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A New View of the T-Loop Junction: Implications for Self-Primed Telomere Extension, Expansion of Disease-Related Nucleotide Repeat Blocks, and Telomere Evolution.

Tomaska L, Nosek J, Kar A, Willcox S, Griffith JD.

Front Genet. 2019 Aug 14;10:792. doi: 10.3389/fgene.2019.00792. eCollection 2019.


Distinct Binding Modes of Vinculin Isoforms Underlie Their Functional Differences.

Krokhotin A, Sarker M, Sevilla EA, Costantini LM, Griffith JD, Campbell SL, Dokholyan NV.

Structure. 2019 Aug 7. pii: S0969-2126(19)30245-X. doi: 10.1016/j.str.2019.07.013. [Epub ahead of print]


Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming.

McNamara RP, Chugh PE, Bailey A, Costantini LM, Ma Z, Bigi R, Cheves A, Eason AB, Landis JT, Host KM, Xiong J, Griffith JD, Damania B, Dittmer DP.

PLoS Pathog. 2019 Feb 4;15(2):e1007536. doi: 10.1371/journal.ppat.1007536. eCollection 2019 Feb.


Commentary: Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function.

Tomáška Ĺ, Nosek J, Sepšiová R, Červenák F, Juríková K, Procházková K, Neboháčová M, Willcox S, Griffith JD.

Front Genet. 2019 Jan 15;9:742. doi: 10.3389/fgene.2018.00742. eCollection 2018. No abstract available.


Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles.

McNamara RP, Caro-Vegas CP, Costantini LM, Landis JT, Griffith JD, Damania BA, Dittmer DP.

J Extracell Vesicles. 2018 Nov 30;7(1):1541396. doi: 10.1080/20013078.2018.1541396. eCollection 2018.


Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC.

Cell Rep. 2018 Jun 19;23(12):3419-3428. doi: 10.1016/j.celrep.2018.05.061.


A Cross-Sectional View of Fear of Death and Dying Among Skydivers.

Griffith JD, Gassem M, Hart CL, Adams LT, Sargent R.

Omega (Westport). 2018 Jun;77(2):173-187. doi: 10.1177/0030222815600178. Epub 2015 Aug 16.


Long repeating (TTAGGG) n single-stranded DNA self-condenses into compact beaded filaments stabilized by G-quadruplex formation.

Kar A, Jones N, Arat NÖ, Fishel R, Griffith JD.

J Biol Chem. 2018 Jun 15;293(24):9473-9485. doi: 10.1074/jbc.RA118.002158. Epub 2018 Apr 19.


Large SOD1 aggregates, unlike trimeric SOD1, do not impact cell viability in a model of amyotrophic lateral sclerosis.

Zhu C, Beck MV, Griffith JD, Deshmukh M, Dokholyan NV.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4661-4665. doi: 10.1073/pnas.1800187115. Epub 2018 Apr 16.


Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.

McNamara RP, Costantini LM, Myers TA, Schouest B, Maness NJ, Griffith JD, Damania BA, MacLean AG, Dittmer DP.

MBio. 2018 Feb 6;9(1). pii: e02344-17. doi: 10.1128/mBio.02344-17.


Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase.

Ciesielski GL, Nadalutti CA, Oliveira MT, Jacobs HT, Griffith JD, Kaguni LS.

Nucleic Acids Res. 2018 Apr 6;46(6):3034-3046. doi: 10.1093/nar/gky094.


Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA.

Nicholls TJ, Nadalutti CA, Motori E, Sommerville EW, Gorman GS, Basu S, Hoberg E, Turnbull DM, Chinnery PF, Larsson NG, Larsson E, Falkenberg M, Taylor RW, Griffith JD, Gustafsson CM.

Mol Cell. 2018 Jan 4;69(1):9-23.e6. doi: 10.1016/j.molcel.2017.11.033. Epub 2017 Dec 28.


DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.

Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH.

DNA Repair (Amst). 2017 Dec;60:77-88. doi: 10.1016/j.dnarep.2017.10.011. Epub 2017 Oct 28.


The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks.

Bermek O, Weller SK, Griffith JD.

J Biol Chem. 2017 Sep 22;292(38):15611-15621. doi: 10.1074/jbc.M117.799064. Epub 2017 Jul 25.


Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways.

Abdullah LH, Evans JR, Wang TT, Ford AA, Makhov AM, Nguyen K, Coakley RD, Griffith JD, Davis CW, Ballard ST, Kesimer M.

JCI Insight. 2017 Mar 23;2(6):e89752. doi: 10.1172/jci.insight.89752.


Telomere Recognition and Assembly Mechanism of Mammalian Shelterin.

Erdel F, Kratz K, Willcox S, Griffith JD, Greene EC, de Lange T.

Cell Rep. 2017 Jan 3;18(1):41-53. doi: 10.1016/j.celrep.2016.12.005.


Transcription of telomeric DNA leads to high levels of homologous recombination and t-loops.

Kar A, Willcox S, Griffith JD.

Nucleic Acids Res. 2016 Nov 2;44(19):9369-9380. Epub 2016 Sep 7.


Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.

Sepsiova R, Necasova I, Willcox S, Prochazkova K, Gorilak P, Nosek J, Hofr C, Griffith JD, Tomaska L.

PLoS One. 2016 Apr 21;11(4):e0154225. doi: 10.1371/journal.pone.0154225. eCollection 2016.


Yeast mitochondrial HMG proteins: DNA-binding properties of the most evolutionarily divergent component of mitochondrial nucleoids.

Bakkaiova J, Marini V, Willcox S, Nosek J, Griffith JD, Krejci L, Tomaska L.

Biosci Rep. 2015 Dec 8;36(1):e00288. doi: 10.1042/BSR20150275.


Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.

Ciesielski GL, Bermek O, Rosado-Ruiz FA, Hovde SL, Neitzke OJ, Griffith JD, Kaguni LS.

J Biol Chem. 2015 Nov 27;290(48):28697-707. doi: 10.1074/jbc.M115.673707. Epub 2015 Oct 7.


Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity.

Dillon LW, Kumar P, Shibata Y, Wang YH, Willcox S, Griffith JD, Pommier Y, Takeda S, Dutta A.

Cell Rep. 2015 Jun 23;11(11):1749-59. doi: 10.1016/j.celrep.2015.05.020. Epub 2015 Jun 4.


A rolling circle replication mechanism produces multimeric lariats of mitochondrial DNA in Caenorhabditis elegans.

Lewis SC, Joers P, Willcox S, Griffith JD, Jacobs HT, Hyman BC.

PLoS Genet. 2015 Feb 18;11(2):e1004985. doi: 10.1371/journal.pgen.1004985. eCollection 2015 Feb.


DNA replication catalyzed by herpes simplex virus type 1 proteins reveals trombone loops at the fork.

Bermek O, Willcox S, Griffith JD.

J Biol Chem. 2015 Jan 30;290(5):2539-45. doi: 10.1074/jbc.M114.623009. Epub 2014 Dec 3.


TRF1 and TRF2 differentially modulate Rad51-mediated telomeric and nontelomeric displacement loop formation in vitro.

Bower BD, Griffith JD.

Biochemistry. 2014 Sep 2;53(34):5485-95. doi: 10.1021/bi5006249. Epub 2014 Aug 21.


Attitudes toward dying and death: a comparison of recreational groups among older men.

Griffith JD, Toms A, Reese J, Hamel M, Gu LL, Hart CL.

Omega (Westport). 2013;67(4):379-91.


Top3α is required during the convergent migration step of double Holliday junction dissolution.

Chen SH, Plank JL, Willcox S, Griffith JD, Hsieh TS.

PLoS One. 2014 Jan 2;9(1):e83582. doi: 10.1371/journal.pone.0083582. eCollection 2014.


Reconstitution of long and short patch mismatch repair reactions using Saccharomyces cerevisiae proteins.

Bowen N, Smith CE, Srivatsan A, Willcox S, Griffith JD, Kolodner RD.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18472-7. doi: 10.1073/pnas.1318971110. Epub 2013 Nov 1.


Many ways to loop DNA.

Griffith JD.

J Biol Chem. 2013 Oct 11;288(41):29724-35. doi: 10.1074/jbc.X113.515981. Epub 2013 Sep 4.


Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.

Lee SH, Siaw GE, Willcox S, Griffith JD, Hsieh TS.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):E3587-94. doi: 10.1073/pnas.1304103110. Epub 2013 Sep 3.


Modulation of B-cell exosome proteins by gamma herpesvirus infection.

Meckes DG Jr, Gunawardena HP, Dekroon RM, Heaton PR, Edwards RH, Ozgur S, Griffith JD, Damania B, Raab-Traub N.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2925-33. doi: 10.1073/pnas.1303906110. Epub 2013 Jul 1.


Details of ssDNA annealing revealed by an HSV-1 ICP8-ssDNA binary complex.

Tolun G, Makhov AM, Ludtke SJ, Griffith JD.

Nucleic Acids Res. 2013 Jun;41(11):5927-37. doi: 10.1093/nar/gkt266. Epub 2013 Apr 19.


Improved methods for creating migratable Holliday junction substrates.

Chen SH, Plank JL, Willcox S, Griffith JD, Hsieh TS.

Nucleic Acids Res. 2013 Mar 1;41(5):e60. doi: 10.1093/nar/gks1343. Epub 2012 Dec 28.


Biophysical and ultrastructural characterization of adeno-associated virus capsid uncoating and genome release.

Horowitz ED, Rahman KS, Bower BD, Dismuke DJ, Falvo MR, Griffith JD, Harvey SC, Asokan A.

J Virol. 2013 Mar;87(6):2994-3002. doi: 10.1128/JVI.03017-12. Epub 2012 Dec 26.


Characteristics of pornography film actors: self-report versus perceptions of college students.

Griffith JD, Hayworth M, Adams LT, Mitchell S, Hart C.

Arch Sex Behav. 2013 May;42(4):637-47. doi: 10.1007/s10508-012-0033-5. Epub 2012 Nov 22.


Pornography actresses: an assessment of the damaged goods hypothesis.

Griffith JD, Mitchell S, Hart CL, Adams LT, Gu LL.

J Sex Res. 2013;50(7):621-32. doi: 10.1080/00224499.2012.719168. Epub 2012 Nov 20.


Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere.

Arat NÖ, Griffith JD.

J Biol Chem. 2012 Dec 7;287(50):41583-94. doi: 10.1074/jbc.M112.415984. Epub 2012 Oct 20.


The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status.

Guo X, Kesimer M, Tolun G, Zheng X, Xu Q, Lu J, Sheehan JK, Griffith JD, Li X.

Sci Rep. 2012;2:640. doi: 10.1038/srep00640. Epub 2012 Sep 7.


Synergism of the two Myb domains of Tay1 protein results in high affinity binding to telomeres.

Visacka K, Hofr C, Willcox S, Necasova I, Pavlouskova J, Sepsiova R, Wimmerova M, Simonicova L, Nosek J, Fajkus J, Griffith JD, Tomaska L.

J Biol Chem. 2012 Sep 14;287(38):32206-15. doi: 10.1074/jbc.M112.385591. Epub 2012 Jul 18.


Extrachromosomal microDNAs and chromosomal microdeletions in normal tissues.

Shibata Y, Kumar P, Layer R, Willcox S, Gagan JR, Griffith JD, Dutta A.

Science. 2012 Apr 6;336(6077):82-6. doi: 10.1126/science.1213307. Epub 2012 Mar 8. Erratum in: Science. 2012 Jun 22;336(6088):1506.


Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis.

Wu C, Asokan SB, Berginski ME, Haynes EM, Sharpless NE, Griffith JD, Gomez SM, Bear JE.

Cell. 2012 Mar 2;148(5):973-87. doi: 10.1016/j.cell.2011.12.034.


E. coli DNA replication in the absence of free β clamps.

Tanner NA, Tolun G, Loparo JJ, Jergic S, Griffith JD, Dixon NE, van Oijen AM.

EMBO J. 2011 May 4;30(9):1830-40. doi: 10.1038/emboj.2011.84. Epub 2011 Mar 25.


The killing of African trypanosomes by ethidium bromide.

Roy Chowdhury A, Bakshi R, Wang J, Yildirir G, Liu B, Pappas-Brown V, Tolun G, Griffith JD, Shapiro TA, Jensen RE, Englund PT.

PLoS Pathog. 2010 Dec 16;6(12):e1001226. doi: 10.1371/journal.ppat.1001226.


Tay1 protein, a novel telomere binding factor from Yarrowia lipolytica.

Kramara J, Willcox S, Gunisova S, Kinsky S, Nosek J, Griffith JD, Tomaska L.

J Biol Chem. 2010 Dec 3;285(49):38078-92. doi: 10.1074/jbc.M110.127605. Epub 2010 Oct 5.


The breast cancer tumor suppressor BRCA2 promotes the specific targeting of RAD51 to single-stranded DNA.

Thorslund T, McIlwraith MJ, Compton SA, Lekomtsev S, Petronczki M, Griffith JD, West SC.

Nat Struct Mol Biol. 2010 Oct;17(10):1263-5. doi: 10.1038/nsmb.1905. Epub 2010 Aug 22.


Mechanism of Holliday junction resolution by the human GEN1 protein.

Rass U, Compton SA, Matos J, Singleton MR, Ip SC, Blanco MG, Griffith JD, West SC.

Genes Dev. 2010 Jul 15;24(14):1559-69. doi: 10.1101/gad.585310.


Aortic dissection: an emergent clinical presentation.

Griffith JD, Wang EE, Coleman P, Aitchison P, Kharasch M.

Acad Emerg Med. 2010 Apr;17(4):466. doi: 10.1111/j.1553-2712.2010.00712.x. No abstract available.


Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.

Compton SA, Ozgür S, Griffith JD.

J Biol Chem. 2010 Apr 30;285(18):13349-56. doi: 10.1074/jbc.M109.074286. Epub 2010 Mar 5.


Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.

Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, Jacobs HT, Holt IJ.

J Mol Biol. 2010 Apr 16;397(5):1144-55. doi: 10.1016/j.jmb.2010.02.029. Epub 2010 Feb 23.


TbPIF1, a Trypanosoma brucei mitochondrial DNA helicase, is essential for kinetoplast minicircle replication.

Liu B, Yildirir G, Wang J, Tolun G, Griffith JD, Englund PT.

J Biol Chem. 2010 Mar 5;285(10):7056-66. doi: 10.1074/jbc.M109.084038. Epub 2009 Dec 30.


Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing.

Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF.

Cell. 2009 Nov 13;139(4):719-30. doi: 10.1016/j.cell.2009.10.015. Epub 2009 Nov 5.

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