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Items: 1 to 50 of 290

1.

Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression.

Bartels M, Weckbecker D, Kuhn PH, Ryazanov S, Leonov A, Griesinger C, Lichtenthaler SF, Bötzel K, Giese A.

Sci Rep. 2019 Jun 24;9(1):9100. doi: 10.1038/s41598-019-45298-6.

2.

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

Wegrzynowicz M, Bar-On D, Calo' L, Anichtchik O, Iovino M, Xia J, Ryazanov S, Leonov A, Giese A, Dalley JW, Griesinger C, Ashery U, Spillantini MG.

Acta Neuropathol. 2019 May 31. doi: 10.1007/s00401-019-02023-x. [Epub ahead of print]

PMID:
31165254
3.

relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d'Auvergne EJ.

Bioinformatics. 2019 Jun 4. pii: btz397. doi: 10.1093/bioinformatics/btz397. [Epub ahead of print] No abstract available.

PMID:
31161193
4.

Bisnorgammacerane traces predatory pressure and the persistent rise of algal ecosystems after Snowball Earth.

van Maldegem LM, Sansjofre P, Weijers JWH, Wolkenstein K, Strother PK, Wörmer L, Hefter J, Nettersheim BJ, Hoshino Y, Schouten S, Sinninghe Damsté JS, Nath N, Griesinger C, Kuznetsov NB, Elie M, Elvert M, Tegelaar E, Gleixner G, Hallmann C.

Nat Commun. 2019 Jan 29;10(1):476. doi: 10.1038/s41467-019-08306-x.

5.

Hypalocrinins, Taurine-Conjugated Anthraquinone and Biaryl Pigments from the Deep Sea Crinoid Hypalocrinus naresianus.

Wolkenstein K, Fuentes-Monteverde JC, Nath N, Oji T, Griesinger C.

J Nat Prod. 2019 Jan 25;82(1):163-167. doi: 10.1021/acs.jnatprod.8b00803. Epub 2018 Dec 31.

PMID:
30596488
6.

Application of anisotropic NMR parameters to the confirmation of molecular structure.

Liu Y, Navarro-Vázquez A, Gil RR, Griesinger C, Martin GE, Williamson RT.

Nat Protoc. 2019 Jan;14(1):217-247. doi: 10.1038/s41596-018-0091-9.

PMID:
30552410
7.

Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy.

Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N.

Mov Disord. 2019 Feb;34(2):255-263. doi: 10.1002/mds.27562. Epub 2018 Nov 19.

8.

Interaction of Cu(i) with the Met-X3-Met motif of alpha-synuclein: binding ligands, affinity and structural features.

Gentile I, Garro HA, Delgado Ocaña S, Gonzalez N, Strohäker T, Schibich D, Quintanar L, Sambrotta L, Zweckstetter M, Griesinger C, Menacho Márquez M, Fernández CO.

Metallomics. 2018 Oct 17;10(10):1383-1389. doi: 10.1039/c8mt00232k.

PMID:
30246210
9.

Utilizing dipole-dipole cross-correlated relaxation for the measurement of angles between pairs of opposing CαHα-CαHα bonds in anti-parallel β-sheets.

Sabo TM, Gapsys V, Walter KFA, Fenwick RB, Becker S, Salvatella X, de Groot BL, Lee D, Griesinger C.

Methods. 2018 Apr 1;138-139:85-92. doi: 10.1016/j.ymeth.2018.04.007. Epub 2018 Apr 12.

PMID:
29656081
10.

Binding Modes of Phthalocyanines to Amyloid β Peptide and Their Effects on Amyloid Fibril Formation.

Valiente-Gabioud AA, Riedel D, Outeiro TF, Menacho-Márquez MA, Griesinger C, Fernández CO.

Biophys J. 2018 Mar 13;114(5):1036-1045. doi: 10.1016/j.bpj.2018.01.003.

11.

Sensitivity-Enhanced Four-Dimensional Amide-Amide Correlation NMR Experiments for Sequential Assignment of Proline-Rich Disordered Proteins.

Wong LE, Maier J, Wienands J, Becker S, Griesinger C.

J Am Chem Soc. 2018 Mar 14;140(10):3518-3522. doi: 10.1021/jacs.8b00215. Epub 2018 Mar 6.

PMID:
29489342
12.

Measurement of residual chemical shift anisotropies in compressed polymethylmethacrylate gels. Automatic compensation of gel isotropic shift contribution.

Hallwass F, Teles RR, Hellemann E, Griesinger C, Gil RR, Navarro-Vázquez A.

Magn Reson Chem. 2018 May;56(5):321-328. doi: 10.1002/mrc.4711. Epub 2018 Feb 8.

PMID:
29327368
13.

Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates.

Reiner AM, Schmidt F, Ryazanov S, Leonov A, Weckbecker D, Deeg AA, Griesinger C, Giese A, Zinth W.

Biochim Biophys Acta Gen Subj. 2018 Apr;1862(4):800-807. doi: 10.1016/j.bbagen.2017.12.007. Epub 2017 Dec 19.

PMID:
29273222
14.

The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.

Martinez Hernandez A, Urbanke H, Gillman AL, Lee J, Ryazanov S, Agbemenyah HY, Benito E, Jain G, Kaurani L, Grigorian G, Leonov A, Rezaei-Ghaleh N, Wilken P, Arce FT, Wagner J, Fuhrmann M, Caruana M, Camilleri A, Vassallo N, Zweckstetter M, Benz R, Giese A, Schneider A, Korte M, Lal R, Griesinger C, Eichele G, Fischer A.

EMBO Mol Med. 2018 Jan;10(1):32-47. doi: 10.15252/emmm.201707825.

15.

Insight into the molecular recognition mechanism of the coactivator NCoA1 by STAT6.

Russo L, Giller K, Pfitzner E, Griesinger C, Becker S.

Sci Rep. 2017 Dec 4;7(1):16845. doi: 10.1038/s41598-017-17088-5.

16.

Simultaneous determination of fast and slow dynamics in molecules using extreme CPMG relaxation dispersion experiments.

Reddy JG, Pratihar S, Ban D, Frischkorn S, Becker S, Griesinger C, Lee D.

J Biomol NMR. 2018 Jan;70(1):1-9. doi: 10.1007/s10858-017-0155-0. Epub 2017 Nov 29.

PMID:
29188417
17.

Label-free NMR-based dissociation kinetics determination.

Trigo-Mouriño P, Griesinger C, Lee D.

J Biomol NMR. 2017 Dec;69(4):229-235. doi: 10.1007/s10858-017-0150-5. Epub 2017 Nov 16.

PMID:
29143948
18.

Resolving the Atomistic Modes of Anle138b Inhibitory Action on Peptide Oligomer Formation.

Matthes D, Gapsys V, Griesinger C, de Groot BL.

ACS Chem Neurosci. 2017 Dec 20;8(12):2791-2808. doi: 10.1021/acschemneuro.7b00325. Epub 2017 Sep 28.

19.

Solution NMR views of dynamical ordering of biomacromolecules.

Ikeya T, Ban D, Lee D, Ito Y, Kato K, Griesinger C.

Biochim Biophys Acta Gen Subj. 2018 Feb;1862(2):287-306. doi: 10.1016/j.bbagen.2017.08.020. Epub 2017 Aug 25. Review.

PMID:
28847507
20.

Bioinorganic Chemistry of Parkinson's Disease: Affinity and Structural Features of Cu(I) Binding to the Full-Length β-Synuclein Protein.

Miotto MC, Pavese MD, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.

Inorg Chem. 2017 Sep 5;56(17):10387-10395. doi: 10.1021/acs.inorgchem.7b01292. Epub 2017 Aug 18.

PMID:
28820253
21.

Treatment with diphenyl-pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death.

Turriani E, Lázaro DF, Ryazanov S, Leonov A, Giese A, Schön M, Schön MP, Griesinger C, Outeiro TF, Arndt-Jovin DJ, Becker D.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E4971-E4977. doi: 10.1073/pnas.1700200114. Epub 2017 Jun 5.

22.

Recent advances in measuring the kinetics of biomolecules by NMR relaxation dispersion spectroscopy.

Ban D, Smith CA, de Groot BL, Griesinger C, Lee D.

Arch Biochem Biophys. 2017 Aug 15;628:81-91. doi: 10.1016/j.abb.2017.05.016. Epub 2017 May 30. Review.

PMID:
28576576
23.

Nanodiscs for INPHARMA NMR Characterization of GPCRs: Ligand Binding to the Human A2A Adenosine Receptor.

Fredriksson K, Lottmann P, Hinz S, Onila I, Shymanets A, Harteneck C, Müller CE, Griesinger C, Exner TE.

Angew Chem Int Ed Engl. 2017 May 15;56(21):5750-5754. doi: 10.1002/anie.201612547. Epub 2017 Apr 21.

PMID:
28429411
24.

Sensory domain contraction in histidine kinase CitA triggers transmembrane signaling in the membrane-bound sensor.

Salvi M, Schomburg B, Giller K, Graf S, Unden G, Becker S, Lange A, Griesinger C.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3115-3120. doi: 10.1073/pnas.1620286114. Epub 2017 Mar 6.

25.

A Two-Component Adhesive: Tau Fibrils Arise from a Combination of a Well-Defined Motif and Conformationally Flexible Interactions.

Xiang S, Kulminskaya N, Habenstein B, Biernat J, Tepper K, Paulat M, Griesinger C, Becker S, Lange A, Mandelkow E, Linser R.

J Am Chem Soc. 2017 Feb 22;139(7):2639-2646. doi: 10.1021/jacs.6b09619. Epub 2017 Feb 8.

PMID:
28124562
26.

Cryogenic optical localization provides 3D protein structure data with Angstrom resolution.

Weisenburger S, Boening D, Schomburg B, Giller K, Becker S, Griesinger C, Sandoghdar V.

Nat Methods. 2017 Feb;14(2):141-144. doi: 10.1038/nmeth.4141. Epub 2017 Jan 9.

PMID:
28068317
27.

International Harmonization and Cooperation in the Validation of Alternative Methods.

Barroso J, Ahn IY, Caldeira C, Carmichael PL, Casey W, Coecke S, Curren R, Desprez B, Eskes C, Griesinger C, Guo J, Hill E, Roi AJ, Kojima H, Li J, Lim CH, Moura W, Nishikawa A, Park H, Peng S, Presgrave O, Singer T, Sohn SJ, Westmoreland C, Whelan M, Yang X, Yang Y, Zuang V.

Adv Exp Med Biol. 2016;856:343-386. Review.

PMID:
27671730
28.

Practical Aspects of Designing and Conducting Validation Studies Involving Multi-study Trials.

Coecke S, Bernasconi C, Bowe G, Bostroem AC, Burton J, Cole T, Fortaner S, Gouliarmou V, Gray A, Griesinger C, Louhimies S, Gyves EM, Joossens E, Prinz MJ, Milcamps A, Parissis N, Wilk-Zasadna I, Barroso J, Desprez B, Langezaal I, Liska R, Morath S, Reina V, Zorzoli C, Zuang V.

Adv Exp Med Biol. 2016;856:133-163. Review.

PMID:
27671721
29.

Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Tools.

Griesinger C, Desprez B, Coecke S, Casey W, Zuang V.

Adv Exp Med Biol. 2016;856:65-132. Review.

PMID:
27671720
30.

Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1.

Briones R, Weichbrodt C, Paltrinieri L, Mey I, Villinger S, Giller K, Lange A, Zweckstetter M, Griesinger C, Becker S, Steinem C, de Groot BL.

Biophys J. 2016 Sep 20;111(6):1223-1234. doi: 10.1016/j.bpj.2016.08.007.

31.

Complete NMR assignment and conformational analysis of 17-α-ethinylestradiol by using RDCs obtained in grafted graphene oxide.

França JA, Navarro-Vázquez A, Lei X, Sun H, Griesinger C, Hallwass F.

Magn Reson Chem. 2017 Apr;55(4):297-303. doi: 10.1002/mrc.4526. Epub 2016 Oct 11.

PMID:
27637176
32.

High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.

Jaremko M, Jaremko Ł, Villinger S, Schmidt CD, Griesinger C, Becker S, Zweckstetter M.

Angew Chem Int Ed Engl. 2016 Aug 22;55(35):10518-21. doi: 10.1002/anie.201602639. Epub 2016 Jul 27.

33.

The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.

Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J.

Sci Signal. 2016 Jun 28;9(434):ra66. doi: 10.1126/scisignal.aad6275.

PMID:
27353366
34.

Kinetics of the Antibody Recognition Site in the Third IgG-Binding Domain of Protein G.

Pratihar S, Sabo TM, Ban D, Fenwick RB, Becker S, Salvatella X, Griesinger C, Lee D.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9567-70. doi: 10.1002/anie.201603501. Epub 2016 Jun 27.

PMID:
27345359
35.

Determination of Relative Configuration from Residual Chemical Shift Anisotropy.

Nath N, Schmidt M, Gil RR, Williamson RT, Martin GE, Navarro-Vázquez A, Griesinger C, Liu Y.

J Am Chem Soc. 2016 Aug 3;138(30):9548-56. doi: 10.1021/jacs.6b04082. Epub 2016 Jul 22.

PMID:
27294984
36.

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism.

Saab AS, Tzvetavona ID, Trevisiol A, Baltan S, Dibaj P, Kusch K, Möbius W, Goetze B, Jahn HM, Huang W, Steffens H, Schomburg ED, Pérez-Samartín A, Pérez-Cerdá F, Bakhtiari D, Matute C, Löwel S, Griesinger C, Hirrlinger J, Kirchhoff F, Nave KA.

Neuron. 2016 Jul 6;91(1):119-32. doi: 10.1016/j.neuron.2016.05.016. Epub 2016 Jun 9.

37.

High-power (1)H composite pulse decoupling provides artifact free exchange-mediated saturation transfer (EST) experiments.

Chakrabarti KS, Ban D, Pratihar S, Reddy JG, Becker S, Griesinger C, Lee D.

J Magn Reson. 2016 Aug;269:65-69. doi: 10.1016/j.jmr.2016.05.013. Epub 2016 May 21.

PMID:
27240144
38.

Molecular Plasticity of the Human Voltage-Dependent Anion Channel Embedded Into a Membrane.

Ge L, Villinger S, Mari SA, Giller K, Griesinger C, Becker S, Müller DJ, Zweckstetter M.

Structure. 2016 Apr 5;24(4):585-594. doi: 10.1016/j.str.2016.02.012. Epub 2016 Mar 24.

39.

Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy.

Fellner L, Kuzdas-Wood D, Levin J, Ryazanov S, Leonov A, Griesinger C, Giese A, Wenning GK, Stefanova N.

Front Neurosci. 2016 Mar 10;10:99. doi: 10.3389/fnins.2016.00099. eCollection 2016.

40.

Allosteric switch regulates protein-protein binding through collective motion.

Smith CA, Ban D, Pratihar S, Giller K, Paulat M, Becker S, Griesinger C, Lee D, de Groot BL.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3269-74. doi: 10.1073/pnas.1519609113. Epub 2016 Mar 9.

41.

An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes.

Zong W, Li GW, Cao JM, Lei X, Hu ML, Sun H, Griesinger C, Tan RX.

Angew Chem Int Ed Engl. 2016 Mar 7;55(11):3690-3. doi: 10.1002/anie.201511435. Epub 2016 Feb 17.

PMID:
26890579
42.

The Use of a Combination of RDC and Chiroptical Spectroscopy for Determination of the Absolute Configuration of Fusariumin A from the Fungus Fusarium sp.

Liu LY, Sun H, Griesinger C, Liu JK.

Nat Prod Bioprospect. 2016 Feb;6(1):41-8. doi: 10.1007/s13659-015-0084-0. Epub 2016 Jan 20.

43.

Structure and Absolute Configuration of Jurassic Polyketide-Derived Spiroborate Pigments Obtained from Microgram Quantities.

Wolkenstein K, Sun H, Falk H, Griesinger C.

J Am Chem Soc. 2015 Oct 28;137(42):13460-3. doi: 10.1021/jacs.5b08191. Epub 2015 Oct 20.

44.

Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.

Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M.

Acta Neuropathol. 2015 Nov;130(5):619-31. doi: 10.1007/s00401-015-1483-3. Epub 2015 Oct 6.

45.

Long-Range Residual Dipolar Couplings: A Tool for Determining the Configuration of Small Molecules.

Nath N, d'Auvergne EJ, Griesinger C.

Angew Chem Int Ed Engl. 2015 Oct 19;54(43):12706-10. doi: 10.1002/anie.201504432. Epub 2015 Sep 11.

PMID:
26359945
46.

Speeding-up exchange-mediated saturation transfer experiments by Fourier transform.

Carneiro MG, Reddy JG, Griesinger C, Lee D.

J Biomol NMR. 2015 Nov;63(3):237-44. doi: 10.1007/s10858-015-9985-9. Epub 2015 Sep 9.

PMID:
26350257
47.

Two novel prediction models improve predictions of skin corrosive sub-categories by test methods of OECD Test Guideline No. 431.

Desprez B, Barroso J, Griesinger C, Kandárová H, Alépée N, Fuchs HW.

Toxicol In Vitro. 2015 Dec;29(8):2055-80. doi: 10.1016/j.tiv.2015.08.015. Epub 2015 Aug 29.

48.

Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice.

Shi S, Wagner J, Mitteregger-Kretzschmar G, Ryazanov S, Leonov A, Griesinger C, Giese A.

J Neuropathol Exp Neurol. 2015 Sep;74(9):924-33. doi: 10.1097/NEN.0000000000000233.

PMID:
26247395
49.

On-the-Fly Integration of Data from a Spin-Diffusion-Based NMR Experiment into Protein-Ligand Docking.

Onila I, ten Brink T, Fredriksson K, Codutti L, Mazur A, Griesinger C, Carlomagno T, Exner TE.

J Chem Inf Model. 2015 Sep 28;55(9):1962-72. doi: 10.1021/acs.jcim.5b00235. Epub 2015 Aug 14.

PMID:
26226383
50.

Knowledge sharing to facilitate regulatory decision-making in regard to alternatives to animal testing: Report of an EPAA workshop.

Ramirez T, Beken S, Chlebus M, Ellis G, Griesinger C, De Jonghe S, Manou I, Mehling A, Reisinger K, Rossi LH, van Benthem J, van der Laan JW, Weissenhorn R, Sauer UG.

Regul Toxicol Pharmacol. 2015 Oct;73(1):210-26. doi: 10.1016/j.yrtph.2015.07.007. Epub 2015 Jul 15.

PMID:
26188116

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