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How can parental obesity promote OA across generations?

Griffin TM, Friedman JE.

Nat Rev Rheumatol. 2020 Jan 16. doi: 10.1038/s41584-020-0369-5. [Epub ahead of print] No abstract available.


Innate inflammation and synovial macrophages in osteoarthritis pathophysiology.

Griffin TM, Scanzello CR.

Clin Exp Rheumatol. 2019 Sep-Oct;37 Suppl 120(5):57-63. Epub 2019 Oct 15. Review.


Glutathione as a mediator of cartilage oxidative stress resistance and resilience during aging and osteoarthritis.

Zhu S, Makosa D, Miller B, Griffin TM.

Connect Tissue Res. 2020 Jan;61(1):34-47. doi: 10.1080/03008207.2019.1665035. Epub 2019 Sep 15.


Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility.

Yang X, Brobst D, Chan WS, Tse MCL, Herlea-Pana O, Ahuja P, Bi X, Zaw AM, Kwong ZSW, Jia WH, Zhang ZG, Zhang N, Chow SKH, Cheung WH, Louie JCY, Griffin TM, Nong W, Hui JHL, Du GH, Noh HL, Saengnipanthkul S, Chow BKC, Kim JK, Lee CW, Chan CB.

Sci Signal. 2019 Aug 13;12(594). pii: eaau1468. doi: 10.1126/scisignal.aau1468.


GC-MS method for metabolic profiling of mouse femoral head articular cartilage reveals distinct effects of tissue culture and development.

Batushansky A, Lopes EBP, Zhu S, Humphries KM, Griffin TM.

Osteoarthritis Cartilage. 2019 Sep;27(9):1361-1371. doi: 10.1016/j.joca.2019.05.010. Epub 2019 May 25.


TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice.

Kalaitzoglou E, Lopes EBP, Fu Y, Herron JC, Flaming JM, Donovan EL, Hu Y, Filiberti A, Griffin TM, Humphrey MB.

JBMR Plus. 2018 Oct 4;3(4):e10079. doi: 10.1002/jbm4.10079. eCollection 2019 Apr.


GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting.

Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, Humphries KM.

Metabolomics. 2019 Jan 28;15(2):18. doi: 10.1007/s11306-019-1478-5.


Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.

Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):411-428. doi: 10.1002/jcsm.12375. Epub 2019 Feb 1. Erratum in: J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1148.


Topical nicotinic receptor activation improves wound bacterial infection outcomes and TLR2-mediated inflammation in diabetic mouse wounds.

Kishibe M, Griffin TM, Goslawski M, Sinacore J, Kristian SA, Radek KA.

Wound Repair Regen. 2018 Nov;26(6):403-412. doi: 10.1111/wrr.12674. Epub 2018 Oct 24.


Independent effects of dietary fat and sucrose content on chondrocyte metabolism and osteoarthritis pathology in mice.

Donovan EL, Lopes EBP, Batushansky A, Kinter M, Griffin TM.

Dis Model Mech. 2018 Aug 31;11(9). pii: dmm034827. doi: 10.1242/dmm.034827.


The Effect of Subclinical Varicocele on Pregnancy Rates and Semen Parameters: a Systematic Review and Meta-Analysis.

Kohn TP, Ohlander SJ, Jacob JS, Griffin TM, Lipshultz LI, Pastuszak AW.

Curr Urol Rep. 2018 May 17;19(7):53. doi: 10.1007/s11934-018-0798-8. Review.


Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS.

EMBO Rep. 2018 Mar;19(3). pii: e45009. doi: 10.15252/embr.201745009. Epub 2018 Feb 2.


STAT1 modulates tissue wasting or overgrowth downstream from PDGFRβ.

He C, Medley SC, Kim J, Sun C, Kwon HR, Sakashita H, Pincu Y, Yao L, Eppard D, Dai B, Berry WL, Griffin TM, Olson LE.

Genes Dev. 2017 Aug 15;31(16):1666-1678. doi: 10.1101/gad.300384.117. Epub 2017 Sep 18.


Effect of biomechanical stress on endogenous antioxidant networks in bovine articular cartilage.

Issa R, Boeving M, Kinter M, Griffin TM.

J Orthop Res. 2018 Feb;36(2):760-769. doi: 10.1002/jor.23728. Epub 2017 Oct 17.


Innate Immune Responses and Osteoarthritis.

Kalaitzoglou E, Griffin TM, Humphrey MB.

Curr Rheumatol Rep. 2017 Aug;19(8):45. doi: 10.1007/s11926-017-0672-6. Review.


Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity.

Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM.

Arthritis Rheumatol. 2017 Jun;69(6):1221-1232. doi: 10.1002/art.40056. Epub 2017 Apr 28.


Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis.

June RK, Liu-Bryan R, Long F, Griffin TM.

J Orthop Res. 2016 Dec;34(12):2048-2058. doi: 10.1002/jor.23420. Epub 2016 Sep 26. Review.


Review: Metabolic Regulation of Inflammation in Osteoarthritis.

Berenbaum F, Griffin TM, Liu-Bryan R.

Arthritis Rheumatol. 2017 Jan;69(1):9-21. doi: 10.1002/art.39842. Review. No abstract available.


Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis.

Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM.

Arthritis Rheumatol. 2016 Aug;68(8):1887-98. doi: 10.1002/art.39618.


Editorial: Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis?

Griffin TM, Huffman KM.

Arthritis Rheumatol. 2016 Jun;68(6):1330-3. doi: 10.1002/art.39586. No abstract available.


Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.

Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI.

Biochimie. 2016 May;124:74-83. doi: 10.1016/j.biochi.2015.10.013. Epub 2015 Oct 22. Review.


Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats.

Fu Y, Huebner JL, Kraus VB, Griffin TM.

J Gerontol A Biol Sci Med Sci. 2016 Sep;71(9):1131-40. doi: 10.1093/gerona/glv151. Epub 2015 Oct 8.


Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses.

Kishibe M, Griffin TM, Radek KA.

Int Immunopharmacol. 2015 Nov;29(1):63-70. doi: 10.1016/j.intimp.2015.05.047. Epub 2015 Jun 10.


Mitochondrial respiration and redox coupling in articular chondrocytes.

Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM.

Arthritis Res Ther. 2015 Mar 10;17:54. doi: 10.1186/s13075-015-0566-9.


Deficiency in adipocyte chemokine receptor CXCR4 exacerbates obesity and compromises thermoregulatory responses of brown adipose tissue in a mouse model of diet-induced obesity.

Yao L, Heuser-Baker J, Herlea-Pana O, Zhang N, Szweda LI, Griffin TM, Barlic-Dicen J.

FASEB J. 2014 Oct;28(10):4534-50. doi: 10.1096/fj.14-249797. Epub 2014 Jul 11.


Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice.

Cai A, Hutchison E, Hudson J, Kawashima Y, Komori N, Singh A, Brush RS, Anderson RE, Sonntag WE, Matsumoto H, Griffin TM.

Osteoarthritis Cartilage. 2014 Sep;22(9):1301-9. doi: 10.1016/j.joca.2014.06.033. Epub 2014 Jul 4.


Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice.

Garteiser P, Doblas S, Towner RA, Griffin TM.

Metabolism. 2013 Nov;62(11):1686-95. doi: 10.1016/j.metabol.2013.06.009. Epub 2013 Jul 25.


Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet.

O'Conor CJ, Griffin TM, Liedtke W, Guilak F.

Ann Rheum Dis. 2013 Feb;72(2):300-4. doi: 10.1136/annrheumdis-2012-202272. Epub 2012 Nov 23.


Nicotinic acetylcholine receptor stimulation impairs epidermal permeability barrier function and recovery and modulates cornified envelope proteins.

Curtis BJ, Plichta JK, Blatt H, Droho S, Griffin TM, Radek KA.

Life Sci. 2012 Nov 27;91(21-22):1070-6. doi: 10.1016/j.lfs.2012.08.020. Epub 2012 Aug 22.


A novel mouse running wheel that senses individual limb forces: biomechanical validation and in vivo testing.

Roach GC, Edke M, Griffin TM.

J Appl Physiol (1985). 2012 Aug 15;113(4):627-35. doi: 10.1152/japplphysiol.00272.2012. Epub 2012 Jun 21.


Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation.

Issa RI, Griffin TM.

Pathobiol Aging Age Relat Dis. 2012 May 9;2(2012). pii: 17470.


Secondary transfer effects of interracial contact: the moderating role of social status.

Bowman NA, Griffin TM.

Cultur Divers Ethnic Minor Psychol. 2012 Jan;18(1):35-44. doi: 10.1037/a0026745.


Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise.

Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F.

Arthritis Rheum. 2012 Feb;64(2):443-53. doi: 10.1002/art.33332.


Adenovirus type 5 rupture of lysosomes leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species.

McGuire KA, Barlan AU, Griffin TM, Wiethoff CM.

J Virol. 2011 Oct;85(20):10806-13. doi: 10.1128/JVI.00675-11. Epub 2011 Aug 10.


Adenovirus membrane penetration activates the NLRP3 inflammasome.

Barlan AU, Griffin TM, McGuire KA, Wiethoff CM.

J Virol. 2011 Jan;85(1):146-55. doi: 10.1128/JVI.01265-10. Epub 2010 Oct 27.


Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice.

Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F.

Arthritis Res Ther. 2010;12(4):R130. doi: 10.1186/ar3068. Epub 2010 Jul 6.


Locomotor activity and gait in aged mice deficient for type IX collagen.

Costello KE, Guilak F, Setton LA, Griffin TM.

J Appl Physiol (1985). 2010 Jul;109(1):211-8. doi: 10.1152/japplphysiol.00056.2010. Epub 2010 Apr 1.


Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis.

Griffin TM, Huebner JL, Kraus VB, Guilak F.

Arthritis Rheum. 2009 Oct;60(10):2935-44. doi: 10.1002/art.24854.


Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen.

Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, Boyd LM, Setton LA.

Arthritis Rheum. 2009 Sep;60(9):2684-93. doi: 10.1002/art.24783.


The energetic cost of climbing in primates.

Hanna JB, Schmitt D, Griffin TM.

Science. 2008 May 16;320(5878):898. doi: 10.1126/science.1155504.


Influence of PKC-alpha overexpression on HSP70 and cardioprotection.

Coaxum SD, Griffin TM, Martin JL, Mestril R.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2220-6. Epub 2007 Jan 5.


Powering locomotion? It's a loaded question.

Griffin TM.

J Appl Physiol (1985). 2006 Nov;101(5):1273-4. Epub 2006 Jul 27. No abstract available.


Adaptive value of ambling gaits in primates and other mammals.

Schmitt D, Cartmill M, Griffin TM, Hanna JB, Lemelin P.

J Exp Biol. 2006 Jun;209(Pt 11):2042-9.


Overexpression of inducible 70-kDa heat shock protein in mouse attenuates skeletal muscle damage induced by cryolesioning.

Miyabara EH, Martin JL, Griffin TM, Moriscot AS, Mestril R.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1128-38. Epub 2005 Nov 16.


The role of mechanical loading in the onset and progression of osteoarthritis.

Griffin TM, Guilak F.

Exerc Sport Sci Rev. 2005 Oct;33(4):195-200. Review.


Biomechanical and energetic determinants of the walk-trot transition in horses.

Griffin TM, Kram R, Wickler SJ, Hoyt DF.

J Exp Biol. 2004 Nov;207(Pt 24):4215-23.

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