PLoS Biol. 2016 Mar 3;14(3):e1002364. doi: 10.1371/journal.pbio.1002364. eCollection 2016 Mar.

37.

New methods for analysis of oxysterols and related compounds by LC-MS.

Griffiths WJ, Abdel-Khalik J, Crick PJ, Yutuc E, Wang Y.

J Steroid Biochem Mol Biol. 2016 Sep;162:4-26. doi: 10.1016/j.jsbmb.2015.11.017. Epub 2015 Nov 27. Review.

38.

Preimplant Normothermic Liver Perfusion of a Suboptimal Liver Donated After Circulatory Death.

Watson CJ, Kosmoliaptsis V, Randle LV, Russell NK, Griffiths WJ, Davies S, Mergental H, Butler AJ.

Am J Transplant. 2016 Jan;16(1):353-7. doi: 10.1111/ajt.13448. Epub 2015 Sep 22.

39.

A retrospective study assessing fully covered metal stents as first-line management for malignant biliary strictures.

Sampaziotis F, Elias J, Gelson WT, Gimson AE, Griffiths WJ, Woodward J, Shariff M, Macfarlane B, King A, Corbett G, Leahy A.

Eur J Gastroenterol Hepatol. 2015 Nov;27(11):1347-53. doi: 10.1097/MEG.0000000000000455.

PMID:
26275083
40.

Revised sample preparation for the analysis of oxysterols by enzyme-assisted derivatisation for sterol analysis (EADSA).

Crick PJ, Bentley TW, Wang Y, Griffiths WJ.

Anal Bioanal Chem. 2015 Jul;407(17):5235-9. doi: 10.1007/s00216-015-8609-2. Epub 2015 Mar 22.

41.

The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid.

Crick PJ, Beckers L, Baes M, Van Veldhoven PP, Wang Y, Griffiths WJ.

Steroids. 2015 Jul;99(Pt B):172-7. doi: 10.1016/j.steroids.2015.02.021. Epub 2015 Mar 7.

42.

Cholesterol metabolites exported from human brain.

Iuliano L, Crick PJ, Zerbinati C, Tritapepe L, Abdel-Khalik J, Poirot M, Wang Y, Griffiths WJ.

Steroids. 2015 Jul;99(Pt B):189-93. doi: 10.1016/j.steroids.2015.01.026. Epub 2015 Feb 7.

43.

Quantitative charge-tags for sterol and oxysterol analysis.

Crick PJ, William Bentley T, Abdel-Khalik J, Matthews I, Clayton PT, Morris AA, Bigger BW, Zerbinati C, Tritapepe L, Iuliano L, Wang Y, Griffiths WJ.

Clin Chem. 2015 Feb;61(2):400-11. doi: 10.1373/clinchem.2014.231332. Epub 2014 Dec 15.

44.

Cholestenoic acids regulate motor neuron survival via liver X receptors.

Theofilopoulos S, Griffiths WJ, Crick PJ, Yang S, Meljon A, Ogundare M, Kitambi SS, Lockhart A, Tuschl K, Clayton PT, Morris AA, Martinez A, Reddy MA, Martinuzzi A, Bassi MT, Honda A, Mizuochi T, Kimura A, Nittono H, De Michele G, Carbone R, Criscuolo C, Yau JL, Seckl JR, Schüle R, Schöls L, Sailer AW, Kuhle J, Fraidakis MJ, Gustafsson JÅ, Steffensen KR, Björkhem I, Ernfors P, Sjövall J, Arenas E, Wang Y.

J Clin Invest. 2014 Nov;124(11):4829-42. doi: 10.1172/JCI68506. Epub 2014 Oct 1.

45.

Salvage of liver transplant with hepatolithiasis by percutaneous transhepatic cholangioscopic hepatolithotomy.

Ali JM, See TC, Wiseman O, Griffiths WJ, Jah A.

Transpl Int. 2014 Dec;27(12):e126-8. doi: 10.1111/tri.12387. Epub 2014 Aug 22. No abstract available.

46.

Impact of D181V and A69T on the function of ferroportin as an iron export pump and hepcidin receptor.

Praschberger R, Schranz M, Griffiths WJ, Baumgartner N, Hermann M, Lomas DJ, Pietrangelo A, Cox TM, Vogel W, Zoller H.

Biochim Biophys Acta. 2014 Sep;1842(9):1406-12. doi: 10.1016/j.bbadis.2014.05.011. Epub 2014 May 21.

47.

24S,25-Epoxycholesterol in mouse and rat brain.

Wang Y, Karu K, Meljon A, Turton J, Yau JL, Seckl JR, Wang Y, Griffiths WJ.

Biochem Biophys Res Commun. 2014 Jun 27;449(2):229-34. doi: 10.1016/j.bbrc.2014.05.012. Epub 2014 May 14.

48.

On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO.

Björkhem I, Diczfalusy U, Lövgren-Sandblom A, Starck L, Jonsson M, Tallman K, Schirmer H, Ousager LB, Crick PJ, Wang Y, Griffiths WJ, Guengerich FP.

J Lipid Res. 2014 Jun;55(6):1165-72. doi: 10.1194/jlr.P048603. Epub 2014 Apr 25.

49.

Role of AMACR (α-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice.

Autio KJ, Schmitz W, Nair RR, Selkälä EM, Sormunen RT, Miinalainen IJ, Crick PJ, Wang Y, Griffiths WJ, Reddy JK, Baes M, Hiltunen JK.

Biochem J. 2014 Jul 1;461(1):125-35. doi: 10.1042/BJ20130915.

PMID:
24735479
50.

Liver disease in infancy caused by oxysterol 7 α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid.

Dai D, Mills PB, Footitt E, Gissen P, McClean P, Stahlschmidt J, Coupry I, Lavie J, Mochel F, Goizet C, Mizuochi T, Kimura A, Nittono H, Schwarz K, Crick PJ, Wang Y, Griffiths WJ, Clayton PT.

J Inherit Metab Dis. 2014 Sep;37(5):851-61.

PMID:
24658845

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