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Items: 1 to 50 of 982

1.

Structure-guided design of immunomodulatory RNAs specifically targeting the cytoplasmic viral RNA sensor RIG-I.

Yong HY, Zheng J, Ho VCY, Nguyen MT, Fink K, Griffin PR, Luo D.

FEBS Lett. 2019 Aug 1. doi: 10.1002/1873-3468.13564. [Epub ahead of print]

PMID:
31369683
2.

Protein dynamics and conformational changes explored by hydrogen/deuterium exchange mass spectrometry.

Zheng J, Strutzenberg T, Pascal BD, Griffin PR.

Curr Opin Struct Biol. 2019 Jul 25. pii: S0959-440X(18)30027-7. doi: 10.1016/j.sbi.2019.06.007. [Epub ahead of print] Review.

PMID:
31351767
3.

Learning in Practice: Collaboration Is the Way to Improve Health System Outcomes.

Van Dam PJ, Griffin P, Reeves NS, Prior SJ, Paton B, Verma R, Giles A, Kirkwood L, Peterson GM.

Healthcare (Basel). 2019 Jul 9;7(3). pii: E90. doi: 10.3390/healthcare7030090.

4.

Blunted Evoked Prouroguanylin Endocrine Secretion in Chronic Constipation.

Waldman SA, Tenenbaum R, Foehl HC, Winkle P, Griffin P.

Clin Transl Gastroenterol. 2019 Jul;10(7):e00016. doi: 10.14309/ctg.0000000000000016.

PMID:
31318728
5.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2019 Jul 11;178(2):507-508. doi: 10.1016/j.cell.2019.06.028. No abstract available.

PMID:
31299203
6.

Tracking genetic invasions: Genome-wide single nucleotide polymorphisms reveal the source of pyrethroid-resistant Aedes aegypti (yellow fever mosquito) incursions at international ports.

Schmidt TL, van Rooyen AR, Chung J, Endersby-Harshman NM, Griffin PC, Sly A, Hoffmann AA, Weeks AR.

Evol Appl. 2019 Mar 18;12(6):1136-1146. doi: 10.1111/eva.12787. eCollection 2019 Jun.

7.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.

8.

Rev-erbs and Glia-Implications for Neurodegenerative Diseases.

Griffin P, Dimitry JM, Musiek ES.

J Exp Neurosci. 2019 Jun 4;13:1179069519853233. doi: 10.1177/1179069519853233. eCollection 2019.

9.

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists.

Strutzenberg TS, Garcia-Ordonez RD, Novick SJ, Park H, Chang MR, Doebellin C, He Y, Patouret R, Kamenecka TM, Griffin PR.

Elife. 2019 Jun 7;8. pii: e47172. doi: 10.7554/eLife.47172.

10.

Preliminary incidence and trends of infections with pathogens transmitted commonly through food - Foodborne Diseases Active Surveillance Network, 10 U.S. sites, 2015-2018.

Tack DM, Marder EP, Griffin PM, Cieslak PR, Dunn J, Hurd S, Scallan E, Lathrop S, Muse A, Ryan P, Smith K, Tobin-D'Angelo M, Vugia DJ, Holt KG, Wolpert BJ, Tauxe R, Geissler AL.

Am J Transplant. 2019 Jun;19(6):1859-1863. doi: 10.1111/ajt.15412. No abstract available.

PMID:
31136702
11.

Altered airway ciliary orientation in patients with X-linked retinitis pigmentosa.

McCray G, Griffin P, Martinello P, de Iongh R, Ruddle J, Robinson P.

Thorax. 2019 Sep;74(9):914-916. doi: 10.1136/thoraxjnl-2018-212584. Epub 2019 May 20.

PMID:
31110053
12.

Data-driven modeling of diabetes care teams using social network analysis.

Ostovari M, Steele-Morris CJ, Griffin PM, Yu D.

J Am Med Inform Assoc. 2019 May 2. pii: ocz022. doi: 10.1093/jamia/ocz022. [Epub ahead of print]

PMID:
31045227
13.

Preliminary Incidence and Trends of Infections with Pathogens Transmitted Commonly Through Food - Foodborne Diseases Active Surveillance Network, 10 U.S. Sites, 2015-2018.

Tack DM, Marder EP, Griffin PM, Cieslak PR, Dunn J, Hurd S, Scallan E, Lathrop S, Muse A, Ryan P, Smith K, Tobin-D'Angelo M, Vugia DJ, Holt KG, Wolpert BJ, Tauxe R, Geissler AL.

MMWR Morb Mortal Wkly Rep. 2019 Apr 26;68(16):369-373. doi: 10.15585/mmwr.mm6816a2. Erratum in: MMWR Morb Mortal Wkly Rep. 2019 May 24;68(20):465.

14.

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase.

Law YS, Utt A, Tan YB, Zheng J, Wang S, Chen MW, Griffin PR, Merits A, Luo D.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9558-9567. doi: 10.1073/pnas.1900656116. Epub 2019 Apr 18.

PMID:
31000599
15.

A Re-Evaluation of Chironomid Deformities as an Environmental Stress Response: Avoiding Survivorship Bias and Testing Noncontaminant Biological Factors.

Gagliardi B, Long SM, Pettigrove VJ, Griffin PC, Hoffmann AA.

Environ Toxicol Chem. 2019 Aug;38(8):1658-1667. doi: 10.1002/etc.4446. Epub 2019 Jun 28.

PMID:
30998288
16.

Unique Polypharmacology Nuclear Receptor Modulator Blocks Inflammatory Signaling Pathways.

Chang MR, Ciesla A, Strutzenberg TS, Novick SJ, He Y, Garcia-Ordonez RD, Frkic RL, Bruning JB, Kamenecka TM, Griffin PR.

ACS Chem Biol. 2019 May 17;14(5):1051-1062. doi: 10.1021/acschembio.9b00236. Epub 2019 Apr 15.

PMID:
30951276
17.

International multiphase mixed methods study protocol to develop a cross-cultural patient-reported outcome and experience measure for hand conditions (HAND-Q).

Sierakowski K, Dean NR, Pusic AL, Cano SJ, Griffin PA, Bain GI, Klassen A, Lalonde D.

BMJ Open. 2019 Mar 20;9(3):e025822. doi: 10.1136/bmjopen-2018-025822.

18.

DSM265 at 400 Milligrams Clears Asexual Stage Parasites but Not Mature Gametocytes from the Blood of Healthy Subjects Experimentally Infected with Plasmodium falciparum.

Collins KA, Rückle T, Elliott S, Marquart L, Ballard E, Chalon S, Griffin P, Möhrle JJ, McCarthy JS.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01837-18. doi: 10.1128/AAC.01837-18. Print 2019 Apr.

19.

Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related receptor-α.

Doebelin C, He Y, Campbell S, Nuhant P, Kumar N, Koenig M, Garcia-Ordonez R, Chang MR, Roush WR, Lin L, Kahn S, Cameron MD, Griffin PR, Solt LA, Kamenecka TM.

Med Chem. 2019 Feb 22. doi: 10.2174/1573406415666190222124745. [Epub ahead of print]

PMID:
30799793
20.

Circadian clock protein Rev-erbα regulates neuroinflammation.

Griffin P, Dimitry JM, Sheehan PW, Lananna BV, Guo C, Robinette ML, Hayes ME, Cedeño MR, Nadarajah CJ, Ezerskiy LA, Colonna M, Zhang J, Bauer AQ, Burris TP, Musiek ES.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5102-5107. doi: 10.1073/pnas.1812405116. Epub 2019 Feb 21.

21.

Projecting the economic impact of silver diamine fluoride on caries treatment expenditures and outcomes in young U.S. children.

Johhnson B, Serban N, Griffin PM, Tomar SL.

J Public Health Dent. 2019 Feb 11. doi: 10.1111/jphd.12312. [Epub ahead of print]

PMID:
30741498
22.

Changes in Older Adults' Oral Health and Disparities: 1999 to 2004 and 2011 to 2016.

Griffin SO, Griffin PM, Li CH, Bailey WD, Brunson D, Jones JA.

J Am Geriatr Soc. 2019 Jun;67(6):1152-1157. doi: 10.1111/jgs.15777. Epub 2019 Jan 30.

PMID:
30698819
23.

The Scripps Molecular Screening Center and Translational Research Institute.

Baillargeon P, Fernandez-Vega V, Sridharan BP, Brown S, Griffin PR, Rosen H, Cravatt B, Scampavia L, Spicer TP.

SLAS Discov. 2019 Mar;24(3):386-397. doi: 10.1177/2472555218820809. Epub 2019 Jan 25.

PMID:
30682260
24.

Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone.

Mosure SA, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S, Kojetin DJ.

J Med Chem. 2019 Feb 28;62(4):2008-2023. doi: 10.1021/acs.jmedchem.8b01573. Epub 2019 Feb 7.

PMID:
30676741
25.

Genomic changes associated with adaptation to arid environments in cactophilic Drosophila species.

Rane RV, Pearce SL, Li F, Coppin C, Schiffer M, Shirriffs J, Sgrò CM, Griffin PC, Zhang G, Lee SF, Hoffmann AA, Oakeshott JG.

BMC Genomics. 2019 Jan 16;20(1):52. doi: 10.1186/s12864-018-5413-3.

26.

Qualitative study investigating the underlying motivations of healthy participants in phase I clinical trials.

Manton KJ, Gauld CS, White KM, Griffin PM, Elliott SL.

BMJ Open. 2019 Jan 15;9(1):e024224. doi: 10.1136/bmjopen-2018-024224.

27.

Dietary calcium affects body composition and lipid metabolism in rats.

Alomaim H, Griffin P, Swist E, Plouffe LJ, Vandeloo M, Demonty I, Kumar A, Bertinato J.

PLoS One. 2019 Jan 10;14(1):e0210760. doi: 10.1371/journal.pone.0210760. eCollection 2019.

28.

Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling.

Longbotham JE, Chio CM, Dharmarajan V, Trnka MJ, Torres IO, Goswami D, Ruiz K, Burlingame AL, Griffin PR, Fujimori DG.

Nat Commun. 2019 Jan 9;10(1):94. doi: 10.1038/s41467-018-07829-z.

29.

HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity.

Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR.

Nat Commun. 2018 Dec 18;9(1):5366. doi: 10.1038/s41467-018-07780-z.

30.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM.

Cell. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025. Erratum in: Cell. 2019 Jul 11;178(2):507-508.

PMID:
30550785
31.

Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex.

Patil DN, Rangarajan ES, Novick SJ, Pascal BD, Kojetin DJ, Griffin PR, Izard T, Martemyanov KA.

Elife. 2018 Dec 12;7. pii: e42150. doi: 10.7554/eLife.42150.

32.

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.

Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL.

Elife. 2018 Nov 29;7. pii: e37161. doi: 10.7554/eLife.37161.

33.

Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.

Yan Y, Zhou XE, Novick SJ, Shaw SJ, Li Y, Brunzelle JS, Hitoshi Y, Griffin PR, Xu HE, Melcher K.

J Biol Chem. 2019 Jan 18;294(3):953-967. doi: 10.1074/jbc.RA118.004883. Epub 2018 Nov 26.

PMID:
30478170
34.

Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1.

de Vera IMS, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, Hughes TS, Rance M, Griffin PR, Kojetin DJ.

Structure. 2019 Jan 2;27(1):66-77.e5. doi: 10.1016/j.str.2018.10.002. Epub 2018 Nov 8.

PMID:
30416039
35.

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ.

Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, Cano A, Heidari Z, Chrisman IM, Nemetchek MD, Blayo AL, Griffin PR, Kamenecka TM, Hughes TS, Kojetin DJ.

Nat Commun. 2018 Nov 8;9(1):4687. doi: 10.1038/s41467-018-07133-w.

36.

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1.

Lananna BV, Nadarajah CJ, Izumo M, Cedeño MR, Xiong DD, Dimitry J, Tso CF, McKee CA, Griffin P, Sheehan PW, Haspel JA, Barres BA, Liddelow SA, Takahashi JS, Karatsoreos IN, Musiek ES.

Cell Rep. 2018 Oct 2;25(1):1-9.e5. doi: 10.1016/j.celrep.2018.09.015.

37.

Long-term treatment with plecanatide was safe and tolerable in patients with irritable bowel syndrome with constipation.

Barish CF, Crozier RA, Griffin PH.

Curr Med Res Opin. 2018 Oct 9:1-5. doi: 10.1080/03007995.2018.1527303. [Epub ahead of print]

PMID:
30277094
38.

Concomitant HPV and MenACWY vaccination among sixth and seventh graders receiving Tdap.

Doke K, Fitzgerald SA, Barral RL, Griffin P, Ellerbeck EF.

Vaccine. 2018 Oct 29;36(45):6819-6825. doi: 10.1016/j.vaccine.2018.08.076. Epub 2018 Sep 25.

PMID:
30266487
39.

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.

Zhang C, Konermann S, Brideau NJ, Lotfy P, Wu X, Novick SJ, Strutzenberg T, Griffin PR, Hsu PD, Lyumkis D.

Cell. 2018 Sep 20;175(1):212-223.e17. doi: 10.1016/j.cell.2018.09.001.

PMID:
30241607
40.

A comparison of emotion-focused therapy and cognitive-behavioural therapy in the treatment of generalised anxiety disorder: study protocol for a randomised controlled trial.

Timulak L, Keogh D, Chigwedere C, Wilson C, Ward F, Hevey D, Griffin P, Jacobs L, Irwin B.

Trials. 2018 Sep 19;19(1):506. doi: 10.1186/s13063-018-2892-0.

41.

Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial.

Harris PNA, Tambyah PA, Lye DC, Mo Y, Lee TH, Yilmaz M, Alenazi TH, Arabi Y, Falcone M, Bassetti M, Righi E, Rogers BA, Kanj S, Bhally H, Iredell J, Mendelson M, Boyles TH, Looke D, Miyakis S, Walls G, Al Khamis M, Zikri A, Crowe A, Ingram P, Daneman N, Griffin P, Athan E, Lorenc P, Baker P, Roberts L, Beatson SA, Peleg AY, Harris-Brown T, Paterson DL; MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN).

JAMA. 2018 Sep 11;320(10):984-994. doi: 10.1001/jama.2018.12163. Erratum in: JAMA. 2019 Jun 18;321(23):2370.

42.

Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.

Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR.

Structure. 2018 Nov 6;26(11):1431-1439.e6. doi: 10.1016/j.str.2018.07.007. Epub 2018 Aug 23.

43.

Identification of potent RORβ modulators: Scaffold variation.

Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Novick S, Ciesla A, Campbell S, Solt LA, Griffin PR, Kamenecka TM.

Bioorg Med Chem Lett. 2018 Oct 15;28(19):3210-3215. doi: 10.1016/j.bmcl.2018.08.017. Epub 2018 Aug 16.

PMID:
30143422
44.

Identification of Antimalarial Inhibitors Using Late-Stage Gametocytes in a Phenotypic Live/Dead Assay.

Spicer TP, Gardiner DL, Schoenen FJ, Roy S, Griffin PR, Chase P, Scampavia L, Hodder P, Trenholme KR.

SLAS Discov. 2019 Jan;24(1):38-46. doi: 10.1177/2472555218796410. Epub 2018 Aug 24.

PMID:
30142014
45.

A Wolbachia infection from Drosophila that causes cytoplasmic incompatibility despite low prevalence and densities in males.

Richardson KM, Griffin PC, Lee SF, Ross PA, Endersby-Harshman NM, Schiffer M, Hoffmann AA.

Heredity (Edinb). 2019 Apr;122(4):428-440. doi: 10.1038/s41437-018-0133-7. Epub 2018 Aug 23.

PMID:
30139962
46.

Porous AlGaN-Based Ultraviolet Distributed Bragg Reflectors.

Griffin P, Zhu T, Oliver R.

Materials (Basel). 2018 Aug 21;11(9). pii: E1487. doi: 10.3390/ma11091487.

47.

T Cell Receptor-Independent, CD31/IL-17A-Driven Inflammatory Axis Shapes Synovitis in Juvenile Idiopathic Arthritis.

Ferguson ID, Griffin P, Michel JJ, Yano H, Gaffen SL, Mueller RG, Dvergsten JA, Piganelli JD, Rosenkranz ME, Kietz DA, Vallejo AN.

Front Immunol. 2018 Aug 6;9:1802. doi: 10.3389/fimmu.2018.01802. eCollection 2018.

48.

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix.

Frkic RL, Marshall AC, Blayo AL, Pukala TL, Kamenecka TM, Griffin PR, Bruning JB.

iScience. 2018 Feb 27;5:69-79. doi: 10.1016/j.isci.2018.06.012. Epub 2018 Jul 2.

49.

A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.

Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP.

J Mol Biol. 2018 Oct 19;430(21):4102-4118. doi: 10.1016/j.jmb.2018.08.009. Epub 2018 Aug 16.

PMID:
30120952
50.

Best practice data life cycle approaches for the life sciences.

Griffin PC, Khadake J, LeMay KS, Lewis SE, Orchard S, Pask A, Pope B, Roessner U, Russell K, Seemann T, Treloar A, Tyagi S, Christiansen JH, Dayalan S, Gladman S, Hangartner SB, Hayden HL, Ho WWH, Keeble-Gagnère G, Korhonen PK, Neish P, Prestes PR, Richardson MF, Watson-Haigh NS, Wyres KL, Young ND, Schneider MV.

Version 2. F1000Res. 2017 Aug 31 [revised 2018 Jan 1];6:1618. doi: 10.12688/f1000research.12344.2. eCollection 2017.

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