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Items: 1 to 50 of 160


Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study.

Lemon J, Cooper J, Defres S, Easton A, Sadarangani M, Griffiths MJ, Pollard AJ, Solomon T, Kneen R.

PLoS One. 2019 Sep 16;14(9):e0220042. doi: 10.1371/journal.pone.0220042. eCollection 2019.


Antibiotic or silver versus standard ventriculoperitoneal shunts (BASICS): a multicentre, single-blinded, randomised trial and economic evaluation.

Mallucci CL, Jenkinson MD, Conroy EJ, Hartley JC, Brown M, Dalton J, Kearns T, Moitt T, Griffiths MJ, Culeddu G, Solomon T, Hughes D, Gamble C; BASICS Study collaborators.

Lancet. 2019 Sep 12. pii: S0140-6736(19)31603-4. doi: 10.1016/S0140-6736(19)31603-4. [Epub ahead of print] Erratum in: Lancet. 2019 Sep 18;:.


Guidelines on the management of acute respiratory distress syndrome.

Griffiths MJD, McAuley DF, Perkins GD, Barrett N, Blackwood B, Boyle A, Chee N, Connolly B, Dark P, Finney S, Salam A, Silversides J, Tarmey N, Wise MP, Baudouin SV.

BMJ Open Respir Res. 2019 May 24;6(1):e000420. doi: 10.1136/bmjresp-2019-000420. eCollection 2019.


Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: A case for further catch up campaigns?

Turtle L, Brindle HE, Schluter WW, Faragher B, Rayamajhi A, Bohara R, Gurung S, Shakya G, Yoksan S, Dixit S, Rajbhandari R, Paudel B, Adhikari S, Solomon T, Griffiths MJ.

PLoS Negl Trop Dis. 2019 Apr 15;13(4):e0007269. doi: 10.1371/journal.pntd.0007269. eCollection 2019 Apr.


Subtype-specific regulatory network rewiring in acute myeloid leukemia.

Assi SA, Imperato MR, Coleman DJL, Pickin A, Potluri S, Ptasinska A, Chin PS, Blair H, Cauchy P, James SR, Zacarias-Cabeza J, Gilding LN, Beggs A, Clokie S, Loke JC, Jenkin P, Uddin A, Delwel R, Richards SJ, Raghavan M, Griffiths MJ, Heidenreich O, Cockerill PN, Bonifer C.

Nat Genet. 2019 Jan;51(1):151-162. doi: 10.1038/s41588-018-0270-1. Epub 2018 Nov 12.


Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study.

McGill F, Griffiths MJ, Bonnett LJ, Geretti AM, Michael BD, Beeching NJ, McKee D, Scarlett P, Hart IJ, Mutton KJ, Jung A, Adan G, Gummery A, Sulaiman WAW, Ennis K, Martin AP, Haycox A, Miller A, Solomon T; UK Meningitis Study Investigators.

Lancet Infect Dis. 2018 Sep;18(9):992-1003. doi: 10.1016/S1473-3099(18)30245-7. Epub 2018 Jun 29.



Griffiths MJ, McGill F, Solomon T.

Clin Med (Lond). 2018 Aug;18(4):352. doi: 10.7861/clinmedicine.18-4-352. No abstract available.


Airway Alterations and Diffuse Alveolar Damage in Acute Respiratory Distress Syndrome: Is There Any Association?

Roca O, García-de-Acilu M, Soriano-Navarro T, Griffiths MJD.

Arch Bronconeumol. 2019 Jan;55(1):3-4. doi: 10.1016/j.arbres.2018.04.003. Epub 2018 May 31. English, Spanish. No abstract available.


Management of acute meningitis.

Griffiths MJ, McGill F, Solomon T.

Clin Med (Lond). 2018 Mar;18(2):164-169. doi: 10.7861/clinmedicine.18-2-164.


The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series.

Mehta R, Soares CN, Medialdea-Carrera R, Ellul M, da Silva MTT, Rosala-Hallas A, Jardim MR, Burnside G, Pamplona L, Bhojak M, Manohar R, da Silva GAM, Adriano MV, Brasil P, Nogueira RMR, Dos Santos CC, Turtle L, de Sequeira PC, Brown DW, Griffiths MJ, de Filippis AMB, Solomon T.

PLoS Negl Trop Dis. 2018 Feb 12;12(2):e0006212. doi: 10.1371/journal.pntd.0006212. eCollection 2018 Feb. Erratum in: PLoS Negl Trop Dis. 2019 Jan 31;13(1):e0007166.


Recommendations for enterovirus diagnostics and characterisation within and beyond Europe.

Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, López-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbø S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK.

J Clin Virol. 2018 Apr;101:11-17. doi: 10.1016/j.jcv.2018.01.008. Epub 2018 Feb 6. Review.


The inter-rater reliability and prognostic value of coma scales in Nepali children with acute encephalitis syndrome.

Ray S, Rayamajhi A, Bonnett LJ, Solomon T, Kneen R, Griffiths MJ.

Paediatr Int Child Health. 2018 Feb;38(1):60-65. doi: 10.1080/20469047.2017.1398503. Epub 2017 Nov 16.


Childhood tuberculosis is associated with decreased abundance of T cell gene transcripts and impaired T cell function.

Hemingway C, Berk M, Anderson ST, Wright VJ, Hamilton S, Eleftherohorinou H, Kaforou M, Goldgof GM, Hickman K, Kampmann B, Schoeman J, Eley B, Beatty D, Pienaar S, Nicol MP, Griffiths MJ, Waddell SJ, Newton SM, Coin LJ, Relman DA, Montana G, Levin M.

PLoS One. 2017 Nov 15;12(11):e0185973. doi: 10.1371/journal.pone.0185973. eCollection 2017.


MicroRNA-542 Promotes Mitochondrial Dysfunction and SMAD Activity and Is Elevated in Intensive Care Unit-acquired Weakness.

Garros RF, Paul R, Connolly M, Lewis A, Garfield BE, Natanek SA, Bloch S, Mouly V, Griffiths MJ, Polkey MI, Kemp PR.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1422-1433. doi: 10.1164/rccm.201701-0101OC.


Rapid Accurate Identification of Tuberculous Meningitis Among South African Children Using a Novel Clinical Decision Tool.

Goenka A, Jeena PM, Mlisana K, Solomon T, Spicer K, Stephenson R, Verma A, Dhada B, Griffiths MJ.

Pediatr Infect Dis J. 2018 Mar;37(3):229-234. doi: 10.1097/INF.0000000000001726.


Decoding the association between herpes simplex virus and antibody-mediated encephalitis.

Ellul MA, Griffiths MJ.

Dev Med Child Neurol. 2017 Aug;59(8):776-777. doi: 10.1111/dmcn.13471. Epub 2017 Jun 5. No abstract available.


Viral meningitis: current issues in diagnosis and treatment.

McGill F, Griffiths MJ, Solomon T.

Curr Opin Infect Dis. 2017 Apr;30(2):248-256. doi: 10.1097/QCO.0000000000000355. Review.


Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema.

Ng-Blichfeldt JP, Alçada J, Montero MA, Dean CH, Griesenbach U, Griffiths MJ, Hind M.

Thorax. 2017 Jun;72(6):510-521. doi: 10.1136/thoraxjnl-2016-208846. Epub 2017 Jan 13.


A comparison of HMGB1 concentrations between cerebrospinal fluid and blood in patients with neurological disease.

Walker LE, Griffiths MJ, McGill F, Lewthwaite P, Sills GJ, Jorgensen A, Antoine DJ, Solomon T, Marson AG, Pirmohamed M.

Biomarkers. 2017 Nov;22(7):635-642. doi: 10.1080/1354750X.2016.1265003. Epub 2016 Dec 8.


Muscle Regeneration after Critical Illness: Are Satellite Cells the Answer?

Polkey MI, Griffiths MJ, Kemp PR.

Am J Respir Crit Care Med. 2016 Oct 1;194(7):780-782. No abstract available.


Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study.

Wnęk M, Ressel L, Ricci E, Rodriguez-Martinez C, Guerrero JC, Ismail Z, Smith C, Kipar A, Sodeik B, Chinnery PF, Solomon T, Griffiths MJ.

Acta Neuropathol. 2016 Sep;132(3):433-51. doi: 10.1007/s00401-016-1597-2. Epub 2016 Jul 25.


The role of hypnotherapy in evidence-based clinical practice.

Griffiths MJ.

Oral Dis. 2017 May;23(4):420-423. doi: 10.1111/odi.12532. Epub 2016 Jul 29. Review.


The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities.

Millar FR, Summers C, Griffiths MJ, Toshner MR, Proudfoot AG.

Thorax. 2016 May;71(5):462-73. doi: 10.1136/thoraxjnl-2015-207461. Epub 2016 Mar 11. Review.


Characteristic Cytokine and Chemokine Profiles in Encephalitis of Infectious, Immune-Mediated, and Unknown Aetiology.

Michael BD, Griffiths MJ, Granerod J, Brown D, Davies NW, Borrow R, Solomon T.

PLoS One. 2016 Jan 25;11(1):e0146288. doi: 10.1371/journal.pone.0146288. eCollection 2016.


The Interleukin-1 Balance During Encephalitis Is Associated With Clinical Severity, Blood-Brain Barrier Permeability, Neuroimaging Changes, and Disease Outcome.

Michael BD, Griffiths MJ, Granerod J, Brown D, Keir G, Wnęk M, Cox DJ, Vidyasagar R, Borrow R, Parkes LM, Solomon T.

J Infect Dis. 2016 May 15;213(10):1651-60. doi: 10.1093/infdis/jiv771. Epub 2015 Dec 27. Erratum in: J Infect Dis. 2017 Jun 1;215(11):1774.


Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection.

Ellul MA, Griffiths MJ, Iyer A, Avula S, Defres S, Baborie A, Vincent A, Martin NG, Sadarangani M, Pollard AJ, Solomon T, Kneen R.

Pediatr Infect Dis J. 2016 Mar;35(3):347-9. doi: 10.1097/INF.0000000000001011.


Mechanical ventilation after lung transplantation.

Thakuria L, Davey R, Romano R, Carby MR, Kaul S, Griffiths MJ, Simon AR, Reed AK, Marczin N.

J Crit Care. 2016 Feb;31(1):110-8. doi: 10.1016/j.jcrc.2015.09.021. Epub 2015 Oct 5.


Systemic inflammation and oxidative stress post-lung resection: Effect of pretreatment with N-acetylcysteine.

Bastin AJ, Davies N, Lim E, Quinlan GJ, Griffiths MJ.

Respirology. 2016 Jan;21(1):180-7. doi: 10.1111/resp.12662. Epub 2015 Oct 27.


The effects of pleural fluid drainage on respiratory function in mechanically ventilated patients after cardiac surgery.

Brims FJ, Davies MG, Elia A, Griffiths MJ.

BMJ Open Respir Res. 2015 Aug 28;2(1):e000080. doi: 10.1136/bmjresp-2015-000080. eCollection 2015.


Correction: A Preliminary Randomized Double Blind Placebo-Controlled Trial of Intravenous Immunoglobulin for Japanese Encephalitis in Nepal.

Rayamajhi A, Nightingale S, Bhatta NK, Singh R, Ledger E, Bista KP, Lewthwaite P, Mahaseth C, Turtle L, Robinson JS, Galbraith SE, Wnek M, Johnson BW, Faragher B, Kneen R, Griffiths MJ, Solomon T.

PLoS One. 2015 Aug 13;10(8):e0136008. doi: 10.1371/journal.pone.0136008. eCollection 2015. No abstract available.


Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature.

Cauchy P, James SR, Zacarias-Cabeza J, Ptasinska A, Imperato MR, Assi SA, Piper J, Canestraro M, Hoogenkamp M, Raghavan M, Loke J, Akiki S, Clokie SJ, Richards SJ, Westhead DR, Griffiths MJ, Ott S, Bonifer C, Cockerill PN.

Cell Rep. 2015 Aug 4;12(5):821-36. doi: 10.1016/j.celrep.2015.06.069. Epub 2015 Jul 23.


Cost-utility of fingolimod compared with dimethyl fumarate in highly active relapsing-remitting multiple sclerosis (RRMS) in England.

Maruszczak MJ, Montgomery SM, Griffiths MJ, Bergvall N, Adlard N.

J Med Econ. 2015;18(11):874-85. doi: 10.3111/13696998.2015.1056794. Epub 2015 Jul 1.


MiR-181a: a potential biomarker of acute muscle wasting following elective high-risk cardiothoracic surgery.

Bloch SA, Donaldson AV, Lewis A, Banya WA, Polkey MI, Griffiths MJ, Kemp PR.

Crit Care. 2015 Apr 7;19:147. doi: 10.1186/s13054-015-0853-5.


A preliminary randomized double blind placebo-controlled trial of intravenous immunoglobulin for Japanese encephalitis in Nepal.

Rayamajhi A, Nightingale S, Bhatta NK, Singh R, Kneen R, Ledger E, Bista KP, Lewthwaite P, Mahaseth C, Turtle L, Robinson JS, Galbraith SE, Wnek M, Johnson BW, Faragher B, Griffiths MJ, Solomon T.

PLoS One. 2015 Apr 17;10(4):e0122608. doi: 10.1371/journal.pone.0122608. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136008. Kneen, Rachel [added].


Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs.

Bloch SA, Lee JY, Syburra T, Rosendahl U, Griffiths MJ, Kemp PR, Polkey MI.

Thorax. 2015 Mar;70(3):219-28. doi: 10.1136/thoraxjnl-2014-206225. Epub 2014 Dec 16.


Pulmonary venous hypertension and mechanical strain stimulate monocyte chemoattractant protein-1 release and structural remodelling of the lung in human and rodent chronic heart failure models.

Park JE, Lyon AR, Shao D, Hector LR, Xu H, O'Gara P, Pinhu L, Chambers RC, Wort SJ, Griffiths MJ.

Thorax. 2014 Dec;69(12):1120-7. doi: 10.1136/thoraxjnl-2013-204190. Epub 2014 Sep 15.


Japanese encephalitis virus infection.

Griffiths MJ, Turtle L, Solomon T.

Handb Clin Neurol. 2014;123:561-76. doi: 10.1016/B978-0-444-53488-0.00026-2. Review. No abstract available.


The effect of degree and timing of nitrogen limitation on lipid productivity in Chlorella vulgaris.

Griffiths MJ, van Hille RP, Harrison ST.

Appl Microbiol Biotechnol. 2014 Jul;98(13):6147-59. doi: 10.1007/s00253-014-5757-9. Epub 2014 May 14.


The effect of nitrogen limitation on lipid productivity and cell composition in Chlorella vulgaris.

Griffiths MJ, van Hille RP, Harrison ST.

Appl Microbiol Biotechnol. 2014 Mar;98(5):2345-56. doi: 10.1007/s00253-013-5442-4. Epub 2014 Jan 12.


The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol.

Jenkinson MD, Gamble C, Hartley JC, Hickey H, Hughes D, Blundell M, Griffiths MJ, Solomon T, Mallucci CL.

Trials. 2014 Jan 3;15:4. doi: 10.1186/1745-6215-15-4.


Methemoglobin-induced signaling and chemokine responses in human alveolar epithelial cells.

Mumby S, Ramakrishnan L, Evans TW, Griffiths MJ, Quinlan GJ.

Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L88-100. doi: 10.1152/ajplung.00066.2013. Epub 2013 Oct 18.


The functional, social and economic impact of acute encephalitis syndrome in Nepal--a longitudinal follow-up study.

Griffiths MJ, Lemon JV, Rayamajhi A, Poudel P, Shrestha P, Srivastav V, Kneen R, Medina-Lara A, Singh RR, Solomon T.

PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2383. doi: 10.1371/journal.pntd.0002383. eCollection 2013.


Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms - a pilot study.

Michael BD, Elsone L, Griffiths MJ, Faragher B, Borrow R, Solomon T, Jacob A.

Cytokine. 2013 Oct;64(1):90-6. doi: 10.1016/j.cyto.2013.07.019. Epub 2013 Aug 12.


Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial.

Shyamsundar M, McAuley DF, Shields MO, MacSweeney R, Duffy MJ, Johnston JR, McGuigan J, Backman JT, Calfee CS, Matthay MM, Griffiths MJ, McDowell C, Elborn SJ, OʼKane CM.

Ann Surg. 2014 Jan;259(1):26-31. doi: 10.1097/SLA.0b013e31829d686b.


Strategies to reduce ventilator-associated lung injury (VALI).

Salman D, Finney SJ, Griffiths MJ.

Burns. 2013 Mar;39(2):200-11. doi: 10.1016/j.burns.2012.10.013. Epub 2012 Nov 24. Review.


In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1β, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis.

Griffiths MJ, Ooi MH, Wong SC, Mohan A, Podin Y, Perera D, Chieng CH, Tio PH, Cardosa MJ, Solomon T.

J Infect Dis. 2012 Sep 15;206(6):881-92. doi: 10.1093/infdis/jis446. Epub 2012 Jul 24.


Influenza-related pneumonia.

Almond MH, McAuley DF, Wise MP, Griffiths MJ.

Clin Med (Lond). 2012 Feb;12(1):67-70. Review.


Encephalitis caused by flaviviruses.

Turtle L, Griffiths MJ, Solomon T.

QJM. 2012 Mar;105(3):219-23. doi: 10.1093/qjmed/hcs013. Review.


BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.

Park JE, Shao D, Upton PD, Desouza P, Adcock IM, Davies RJ, Morrell NW, Griffiths MJ, Wort SJ.

PLoS One. 2012;7(1):e30075. doi: 10.1371/journal.pone.0030075. Epub 2012 Jan 27.

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