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Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.

Gawden-Bone CM, Griffiths GM.

Front Immunol. 2019 Apr 11;10:700. doi: 10.3389/fimmu.2019.00700. eCollection 2019. Review.


PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.

Gawden-Bone CM, Frazer GL, Richard AC, Ma CY, Strege K, Griffiths GM.

Immunity. 2018 Sep 18;49(3):427-437.e4. doi: 10.1016/j.immuni.2018.08.017. Epub 2018 Sep 11.


T cell cytolytic capacity is independent of initial stimulation strength.

Richard AC, Lun ATL, Lau WWY, Göttgens B, Marioni JC, Griffiths GM.

Nat Immunol. 2018 Aug;19(8):849-858. doi: 10.1038/s41590-018-0160-9. Epub 2018 Jul 16.


An early history of T cell-mediated cytotoxicity.

Golstein P, Griffiths GM.

Nat Rev Immunol. 2018 Aug;18(8):527-535. doi: 10.1038/s41577-018-0009-3. Review.


Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Lee J, Dieckmann NMG, Edgar JR, Griffiths GM, Siegel RM.

Immun Inflamm Dis. 2018 Jun;6(2):312-321. doi: 10.1002/iid3.219. Epub 2018 Apr 11.


Cortical actin recovery at the immunological synapse leads to termination of lytic granule secretion in cytotoxic T lymphocytes.

Ritter AT, Kapnick SM, Murugesan S, Schwartzberg PL, Griffiths GM, Lippincott-Schwartz J.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6585-E6594. doi: 10.1073/pnas.1710751114. Epub 2017 Jul 17.


Imaging the Effector CD8 Synapse.

Frazer GL, Asano Y, Griffiths GM.

Methods Mol Biol. 2017;1584:473-486. doi: 10.1007/978-1-4939-6881-7_29.


Inducible T Cell Kinase Regulates the Acquisition of Cytolytic Capacity and Degranulation in CD8+ CTLs.

Kapnick SM, Stinchcombe JC, Griffiths GM, Schwartzberg PL.

J Immunol. 2017 Apr 1;198(7):2699-2711. doi: 10.4049/jimmunol.1601202. Epub 2017 Feb 17.


Secretion from Myeloid Cells: Secretory Lysosomes.

Griffiths GM.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.MCHD-0030-2016. Review.


The cytotoxic T lymphocyte immune synapse at a glance.

Dieckmann NM, Frazer GL, Asano Y, Stinchcombe JC, Griffiths GM.

J Cell Sci. 2016 Aug 1;129(15):2881-6. doi: 10.1242/jcs.186205. Review.


Origins of the cytolytic synapse.

de la Roche M, Asano Y, Griffiths GM.

Nat Rev Immunol. 2016 Jul;16(7):421-32. doi: 10.1038/nri.2016.54. Epub 2016 Jun 6. Review.


Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.

Dieckmann NM, Hackmann Y, Aricò M, Griffiths GM.

Traffic. 2015 Dec;16(12):1330-41. doi: 10.1111/tra.12337. Epub 2015 Nov 2.


Mutations in AP3D1 associated with immunodeficiency and seizures define a new type of Hermansky-Pudlak syndrome.

Ammann S, Schulz A, Krägeloh-Mann I, Dieckmann NM, Niethammer K, Fuchs S, Eckl KM, Plank R, Werner R, Altmüller J, Thiele H, Nürnberg P, Bank J, Strauss A, von Bernuth H, Zur Stadt U, Grieve S, Griffiths GM, Lehmberg K, Hennies HC, Ehl S.

Blood. 2016 Feb 25;127(8):997-1006. doi: 10.1182/blood-2015-09-671636. Epub 2016 Jan 7.


Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.

Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM.

Curr Biol. 2015 Dec 21;25(24):3239-44. doi: 10.1016/j.cub.2015.10.028. Epub 2015 Dec 5.


Genetic predisposition to hemophagocytic lymphohistiocytosis: Report on 500 patients from the Italian registry.

Cetica V, Sieni E, Pende D, Danesino C, De Fusco C, Locatelli F, Micalizzi C, Putti MC, Biondi A, Fagioli F, Moretta L, Griffiths GM, Luzzatto L, Aricò M.

J Allergy Clin Immunol. 2016 Jan;137(1):188-196.e4. doi: 10.1016/j.jaci.2015.06.048. Epub 2015 Sep 2.


Actin depletion initiates events leading to granule secretion at the immunological synapse.

Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM.

Immunity. 2015 May 19;42(5):864-76. doi: 10.1016/j.immuni.2015.04.013.


Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.

Cetica V, Hackmann Y, Grieve S, Sieni E, Ciambotti B, Coniglio ML, Pende D, Gilmour K, Romagnoli P, Griffiths GM, Aricò M.

J Allergy Clin Immunol. 2015 May;135(5):1310-8.e1. doi: 10.1016/j.jaci.2014.08.039. Epub 2014 Oct 11.


The biogenesis of lysosomes and lysosome-related organelles.

Luzio JP, Hackmann Y, Dieckmann NM, Griffiths GM.

Cold Spring Harb Perspect Biol. 2014 Sep 2;6(9):a016840. doi: 10.1101/cshperspect.a016840. Review.


Communication, the centrosome and the immunological synapse.

Stinchcombe JC, Griffiths GM.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130463. doi: 10.1098/rstb.2013.0463. Review.


Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis.

Meazza R, Tuberosa C, Cetica V, Falco M, Parolini S, Grieve S, Griffiths GM, Sieni E, Marcenaro S, Micalizzi C, Montin D, Fagioli F, Moretta A, Mingari MC, Moretta L, Notarangelo LD, Bottino C, Aricò M, Pende D.

J Allergy Clin Immunol. 2014 Dec;134(6):1381-1387.e7. doi: 10.1016/j.jaci.2014.04.043. Epub 2014 Jun 27.


Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.

Jenkins MR, Stinchcombe JC, Au-Yeung BB, Asano Y, Ritter AT, Weiss A, Griffiths GM.

Elife. 2014 Mar 4;3:e01310. doi: 10.7554/eLife.01310.


Hedgehog signaling controls T cell killing at the immunological synapse.

de la Roche M, Ritter AT, Angus KL, Dinsmore C, Earnshaw CH, Reiter JF, Griffiths GM.

Science. 2013 Dec 6;342(6163):1247-50. doi: 10.1126/science.1244689.


Syntaxin binding mechanism and disease-causing mutations in Munc18-2.

Hackmann Y, Graham SC, Ehl S, Höning S, Lehmberg K, Aricò M, Owen DJ, Griffiths GM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4482-91. doi: 10.1073/pnas.1313474110. Epub 2013 Nov 5.


The role of the cytoskeleton at the immunological synapse.

Ritter AT, Angus KL, Griffiths GM.

Immunol Rev. 2013 Nov;256(1):107-17. doi: 10.1111/imr.12117. Review.


Open questions: missing pieces from the immunological jigsaw puzzle.

Griffiths GM.

BMC Biol. 2013 Jan 31;11:10. doi: 10.1186/1741-7007-11-10. No abstract available.


Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency.

Lang PA, Shaabani N, Borkens S, Honke N, Scheu S, Booth S, Brenner D, Meryk A, Barthuber C, Recher M, Mak TW, Ohashi PS, Häussinger D, Griffiths GM, Thrasher AJ, Bouma G, Lang KS.

J Allergy Clin Immunol. 2013 Mar;131(3):815-24. doi: 10.1016/j.jaci.2012.08.050. Epub 2012 Nov 6.


Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation.

D'Orlando O, Zhao F, Kasper B, Orinska Z, Müller J, Hermans-Borgmeyer I, Griffiths GM, Zur Stadt U, Bulfone-Paus S.

Eur J Immunol. 2013 Jan;43(1):194-208. doi: 10.1002/eji.201142343. Epub 2012 Dec 12.


Cell polarisation and the immunological synapse.

Angus KL, Griffiths GM.

Curr Opin Cell Biol. 2013 Feb;25(1):85-91. doi: 10.1016/ Epub 2012 Sep 16. Review.


Cytotoxic T lymphocyte effector function is independent of nucleus-centrosome dissociation.

Lui-Roberts WW, Stinchcombe JC, Ritter AT, Akhmanova A, Karakesisoglou I, Griffiths GM.

Eur J Immunol. 2012 Aug;42(8):2132-41. doi: 10.1002/eji.201242525.


Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis.

Zhao F, Cannons JL, Dutta M, Griffiths GM, Schwartzberg PL.

Immunity. 2012 Jun 29;36(6):1003-16. doi: 10.1016/j.immuni.2012.05.017. Epub 2012 Jun 7.


Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems.

Stinchcombe JC, Salio M, Cerundolo V, Pende D, Arico M, Griffiths GM.

BMC Biol. 2011 Jun 28;9:45. doi: 10.1186/1741-7007-9-45.


A role for Rab7 in the movement of secretory granules in cytotoxic T lymphocytes.

Daniele T, Hackmann Y, Ritter AT, Wenham M, Booth S, Bossi G, Schintler M, Auer-Grumbach M, Griffiths GM.

Traffic. 2011 Jul;12(7):902-11. doi: 10.1111/j.1600-0854.2011.01194.x. Epub 2011 Apr 21.


Centrosome docking at the immunological synapse is controlled by Lck signaling.

Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM.

J Cell Biol. 2011 Feb 21;192(4):663-74. doi: 10.1083/jcb.201008140.


Genotype-phenotype study of familial haemophagocytic lymphohistiocytosis type 3.

Sieni E, Cetica V, Santoro A, Beutel K, Mastrodicasa E, Meeths M, Ciambotti B, Brugnolo F, zur Stadt U, Pende D, Moretta L, Griffiths GM, Henter JI, Janka G, Aricò M.

J Med Genet. 2011 May;48(5):343-52. doi: 10.1136/jmg.2010.085456. Epub 2011 Jan 19.


STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5.

Cetica V, Santoro A, Gilmour KC, Sieni E, Beutel K, Pende D, Marcenaro S, Koch F, Grieve S, Wheeler R, Zhao F, zur Stadt U, Griffiths GM, Aricò M.

J Med Genet. 2010 Sep;47(9):595-600. doi: 10.1136/jmg.2009.075341.


The immunological synapse: a focal point for endocytosis and exocytosis.

Griffiths GM, Tsun A, Stinchcombe JC.

J Cell Biol. 2010 May 3;189(3):399-406. doi: 10.1083/jcb.201002027. Review.


Molecular basis of familial hemophagocytic lymphohistiocytosis.

Cetica V, Pende D, Griffiths GM, Aricò M.

Haematologica. 2010 Apr;95(4):538-41. doi: 10.3324/haematol.2009.019562. No abstract available.


The synapse and cytolytic machinery of cytotoxic T cells.

Jenkins MR, Griffiths GM.

Curr Opin Immunol. 2010 Jun;22(3):308-13. doi: 10.1016/j.coi.2010.02.008. Epub 2010 Mar 11. Review.


Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.

Chen JL, Morgan AJ, Stewart-Jones G, Shepherd D, Bossi G, Wooldridge L, Hutchinson SL, Sewell AK, Griffiths GM, van der Merwe PA, Jones EY, Galione A, Cerundolo V.

J Immunol. 2010 Feb 15;184(4):1829-1839. doi: 10.4049/jimmunol.0902103. Epub 2010 Jan 6.


The strength of T cell receptor signal controls the polarization of cytotoxic machinery to the immunological synapse.

Jenkins MR, Tsun A, Stinchcombe JC, Griffiths GM.

Immunity. 2009 Oct 16;31(4):621-31. doi: 10.1016/j.immuni.2009.08.024.


Two patients with Hermansky Pudlak syndrome type 2 and novel mutations in AP3B1.

Wenham M, Grieve S, Cummins M, Jones ML, Booth S, Kilner R, Ancliff PJ, Griffiths GM, Mumford AD.

Haematologica. 2010 Feb;95(2):333-7. doi: 10.3324/haematol.2009.012286. Epub 2009 Aug 13.


Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3.

Santoro A, Cannella S, Trizzino A, Bruno G, De Fusco C, Notarangelo LD, Pende D, Griffiths GM, Aricò M.

Haematologica. 2008 Jul;93(7):1086-90. doi: 10.3324/haematol.12622. Epub 2008 May 19.


Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.

Holt O, Kanno E, Bossi G, Booth S, Daniele T, Santoro A, Arico M, Saegusa C, Fukuda M, Griffiths GM.

Traffic. 2008 Apr;9(4):446-57. doi: 10.1111/j.1600-0854.2008.00714.x. Epub 2008 Feb 11.


Gaucher disease: forging a new path to the lysosome.

Griffiths GM.

Cell. 2007 Nov 16;131(4):647-9.


Secretory mechanisms in cell-mediated cytotoxicity.

Stinchcombe JC, Griffiths GM.

Annu Rev Cell Dev Biol. 2007;23:495-517. Review.


The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.

McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy BG, Schmidt RR, Reiter Y, Griffiths GM, van der Merwe PA, Besra GS, Jones EY, Batista FD, Cerundolo V.

J Exp Med. 2007 May 14;204(5):1131-44. Epub 2007 May 7.


Sorting of Fas ligand to secretory lysosomes is regulated by mono-ubiquitylation and phosphorylation.

Zuccato E, Blott EJ, Holt O, Sigismund S, Shaw M, Bossi G, Griffiths GM.

J Cell Sci. 2007 Jan 1;120(Pt 1):191-9. Epub 2006 Dec 12.


Centrosome polarization delivers secretory granules to the immunological synapse.

Stinchcombe JC, Majorovits E, Bossi G, Fuller S, Griffiths GM.

Nature. 2006 Sep 28;443(7110):462-5. Erratum in: Nature. 2006 Nov 9;444(7116):236.


Regulating secretory lysosomes.

Holt OJ, Gallo F, Griffiths GM.

J Biochem. 2006 Jul;140(1):7-12. Review.


Novel Munc13-4 mutations in children and young adult patients with haemophagocytic lymphohistiocytosis.

Santoro A, Cannella S, Bossi G, Gallo F, Trizzino A, Pende D, Dieli F, Bruno G, Stinchcombe JC, Micalizzi C, De Fusco C, Danesino C, Moretta L, Notarangelo LD, Griffiths GM, Aricò M.

J Med Genet. 2006 Dec;43(12):953-60. Epub 2006 Jul 6.

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