Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 121

1.

Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels.

Kaushik G, Gil DA, Torr E, Berge ES, Soref C, Uhl P, Fontana G, Antosiewicz-Bourget J, Edington C, Schwartz MP, Griffith LG, Thomson JA, Skala MC, Daly WT, Murphy WL.

Adv Healthc Mater. 2019 Jan;8(2):e1801186. doi: 10.1002/adhm.201801186. Epub 2018 Dec 19.

PMID:
30565891
2.

ADAM10 Sheddase Activity is a Potential Lung-Cancer Biomarker.

Yoneyama T, Gorry M, Sobo-Vujanovic A, Lin Y, Vujanovic L, Gaither-Davis A, Moss ML, Miller MA, Griffith LG, Lauffenburger DA, Stabile LP, Herman J, Vujanovic NL.

J Cancer. 2018 Jun 23;9(14):2559-2570. doi: 10.7150/jca.24601. eCollection 2018.

3.

Folding artificial mucosa with cell-laden hydrogels guided by mechanics models.

Chan HF, Zhao R, Parada GA, Meng H, Leong KW, Griffith LG, Zhao X.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7503-7508. doi: 10.1073/pnas.1802361115. Epub 2018 Jul 2.

4.

Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis.

Ravindra KC, Ahrens CC, Wang Y, Ramseier JY, Wishnok JS, Griffith LG, Grodzinsky AJ, Tannenbaum SR.

J Biol Chem. 2018 Jul 20;293(29):11459-11469. doi: 10.1074/jbc.M117.818542. Epub 2018 May 23.

PMID:
29794029
5.

Establishing quasi-steady state operations of microphysiological systems (MPS) using tissue-specific metabolic dependencies.

Maass C, Dallas M, LaBarge ME, Shockley M, Valdez J, Geishecker E, Stokes CL, Griffith LG, Cirit M.

Sci Rep. 2018 May 22;8(1):8015. doi: 10.1038/s41598-018-25971-y.

6.

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.

Edington CD, Chen WLK, Geishecker E, Kassis T, Soenksen LR, Bhushan BM, Freake D, Kirschner J, Maass C, Tsamandouras N, Valdez J, Cook CD, Parent T, Snyder S, Yu J, Suter E, Shockley M, Velazquez J, Velazquez JJ, Stockdale L, Papps JP, Lee I, Vann N, Gamboa M, LaBarge ME, Zhong Z, Wang X, Boyer LA, Lauffenburger DA, Carrier RL, Communal C, Tannenbaum SR, Stokes CL, Hughes DJ, Rohatgi G, Trumper DL, Cirit M, Griffith LG.

Sci Rep. 2018 Mar 14;8(1):4530. doi: 10.1038/s41598-018-22749-0.

7.

Closed-loop feedback control for microfluidic systems through automated capacitive fluid height sensing.

Soenksen LR, Kassis T, Noh M, Griffith LG, Trumper DL.

Lab Chip. 2018 Mar 13;18(6):902-914. doi: 10.1039/c7lc01223c.

PMID:
29437172
8.

A Model of Dormant-Emergent Metastatic Breast Cancer Progression Enabling Exploration of Biomarker Signatures.

Clark AM, Kumar MP, Wheeler SE, Young CL, Venkataramanan R, Stolz DB, Griffith LG, Lauffenburger DA, Wells A.

Mol Cell Proteomics. 2018 Apr;17(4):619-630. doi: 10.1074/mcp.RA117.000370. Epub 2018 Jan 20.

PMID:
29353230
9.

Modification of proteolytic activity matrix analysis (PrAMA) to measure ADAM10 and ADAM17 sheddase activities in cell and tissue lysates.

Yoneyama T, Gorry M, Miller MA, Gaither-Davis A, Lin Y, Moss ML, Griffith LG, Lauffenburger DA, Stabile LP, Herman JG, Vujanovic NL.

J Cancer. 2017 Oct 23;8(19):3916-3932. doi: 10.7150/jca.20779. eCollection 2017.

10.

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies.

Tsamandouras N, Chen WLK, Edington CD, Stokes CL, Griffith LG, Cirit M.

AAPS J. 2017 Sep;19(5):1499-1512. doi: 10.1208/s12248-017-0122-4. Epub 2017 Jul 27.

PMID:
28752430
11.

Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.

Chen WLK, Edington C, Suter E, Yu J, Velazquez JJ, Velazquez JG, Shockley M, Large EM, Venkataramanan R, Hughes DJ, Stokes CL, Trumper DL, Carrier RL, Cirit M, Griffith LG, Lauffenburger DA.

Biotechnol Bioeng. 2017 Nov;114(11):2648-2659. doi: 10.1002/bit.26370. Epub 2017 Jul 27.

12.

Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System.

Sarkar U, Ravindra KC, Large E, Young CL, Rivera-Burgos D, Yu J, Cirit M, Hughes DJ, Wishnok JS, Lauffenburger DA, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2017 Jul;45(7):855-866. doi: 10.1124/dmd.116.074005. Epub 2017 Apr 27.

13.

Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility.

Jørgensen H, Hill AS, Beste MT, Kumar MP, Chiswick E, Fedorcsak P, Isaacson KB, Lauffenburger DA, Griffith LG, Qvigstad E.

Fertil Steril. 2017 May;107(5):1191-1199.e2. doi: 10.1016/j.fertnstert.2017.03.013. Epub 2017 Apr 19.

PMID:
28433374
14.

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function.

Cook CD, Hill AS, Guo M, Stockdale L, Papps JP, Isaacson KB, Lauffenburger DA, Griffith LG.

Integr Biol (Camb). 2017 Apr 18;9(4):271-289. doi: 10.1039/c6ib00245e.

15.

Multi-functional scaling methodology for translational pharmacokinetic and pharmacodynamic applications using integrated microphysiological systems (MPS).

Maass C, Stokes CL, Griffith LG, Cirit M.

Integr Biol (Camb). 2017 Apr 18;9(4):290-302. doi: 10.1039/c6ib00243a.

16.

A process engineering approach to increase organoid yield.

Arora N, Imran Alsous J, Guggenheim JW, Mak M, Munera J, Wells JM, Kamm RD, Asada HH, Shvartsman SY, Griffith LG.

Development. 2017 Mar 15;144(6):1128-1136. doi: 10.1242/dev.142919. Epub 2017 Feb 7.

17.

Modeling Therapeutic Antibody-Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform.

Long TJ, Cosgrove PA, Dunn RT 2nd, Stolz DB, Hamadeh H, Afshari C, McBride H, Griffith LG.

Drug Metab Dispos. 2016 Dec;44(12):1940-1948. Epub 2016 Sep 12.

18.

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System.

Tsamandouras N, Kostrzewski T, Stokes CL, Griffith LG, Hughes DJ, Cirit M.

J Pharmacol Exp Ther. 2017 Jan;360(1):95-105. Epub 2016 Oct 19.

19.

Design Principles for SuCESsFul Biosensors: Specific Fluorophore/Analyte Binding and Minimization of Fluorophore/Scaffold Interactions.

de Picciotto S, Dickson PM, Traxlmayr MW, Marques BS, Socher E, Zhao S, Cheung S, Kiefer JD, Wand AJ, Griffith LG, Imperiali B, Wittrup KD.

J Mol Biol. 2016 Oct 9;428(20):4228-4241. doi: 10.1016/j.jmb.2016.07.004. Epub 2016 Jul 21.

20.

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA.

Cancer Discov. 2016 Apr;6(4):382-99. doi: 10.1158/2159-8290.CD-15-0933. Epub 2016 Mar 16.

21.

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG 3rd, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE.

Sci Transl Med. 2016 Jan 6;8(320):320ra4. doi: 10.1126/scitranslmed.aad0293.

22.

Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.

Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R.

Nat Commun. 2016 Jan 6;7:10243. doi: 10.1038/ncomms10243.

23.

Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration.

Yu J, Cilfone NA, Large EM, Sarkar U, Wishnok JS, Tannenbaum SR, Hughes DJ, Lauffenburger DA, Griffith LG, Stokes CL, Cirit M.

CPT Pharmacometrics Syst Pharmacol. 2015 Oct;4(10):585-94. doi: 10.1002/psp4.12010. Epub 2015 Oct 5.

24.

Targeting autocrine HB-EGF signaling with specific ADAM12 inhibition using recombinant ADAM12 prodomain.

Miller MA, Moss ML, Powell G, Petrovich R, Edwards L, Meyer AS, Griffith LG, Lauffenburger DA.

Sci Rep. 2015 Oct 19;5:15150. doi: 10.1038/srep15150.

25.

Uncharged Helical Modular Polypeptide Hydrogels for Cellular Scaffolds.

Ahrens CC, Welch ME, Griffith LG, Hammond PT.

Biomacromolecules. 2015 Dec 14;16(12):3774-83. doi: 10.1021/acs.biomac.5b01076. Epub 2015 Nov 9.

PMID:
26461932
26.

Tethering of Epidermal Growth Factor (EGF) to Beta Tricalcium Phosphate (βTCP) via Fusion to a High Affinity, Multimeric βTCP-Binding Peptide: Effects on Human Multipotent Stromal Cells/Connective Tissue Progenitors.

Alvarez LM, Rivera JJ, Stockdale L, Saini S, Lee RT, Griffith LG.

PLoS One. 2015 Jun 29;10(6):e0129600. doi: 10.1371/journal.pone.0129600. eCollection 2015.

27.

Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation.

Cambria E, Renggli K, Ahrens CC, Cook CD, Kroll C, Krueger AT, Imperiali B, Griffith LG.

Biomacromolecules. 2015 Aug 10;16(8):2316-26. doi: 10.1021/acs.biomac.5b00549. Epub 2015 Jul 10.

28.

Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor.

Sarkar U, Rivera-Burgos D, Large EM, Hughes DJ, Ravindra KC, Dyer RL, Ebrahimkhani MR, Wishnok JS, Griffith LG, Tannenbaum SR.

Drug Metab Dispos. 2015 Jul;43(7):1091-9. doi: 10.1124/dmd.115.063495. Epub 2015 Apr 29.

29.

Regenerating the cell resistance of micromolded PEG hydrogels.

Heath DE, Sharif AR, Ng CP, Rhoads MG, Griffith LG, Hammond PT, Chan-Park MB.

Lab Chip. 2015 May 7;15(9):2073-89. doi: 10.1039/c4lc01416b.

PMID:
25813089
30.

Photopatterning of hydrogel scaffolds coupled to filter materials using stereolithography for perfused 3D culture of hepatocytes.

Neiman JA, Raman R, Chan V, Rhoads MG, Raredon MS, Velazquez JJ, Dyer RL, Bashir R, Hammond PT, Griffith LG.

Biotechnol Bioeng. 2015 Apr;112(4):777-87. doi: 10.1002/bit.25494. Epub 2015 Feb 23.

31.

Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells.

Belair DG, Whisler JA, Valdez J, Velazquez J, Molenda JA, Vickerman V, Lewis R, Daigh C, Hansen TD, Mann DA, Thomson JA, Griffith LG, Kamm RD, Schwartz MP, Murphy WL.

Stem Cell Rev. 2015 Jun;11(3):511-25. doi: 10.1007/s12015-014-9549-5.

32.

Three dimensional human small intestine models for ADME-Tox studies.

Yu J, Carrier RL, March JC, Griffith LG.

Drug Discov Today. 2014 Oct;19(10):1587-94. doi: 10.1016/j.drudis.2014.05.003. Epub 2014 May 20. Review.

PMID:
24853950
33.

A microphysiological system model of therapy for liver micrometastases.

Clark AM, Wheeler SE, Taylor DP, Pillai VC, Young CL, Prantil-Baun R, Nguyen T, Stolz DB, Borenstein JT, Lauffenburger DA, Venkataramanan R, Griffith LG, Wells A.

Exp Biol Med (Maywood). 2014 Sep;239(9):1170-9. doi: 10.1177/1535370214532596. Epub 2014 May 12. Review.

34.

Equilibrium and dynamic design principles for binding molecules engineered for reagentless biosensors.

de Picciotto S, Imperiali B, Griffith LG, Wittrup KD.

Anal Biochem. 2014 Sep 1;460:9-15. doi: 10.1016/j.ab.2014.04.036. Epub 2014 May 9.

35.

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Ebrahimkhani MR, Young CL, Lauffenburger DA, Griffith LG, Borenstein JT.

Drug Discov Today. 2014 Jun;19(6):754-62. doi: 10.1016/j.drudis.2014.04.017. Epub 2014 May 2. Review.

36.

Engineering liver.

Griffith LG, Wells A, Stolz DB.

Hepatology. 2014 Oct;60(4):1426-34. doi: 10.1002/hep.27150. Epub 2014 May 19. Review.

37.

Bioreactor technologies to support liver function in vitro.

Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG.

Adv Drug Deliv Rev. 2014 Apr;69-70:132-57. doi: 10.1016/j.addr.2014.02.011. Epub 2014 Mar 5. Review.

38.

Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM.

Ng CP, Sharif AR, Heath DE, Chow JW, Zhang CB, Chan-Park MB, Hammond PT, Chan JK, Griffith LG.

Biomaterials. 2014 Apr;35(13):4046-57. doi: 10.1016/j.biomaterials.2014.01.081. Epub 2014 Feb 21.

39.

Molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation.

Beste MT, Pfäffle-Doyle N, Prentice EA, Morris SN, Lauffenburger DA, Isaacson KB, Griffith LG.

Sci Transl Med. 2014 Feb 5;6(222):222ra16. doi: 10.1126/scitranslmed.3007988.

40.

Tailoring chimeric ligands for studying and biasing ErbB receptor family interactions.

Krueger AT, Kroll C, Sanchez E, Griffith LG, Imperiali B.

Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2662-6. doi: 10.1002/anie.201307869. Epub 2014 Jan 31.

41.

Co-regulation of primary mouse hepatocyte viability and function by oxygen and matrix.

Buck LD, Inman SW, Rusyn I, Griffith LG.

Biotechnol Bioeng. 2014 May;111(5):1018-27. doi: 10.1002/bit.25152. Epub 2014 Jan 31.

42.

An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential.

Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT.

Circulation. 2013 Jul 9;128(2):152-61. doi: 10.1161/CIRCULATIONAHA.113.002203. Epub 2013 Jun 11.

43.

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling.

Miller MA, Meyer AS, Beste MT, Lasisi Z, Reddy S, Jeng KW, Chen CH, Han J, Isaacson K, Griffith LG, Lauffenburger DA.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2074-83. doi: 10.1073/pnas.1222387110. Epub 2013 May 14.

44.

In vitro models for liver toxicity testing.

Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I.

Toxicol Res (Camb). 2013 Jan 1;2(1):23-39. Epub 2012 Nov 23.

45.

Multiplexed protease activity assay for low-volume clinical samples using droplet-based microfluidics and its application to endometriosis.

Chen CH, Miller MA, Sarkar A, Beste MT, Isaacson KB, Lauffenburger DA, Griffith LG, Han J.

J Am Chem Soc. 2013 Feb 6;135(5):1645-8. doi: 10.1021/ja307866z. Epub 2012 Nov 29.

46.

Helix versus coil polypeptide macromers: gel networks with decoupled stiffness and permeability.

Oelker AM, Morey SM, Griffith LG, Hammond PT.

Soft Matter. 2012 Nov 14;42(8):10887-10895.

47.

Multilayer thin film coatings capable of extended programmable drug release: application to human mesenchymal stem cell differentiation.

Hong J, Alvarez LM, Shah NJ, Griffith LG, Kim BS, Char K, Hammond PT.

Drug Deliv Transl Res. 2012 Oct;2(5):375-83. doi: 10.1007/s13346-012-0093-z.

48.

Dual responsiveness of a tunable thermo-sensitive polypeptide.

Chopko CM, Lowden EL, Engler AC, Griffith LG, Hammond PT.

ACS Macro Lett. 2012 Jun 19;1(6):727-731.

49.

Production of reactive oxygen species by multipotent stromal cells/mesenchymal stem cells upon exposure to fas ligand.

Rodrigues M, Turner O, Stolz D, Griffith LG, Wells A.

Cell Transplant. 2012;21(10):2171-87. doi: 10.3727/096368912X639035. Epub 2012 Apr 17.

50.

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging.

Mito JK, Ferrer JM, Brigman BE, Lee CL, Dodd RD, Eward WC, Marshall LF, Cuneo KC, Carter JE, Ramasunder S, Kim Y, Lee WD, Griffith LG, Bawendi MG, Kirsch DG.

Cancer. 2012 Nov 1;118(21):5320-30. doi: 10.1002/cncr.27458. Epub 2012 Mar 21.

Supplemental Content

Loading ...
Support Center