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FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cader MZ, de Almeida Rodrigues RP, West JA, Sewell GW, Md-Ibrahim MN, Reikine S, Sirago G, Unger LW, Iglesias-Romero AB, Ramshorn K, Haag LM, Saveljeva S, Ebel JF, Rosenstiel P, Kaneider NC, Lee JC, Lawley TD, Bradley A, Dougan G, Modis Y, Griffin JL, Kaser A.

Cell. 2020 Jan 23;180(2):278-295.e23. doi: 10.1016/j.cell.2019.12.017.


Twenty years of metabonomics: so what has metabonomics done for toxicology?

Griffin JL.

Xenobiotica. 2020 Jan;50(1):110-114. doi: 10.1080/00498254.2019.1697015. Epub 2019 Dec 12.


A model for determining cardiac mitochondrial substrate utilisation using stable 13C-labelled metabolites.

Lindsay RT, Demetriou D, Manetta-Jones D, West JA, Murray AJ, Griffin JL.

Metabolomics. 2019 Nov 26;15(12):154. doi: 10.1007/s11306-019-1618-y.


The microbiota regulates murine inflammatory responses to toxin-induced CNS demyelination but has minimal impact on remyelination.

McMurran CE, Guzman de la Fuente A, Penalva R, Ben Menachem-Zidon O, Dombrowski Y, Falconer J, Gonzalez GA, Zhao C, Krause FN, Young AMH, Griffin JL, Jones CA, Hollins C, Heimesaat MM, Fitzgerald DC, Franklin RJM.

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25311-25321. doi: 10.1073/pnas.1905787116. Epub 2019 Nov 18.


A Combination of Metabolites Predicts Adherence to the Mediterranean Diet Pattern and Its Associations with Insulin Sensitivity and Lipid Homeostasis in the General Population: The Fenland Study, United Kingdom.

Tong TYN, Koulman A, Griffin JL, Wareham NJ, Forouhi NG, Imamura F.

J Nutr. 2019 Oct 26. pii: nxz263. doi: 10.1093/jn/nxz263. [Epub ahead of print]


NMR-Based Metabolomics in Cardiac Research.

Griffin JL, Castro C.

Methods Mol Biol. 2019;2037:189-194. doi: 10.1007/978-1-4939-9690-2_11.


Dysbiosis associated with acute helminth infections in herbivorous youngstock - observations and implications.

Peachey LE, Castro C, Molena RA, Jenkins TP, Griffin JL, Cantacessi C.

Sci Rep. 2019 Jul 31;9(1):11121. doi: 10.1038/s41598-019-47204-6.


XBP-1 Remodels Lipid Metabolism to Extend Longevity.

Imanikia S, Sheng M, Castro C, Griffin JL, Taylor RC.

Cell Rep. 2019 Jul 16;28(3):581-589.e4. doi: 10.1016/j.celrep.2019.06.057.


Metabolic Profiling of the Diabetic Heart: Toward a Richer Picture.

Sowton AP, Griffin JL, Murray AJ.

Front Physiol. 2019 May 31;10:639. doi: 10.3389/fphys.2019.00639. eCollection 2019. Review.


Cytosine-5 RNA methylation links protein synthesis to cell metabolism.

Gkatza NA, Castro C, Harvey RF, Heiß M, Popis MC, Blanco S, Bornelöv S, Sajini AA, Gleeson JG, Griffin JL, West JA, Kellner S, Willis AE, Dietmann S, Frye M.

PLoS Biol. 2019 Jun 14;17(6):e3000297. doi: 10.1371/journal.pbio.3000297. eCollection 2019 Jun.


Author Correction: A comprehensive analysis of the faecal microbiome and metabolome of Strongyloides stercoralis infected volunteers from a non-endemic area.

Jenkins TP, Formenti F, Castro C, Piubelli C, Perandin F, Buonfrate D, Otranto D, Griffin JL, Krause L, Bisoffi Z, Cantacessi C.

Sci Rep. 2019 Jun 7;9(1):8571. doi: 10.1038/s41598-019-43508-9.


A randomized 3-way crossover study indicates that high-protein feeding induces de novo lipogenesis in healthy humans.

Charidemou E, Ashmore T, Li X, McNally BD, West JA, Liggi S, Harvey M, Orford E, Griffin JL.

JCI Insight. 2019 May 30;4(12). pii: 124819. doi: 10.1172/jci.insight.124819. eCollection 2019 Jun 20.


Ice-Age Climate Adaptations Trap the Alpine Marmot in a State of Low Genetic Diversity.

Gossmann TI, Shanmugasundram A, Börno S, Duvaux L, Lemaire C, Kuhl H, Klages S, Roberts LD, Schade S, Gostner JM, Hildebrand F, Vowinckel J, Bichet C, Mülleder M, Calvani E, Zelezniak A, Griffin JL, Bork P, Allaine D, Cohas A, Welch JJ, Timmermann B, Ralser M.

Curr Biol. 2019 May 20;29(10):1712-1720.e7. doi: 10.1016/j.cub.2019.04.020. Epub 2019 May 9.


A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids.

Hinz C, Liggi S, Mocciaro G, Jung S, Induruwa I, Pereira M, Bryant CE, Meckelmann SW, O'Donnell VB, Farndale RW, Fjeldsted J, Griffin JL.

Anal Chem. 2019 Jul 2;91(13):8025-8035. doi: 10.1021/acs.analchem.8b04615. Epub 2019 Jun 18.


The Metabolomics Society-Current State of the Membership and Future Directions.

Zanetti KA, Hall RD, Griffin JL, Putri S, Salek RM, Styczynski MP, Tugizimana F, van der Hooft JJJ.

Metabolites. 2019 May 3;9(5). pii: E89. doi: 10.3390/metabo9050089.


Changes in plasma phospholipid fatty acid profiles over 13 years and correlates of change: European Prospective Investigation into Cancer and Nutrition-Norfolk Study.

Zheng JS, Imamura F, Sharp SJ, Koulman A, Griffin JL, Mulligan AA, Luben R, Khaw KT, Wareham NJ, Forouhi NG.

Am J Clin Nutr. 2019 Jun 1;109(6):1527-1534. doi: 10.1093/ajcn/nqz030.


An Unbiased Lipid Phenotyping Approach To Study the Genetic Determinants of Lipids and Their Association with Coronary Heart Disease Risk Factors.

Harshfield EL, Koulman A, Ziemek D, Marney L, Fauman EB, Paul DS, Stacey D, Rasheed A, Lee JJ, Shah N, Jabeen S, Imran A, Abbas S, Hina Z, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Qureshi IH, Ishaq M, Frossard P, Danesh J, Saleheen D, Butterworth AS, Wood AM, Griffin JL.

J Proteome Res. 2019 Jun 7;18(6):2397-2410. doi: 10.1021/acs.jproteome.8b00786. Epub 2019 Apr 26.


Assessing the causal association of glycine with risk of cardio-metabolic diseases.

Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P, Karthikeyan S, Day FR, Koulman A, Imamura F, Zeng L, Erdmann J, Schunkert H, Khaw KT, Griffin JL, Forouhi NG, Scott RA, Wood AM, Burgess S, Howson JMM, Danesh J, Wareham NJ, Butterworth AS, Langenberg C.

Nat Commun. 2019 Mar 5;10(1):1060. doi: 10.1038/s41467-019-08936-1.


Italian cohort of patients affected by inflammatory bowel disease is characterised by variation in glycerophospholipid, free fatty acids and amino acid levels.

Murgia A, Hinz C, Liggi S, Denes J, Hall Z, West J, Santoru ML, Piras C, Manis C, Usai P, Atzori L, Griffin JL, Caboni P.

Metabolomics. 2018 Oct 10;14(10):140. doi: 10.1007/s11306-018-1439-4.


Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp.

O'Brien KA, Atkinson RA, Richardson L, Koulman A, Murray AJ, Harridge SDR, Martin DS, Levett DZH, Mitchell K, Mythen MG, Montgomery HE, Grocott MPW, Griffin JL, Edwards LM.

Sci Rep. 2019 Feb 19;9(1):2297. doi: 10.1038/s41598-019-38832-z.


Ten years of Genome Medicine.

Auffray C, Griffin JL, Khoury MJ, Lupski JR, Schwab M.

Genome Med. 2019 Feb 15;11(1):7. doi: 10.1186/s13073-019-0618-x. No abstract available.


Crosstalk between Metabolic Alterations and Altered Redox Balance in PTC-Derived Cell Lines.

Tronci L, Caria P, Frau DV, Liggi S, Piras C, Murgia F, Santoru ML, Pibiri M, Deiana M, Griffin JL, Vanni R, Atzori L.

Metabolites. 2019 Feb 1;9(2). pii: E23. doi: 10.3390/metabo9020023.


The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.

Perucha E, Melchiotti R, Bibby JA, Wu W, Frederiksen KS, Roberts CA, Hall Z, LeFriec G, Robertson KA, Lavender P, Gerwien JG, Taams LS, Griffin JL, de Rinaldis E, van Baarsen LGM, Kemper C, Ghazal P, Cope AP.

Nat Commun. 2019 Jan 30;10(1):498. doi: 10.1038/s41467-019-08332-9.


A comprehensive analysis of the faecal microbiome and metabolome of Strongyloides stercoralis infected volunteers from a non-endemic area.

Jenkins TP, Formenti F, Castro C, Piubelli C, Perandin F, Buonfrate D, Otranto D, Griffin JL, Krause L, Bisoffi Z, Cantacessi C.

Sci Rep. 2018 Oct 23;8(1):15651. doi: 10.1038/s41598-018-33937-3. Erratum in: Sci Rep. 2019 Jun 7;9(1):8571.


Devil in the Detail: Intratumour Heterogeneity and Personalised Medicine for Bladder Cancer.

Griffin JL.

Eur Urol. 2019 Jan;75(1):23-24. doi: 10.1016/j.eururo.2018.09.036. Epub 2018 Oct 3. No abstract available.


Metabolomic Alterations in Thyrospheres and Adherent Parental Cells in Papillary Thyroid Carcinoma Cell Lines: A Pilot Study.

Caria P, Tronci L, Dettori T, Murgia F, Santoru ML, Griffin JL, Vanni R, Atzori L.

Int J Mol Sci. 2018 Sep 27;19(10). pii: E2948. doi: 10.3390/ijms19102948.


Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes.

Dodd MS, Sousa Fialho MDL, Montes Aparicio CN, Kerr M, Timm KN, Griffin JL, Luiken JJFP, Glatz JFC, Tyler DJ, Heather LC.

JACC Basic Transl Sci. 2018 Aug 28;3(4):485-498. doi: 10.1016/j.jacbts.2018.04.005. eCollection 2018 Aug.


Deletion of Stearoyl-CoA Desaturase-1 From the Intestinal Epithelium Promotes Inflammation and Tumorigenesis, Reversed by Dietary Oleate.

Ducheix S, Peres C, Härdfeldt J, Frau C, Mocciaro G, Piccinin E, Lobaccaro JM, De Santis S, Chieppa M, Bertrand-Michel J, Plateroti M, Griffin JL, Sabbà C, Ntambi JM, Moschetta A.

Gastroenterology. 2018 Nov;155(5):1524-1538.e9. doi: 10.1053/j.gastro.2018.07.032. Epub 2018 Jul 29.


A dietary pattern derived using B-vitamins and its relationship with vascular markers over the life course.

Maddock J, Ambrosini GL, Griffin JL, West JA, Wong A, Hardy R, Ray S.

Clin Nutr. 2019 Jun;38(3):1464-1473. doi: 10.1016/j.clnu.2018.06.969. Epub 2018 Jun 28.


Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA.

Circulation. 2018 Nov 20;138(21):2367-2378. doi: 10.1161/CIRCULATIONAHA.118.033540.


Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL.

Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8.


Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes.

Mena P, Ludwig IA, Tomatis VB, Acharjee A, Calani L, Rosi A, Brighenti F, Ray S, Griffin JL, Bluck LJ, Del Rio D.

Eur J Nutr. 2019 Jun;58(4):1529-1543. doi: 10.1007/s00394-018-1683-4. Epub 2018 Apr 3.


KniMet: a pipeline for the processing of chromatography-mass spectrometry metabolomics data.

Liggi S, Hinz C, Hall Z, Santoru ML, Poddighe S, Fjeldsted J, Atzori L, Griffin JL.

Metabolomics. 2018;14(4):52. doi: 10.1007/s11306-018-1349-5. Epub 2018 Mar 16.


Author Correction: Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

Santoru ML, Piras C, Murgia A, Palmas V, Camboni T, Liggi S, Ibba I, Lai MA, Orrù S, Blois S, Loizedda AL, Griffin JL, Usai P, Caboni P, Atzori L, Manzin A.

Sci Rep. 2018 Mar 19;8(1):4993. doi: 10.1038/s41598-018-23330-5.


Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes.

Mazzon M, Castro C, Thaa B, Liu L, Mutso M, Liu X, Mahalingam S, Griffin JL, Marsh M, McInerney GM.

PLoS Pathog. 2018 Jan 29;14(1):e1006835. doi: 10.1371/journal.ppat.1006835. eCollection 2018 Jan.


Nox4 reprograms cardiac substrate metabolism via protein O-GlcNAcylation to enhance stress adaptation.

Nabeebaccus AA, Zoccarato A, Hafstad AD, Santos CX, Aasum E, Brewer AC, Zhang M, Beretta M, Yin X, West JA, Schröder K, Griffin JL, Eykyn TR, Abel ED, Mayr M, Shah AM.

JCI Insight. 2017 Dec 21;2(24). pii: 96184. doi: 10.1172/jci.insight.96184.


The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics.

Hinz C, Liggi S, Griffin JL.

Curr Opin Chem Biol. 2018 Feb;42:42-50. doi: 10.1016/j.cbpa.2017.10.018. Epub 2017 Nov 13. Review.


How to bridge metabolomics and genomics.

Atzori L, Griffin JL.

Int J Biochem Cell Biol. 2017 Dec;93:87-88. doi: 10.1016/j.biocel.2017.11.001. Epub 2017 Nov 8. No abstract available.


Metabolomics applied to diabetes-lessons from human population studies.

Liggi S, Griffin JL.

Int J Biochem Cell Biol. 2017 Dec;93:136-147. doi: 10.1016/j.biocel.2017.10.011. Epub 2017 Oct 23. Review.


nmrML: A Community Supported Open Data Standard for the Description, Storage, and Exchange of NMR Data.

Schober D, Jacob D, Wilson M, Cruz JA, Marcu A, Grant JR, Moing A, Deborde C, de Figueiredo LF, Haug K, Rocca-Serra P, Easton J, Ebbels TMD, Hao J, Ludwig C, Günther UL, Rosato A, Klein MS, Lewis IA, Luchinat C, Jones AR, Grauslys A, Larralde M, Yokochi M, Kobayashi N, Porzel A, Griffin JL, Viant MR, Wishart DS, Steinbeck C, Salek RM, Neumann S.

Anal Chem. 2018 Jan 2;90(1):649-656. doi: 10.1021/acs.analchem.7b02795. Epub 2017 Dec 14.


A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study.

Imamura F, Sharp SJ, Koulman A, Schulze MB, Kröger J, Griffin JL, Huerta JM, Guevara M, Sluijs I, Agudo A, Ardanaz E, Balkau B, Boeing H, Chajes V, Dahm CC, Dow C, Fagherazzi G, Feskens EJM, Franks PW, Gavrila D, Gunter M, Kaaks R, Key TJ, Khaw KT, Kühn T, Melander O, Molina-Portillo E, Nilsson PM, Olsen A, Overvad K, Palli D, Panico S, Rolandsson O, Sieri S, Sacerdote C, Slimani N, Spijkerman AMW, Tjønneland A, Tumino R, van der Schouw YT, Langenberg C, Riboli E, Forouhi NG, Wareham NJ.

PLoS Med. 2017 Oct 11;14(10):e1002409. doi: 10.1371/journal.pmed.1002409. eCollection 2017 Oct.


Metabolomics and Lipidomics Study of Mouse Models of Type 1 Diabetes Highlights Divergent Metabolism in Purine and Tryptophan Metabolism Prior to Disease Onset.

Murfitt SA, Zaccone P, Wang X, Acharjee A, Sawyer Y, Koulman A, Roberts LD, Cooke A, Griffin JL.

J Proteome Res. 2018 Mar 2;17(3):946-960. doi: 10.1021/acs.jproteome.7b00489. Epub 2018 Feb 12.


massPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.

Bond NJ, Koulman A, Griffin JL, Hall Z.

Metabolomics. 2017;13(11):128. doi: 10.1007/s11306-017-1252-5. Epub 2017 Sep 21.


Metabolomics As a Tool for the Characterization of Drug-Resistant Epilepsy.

Murgia F, Muroni A, Puligheddu M, Polizzi L, Barberini L, Orofino G, Solla P, Poddighe S, Del Carratore F, Griffin JL, Atzori L, Marrosu F.

Front Neurol. 2017 Sep 4;8:459. doi: 10.3389/fneur.2017.00459. eCollection 2017.


Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.

Santoru ML, Piras C, Murgia A, Palmas V, Camboni T, Liggi S, Ibba I, Lai MA, Orrù S, Blois S, Loizedda AL, Griffin JL, Usai P, Caboni P, Atzori L, Manzin A.

Sci Rep. 2017 Aug 25;7(1):9523. doi: 10.1038/s41598-017-10034-5. Erratum in: Sci Rep. 2018 Mar 19;8(1):4993.


The use of stable isotopes in the study of human pathophysiology.

Charidemou E, Ashmore T, Griffin JL.

Int J Biochem Cell Biol. 2017 Dec;93:102-109. doi: 10.1016/j.biocel.2017.07.012. Epub 2017 Jul 20. Review.


Lipidomics Profiling of Human Adipose Tissue Identifies a Pattern of Lipids Associated with Fish Oil Supplementation.

Stanley EG, Jenkins BJ, Walker CG, Koulman A, Browning L, West AL, Calder PC, Jebb SA, Griffin JL.

J Proteome Res. 2017 Sep 1;16(9):3168-3179. doi: 10.1021/acs.jproteome.7b00161. Epub 2017 Aug 16.


Metabolic basis to Sherpa altitude adaptation.

Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL, Ament Z, Gilbert-Kawai ET, Vercueil A, Landis BD, Mitchell K, Mythen MG, Branco C, Johnson RS, Feelisch M, Montgomery HE, Griffin JL, Grocott MPW, Gnaiger E, Martin DS, Murray AJ.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):6382-6387. doi: 10.1073/pnas.1700527114. Epub 2017 May 22.


Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation.

Mansor LS, Sousa Fialho MDL, Yea G, Coumans WA, West JA, Kerr M, Carr CA, Luiken JJFP, Glatz JFC, Evans RD, Griffin JL, Tyler DJ, Clarke K, Heather LC.

Cardiovasc Res. 2017 Jun 1;113(7):737-748. doi: 10.1093/cvr/cvx045.


Alterations in endo-lysosomal function induce similar hepatic lipid profiles in rodent models of drug-induced phospholipidosis and Sandhoff disease.

Lecommandeur E, Baker D, Cox TM, Nicholls AW, Griffin JL.

J Lipid Res. 2017 Jul;58(7):1306-1314. doi: 10.1194/jlr.M073395. Epub 2017 Apr 4.

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