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Globalization of Traditional Chinese Medicine: what are the issues for ensuring evidence-based diagnosis and therapy?

Fears R, Griffin GE, Larhammar D, Ter Meulen V, van der Meer JWM.

J Intern Med. 2019 Nov 7. doi: 10.1111/joim.12989. [Epub ahead of print] No abstract available.


Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9.

Li C, Guan X, Du T, Jin W, Wu B, Liu Y, Wang P, Hu B, Griffin GE, Shattock RJ, Hu Q.

J Gen Virol. 2015 Aug;96(8):2381-93. doi: 10.1099/vir.0.000139. Epub 2015 Apr 8.


Hearing loss: a global health issue.

Looi LM, Ganten D, McGrath PF, Gross M, Griffin GE.

Lancet. 2015 Mar 14;385(9972):943-4. doi: 10.1016/S0140-6736(15)60208-2. Epub 2015 Mar 3. No abstract available.


Tetherin restricts HSV-2 release and is counteracted by multiple viral glycoproteins.

Liu Y, Luo S, He S, Zhang M, Wang P, Li C, Huang W, Hu B, Griffin GE, Shattock RJ, Hu Q.

Virology. 2015 Jan 15;475:96-109. doi: 10.1016/j.virol.2014.11.005. Epub 2014 Nov 27.


HIV enteropathy: HAART reduces HIV-induced stem cell hyperproliferation and crypt hypertrophy to normal in jejunal mucosa.

Batman PA, Kapembwa MS, Belmonte L, Tudor G, Kotler DP, Potten CS, Booth C, Cahn P, Griffin GE.

J Clin Pathol. 2014 Jan;67(1):14-8. doi: 10.1136/jclinpath-2012-201289. Epub 2013 Jul 23.


CCL19 and CCL28 augment mucosal and systemic immune responses to HIV-1 gp140 by mobilizing responsive immunocytes into secondary lymph nodes and mucosal tissue.

Hu K, Luo S, Tong L, Huang X, Jin W, Huang W, Du T, Yan Y, He S, Griffin GE, Shattock RJ, Hu Q.

J Immunol. 2013 Aug 15;191(4):1935-47. doi: 10.4049/jimmunol.1300120. Epub 2013 Jul 15.


Bifunctional CD4-DC-SIGN fusion proteins demonstrate enhanced avidity to gp120 and inhibit HIV-1 infection and dissemination.

Du T, Hu K, Yang J, Jin J, Li C, Stieh D, Griffin GE, Shattock RJ, Hu Q.

Antimicrob Agents Chemother. 2012 Sep;56(9):4640-9. doi: 10.1128/AAC.00623-12. Epub 2012 Jun 11.


Herpes simplex virus type 2 infection of human epithelial cells induces CXCL9 expression and CD4+ T cell migration via activation of p38-CCAAT/enhancer-binding protein-β pathway.

Huang W, Hu K, Luo S, Zhang M, Li C, Jin W, Liu Y, Griffin GE, Shattock RJ, Hu Q.

J Immunol. 2012 Jun 15;188(12):6247-57. doi: 10.4049/jimmunol.1103706. Epub 2012 May 14.


Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction.

Huang X, Jin W, Hu K, Luo S, Du T, Griffin GE, Shattock RJ, Hu Q.

Virology. 2012 Feb 5;423(1):97-106. doi: 10.1016/j.virol.2011.11.023. Epub 2011 Dec 20.


Removal of two high-mannose N-linked glycans on gp120 renders human immunodeficiency virus 1 largely resistant to the carbohydrate-binding agent griffithsin.

Huang X, Jin W, Griffin GE, Shattock RJ, Hu Q.

J Gen Virol. 2011 Oct;92(Pt 10):2367-73. doi: 10.1099/vir.0.033092-0. Epub 2011 Jun 29.


Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study.

Cooper PJ, Chico ME, Guadalupe I, Sandoval CA, Mitre E, Platts-Mills TA, Barreto ML, Rodrigues LC, Strachan DP, Griffin GE.

BMC Infect Dis. 2011 Jun 29;11:184. doi: 10.1186/1471-2334-11-184.


Challenges to the development of new drugs and regimens for tuberculosis.

Jindani A, Griffin GE.

Tuberculosis (Edinb). 2010 May;90(3):168-70. doi: 10.1016/ Epub 2010 Apr 10. Review.


Repeated treatments with albendazole enhance Th2 responses to Ascaris Lumbricoides, but not to aeroallergens, in children from rural communities in the Tropics.

Cooper PJ, Moncayo AL, Guadalupe I, Benitez S, Vaca M, Chico M, Griffin GE.

J Infect Dis. 2008 Oct 15;198(8):1237-42. doi: 10.1086/591945.


Environmental determinants of total IgE among school children living in the rural Tropics: importance of geohelminth infections and effect of anthelmintic treatment.

Cooper PJ, Alexander N, Moncayo AL, Benitez SM, Chico ME, Vaca MG, Griffin GE.

BMC Immunol. 2008 Jun 27;9:33. doi: 10.1186/1471-2172-9-33.


Gene expression subtypes in patients with chronic fatigue syndrome/myalgic encephalomyelitis.

Kerr JR, Petty R, Burke B, Gough J, Fear D, Sinclair LI, Mattey DL, Richards SC, Montgomery J, Baldwin DA, Kellam P, Harrison TJ, Griffin GE, Main J, Enlander D, Nutt DJ, Holgate ST.

J Infect Dis. 2008 Apr 15;197(8):1171-84. doi: 10.1086/533453.


Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 DeltaicsA Deltaent Deltafep DeltastxA:HgR oral vaccine SC599 in healthy human adult volunteers.

Sadorge C, Ndiaye A, Beveridge N, Frazer S, Giemza R, Jolly N, Johnson J, Liddy H, Cosgrove CA, Allavena P, Mantovani A, Béchet S, Fontaine-Thompson A, Griffin GE, Dupont F, Sansonetti PJ, Lewis DJ.

Vaccine. 2008 Feb 13;26(7):978-87. doi: 10.1016/j.vaccine.2007.11.024. Epub 2007 Dec 3.


Mycobacterium tuberculosis antigens specifically modulate CCR2 and MCP-1/CCL2 on lymphoid cells from human pulmonary hilar lymph nodes.

Arias MA, Jaramillo G, López YP, Mejía N, Mejía C, Pantoja AE, Shattock RJ, García LF, Griffin GE.

J Immunol. 2007 Dec 15;179(12):8381-91.


In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection.

Asquith B, Zhang Y, Mosley AJ, de Lara CM, Wallace DL, Worth A, Kaftantzi L, Meekings K, Griffin GE, Tanaka Y, Tough DF, Beverley PC, Taylor GP, Macallan DC, Bangham CR.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8035-40. Epub 2007 May 1.


Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans.

Khan S, Chatfield S, Stratford R, Bedwell J, Bentley M, Sulsh S, Giemza R, Smith S, Bongard E, Cosgrove CA, Johnson J, Dougan G, Griffin GE, Makin J, Lewis DJ.

Vaccine. 2007 May 22;25(21):4175-82. Epub 2007 Mar 21.


In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection.

Zhang Y, Wallace DL, de Lara CM, Ghattas H, Asquith B, Worth A, Griffin GE, Taylor GP, Tough DF, Beverley PC, Macallan DC.

Immunology. 2007 Jun;121(2):258-65. Epub 2007 Mar 7.


Chemokine/cytokine production by mononuclear cells from human lymphoid tissues and their modulation by Mycobacterium tuberculosis antigens.

Arias MA, Pantoja AE, Jaramillo G, López YP, Mejía N, Mejía C, Paris SC, Shattock RJ, Griffin GE, García LF.

FEMS Immunol Med Microbiol. 2007 Mar;49(2):272-9.


HIV enteropathy: crypt stem and transit cell hyperproliferation induces villous atrophy in HIV/Microsporidia-infected jejunal mucosa.

Batman PA, Kotler DP, Kapembwa MS, Booth D, Potten CS, Orenstein JM, Scally AJ, Griffin GE.

AIDS. 2007 Feb 19;21(4):433-9.


Long-term effects of perinatal nutrition on T lymphocyte kinetics in young Gambian men.

Ghattas H, Wallace DL, Solon JA, Henson SM, Zhang Y, Ngom PT, Aspinall R, Morgan G, Griffin GE, Prentice AM, Macallan DC.

Am J Clin Nutr. 2007 Feb;85(2):480-7.


Pertussis toxin and its binding unit inhibit HIV-1 infection of human cervical tissue and macrophages involving a CD14 pathway.

Hu Q, Younson J, Griffin GE, Kelly C, Shattock RJ.

J Infect Dis. 2006 Dec 1;194(11):1547-56. Epub 2006 Oct 19.


Chemokine receptor expression and modulation by Mycobacterium tuberculosis antigens on mononuclear cells from human lymphoid tissues.

Arias MA, Pantoja AE, Jaramillo G, Paris SC, Shattock RJ, García LF, Griffin GE.

Immunology. 2006 Jun;118(2):171-84.


Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial.

Cooper PJ, Chico ME, Vaca MG, Moncayo AL, Bland JM, Mafla E, Sanchez F, Rodrigues LC, Strachan DP, Griffin GE.

Lancet. 2006 May 13;367(9522):1598-603.


Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine.

Cosgrove CA, Castello-Branco LR, Hussell T, Sexton A, Giemza R, Phillips R, Williams A, Griffin GE, Dougan G, Lewis DJ.

Infect Immun. 2006 Apr;74(4):2449-52.


Measuring lymphocyte kinetics in tropical field settings.

Ghattas H, Darboe BM, Wallace DL, Griffin GE, Prentice AM, Macallan DC.

Trans R Soc Trop Med Hyg. 2005 Sep;99(9):675-85.


Restricted variable residues in the C-terminal segment of HIV-1 V3 loop regulate the molecular anatomy of CCR5 utilization.

Hu Q, Napier KB, Trent JO, Wang Z, Taylor S, Griffin GE, Peiper SC, Shattock RJ.

J Mol Biol. 2005 Jul 22;350(4):699-712.


Effect of recombinant human growth hormone on exercise capacity in patients with HIV-associated wasting on HAART.

Evans WJ, Kotler DP, Staszewski S, Griffin GE, Isgaard J, Gertner JM, O'Brien F, Svanberg E.

AIDS Read. 2005 Jun;15(6):301-3, 306-8, 310, 314.


B-cell kinetics in humans: rapid turnover of peripheral blood memory cells.

Macallan DC, Wallace DL, Zhang Y, Ghattas H, Asquith B, de Lara C, Worth A, Panayiotakopoulos G, Griffin GE, Tough DF, Beverley PC.

Blood. 2005 May 1;105(9):3633-40. Epub 2005 Jan 11.


Geohelminth infections protect against severe inflammatory diarrhoea in children.

Cooper PJ, Sandoval C, Chico ME, Griffin GE.

Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):519-21.


Direct measurement of T cell subset kinetics in vivo in elderly men and women.

Wallace DL, Zhang Y, Ghattas H, Worth A, Irvine A, Bennett AR, Griffin GE, Beverley PC, Tough DF, Macallan DC.

J Immunol. 2004 Aug 1;173(3):1787-94.


Relationship between bacille Calmette-Guérin vaccination, Mantoux test positivity, and geohelminth infection.

Cooper PJ, Chico ME, Gaus D, Griffin GE.

Trans R Soc Trop Med Hyg. 2003 Jul-Aug;97(4):473-6.


Rapid turnover of effector-memory CD4(+) T cells in healthy humans.

Macallan DC, Wallace D, Zhang Y, De Lara C, Worth AT, Ghattas H, Griffin GE, Beverley PC, Tough DF.

J Exp Med. 2004 Jul 19;200(2):255-60. Epub 2004 Jul 12.


Risk factors for atopy among school children in a rural area of Latin America.

Cooper PJ, Chico ME, Rodrigues LC, Strachan DP, Anderson HR, Rodriguez EA, Gaus DP, Griffin GE.

Clin Exp Allergy. 2004 Jun;34(6):845-52.


Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomised trial.

Brouwer AE, Rajanuwong A, Chierakul W, Griffin GE, Larsen RA, White NJ, Harrison TS.

Lancet. 2004 May 29;363(9423):1764-7.


Nutrient partitioning during treatment of tuberculosis: gain in body fat mass but not in protein mass.

Schwenk A, Hodgson L, Wright A, Ward LC, Rayner CF, Grubnic S, Griffin GE, Macallan DC.

Am J Clin Nutr. 2004 Jun;79(6):1006-12.


Blockade of attachment and fusion receptors inhibits HIV-1 infection of human cervical tissue.

Hu Q, Frank I, Williams V, Santos JJ, Watts P, Griffin GE, Moore JP, Pope M, Shattock RJ.

J Exp Med. 2004 Apr 19;199(8):1065-75. Epub 2004 Apr 12.


Rapid and frequent induction of protective immunity exceeding UK recommendations for healthcare settings by MF59-adjuvated hepatitis B vaccine.

Lewis DJ, Eiden JE, Goilav C, Langenberg AG, Suggett F, Griffin GE.

Commun Dis Public Health. 2003 Dec;6(4):320-4.


Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk.

LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labéta MO.

J Immunol. 2003 Dec 15;171(12):6680-9.


Rapid turnover of T cells in acute infectious mononucleosis.

Macallan DC, Wallace DL, Irvine AJ, Asquith B, Worth A, Ghattas H, Zhang Y, Griffin GE, Tough DF, Beverley PC.

Eur J Immunol. 2003 Oct;33(10):2655-65.


Measurement and modeling of human T cell kinetics.

Macallan DC, Asquith B, Irvine AJ, Wallace DL, Worth A, Ghattas H, Zhang Y, Griffin GE, Tough DF, Beverley PC.

Eur J Immunol. 2003 Aug;33(8):2316-26. Erratum in: Eur J Immunol. 2003 Oct;33(10):2947.


Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics.

Cooper PJ, Chico ME, Rodrigues LC, Ordonez M, Strachan D, Griffin GE, Nutman TB.

J Allergy Clin Immunol. 2003 May;111(5):995-1000.


Allergic symptoms, atopy, and geohelminth infections in a rural area of Ecuador.

Cooper PJ, Chico ME, Bland M, Griffin GE, Nutman TB.

Am J Respir Crit Care Med. 2003 Aug 1;168(3):313-7. Epub 2003 Apr 24.


Protective levels of diphtheria-neutralizing antibody induced in healthy volunteers by unilateral priming-boosting intranasal immunization associated with restricted ipsilateral mucosal secretory immunoglobulin a.

Mills KH, Cosgrove C, McNeela EA, Sexton A, Giemza R, Jabbal-Gill I, Church A, Lin W, Illum L, Podda A, Rappuoli R, Pizza M, Griffin GE, Lewis DJ.

Infect Immun. 2003 Feb;71(2):726-32.


Leptin and energy metabolism in pulmonary tuberculosis.

Schwenk A, Hodgson L, Rayner CF, Griffin GE, Macallan DC.

Am J Clin Nutr. 2003 Feb;77(2):392-8.


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