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Editorial: Innovative Biologics and Drugs to Target Renal Inflammation.

Griffin MD, Swaminathan S.

Front Pharmacol. 2020 Feb 6;11:38. doi: 10.3389/fphar.2020.00038. eCollection 2020. No abstract available.


Effects of mesenchymal stromal cells on regulatory T cells: Current understanding and clinical relevance.

Negi N, Griffin MD.

Stem Cells. 2020 Jan 29. doi: 10.1002/stem.3151. [Epub ahead of print]


The basis for non-canonical ROK family function in the N-acetylmannosamine kinase from the pathogen Staphylococcus aureus.

Coombes D, Davies JS, Newton-Vesty MC, Horne CR, Setty TG, Subramanian R, Moir JWB, Friemann R, Panjikar S, Griffin MDW, North RA, Dobson RCJ.

J Biol Chem. 2020 Mar 6;295(10):3301-3315. doi: 10.1074/jbc.RA119.010526. Epub 2020 Jan 15.


Senescence marker activin A is increased in human diabetic kidney disease: association with kidney function and potential implications for therapy.

Bian X, Griffin TP, Zhu X, Islam MN, Conley SM, Eirin A, Tang H, O'Shea PM, Palmer AK, McCoy RG, Herrmann SM, Mehta RA, Woollard JR, Rule AD, Kirkland JL, Tchkonia T, Textor SC, Griffin MD, Lerman LO, Hickson LJ.

BMJ Open Diabetes Res Care. 2019 Dec 15;7(1):e000720. doi: 10.1136/bmjdrc-2019-000720. eCollection 2019.


Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.

Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE.

Cell Death Dis. 2020 Jan 6;11(1):12. doi: 10.1038/s41419-019-2189-6.


Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential.

Griffin TP, Islam MN, Wall D, Ferguson J, Griffin DG, Griffin MD, O'Shea PM.

Sci Rep. 2019 Dec 5;9(1):18452. doi: 10.1038/s41598-019-54762-2.


High-risk Corneal Transplantation: Recent Developments and Future Possibilities.

Armitage WJ, Goodchild C, Griffin MD, Gunn DJ, Hjortdal J, Lohan P, Murphy CC, Pleyer U, Ritter T, Tole DM, Vabres B.

Transplantation. 2019 Dec;103(12):2468-2478. doi: 10.1097/TP.0000000000002938.


Human mesenchymal stromal cells broadly modulate high glucose-induced inflammatory responses of renal proximal tubular cell monolayers.

Islam MN, Griffin TP, Sander E, Rocks S, Qazi J, Cabral J, McCaul J, McMorrow T, Griffin MD.

Stem Cell Res Ther. 2019 Nov 19;10(1):329. doi: 10.1186/s13287-019-1424-5.


Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface.

Hossain MA, Larrous F, Rawlinson SM, Zhan J, Sethi A, Ibrahim Y, Aloi M, Lieu KG, Mok YF, Griffin MDW, Ito N, Ose T, Bourhy H, Moseley GW, Gooley PR.

Cell Rep. 2019 Nov 12;29(7):1934-1945.e8. doi: 10.1016/j.celrep.2019.10.020.


Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3.

Huang A, Burke J, Bunker RD, Mok YF, Griffin MD, Baker EN, Loomes KM.

Biochem J. 2019 Nov 15;476(21):3369-3383. doi: 10.1042/BCJ20190548.


Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.

Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE.

Cell Death Dis. 2019 Aug 16;10(9):622. doi: 10.1038/s41419-019-1847-z. Erratum in: Cell Death Dis. 2020 Jan 6;11(1):12.


The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.

Xie SC, Metcalfe RD, Hanssen E, Yang T, Gillett DL, Leis AP, Morton CJ, Kuiper MJ, Parker MW, Spillman NJ, Wong W, Tsu C, Dick LR, Griffin MDW, Tilley L.

Nat Microbiol. 2019 Nov;4(11):1990-2000. doi: 10.1038/s41564-019-0524-4. Epub 2019 Aug 5.


The Complex Role of Interleukin 6 in Regulating T-cell Responses during Acute Glomerulonephritis.

Cormican S, Griffin MD.

J Am Soc Nephrol. 2019 Aug;30(8):1341-1344. doi: 10.1681/ASN.2019050453. Epub 2019 Jul 16. No abstract available.


Bacterial Cholangitis in Autosomal Dominant Polycystic Kidney and Liver Disease.

Martin WP, Vaughan LE, Yoshida K, Takahashi N, Edwards ME, Metzger A, Senum SR, Masyuk TV, LaRusso NF, Griffin MD, El-Zoghby Z, Harris PC, Kremers WK, Nagorney DM, Kamath PS, Torres VE, Hogan MC.

Mayo Clin Proc Innov Qual Outcomes. 2019 May 27;3(2):149-159. doi: 10.1016/j.mayocpiqo.2019.03.004. eCollection 2019 Jun.


Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study.

McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V, Bellani G, Griffin MD, Ranieri M, Laffey JG; ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators.

Crit Care Med. 2019 Sep;47(9):1216-1225. doi: 10.1097/CCM.0000000000003832.


Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors.

Cheung Tung Shing KS, Broughton SE, Nero TL, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW, Perkins AC, Dhagat U.

Sci Rep. 2019 May 21;9(1):7851. doi: 10.1038/s41598-019-43988-9.


TNF-α/IL-1β-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung.

Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T.

FASEB J. 2019 Aug;33(8):9404-9421. doi: 10.1096/fj.201900047R. Epub 2019 May 20.


Structure-function analyses of two plant meso-diaminopimelate decarboxylase isoforms reveal that active-site gating provides stereochemical control.

Crowther JM, Cross PJ, Oliver MR, Leeman MM, Bartl AJ, Weatherhead AW, North RA, Donovan KA, Griffin MDW, Suzuki H, Hudson AO, Kasanmascheff M, Dobson RCJ.

J Biol Chem. 2019 May 24;294(21):8505-8515. doi: 10.1074/jbc.RA118.006825. Epub 2019 Apr 8.


Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.

Thilakasiri P, Huynh J, Poh AR, Tan CW, Nero TL, Tran K, Parslow AC, Afshar-Sterle S, Baloyan D, Hannan NJ, Buchert M, Scott AM, Griffin MD, Hollande F, Parker MW, Putoczki TL, Ernst M, Chand AL.

EMBO Mol Med. 2019 Apr;11(4). pii: e9539. doi: 10.15252/emmm.201809539.


Monogenic causes of chronic kidney disease in adults.

Connaughton DM, Kennedy C, Shril S, Mann N, Murray SL, Williams PA, Conlon E, Nakayama M, van der Ven AT, Ityel H, Kause F, Kolvenbach CM, Dai R, Vivante A, Braun DA, Schneider R, Kitzler TM, Moloney B, Moran CP, Smyth JS, Kennedy A, Benson K, Stapleton C, Denton M, Magee C, O'Seaghdha CM, Plant WD, Griffin MD, Awan A, Sweeney C, Mane SM, Lifton RP, Griffin B, Leavey S, Casserly L, de Freitas DG, Holian J, Dorman A, Doyle B, Lavin PJ, Little MA, Conlon PJ, Hildebrandt F.

Kidney Int. 2019 Apr;95(4):914-928. doi: 10.1016/j.kint.2018.10.031. Epub 2019 Feb 14.


Chronic Kidney Disease Severity Is Associated With Selective Expansion of a Distinctive Intermediate Monocyte Subpopulation.

Naicker SD, Cormican S, Griffin TP, Maretto S, Martin WP, Ferguson JP, Cotter D, Connaughton EP, Dennedy MC, Griffin MD.

Front Immunol. 2018 Dec 6;9:2845. doi: 10.3389/fimmu.2018.02845. eCollection 2018.


Threading the Needle: Individualized Monitoring Guides the Transition From Cytomegalovirus Prophylaxis to Primary Immune Response in a Face Transplant Recipient.

Griffin MD.

Mayo Clin Proc. 2019 Jan;94(1):10-12. doi: 10.1016/j.mayocp.2018.11.015. No abstract available.


Effect of Sodium Glucose Co-Transporter-2 Inhibition on the Aldosterone/Renin Ratio in Type 2 Diabetes Mellitus.

Griffin TP, Islam MN, Blake L, Bell M, Griffin MD, O'Shea PM.

Horm Metab Res. 2019 Feb;51(2):91-99. doi: 10.1055/a-0794-7026. Epub 2018 Dec 6.


Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation.

Lohan P, Murphy N, Treacy O, Lynch K, Morcos M, Chen B, Ryan AE, Griffin MD, Ritter T.

Front Immunol. 2018 Nov 20;9:2666. doi: 10.3389/fimmu.2018.02666. eCollection 2018.


Increased Weight Gain During the Long Interdialytic Period Is Associated with Minor Effects on Blood Pressure Control in Clinically Stable In-Centre Haemodialysis Patients.

Shantier M, Martin WP, Singh R, McDermott P, Gallen R, Suleiman S, Reddan DN, Giblin L, Lappin D, O'Meara YM, Griffin MD.

Nephron. 2019;141(2):87-97. doi: 10.1159/000494221. Epub 2018 Nov 9.


Influence of Referral to a Combined Diabetology and Nephrology Clinic on Renal Functional Trends and Metabolic Parameters in Adults With Diabetic Kidney Disease.

Martin WP, Griffin TP, Lappin DW, Griffin DG, Ferguson JP, O'Brien T, Griffin MD.

Mayo Clin Proc Innov Qual Outcomes. 2017 Sep 1;1(2):150-160. doi: 10.1016/j.mayocpiqo.2017.07.003. eCollection 2017 Sep.


Defining reference intervals for a serum growth differentiation factor-15 (GDF-15) assay in a Caucasian population and its potential utility in diabetic kidney disease (DKD).

Hamon SM, Griffin TP, Islam MN, Wall D, Griffin MD, O'Shea PM.

Clin Chem Lab Med. 2019 Mar 26;57(4):510-520. doi: 10.1515/cclm-2018-0534.


Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3.

Traore DAK, Wisniewski JA, Flanigan SF, Conroy PJ, Panjikar S, Mok YF, Lao C, Griffin MDW, Adams V, Rood JI, Whisstock JC.

Nat Commun. 2018 Sep 13;9(1):3732. doi: 10.1038/s41467-018-06096-2.


EPO does not promote interaction between the erythropoietin and beta-common receptors.

Cheung Tung Shing KS, Broughton SE, Nero TL, Gillinder K, Ilsley MD, Ramshaw H, Lopez AF, Griffin MDW, Parker MW, Perkins AC, Dhagat U.

Sci Rep. 2018 Aug 20;8(1):12457. doi: 10.1038/s41598-018-29865-x. Erratum in: Sci Rep. 2019 May 21;9(1):7851.


Allogeneic Mesenchymal Stromal Cells (MSCs) are of Comparable Efficacy to Syngeneic MSCs for Therapeutic Revascularization in C57BKSdb/db Mice Despite the Induction of Alloantibody.

Liew A, Baustian C, Thomas D, Vaughan E, Sanz-Nogués C, Creane M, Chen X, Alagesan S, Owens P, Horan J, Dockery P, Griffin MD, Duffy A, O'Brien T.

Cell Transplant. 2018 Aug;27(8):1210-1221. doi: 10.1177/0963689718784862. Epub 2018 Jul 17.


Cryo-EM structure of an essential Plasmodium vivax invasion complex.

Gruszczyk J, Huang RK, Chan LJ, Menant S, Hong C, Murphy JM, Mok YF, Griffin MDW, Pearson RD, Wong W, Cowman AF, Yu Z, Tham WH.

Nature. 2018 Jul;559(7712):135-139. doi: 10.1038/s41586-018-0249-1. Epub 2018 Jun 27.


Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis.

Petrie EJ, Sandow JJ, Jacobsen AV, Smith BJ, Griffin MDW, Lucet IS, Dai W, Young SN, Tanzer MC, Wardak A, Liang LY, Cowan AD, Hildebrand JM, Kersten WJA, Lessene G, Silke J, Czabotar PE, Webb AI, Murphy JM.

Nat Commun. 2018 Jun 21;9(1):2422. doi: 10.1038/s41467-018-04714-7.


Substrate Locking Promotes Dimer-Dimer Docking of an Enzyme Antibiotic Target.

Atkinson SC, Dogovski C, Wood K, Griffin MDW, Gorman MA, Hor L, Reboul CF, Buckle AM, Wuttke J, Parker MW, Dobson RCJ, Perugini MA.

Structure. 2018 Jul 3;26(7):948-959.e5. doi: 10.1016/j.str.2018.04.014. Epub 2018 May 24.


Polymorphism in disease-related apolipoprotein C-II amyloid fibrils: a structural model for rod-like fibrils.

Zlatic CO, Mao Y, Todorova N, Mok YF, Howlett GJ, Yarovsky I, Gooley PR, Griffin MDW.

FEBS J. 2018 Aug;285(15):2799-2812. doi: 10.1111/febs.14517. Epub 2018 Jun 9.


Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat.

Lohan P, Treacy O, Morcos M, Donohoe E, O'donoghue Y, Ryan AE, Elliman SJ, Ritter T, Griffin MD.

Stem Cells. 2018 Aug;36(8):1210-1215. doi: 10.1002/stem.2840. Epub 2018 May 16.


Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A.

Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003.


Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression.

Connaughton EP, Naicker S, Hanley SA, Slevin SM, Eykelenboom JK, Lowndes NF, O'Brien T, Ceredig R, Griffin MD, Dennedy MC.

Immunol Cell Biol. 2018 Mar 5. doi: 10.1111/imcb.12032. [Epub ahead of print]


Anti-donor antibody induction following intramuscular injections of allogeneic mesenchymal stromal cells.

Alagesan S, Sanz-Nogués C, Chen X, Creane M, Ritter T, Ceredig R, O'Brien T, Griffin MD.

Immunol Cell Biol. 2018 May;96(5):536-548. doi: 10.1111/imcb.12024. Epub 2018 Mar 23.


The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis.

Davies KA, Tanzer MC, Griffin MDW, Mok YF, Young SN, Qin R, Petrie EJ, Czabotar PE, Silke J, Murphy JM.

Cell Death Differ. 2018 Sep;25(9):1567-1580. doi: 10.1038/s41418-018-0061-3. Epub 2018 Feb 14.


Extracellular vesicles as modulators of wound healing.

Cabral J, Ryan AE, Griffin MD, Ritter T.

Adv Drug Deliv Rev. 2018 Apr;129:394-406. doi: 10.1016/j.addr.2018.01.018. Epub 2018 Jan 31. Review.


Factors influencing health-related quality of life in patients with Type 1 diabetes.

Raymakers AJN, Gillespie P, O'Hara MC, Griffin MD, Dinneen SF.

Health Qual Life Outcomes. 2018 Feb 2;16(1):27. doi: 10.1186/s12955-018-0848-4.


A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY.

Scott DJ, Gunn NJ, Yong KJ, Wimmer VC, Veldhuis NA, Challis LM, Haidar M, Petrou S, Bathgate RAD, Griffin MDW.

Sci Rep. 2018 Jan 12;8(1):667. doi: 10.1038/s41598-017-18045-y.


Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

Gruszczyk J, Kanjee U, Chan LJ, Menant S, Malleret B, Lim NTY, Schmidt CQ, Mok YF, Lin KM, Pearson RD, Rangel G, Smith BJ, Call MJ, Weekes MP, Griffin MDW, Murphy JM, Abraham J, Sriprawat K, Menezes MJ, Ferreira MU, Russell B, Renia L, Duraisingh MT, Tham WH.

Science. 2018 Jan 5;359(6371):48-55. doi: 10.1126/science.aan1078.


Identification of a second binding site on the TRIM25 B30.2 domain.

D'Cruz AA, Kershaw NJ, Hayman TJ, Linossi EM, Chiang JJ, Wang MK, Dagley LF, Kolesnik TB, Zhang JG, Masters SL, Griffin MDW, Gack MU, Murphy JM, Nicola NA, Babon JJ, Nicholson SE.

Biochem J. 2018 Jan 23;475(2):429-440. doi: 10.1042/BCJ20170427.


Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?

Lohan P, Treacy O, Griffin MD, Ritter T, Ryan AE.

Front Immunol. 2017 Nov 24;8:1626. doi: 10.3389/fimmu.2017.01626. eCollection 2017. Review.


Unravelling the Carbohydrate-Binding Preferences of the Carbohydrate-Binding Modules of AMP-Activated Protein Kinase.

Mobbs JI, Di Paolo A, Metcalfe RD, Selig E, Stapleton DI, Griffin MDW, Gooley PR.

Chembiochem. 2018 Feb 2;19(3):229-238. doi: 10.1002/cbic.201700589. Epub 2018 Jan 9.


Patient reported health status and all-cause mortality in patients with coronary heart disease.

Raymakers AJN, Gillespie P, Murphy E, Cupples ME, Smith SM, Murphy AW, Griffin MD, Benyamini Y, Byrne M.

Fam Pract. 2018 Mar 27;35(2):172-178. doi: 10.1093/fampra/cmx094.


Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association.

Patel O, Griffin MDW, Panjikar S, Dai W, Ma X, Chan H, Zheng C, Kropp A, Murphy JM, Daly RJ, Lucet IS.

Nat Commun. 2017 Oct 27;8(1):1157. doi: 10.1038/s41467-017-01279-9.


Distinctive Surface Glycosylation Patterns Associated With Mouse and Human CD4+ Regulatory T Cells and Their Suppressive Function.

Cabral J, Hanley SA, Gerlach JQ, O'Leary N, Cunningham S, Ritter T, Ceredig R, Joshi L, Griffin MD.

Front Immunol. 2017 Aug 21;8:987. doi: 10.3389/fimmu.2017.00987. eCollection 2017.


Urinary nanovesicles captured by lectins or antibodies demonstrate variations in size and surface glycosylation profile.

Gerlach JQ, Maguire CM, Krüger A, Joshi L, Prina-Mello A, Griffin MD.

Nanomedicine (Lond). 2017 Jun;12(11):1217-1229. doi: 10.2217/nnm-2017-0016. Epub 2017 May 18.


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