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Near-Infrared Photoimmunotherapy: Photoactivatable Antibody-Drug Conjugates (ADCs).

Kobayashi H, Griffiths GL, Choyke PL.

Bioconjug Chem. 2019 Sep 13. doi: 10.1021/acs.bioconjchem.9b00546. [Epub ahead of print]


HATRIC: a study of Pelargonium sidoides root extract EPs®7630 (Kaloba®) for the treatment of acute cough due to lower respiratory tract infection in adults-study protocol for a double blind, placebo-controlled randomised feasibility trial.

Whitehead A, Simpson C, Willcox M, Webley F, Hay AD, Butler C, Yao L, Wrixon E, Bell M, Bostock J, Little P, Griffiths G, Moore M.

Pilot Feasibility Stud. 2019 Jul 31;5:98. doi: 10.1186/s40814-019-0478-6. eCollection 2019.


Scenario-led modelling of broadleaf forest expansion in Wales.

Manzoor SA, Griffiths G, Latham J, Lukac M.

R Soc Open Sci. 2019 May 22;6(5):190026. doi: 10.1098/rsos.190026. eCollection 2019 May.


Long-term Effects of Cholestatic Liver Disease in Childhood on Neuropsychological Outcomes and Neurochemistry.

Talcott JB, Beath SV, Patel T, Griffiths G, Kelly DA.

J Pediatr Gastroenterol Nutr. 2019 Aug;69(2):145-151. doi: 10.1097/MPG.0000000000002380.


Effect of publishing surgeon-specific outcomes on surgical training.

Harries RL, Glasbey J, Gokani VJ, Griffiths G, Allum W.

Br J Surg. 2019 Jul;106(8):1019-1025. doi: 10.1002/bjs.11150. Epub 2019 May 15.


Phospholipids: Pulling Back the Actin Curtain for Granule Delivery to the Immune Synapse.

Gawden-Bone CM, Griffiths GM.

Front Immunol. 2019 Apr 11;10:700. doi: 10.3389/fimmu.2019.00700. eCollection 2019. Review.


Gene-expression profiling of bortezomib added to standard chemoimmunotherapy for diffuse large B-cell lymphoma (REMoDL-B): an open-label, randomised, phase 3 trial.

Davies A, Cummin TE, Barrans S, Maishman T, Mamot C, Novak U, Caddy J, Stanton L, Kazmi-Stokes S, McMillan A, Fields P, Pocock C, Collins GP, Stephens R, Cucco F, Clipson A, Sha C, Tooze R, Care MA, Griffiths G, Du MQ, Westhead DR, Burton C, Johnson PWM.

Lancet Oncol. 2019 May;20(5):649-662. doi: 10.1016/S1470-2045(18)30935-5. Epub 2019 Apr 1.


The effects of human factor related issues on assessors during the recruitment process for general and vascular surgery in the UK.

Scrimgeour D, Patel R, Patel N, Cleland J, Lee AJ, McKinley AJ, Smith F, Griffiths G, Brennan PA.

Ann R Coll Surg Engl. 2019 Apr;101(4):231-234. doi: 10.1308/rcsann.2019.0008. Epub 2019 Feb 18.


Uva-ursi extract and ibuprofen as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial.

Moore M, Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay AD, van der Werf E, Gibbons S, Lewith G, Little P, Griffiths G.

Clin Microbiol Infect. 2019 Aug;25(8):973-980. doi: 10.1016/j.cmi.2019.01.011. Epub 2019 Jan 25.


BA08: An open-label, single-arm, non-randomised, phase 2 trial of cisplatin, methotrexate and vinblastine (CMV) for pure squamous cell cancer of the urinary tract.

Griffiths GO, Cowan RA, Grigor KM, Uscinska BM, Sydes M, Russell M.

PLoS One. 2019 Jan 16;14(1):e0210785. doi: 10.1371/journal.pone.0210785. eCollection 2019.


A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma - the SKOPOS trial.

Lester JF, Casbard AC, Al-Taei S, Harrop R, Katona L, Attanoos RL, Tabi Z, Griffiths GO.

Oncoimmunology. 2018 Sep 7;7(12):e1457597. doi: 10.1080/2162402X.2018.1457597. eCollection 2018.


Expression of growth mediators in the gingival crevicular fluid of patients with aggressive periodontitis undergoing periodontal surgery.

Rakmanee T, Calciolari E, Olsen I, Darbar U, Griffiths GS, Petrie A, Donos N.

Clin Oral Investig. 2019 Aug;23(8):3307-3318. doi: 10.1007/s00784-018-2752-z. Epub 2018 Nov 29.


RIVA - a phase IIa study of rituximab and varlilumab in relapsed or refractory B-cell malignancies: study protocol for a randomized controlled trial.

Lim SH, Linton KM, Collins GP, Dhondt J, Caddy J, Rossiter L, Vadher K, Fines K, Rogers LE, Fernando D, Stanton L, Davies AJ, Johnson PWM, Griffiths G.

Trials. 2018 Nov 9;19(1):619. doi: 10.1186/s13063-018-2996-6.


Highly Linearized Twisted Iridium(III) Complexes.

Davidson R, Hsu YT, Griffiths GC, Li C, Yufit D, Pal R, Beeby A.

Inorg Chem. 2018 Nov 19;57(22):14450-14462. doi: 10.1021/acs.inorgchem.8b02818. Epub 2018 Nov 1.


Does the Intercollegiate Membership of the Royal College of Surgeons (MRCS) examination predict 'on-the-job' performance during UK higher specialty surgical training?

Scrimgeour D, Brennan PA, Griffiths G, Lee AJ, Smith F, Cleland J.

Ann R Coll Surg Engl. 2018 Oct 5:1-7. doi: 10.1308/rcsann.2018.0153. [Epub ahead of print]


Changing Autonomy in Operative Experience Through UK General Surgery Training: A National Cohort Study.

Elsey EJ, Griffiths G, West J, Humes DJ.

Ann Surg. 2019 Mar;269(3):399-406. doi: 10.1097/SLA.0000000000003032.


The Influence of External Focus Instruction Characteristics on Children's Motor Performance.

Marchant DC, Griffiths G, Partridge JA, Belsley L, Porter JM.

Res Q Exerc Sport. 2018 Dec;89(4):418-428. doi: 10.1080/02701367.2018.1512075. Epub 2018 Sep 26.


Virulence-associated protein A from Rhodococcus equi is an intercompartmental pH-neutralising virulence factor.

von Bargen K, Scraba M, Krämer I, Ketterer M, Nehls C, Krokowski S, Repnik U, Wittlich M, Maaser A, Zapka P, Bunge M, Schlesinger M, Huth G, Klees A, Hansen P, Jeschke A, Bendas G, Utermöhlen O, Griffiths G, Gutsmann T, Wohlmann J, Haas A.

Cell Microbiol. 2019 Jan;21(1):e12958. doi: 10.1111/cmi.12958. Epub 2018 Nov 9.


PIP5 Kinases Regulate Membrane Phosphoinositide and Actin Composition for Targeted Granule Secretion by Cytotoxic Lymphocytes.

Gawden-Bone CM, Frazer GL, Richard AC, Ma CY, Strege K, Griffiths GM.

Immunity. 2018 Sep 18;49(3):427-437.e4. doi: 10.1016/j.immuni.2018.08.017. Epub 2018 Sep 11.


A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.

Bennink S, von Bohl A, Ngwa CJ, Henschel L, Kuehn A, Pilch N, Weißbach T, Rosinski AN, Scheuermayer M, Repnik U, Przyborski JM, Minns AM, Orchard LM, Griffiths G, Lindner SE, Llinás M, Pradel G.

PLoS Pathog. 2018 Aug 22;14(8):e1007249. doi: 10.1371/journal.ppat.1007249. eCollection 2018 Aug.


A prospective phase II study of pre-operative chemotherapy then short-course radiotherapy for high risk rectal cancer: COPERNICUS.

Gollins S, West N, Sebag-Montefiore D, Susnerwala S, Falk S, Brown N, Saunders M, Quirke P, Ray R, Parsons P, Griffiths G, Maughan T, Adams R, Hurt C.

Br J Cancer. 2018 Sep;119(6):697-706. doi: 10.1038/s41416-018-0209-4. Epub 2018 Aug 17.


Time Out of General Surgery Specialty Training in the UK: A National Database Study.

Elsey EJ, West J, Griffiths G, Humes DJ.

J Surg Educ. 2019 Jan - Feb;76(1):55-64. doi: 10.1016/j.jsurg.2018.06.011. Epub 2018 Aug 6.


Enhanced Permeability and Retention-like Extravasation of Nanoparticles from the Vasculature into Tuberculosis Granulomas in Zebrafish and Mouse Models.

Fenaroli F, Repnik U, Xu Y, Johann K, Van Herck S, Dey P, Skjeldal FM, Frei DM, Bagherifam S, Kocere A, Haag R, De Geest BG, Barz M, Russell DG, Griffiths G.

ACS Nano. 2018 Aug 28;12(8):8646-8661. doi: 10.1021/acsnano.8b04433. Epub 2018 Aug 15.


Patient understanding and acceptability of an early lung cancer diagnosis trial: a qualitative study.

Prout HC, Barham A, Bongard E, Tudor-Edwards R, Griffiths G, Hamilton W, Harrop E, Hood K, Hurt CN, Nelson R, Porter C, Roberts K, Rogers T, Thomas-Jones E, Tod A, Yeo ST, Neal RD, Nelson A.

Trials. 2018 Aug 4;19(1):419. doi: 10.1186/s13063-018-2803-4.


T cell cytolytic capacity is independent of initial stimulation strength.

Richard AC, Lun ATL, Lau WWY, Göttgens B, Marioni JC, Griffiths GM.

Nat Immunol. 2018 Aug;19(8):849-858. doi: 10.1038/s41590-018-0160-9. Epub 2018 Jul 16.


Impact of performance in a mandatory postgraduate surgical examination on selection into specialty training.

Scrimgeour DSG, Cleland J, Lee AJ, Griffiths G, McKinley AJ, Marx C, Brennan PA.

BJS Open. 2017 Aug 29;1(3):67-74. doi: 10.1002/bjs5.7. eCollection 2017 Jun.


Land Cover and Climate Change May Limit Invasiveness of Rhododendron ponticum in Wales.

Manzoor SA, Griffiths G, Iizuka K, Lukac M.

Front Plant Sci. 2018 May 18;9:664. doi: 10.3389/fpls.2018.00664. eCollection 2018.


Murine alveolar epithelial cells and their lentivirus-mediated immortalisation.

Sapich S, Hittinger M, Hendrix-Jastrzebski R, Repnik U, Griffiths G, May T, Wirth D, Bals R, Schneider-Daum N, Lehr CM.

Altern Lab Anim. 2018 May;46(2):73-89.


Species distribution model transferability and model grain size - finer may not always be better.

Manzoor SA, Griffiths G, Lukac M.

Sci Rep. 2018 May 8;8(1):7168. doi: 10.1038/s41598-018-25437-1.


MENOS4 trial: a multicentre randomised controlled trial (RCT) of a breast care nurse delivered cognitive behavioural therapy (CBT) intervention to reduce the impact of hot flushes in women with breast cancer: Study Protocol.

Fenlon D, Nuttall J, May C, Raftery J, Fields J, Kirkpatrick E, Abab J, Ellis M, Rose T, Khambhaita P, Galanopoulou A, Maishman T, Haviland J, Griffiths G, Turner L, Hunter M.

BMC Womens Health. 2018 May 8;18(1):63. doi: 10.1186/s12905-018-0550-z.


CONFIRM: a double-blind, placebo-controlled phase III clinical trial investigating the effect of nivolumab in patients with relapsed mesothelioma: study protocol for a randomised controlled trial.

Fennell DA, Kirkpatrick E, Cozens K, Nye M, Lester J, Hanna G, Steele N, Szlosarek P, Danson S, Lord J, Ottensmeier C, Barnes D, Hill S, Kalevras M, Maishman T, Griffiths G.

Trials. 2018 Apr 18;19(1):233. doi: 10.1186/s13063-018-2602-y.


An early history of T cell-mediated cytotoxicity.

Golstein P, Griffiths GM.

Nat Rev Immunol. 2018 Aug;18(8):527-535. doi: 10.1038/s41577-018-0009-3. Review.


Fas Ligand localizes to intraluminal vesicles within NK cell cytolytic granules and is enriched at the immune synapse.

Lee J, Dieckmann NMG, Edgar JR, Griffiths GM, Siegel RM.

Immun Inflamm Dis. 2018 Jun;6(2):312-321. doi: 10.1002/iid3.219. Epub 2018 Apr 11.


SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial.

Crabb S, Danson SJ, Catto JWF, McDowell C, Lowder JN, Caddy J, Dunkley D, Rajaram J, Ellis D, Hill S, Hathorn D, Whitehead A, Kalevras M, Huddart R, Griffiths G.

Trials. 2018 Apr 3;19(1):216. doi: 10.1186/s13063-018-2586-7.


Development and Application of High-Content Biological Screening for Modulators of NET Production.

Chicca IJ, Milward MR, Chapple ILC, Griffiths G, Benson R, Dietrich T, Cooper PR.

Front Immunol. 2018 Mar 5;9:337. doi: 10.3389/fimmu.2018.00337. eCollection 2018.


High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma.

Yu KK, Taylor JT, Pathmanaban ON, Youshani AS, Beyit D, Dutko-Gwozdz J, Benson R, Griffiths G, Peers I, Cueppens P, Telfer BA, Williams KJ, McBain C, Kamaly-Asl ID, Bigger BW.

PLoS One. 2018 Mar 2;13(3):e0193694. doi: 10.1371/journal.pone.0193694. eCollection 2018.


Cancer cachexia: rationale for the MENAC (Multimodal-Exercise, Nutrition and Anti-inflammatory medication for Cachexia) trial.

Solheim TS, Laird BJA, Balstad TR, Bye A, Stene G, Baracos V, Strasser F, Griffiths G, Maddocks M, Fallon M, Kaasa S, Fearon K.

BMJ Support Palliat Care. 2018 Sep;8(3):258-265. doi: 10.1136/bmjspcare-2017-001440. Epub 2018 Feb 9. Review.


Phthiocerol dimycocerosates promote access to the cytosol and intracellular burden of Mycobacterium tuberculosis in lymphatic endothelial cells.

Lerner TR, Queval CJ, Fearns A, Repnik U, Griffiths G, Gutierrez MG.

BMC Biol. 2018 Jan 4;16(1):1. doi: 10.1186/s12915-017-0471-6.


Excision of nonmelanoma skin cancer overlying arteriovenous fistulae.

O'Brennan EA, Severn A, Griffiths G, Affleck A.

Clin Exp Dermatol. 2018 Jun;43(4):471-472. doi: 10.1111/ced.13339. Epub 2017 Dec 20. No abstract available.


Effect of ornithine decarboxylase and norspermidine in modulating cell division in the green alga Chlamydomonas reinhardtii.

Tassoni A, Awad N, Griffiths G.

Plant Physiol Biochem. 2018 Feb;123:125-131. doi: 10.1016/j.plaphy.2017.12.014. Epub 2017 Dec 7.


Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer: a post-hoc analysis of the New EPOC trial.

Pugh S, Thiébaut R, Bridgewater J, Grisoni ML, Moutasim K, Rousseau F, Thomas GJ, Griffiths G, Liebaert F, Primrose J, Laurent-Puig P.

Oncotarget. 2017 Sep 27;8(55):93856-93866. doi: 10.18632/oncotarget.21291. eCollection 2017 Nov 7.


Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.

Kletting S, Barthold S, Repnik U, Griffiths G, Loretz B, Schneider-Daum N, de Souza Carvalho-Wodarz C, Lehr CM.

ALTEX. 2018;35(2):211-222. doi: 10.14573/altex.1607191. Epub 2017 Nov 23.


Production, Characterisation and Testing of an Ovine Antitoxin against Ricin; Efficacy, Potency and Mechanisms of Action.

Whitfield SJC, Griffiths GD, Jenner DC, Gwyther RJ, Stahl FM, Cork LJ, Holley JL, Green AC, Clark GC.

Toxins (Basel). 2017 Oct 18;9(10). pii: E329. doi: 10.3390/toxins9100329.


Targeting neutrophils for host-directed therapy to treat tuberculosis.

Dallenga T, Linnemann L, Paudyal B, Repnik U, Griffiths G, Schaible UE.

Int J Med Microbiol. 2018 Jan;308(1):142-147. doi: 10.1016/j.ijmm.2017.10.001. Epub 2017 Oct 7. Review.


M. tuberculosis-Induced Necrosis of Infected Neutrophils Promotes Bacterial Growth Following Phagocytosis by Macrophages.

Dallenga T, Repnik U, Corleis B, Eich J, Reimer R, Griffiths GW, Schaible UE.

Cell Host Microbe. 2017 Oct 11;22(4):519-530.e3. doi: 10.1016/j.chom.2017.09.003.


Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guérin (BCG) via Synergistic Activation of Innate Immune Receptors.

Speth MT, Repnik U, Müller E, Spanier J, Kalinke U, Corthay A, Griffiths G.

Mol Pharm. 2017 Nov 6;14(11):4098-4112. doi: 10.1021/acs.molpharmaceut.7b00795. Epub 2017 Oct 19.


Seeing is understanding: Salmonella's way to penetrate the intestinal epithelium.

Zhang K, Griffiths G, Repnik U, Hornef M.

Int J Med Microbiol. 2018 Jan;308(1):97-106. doi: 10.1016/j.ijmm.2017.09.011. Epub 2017 Sep 14. Review.


Uva-ursi extract and ibuprofen as alternative treatments of adult female urinary tract infection (ATAFUTI): study protocol for a randomised controlled trial.

Trill J, Simpson C, Webley F, Radford M, Stanton L, Maishman T, Galanopoulou A, Flower A, Eyles C, Willcox M, Hay A, Griffiths G, Little P, Lewith G, Moore M.

Trials. 2017 Sep 8;18(1):421. doi: 10.1186/s13063-017-2145-7.


L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes.

Repnik U, Borg Distefano M, Speth MT, Ng MYW, Progida C, Hoflack B, Gruenberg J, Griffiths G.

J Cell Sci. 2017 Sep 15;130(18):3124-3140. doi: 10.1242/jcs.204529. Epub 2017 Jul 28.


Sensitive Detection of MMP9 Enzymatic Activities in Single Cell-Encapsulated Microdroplets as an Assay of Cancer Cell Invasiveness.

Yu Z, Zhou L, Zhang T, Shen R, Li C, Fang X, Griffiths G, Liu J.

ACS Sens. 2017 May 26;2(5):626-634. doi: 10.1021/acssensors.6b00731. Epub 2017 Mar 24.


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