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Dynamic tuning of FRET in a green fluorescent protein biosensor.

Trigo-Mourino P, Thestrup T, Griesbeck O, Griesinger C, Becker S.

Sci Adv. 2019 Aug 7;5(8):eaaw4988. doi: 10.1126/sciadv.aaw4988. eCollection 2019 Aug.


Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles†.

Egbert JR, Fahey PG, Reimer J, Owen CM, Evsikov AV, Nikolaev VO, Griesbeck O, Ray RS, Tolias AS, Jaffe LA.

Biol Reprod. 2019 Aug 1;101(2):433-444. doi: 10.1093/biolre/ioz085.


Phosphodiesterase 1 Bridges Glutamate Inputs with NO- and Dopamine-Induced Cyclic Nucleotide Signals in the Striatum.

Betolngar DB, Mota É, Fabritius A, Nielsen J, Hougaard C, Christoffersen CT, Yang J, Kehler J, Griesbeck O, Castro LRV, Vincent P.

Cereb Cortex. 2019 Mar 16. pii: bhz041. doi: 10.1093/cercor/bhz041. [Epub ahead of print]


Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.

Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M.

Neuron. 2019 Feb 20;101(4):615-624.e5. doi: 10.1016/j.neuron.2018.12.023. Epub 2019 Jan 24.


Imaging-Based Screening Platform Assists Protein Engineering.

Fabritius A, Ng D, Kist AM, Erdogan M, Portugues R, Griesbeck O.

Cell Chem Biol. 2018 Dec 20;25(12):1554-1561.e8. doi: 10.1016/j.chembiol.2018.08.008. Epub 2018 Sep 13.


Color Processing in the Early Visual System of Drosophila.

Schnaitmann C, Haikala V, Abraham E, Oberhauser V, Thestrup T, Griesbeck O, Reiff DF.

Cell. 2018 Jan 11;172(1-2):318-330.e18. doi: 10.1016/j.cell.2017.12.018.


Brain tumour cells interconnect to a functional and resistant network.

Osswald M, Jung E, Sahm F, Solecki G, Venkataramani V, Blaes J, Weil S, Horstmann H, Wiestler B, Syed M, Huang L, Ratliff M, Karimian Jazi K, Kurz FT, Schmenger T, Lemke D, Gömmel M, Pauli M, Liao Y, Häring P, Pusch S, Herl V, Steinhäuser C, Krunic D, Jarahian M, Miletic H, Berghoff AS, Griesbeck O, Kalamakis G, Garaschuk O, Preusser M, Weiss S, Liu H, Heiland S, Platten M, Huber PE, Kuner T, von Deimling A, Wick W, Winkler F.

Nature. 2015 Dec 3;528(7580):93-8. doi: 10.1038/nature16071. Epub 2015 Nov 4.


Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels.

Gopal S, Søgaard P, Multhaupt HA, Pataki C, Okina E, Xian X, Pedersen ME, Stevens T, Griesbeck O, Park PW, Pocock R, Couchman JR.

J Cell Biol. 2015 Sep 28;210(7):1199-211. doi: 10.1083/jcb.201501060. Epub 2015 Sep 21.


Large Scale Bacterial Colony Screening of Diversified FRET Biosensors.

Litzlbauer J, Schifferer M, Ng D, Fabritius A, Thestrup T, Griesbeck O.

PLoS One. 2015 Jun 10;10(6):e0119860. doi: 10.1371/journal.pone.0119860. eCollection 2015.


FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.

Siffrin V, Birkenstock J, Luchtman DW, Gollan R, Baumgart J, Niesner RA, Griesbeck O, Zipp F.

J Neurosci Methods. 2015 Jul 15;249:8-15. doi: 10.1016/j.jneumeth.2015.04.005. Epub 2015 Apr 10.


In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb.

Kovalchuk Y, Homma R, Liang Y, Maslyukov A, Hermes M, Thestrup T, Griesbeck O, Ninkovic J, Cohen LB, Garaschuk O.

Nat Commun. 2015 Feb 19;6:6349. doi: 10.1038/ncomms7349.


A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Williams PR, Marincu BN, Sorbara CD, Mahler CF, Schumacher AM, Griesbeck O, Kerschensteiner M, Misgeld T.

Nat Commun. 2014 Dec 16;5:5683. doi: 10.1038/ncomms6683.


Putting a finishing touch on GECIs.

Rose T, Goltstein PM, Portugues R, Griesbeck O.

Front Mol Neurosci. 2014 Nov 18;7:88. doi: 10.3389/fnmol.2014.00088. eCollection 2014. Review.


High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.


Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo.

Breckwoldt MO, Pfister FM, Bradley PM, Marinković P, Williams PR, Brill MS, Plomer B, Schmalz A, St Clair DK, Naumann R, Griesbeck O, Schwarzländer M, Godinho L, Bareyre FM, Dick TP, Kerschensteiner M, Misgeld T.

Nat Med. 2014 May;20(5):555-60. doi: 10.1038/nm.3520. Epub 2014 Apr 20.


Optimized ratiometric calcium sensors for functional in vivo imaging of neurons and T lymphocytes.

Thestrup T, Litzlbauer J, Bartholomäus I, Mues M, Russo L, Dana H, Kovalchuk Y, Liang Y, Kalamakis G, Laukat Y, Becker S, Witte G, Geiger A, Allen T, Rome LC, Chen TW, Kim DS, Garaschuk O, Griesinger C, Griesbeck O.

Nat Methods. 2014 Feb;11(2):175-82. doi: 10.1038/nmeth.2773. Epub 2014 Jan 5.


Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator.

Mues M, Bartholomäus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G.

Nat Med. 2013 Jun;19(6):778-83. doi: 10.1038/nm.3180. Epub 2013 May 12.


A dynamic FRET reporter of gene expression improved by functional screening.

Schifferer M, Griesbeck O.

J Am Chem Soc. 2012 Sep 19;134(37):15185-8. Epub 2012 Sep 10.


Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model.

Direnberger S, Mues M, Micale V, Wotjak CT, Dietzel S, Schubert M, Scharr A, Hassan S, Wahl-Schott C, Biel M, Krishnamoorthy G, Griesbeck O.

Nat Commun. 2012;3:1031. doi: 10.1038/ncomms2035.


Correlating calcium binding, Förster resonance energy transfer, and conformational change in the biosensor TN-XXL.

Geiger A, Russo L, Gensch T, Thestrup T, Becker S, Hopfner KP, Griesinger C, Witte G, Griesbeck O.

Biophys J. 2012 May 16;102(10):2401-10. doi: 10.1016/j.bpj.2012.03.065. Epub 2012 May 15.


Light-driven calcium signals in mouse cone photoreceptors.

Wei T, Schubert T, Paquet-Durand F, Tanimoto N, Chang L, Koeppen K, Ott T, Griesbeck O, Seeliger MW, Euler T, Wissinger B.

J Neurosci. 2012 May 16;32(20):6981-94. doi: 10.1523/JNEUROSCI.6432-11.2012.


Nanodomain Ca²⁺ of Ca²⁺ channels detected by a tethered genetically encoded Ca²⁺ sensor.

Tay LH, Dick IE, Yang W, Mank M, Griesbeck O, Yue DT.

Nat Commun. 2012 Apr 10;3:778. doi: 10.1038/ncomms1777.


Chronic calcium imaging in neuronal development and disease.

Aramuni G, Griesbeck O.

Exp Neurol. 2013 Apr;242:50-6. doi: 10.1016/j.expneurol.2012.02.008. Epub 2012 Feb 21. Review.


Genetically encoded neural activity indicators.

Looger LL, Griesbeck O.

Curr Opin Neurobiol. 2012 Feb;22(1):18-23. doi: 10.1016/j.conb.2011.10.024. Epub 2011 Nov 19. Review.


An image-free opto-mechanical system for creating virtual environments and imaging neuronal activity in freely moving Caenorhabditis elegans.

Faumont S, Rondeau G, Thiele TR, Lawton KJ, McCormick KE, Sottile M, Griesbeck O, Heckscher ES, Roberts WM, Doe CQ, Lockery SR.

PLoS One. 2011;6(9):e24666. doi: 10.1371/journal.pone.0024666. Epub 2011 Sep 28.


Real-time imaging of Rab5 activity using a prequenched biosensor.

Zhan K, Xie H, Gall J, Ma M, Griesbeck O, Salehi A, Rao J.

ACS Chem Biol. 2011 Jul 15;6(7):692-9. doi: 10.1021/cb100377m. Epub 2011 Apr 20.


In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis.

Siffrin V, Radbruch H, Glumm R, Niesner R, Paterka M, Herz J, Leuenberger T, Lehmann SM, Luenstedt S, Rinnenthal JL, Laube G, Luche H, Lehnardt S, Fehling HJ, Griesbeck O, Zipp F.

Immunity. 2010 Sep 24;33(3):424-36. doi: 10.1016/j.immuni.2010.08.018.


Visualizing retinotopic half-wave rectified input to the motion detection circuitry of Drosophila.

Reiff DF, Plett J, Mank M, Griesbeck O, Borst A.

Nat Neurosci. 2010 Aug;13(8):973-8. doi: 10.1038/nn.2595. Epub 2010 Jul 11.


Imaging CREB activation in living cells.

Friedrich MW, Aramuni G, Mank M, Mackinnon JA, Griesbeck O.

J Biol Chem. 2010 Jul 23;285(30):23285-95. doi: 10.1074/jbc.M110.124545. Epub 2010 May 18.


Application of aptamers and autofluorescent proteins for RNA visualization.

Schifferer M, Griesbeck O.

Integr Biol (Camb). 2009 Sep;1(8-9):499-505. doi: 10.1039/b906870h. Epub 2009 Jun 23. Review.


An in vivo biosensor for neurotransmitter release and in situ receptor activity.

Nguyen QT, Schroeder LF, Mank M, Muller A, Taylor P, Griesbeck O, Kleinfeld D.

Nat Neurosci. 2010 Jan;13(1):127-132. doi: 10.1038/nn.2469. Epub 2009 Dec 13.


Calmodulin is a functional regulator of Cav1.4 L-type Ca2+ channels.

Griessmeier K, Cuny H, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.

J Biol Chem. 2009 Oct 23;284(43):29809-16. doi: 10.1074/jbc.M109.048082. Epub 2009 Aug 28.


Osmotic induction of calcium accumulation in human embryonic kidney cells detected with a high sensitivity FRET calcium sensor.

Hou BH, Takanaga H, Griesbeck O, Frommer WB.

Cell Calcium. 2009 Aug;46(2):130-5. doi: 10.1016/j.ceca.2009.06.003. Epub 2009 Jul 22.


The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores.

Zong X, Schieder M, Cuny H, Fenske S, Gruner C, Rötzer K, Griesbeck O, Harz H, Biel M, Wahl-Schott C.

Pflugers Arch. 2009 Sep;458(5):891-9. doi: 10.1007/s00424-009-0690-y. Epub 2009 Jun 26.


Spectral unmixing: analysis of performance in the olfactory bulb in vivo.

Ducros M, Moreaux L, Bradley J, Tiret P, Griesbeck O, Charpak S.

PLoS One. 2009;4(2):e4418. doi: 10.1371/journal.pone.0004418. Epub 2009 Feb 9.


A genetically encoded calcium indicator for chronic in vivo two-photon imaging.

Mank M, Santos AF, Direnberger S, Mrsic-Flogel TD, Hofer SB, Stein V, Hendel T, Reiff DF, Levelt C, Borst A, Bonhoeffer T, Hübener M, Griesbeck O.

Nat Methods. 2008 Sep;5(9):805-11. doi: 10.1038/nmeth.1243.


Fluorescence changes of genetic calcium indicators and OGB-1 correlated with neural activity and calcium in vivo and in vitro.

Hendel T, Mank M, Schnell B, Griesbeck O, Borst A, Reiff DF.

J Neurosci. 2008 Jul 16;28(29):7399-411. doi: 10.1523/JNEUROSCI.1038-08.2008.


Genetically encoded calcium indicators.

Mank M, Griesbeck O.

Chem Rev. 2008 May;108(5):1550-64. doi: 10.1021/cr078213v. Epub 2008 May 1. Review. No abstract available.


Live-cell transforms between Ca2+ transients and FRET responses for a troponin-C-based Ca2+ sensor.

Tay LH, Griesbeck O, Yue DT.

Biophys J. 2007 Dec 1;93(11):4031-40. Epub 2007 Aug 17.


Troponin C-based biosensors: a new family of genetically encoded indicators for in vivo calcium imaging in the nervous system.

Garaschuk O, Griesbeck O, Konnerth A.

Cell Calcium. 2007 Oct-Nov;42(4-5):351-61. Epub 2007 Apr 23. Review.


Improved calcium imaging in transgenic mice expressing a troponin C-based biosensor.

Heim N, Garaschuk O, Friedrich MW, Mank M, Milos RI, Kovalchuk Y, Konnerth A, Griesbeck O.

Nat Methods. 2007 Feb;4(2):127-9. Epub 2007 Jan 28.


A FRET-based calcium biosensor with fast signal kinetics and high fluorescence change.

Mank M, Reiff DF, Heim N, Friedrich MW, Borst A, Griesbeck O.

Biophys J. 2006 Mar 1;90(5):1790-6. Epub 2005 Dec 9.


From art to engineering? The rise of in vivo mammalian electrophysiology via genetically targeted labeling and nonlinear imaging.

Kleinfeld D, Griesbeck O.

PLoS Biol. 2005 Oct;3(10):e355. Epub 2005 Oct 11. No abstract available.


Fluorescent proteins as sensors for cellular functions.

Griesbeck O.

Curr Opin Neurobiol. 2004 Oct;14(5):636-41. Review.


Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.

Hasan MT, Friedrich RW, Euler T, Larkum ME, Giese G, Both M, Duebel J, Waters J, Bujard H, Griesbeck O, Tsien RY, Nagai T, Miyawaki A, Denk W.

PLoS Biol. 2004 Jun;2(6):e163. Epub 2004 Jun 15.


Genetically encoded indicators of cellular calcium dynamics based on troponin C and green fluorescent protein.

Heim N, Griesbeck O.

J Biol Chem. 2004 Apr 2;279(14):14280-6. Epub 2004 Jan 24.


Efficiently folding and circularly permuted variants of the Sapphire mutant of GFP.

Zapata-Hommer O, Griesbeck O.

BMC Biotechnol. 2003 May 22;3:5. Epub 2003 May 22.


Reducing the environmental sensitivity of yellow fluorescent protein. Mechanism and applications.

Griesbeck O, Baird GS, Campbell RE, Zacharias DA, Tsien RY.

J Biol Chem. 2001 Aug 3;276(31):29188-94. Epub 2001 May 31.


Are there differences between the secretion characteristics of NGF and BDNF? Implications for the modulatory role of neurotrophins in activity-dependent neuronal plasticity.

Griesbeck O, Canossa M, Campana G, Gärtner A, Hoener MC, Nawa H, Kolbeck R, Thoenen H.

Microsc Res Tech. 1999 May 15-Jun 1;45(4-5):262-75.


Dynamic and quantitative Ca2+ measurements using improved cameleons.

Miyawaki A, Griesbeck O, Heim R, Tsien RY.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2135-40.

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