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Items: 1 to 50 of 325

1.

A Combined Chemical Derivatization/Mass Spectrometric Method for the Enhanced Detection and Relative Quantification of Protein Ubiquitination.

Chicooree N, Griffiths JR.

Methods Mol Biol. 2019;1977:17-24. doi: 10.1007/978-1-4939-9232-4_2.

PMID:
30980319
2.

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

Lee SH, McIntyre D, Honess D, Hulikova A, Pacheco-Torres J, Cerdán S, Swietach P, Harris AL, Griffiths JR.

Br J Cancer. 2018 Aug;119(5):622-630. doi: 10.1038/s41416-018-0216-5. Epub 2018 Sep 12.

PMID:
30206370
3.

Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-18F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.

Schelhaas S, Wachsmuth L, Hermann S, Rieder N, Heller A, Heinzmann K, Honess DJ, Smith DM, Fricke IB, Just N, Doblas S, Sinkus R, Döring C, Schäfers KP, Griffiths JR, Faber C, Schneider R, Aboagye EO, Jacobs AH.

J Nucl Med. 2018 Jul;59(7):1063-1069. doi: 10.2967/jnumed.117.206250. Epub 2018 Feb 23.

4.

Correction to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2017 Dec 15;7(1):99. doi: 10.1186/s13550-017-0349-1.

5.

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.

Tyrakis PA, Yurkovich ME, Sciacovelli M, Papachristou EK, Bridges HR, Gaude E, Schreiner A, D'Santos C, Hirst J, Hernandez-Fernaud J, Springett R, Griffiths JR, Frezza C.

Cell Rep. 2017 Oct 24;21(4):1036-1047. doi: 10.1016/j.celrep.2017.09.092.

6.

Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.

Madhu B, Jauhiainen A, McGuire S, Griffiths JR.

PLoS One. 2017 Oct 25;12(10):e0185980. doi: 10.1371/journal.pone.0185980. eCollection 2017.

7.

3'-Deoxy-3'-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.

Schelhaas S, Heinzmann K, Honess DJ, Smith DM, Keen H, Heskamp S, Witney TH, Besret L, Doblas S, Griffiths JR, Aboagye EO, Jacobs AH.

Mol Imaging Biol. 2018 Apr;20(2):194-199. doi: 10.1007/s11307-017-1125-3.

8.

The action of β-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a β-hydroxybutyrate paradox.

Rodrigues LM, Uribe-Lewis S, Madhu B, Honess DJ, Stubbs M, Griffiths JR.

Cancer Metab. 2017 Feb 28;5:4. doi: 10.1186/s40170-017-0166-z. eCollection 2017.

9.

The importance of benthic-pelagic coupling for marine ecosystem functioning in a changing world.

Griffiths JR, Kadin M, Nascimento FJA, Tamelander T, Törnroos A, Bonaglia S, Bonsdorff E, Brüchert V, Gårdmark A, Järnström M, Kotta J, Lindegren M, Nordström MC, Norkko A, Olsson J, Weigel B, Žydelis R, Blenckner T, Niiranen S, Winder M.

Glob Chang Biol. 2017 Jun;23(6):2179-2196. doi: 10.1111/gcb.13642. Epub 2017 Mar 22. Review.

PMID:
28132408
10.

Imaging biomarker roadmap for cancer studies.

O'Connor JP, Aboagye EO, Adams JE, Aerts HJ, Barrington SF, Beer AJ, Boellaard R, Bohndiek SE, Brady M, Brown G, Buckley DL, Chenevert TL, Clarke LP, Collette S, Cook GJ, deSouza NM, Dickson JC, Dive C, Evelhoch JL, Faivre-Finn C, Gallagher FA, Gilbert FJ, Gillies RJ, Goh V, Griffiths JR, Groves AM, Halligan S, Harris AL, Hawkes DJ, Hoekstra OS, Huang EP, Hutton BF, Jackson EF, Jayson GC, Jones A, Koh DM, Lacombe D, Lambin P, Lassau N, Leach MO, Lee TY, Leen EL, Lewis JS, Liu Y, Lythgoe MF, Manoharan P, Maxwell RJ, Miles KA, Morgan B, Morris S, Ng T, Padhani AR, Parker GJ, Partridge M, Pathak AP, Peet AC, Punwani S, Reynolds AR, Robinson SP, Shankar LK, Sharma RA, Soloviev D, Stroobants S, Sullivan DC, Taylor SA, Tofts PS, Tozer GM, van Herk M, Walker-Samuel S, Wason J, Williams KJ, Workman P, Yankeelov TE, Brindle KM, McShane LM, Jackson A, Waterton JC.

Nat Rev Clin Oncol. 2017 Mar;14(3):169-186. doi: 10.1038/nrclinonc.2016.162. Epub 2016 Oct 11. Review.

11.

Response Monitoring with [18F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.

Heskamp S, Heijmen L, Gerrits D, Molkenboer-Kuenen JDM, Ter Voert EGW, Heinzmann K, Honess DJ, Smith DM, Griffiths JR, Doblas S, Sinkus R, Laverman P, Oyen WJG, Heerschap A, Boerman OC.

Mol Imaging Biol. 2017 Aug;19(4):540-549. doi: 10.1007/s11307-016-1021-2.

12.

Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models: a feasibility study comparing the baseline and mid-treatment MRI examinations.

Bedair R, Priest AN, Patterson AJ, McLean MA, Graves MJ, Manavaki R, Gill AB, Abeyakoon O, Griffiths JR, Gilbert FJ.

Eur Radiol. 2017 Jul;27(7):2726-2736. doi: 10.1007/s00330-016-4630-x. Epub 2016 Oct 31.

13.

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.

Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS.

Nature. 2016 Dec 8;540(7632):236-241. doi: 10.1038/nature20165. Epub 2016 Oct 26.

14.

Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.

Schelhaas S, Held A, Wachsmuth L, Hermann S, Honess DJ, Heinzmann K, Smith DM, Griffiths JR, Faber C, Jacobs AH.

Cancer Res. 2016 Dec 15;76(24):7096-7105. Epub 2016 Oct 26.

15.

The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.

Heinzmann K, Honess DJ, Lewis DY, Smith DM, Cawthorne C, Keen H, Heskamp S, Schelhaas S, Witney TH, Soloviev D, Williams KJ, Jacobs AH, Aboagye EO, Griffiths JR, Brindle KM.

EJNMMI Res. 2016 Dec;6(1):63. doi: 10.1186/s13550-016-0218-3. Epub 2016 Aug 11. Erratum in: EJNMMI Res. 2017 Dec 15;7(1):99.

16.

Response of Degarelix treatment in human prostate cancer monitored by HR-MAS 1H NMR spectroscopy.

Madhu B, Shaw GL, Warren AY, Neal DE, Griffiths JR.

Metabolomics. 2016;12:120. Epub 2016 Jun 30.

17.

Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.

Ainsworth NL, McLean MA, McIntyre DJO, Honess DJ, Brown AM, Harden SV, Griffiths JR.

Magn Reson Med. 2017 May;77(5):1987-1995. doi: 10.1002/mrm.26257. Epub 2016 Jun 9.

18.

From Resting State to the Steady State: Mechanistic Studies of Ene-Yne Metathesis Promoted by the Hoveyda Complex.

Griffiths JR, Keister JB, Diver ST.

J Am Chem Soc. 2016 Apr 27;138(16):5380-91. doi: 10.1021/jacs.6b01887. Epub 2016 Apr 14.

PMID:
27076098
19.

Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes.

Julià-Sapé M, Griffiths JR, Tate RA, Howe FA, Acosta D, Postma G, Underwood J, Majós C, Arús C.

NMR Biomed. 2016 Mar;29(3):371. doi: 10.1002/nbm.3483. Epub 2015 Dec 22. No abstract available.

PMID:
26915795
20.

Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes.

Julià-Sapé M, Griffiths JR, Tate AR, Howe FA, Acosta D, Postma G, Underwood J, Majós C, Arús C.

NMR Biomed. 2015 Dec;28(12):1772-87. doi: 10.1002/nbm.3439. Review. Erratum in: NMR Biomed. 2016 Mar;29(3):371. Tate, Rosemary A [Corrected to Tate, A Rosemary].

PMID:
26768492
21.

Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.

Asim M, Massie CE, Orafidiya F, Pértega-Gomes N, Warren AY, Esmaeili M, Selth LA, Zecchini HI, Luko K, Qureshi A, Baridi A, Menon S, Madhu B, Escriu C, Lyons S, Vowler SL, Zecchini VR, Shaw G, Hessenkemper W, Russell R, Mohammed H, Stefanos N, Lynch AG, Grigorenko E, D'Santos C, Taylor C, Lamb A, Sriranjan R, Yang J, Stark R, Dehm SM, Rennie PS, Carroll JS, Griffiths JR, Tavaré S, Mills IG, McEwan IJ, Baniahmad A, Tilley WD, Neal DE.

J Natl Cancer Inst. 2015 Dec 11;108(5). doi: 10.1093/jnci/djv371. Print 2016 May.

22.

Absolute Quantification of Endogenous Ras Isoform Abundance.

Mageean CJ, Griffiths JR, Smith DL, Clague MJ, Prior IA.

PLoS One. 2015 Nov 11;10(11):e0142674. doi: 10.1371/journal.pone.0142674. eCollection 2015.

23.

Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.

Madhu B, Narita M, Jauhiainen A, Menon S, Stubbs M, Tavaré S, Narita M, Griffiths JR.

Metabolomics. 2015;11(6):1848-1863. Epub 2015 Aug 11.

24.

Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.

Price SJ, Young AM, Scotton WJ, Ching J, Mohsen LA, Boonzaier NR, Lupson VC, Griffiths JR, McLean MA, Larkin TJ.

J Magn Reson Imaging. 2016 Feb;43(2):487-94. doi: 10.1002/jmri.24996. Epub 2015 Jul 3.

25.

Cubane: 50 years later.

Biegasiewicz KF, Griffiths JR, Savage GP, Tsanaktsidis J, Priefer R.

Chem Rev. 2015 Jul 22;115(14):6719-45. doi: 10.1021/cr500523x. Epub 2015 Jun 23. Review. No abstract available.

PMID:
26102302
26.

Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.

Doblas S, Almeida GS, Blé FX, Garteiser P, Hoff BA, McIntyre DJ, Wachsmuth L, Chenevert TL, Faber C, Griffiths JR, Jacobs AH, Morris DM, O'Connor JP, Robinson SP, Van Beers BE, Waterton JC.

J Magn Reson Imaging. 2015 Dec;42(6):1759-64. doi: 10.1002/jmri.24955. Epub 2015 May 26.

27.

Fracturing across the multi-scales of diverse materials.

Armstrong RW, Antolovich SD, Griffiths JR, Knott JF.

Philos Trans A Math Phys Eng Sci. 2015 Mar 28;373(2038). pii: 20140474. doi: 10.1098/rsta.2014.0474.

28.

Performance of salmon fishery portfolios across western North America.

Griffiths JR, Schindler DE, Armstrong JB, Scheuerell MD, Whited DC, Clark RA, Hilborn R, Holt CA, Lindley ST, Stanford JA, Volk EC.

J Appl Ecol. 2014 Dec;51(6):1554-1563. Epub 2014 Oct 3.

29.

A PP1-PP2A phosphatase relay controls mitotic progression.

Grallert A, Boke E, Hagting A, Hodgson B, Connolly Y, Griffiths JR, Smith DL, Pines J, Hagan IM.

Nature. 2015 Jan 1;517(7532):94-98. doi: 10.1038/nature14019. Epub 2014 Dec 10.

30.

Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, Orton MR, Panek R, Parkes HG, Jafar M, Koh DM, Robinson SP, Judson IR, Griffiths JR, Leach MO, Eykyn TR, Chung YL.

Br J Cancer. 2014 Jul 15;111(2):375-85. doi: 10.1038/bjc.2014.281. Epub 2014 Jun 3.

31.

Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.

Bapiro TE, Frese KK, Courtin A, Bramhall JL, Madhu B, Cook N, Neesse A, Griffiths JR, Tuveson DA, Jodrell DI, Richards FM.

Br J Cancer. 2014 Jul 15;111(2):318-25. doi: 10.1038/bjc.2014.288. Epub 2014 May 29.

32.

BCR-ABL affects STAT5A and STAT5B differentially.

Schaller-Schönitz M, Barzan D, Williamson AJ, Griffiths JR, Dallmann I, Battmer K, Ganser A, Whetton AD, Scherr M, Eder M.

PLoS One. 2014 May 16;9(5):e97243. doi: 10.1371/journal.pone.0097243. eCollection 2014.

33.

The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications.

Chicooree N, Unwin RD, Griffiths JR.

Mass Spectrom Rev. 2015 Nov-Dec;34(6):595-626. doi: 10.1002/mas.21421. Epub 2014 Apr 15. Review.

PMID:
24737647
34.

Mass spectral enhanced detection of Ubls using SWATH acquisition: MEDUSA--simultaneous quantification of SUMO and ubiquitin-derived isopeptides.

Griffiths JR, Chicooree N, Connolly Y, Neffling M, Lane CS, Knapman T, Smith DL.

J Am Soc Mass Spectrom. 2014 May;25(5):767-77. doi: 10.1007/s13361-014-0835-x. Epub 2014 Feb 19.

PMID:
24549895
35.

Chemically facilitating the generation of diagnostic ions from SUMO(2/3) remnant isopeptides.

Chicooree N, Griffiths JR, Connolly Y, Smith DL.

Rapid Commun Mass Spectrom. 2013 Sep 30;27(18):2108-14. doi: 10.1002/rcm.6670.

PMID:
23943332
36.

Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.

Arias-Mendoza F, Payne GS, Zakian K, Stubbs M, O'Connor OA, Mojahed H, Smith MR, Schwarz AJ, Shukla-Dave A, Howe F, Poptani H, Lee SC, Pettengel R, Schuster SJ, Cunningham D, Heerschap A, Glickson JD, Griffiths JR, Koutcher JA, Leach MO, Brown TR.

Acad Radiol. 2013 Sep;20(9):1122-9. doi: 10.1016/j.acra.2013.04.013.

37.

Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.

Takeda T, Robinson IM, Savoian MM, Griffiths JR, Whetton AD, McMahon HT, Glover DM.

Open Biol. 2013 Aug 7;3(8):130081. doi: 10.1098/rsob.130081.

38.

Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.

Baker LC, Boult JK, Jamin Y, Gilmour LD, Walker-Samuel S, Burrell JS, Ashcroft M, Howe FA, Griffiths JR, Raleigh JA, van der Kogel AJ, Robinson SP.

Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):160-7. doi: 10.1016/j.ijrobp.2013.04.051. Epub 2013 Jul 9.

PMID:
23849692
39.

Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.

Cannon DT, Howe FA, Whipp BJ, Ward SA, McIntyre DJ, Ladroue C, Griffiths JR, Kemp GJ, Rossiter HB.

J Appl Physiol (1985). 2013 Sep;115(6):839-49. doi: 10.1152/japplphysiol.00510.2013. Epub 2013 Jun 27.

40.

How stock of origin affects performance of individuals across a meta-ecosystem: an example from sockeye salmon.

Griffiths JR, Schindler DE, Seeb LW.

PLoS One. 2013;8(3):e58584. doi: 10.1371/journal.pone.0058584. Epub 2013 Mar 7.

41.

Ruthenium hydride-promoted dienyl isomerization: access to highly substituted 1,3-dienes.

Clark JR, Griffiths JR, Diver ST.

J Am Chem Soc. 2013 Mar 6;135(9):3327-30. doi: 10.1021/ja4011207. Epub 2013 Feb 21.

PMID:
23427813
42.

Application of the MIDAS approach for analysis of lysine acetylation sites.

Evans CA, Griffiths JR, Unwin RD, Whetton AD, Corfe BM.

Methods Mol Biol. 2013;981:25-36. doi: 10.1007/978-1-62703-305-3_3.

PMID:
23381851
43.

Enhanced detection of ubiquitin isopeptides using reductive methylation.

Chicooree N, Connolly Y, Tan CT, Malliri A, Li Y, Smith DL, Griffiths JR.

J Am Soc Mass Spectrom. 2013 Mar;24(3):421-30. doi: 10.1007/s13361-012-0538-0. Epub 2013 Jan 30.

PMID:
23361369
44.

A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine.

Chicooree N, Griffiths JR, Connolly Y, Tan CT, Malliri A, Eyers CE, Smith DL.

Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):127-34. doi: 10.1002/rcm.6425.

PMID:
23239325
45.

An assessment of peptide enrichment methods employing mTRAQ quantification approaches.

Potier DN, Griffiths JR, Unwin RD, Walker MJ, Carrick E, Willamson AJ, Whetton AD.

Anal Chem. 2012 Jul 3;84(13):5604-10. doi: 10.1021/ac300584y. Epub 2012 Jun 19.

PMID:
22762262
46.

Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.

Pierce A, Williamson A, Jaworska E, Griffiths JR, Taylor S, Walker M, Aspinall-O'Dea M, Spooncer E, Unwin RD, Poolman T, Ray D, Whetton AD.

PLoS One. 2012;7(6):e38928. doi: 10.1371/journal.pone.0038928. Epub 2012 Jun 22. Erratum in: PLoS One. 2013;8(6). doi:10.1371/annotation/df82a4c0-2909-43a0-8a7f-5bd2ce9ca0bd. O'Dea, Mark Aspinall [corrected to Aspinall-O'Dea, Mark].

47.

Referrals to acute physiotherapy from the emergency department: an audit.

Griffiths JR, Bearder L, Currie S.

Emerg Med J. 2013 May;30(5):428-9. doi: 10.1136/emermed-2012-201478. Epub 2012 Jun 26. No abstract available.

PMID:
22736719
48.

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.

Rodrigues LM, Chung YL, Al Saffar NM, Sharp SY, Jackson LE, Banerji U, Stubbs M, Leach MO, Griffiths JR, Workman P.

BMC Res Notes. 2012 May 23;5:250. doi: 10.1186/1756-0500-5-250.

49.

Repeatability of edited lactate and other metabolites in astrocytoma at 3T.

McLean MA, Sun A, Bradstreet TE, Schaeffer AK, Liu H, Iannone R, Herman G, Railkar RA, Joubert I, Gillard JH, Price SJ, Griffiths JR.

J Magn Reson Imaging. 2012 Aug;36(2):468-75. doi: 10.1002/jmri.23673. Epub 2012 Apr 25.

PMID:
22535478
50.

Magnetic resonance spectroscopy of cancer metabolism and response to therapy.

McIntyre DJ, Madhu B, Lee SH, Griffiths JR.

Radiat Res. 2012 Apr;177(4):398-435. Epub 2012 Mar 8. Review.

PMID:
22401303

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