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Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy.

Kikuchi DS, Campos ACP, Qu H, Forrester SJ, Pagano RL, Lassègue B, Sadikot RT, Griendling KK, Hernandes MS.

J Neuroinflammation. 2019 Nov 28;16(1):241. doi: 10.1186/s12974-019-1575-4.


The interdependent effects of cholesterol and substrate stiffness on vascular smooth muscle cell biomechanics.

Forrester SJ, Griendling KK.

Cardiovasc Res. 2019 Jul 1;115(8):1262-1263. doi: 10.1093/cvr/cvz065. No abstract available.


Platelet microRNAs and vascular injury.

Dolmatova EV, Griendling KK.

J Clin Invest. 2019 Mar 1;129(3):962-964. doi: 10.1172/JCI127580. Epub 2019 Feb 18.


Polymerase-δ-interacting protein 2 activates the RhoGEF epithelial cell transforming sequence 2 in vascular smooth muscle cells.

Huff LP, Kikuchi DS, Faidley E, Forrester SJ, Tsai MZ, Lassègue B, Griendling KK.

Am J Physiol Cell Physiol. 2019 May 1;316(5):C621-C631. doi: 10.1152/ajpcell.00208.2018. Epub 2019 Feb 6.


Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.

Forrester SJ, Xu Q, Kikuchi DS, Okwan-Duodu D, Campos AC, Faidley EA, Zhang G, Lassègue B, Sadikot RT, Griendling KK, Hernandes MS.

Clin Sci (Lond). 2019 Jan 25;133(2):321-334. doi: 10.1042/CS20180944. Print 2019 Jan 31.


High Salt Enhances Reactive Oxygen Species and Angiotensin II Contractions of Glomerular Afferent Arterioles From Mice With Reduced Renal Mass.

Li L, Lai EY, Luo Z, Solis G, Mendonca M, Griendling KK, Wellstein A, Welch WJ, Wilcox CS.

Hypertension. 2018 Nov;72(5):1208-1216. doi: 10.1161/HYPERTENSIONAHA.118.11354.


NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting Protein 2) Induce Filamentous Actin Oxidation and Promote Its Interaction With Vinculin During Integrin-Mediated Cell Adhesion.

Vukelic S, Xu Q, Seidel-Rogol B, Faidley EA, Dikalova AE, Hilenski LL, Jorde U, Poole LB, Lassègue B, Zhang G, Griendling KK.

Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2423-2434. doi: 10.1161/ATVBAHA.118.311668.


Poldip2 knockdown inhibits vascular smooth muscle proliferation and neointima formation by regulating the expression of PCNA and p21.

Datla SR, L Hilenski L, Seidel-Rogol B, Dikalova AE, Harousseau M, Punkova L, Joseph G, Taylor WR, Lassègue B, Griendling KK.

Lab Invest. 2019 Mar;99(3):387-398. doi: 10.1038/s41374-018-0103-y. Epub 2018 Sep 20.


Reply to Bailey et al.: New perspectives on the novel role of the Poldip2/ACSM1 axis in a functional mammalian lipoylation salvage pathway.

Paredes F, Lassègue B, Williams HC, Faidley EA, Benavides GA, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7460-E7461. doi: 10.1073/pnas.1807968115. Epub 2018 Jul 24. No abstract available.


Reactive Oxygen Species in Metabolic and Inflammatory Signaling.

Forrester SJ, Kikuchi DS, Hernandes MS, Xu Q, Griendling KK.

Circ Res. 2018 Mar 16;122(6):877-902. doi: 10.1161/CIRCRESAHA.117.311401. Review.


Cyclic Strain and Hypertension Increase Osteopontin Expression in the Aorta.

Caesar C, Lyle AN, Joseph G, Weiss D, Alameddine FMF, Lassègue B, Griendling KK, Taylor WR.

Cell Mol Bioeng. 2017 Apr;10(2):144-152. Epub 2016 Dec 27.


Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.

Hernandes MS, Lassègue B, Hilenski LL, Adams J, Gao N, Kuan CY, Sun YY, Cheng L, Kikuchi DS, Yepes M, Griendling KK.

J Neuroinflammation. 2018 Feb 17;15(1):45. doi: 10.1186/s12974-017-1032-1.


Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer.

Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, Torres G, Sanhueza-Olivares F, Yeligar SM, Griendling KK, Darley-Usmar V, San Martin A.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1789-1794. doi: 10.1073/pnas.1720693115. Epub 2018 Feb 6.


Design, synthesis, and biological evaluation of inhibitors of the NADPH oxidase, Nox4.

Xu Q, Kulkarni AA, Sajith AM, Hussein D, Brown D, Güner OF, Reddy MD, Watkins EB, Lassègue B, Griendling KK, Bowen JP.

Bioorg Med Chem. 2018 Mar 1;26(5):989-998. doi: 10.1016/j.bmc.2017.12.023. Epub 2017 Dec 17.


Mitochondrial Respiration and Atherosclerosis: R-E-S-P-I-R-E. Find Out What it Means to Mϕ (and VSMC).

Forrester SJ, Griendling KK.

Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):2229-2230. doi: 10.1161/ATVBAHA.117.310298. No abstract available.


Fundamental Cardiovascular Research: Returns on Societal Investment: A Scientific Statement From the American Heart Association.

Hill JA, Ardehali R, Clarke KT, Del Zoppo GJ, Eckhardt LL, Griendling KK, Libby P, Roden DM, Sadek HA, Seidman CE, Vaughan DE; American Heart Association Council on Basic Cardiovascular Sciences; Council on Clinical Cardiology; Council on Epidemiology and Prevention; Council on Functional Genomics and Translational Biology; and Stroke Council.

Circ Res. 2017 Jul 21;121(3):e2-e8. doi: 10.1161/RES.0000000000000155. Epub 2017 Jun 26. Review.


Polymerase δ-interacting Protein 2: A Multifunctional Protein.

Hernandes MS, Lassègue B, Griendling KK.

J Cardiovasc Pharmacol. 2017 Jun;69(6):335-342. doi: 10.1097/FJC.0000000000000465. Review.


Superoxide and hydrogen peroxide counterregulate myogenic contractions in renal afferent arterioles from a mouse model of chronic kidney disease.

Li L, Lai EY, Luo Z, Solis G, Griendling KK, Taylor WR, Jose PA, Wellstein A, Welch WJ, Wilcox CS.

Kidney Int. 2017 Sep;92(3):625-633. doi: 10.1016/j.kint.2017.02.009. Epub 2017 Apr 7. Erratum in: Kidney Int. 2017 Dec;92(6):1558.


Zinc regulates Nox1 expression through a NF-κB and mitochondrial ROS dependent mechanism to induce senescence of vascular smooth muscle cells.

Salazar G, Huang J, Feresin RG, Zhao Y, Griendling KK.

Free Radic Biol Med. 2017 Jul;108:225-235. doi: 10.1016/j.freeradbiomed.2017.03.032. Epub 2017 Mar 29.


Redox regulation of the actin cytoskeleton and its role in the vascular system.

Xu Q, Huff LP, Fujii M, Griendling KK.

Free Radic Biol Med. 2017 Aug;109:84-107. doi: 10.1016/j.freeradbiomed.2017.03.004. Epub 2017 Mar 8. Review.


NADPH Oxidases and Measurement of Reactive Oxygen Species.

Amanso A, Lyle AN, Griendling KK.

Methods Mol Biol. 2017;1527:219-232. doi: 10.1007/978-1-4939-6625-7_18.


NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis.

Di Marco E, Gray SP, Kennedy K, Szyndralewiez C, Lyle AN, Lassègue B, Griendling KK, Cooper ME, Schmidt HHHW, Jandeleit-Dahm KAM.

Free Radic Biol Med. 2016 Aug;97:556-567. doi: 10.1016/j.freeradbiomed.2016.07.013. Epub 2016 Jul 19.


Measurement of Reactive Oxygen Species, Reactive Nitrogen Species, and Redox-Dependent Signaling in the Cardiovascular System: A Scientific Statement From the American Heart Association.

Griendling KK, Touyz RM, Zweier JL, Dikalov S, Chilian W, Chen YR, Harrison DG, Bhatnagar A; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 Aug 19;119(5):e39-75. doi: 10.1161/RES.0000000000000110. Epub 2016 Jul 14. Review.


Redox-Sensitive Regulation of Myocardin-Related Transcription Factor (MRTF-A) Phosphorylation via Palladin in Vascular Smooth Muscle Cell Differentiation Marker Gene Expression.

Lee M, San Martín A, Valdivia A, Martin-Garrido A, Griendling KK.

PLoS One. 2016 Apr 18;11(4):e0153199. doi: 10.1371/journal.pone.0153199. eCollection 2016.


Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells.

Fujii M, Amanso A, Abrahão TB, Lassègue B, Griendling KK.

J Mol Cell Cardiol. 2016 Mar;92:21-9. doi: 10.1016/j.yjmcc.2016.01.016. Epub 2016 Jan 19.


Chemiluminescence and the Nox1-Nox2-Nox4 Triple Knockout.

Pagano PJ, Griendling KK, Miller FJ, Laurindo FR, Touyz RM.

Antioxid Redox Signal. 2015 Nov 20;23(15):1246-7. doi: 10.1089/ars.2015.6382. Epub 2015 Jul 14. No abstract available.


Hic-5 Mediates TGFβ-Induced Adhesion in Vascular Smooth Muscle Cells by a Nox4-Dependent Mechanism.

Fernandez I, Martin-Garrido A, Zhou DW, Clempus RE, Seidel-Rogol B, Valdivia A, Lassègue B, García AJ, Griendling KK, San Martin A.

Arterioscler Thromb Vasc Biol. 2015 May;35(5):1198-206. doi: 10.1161/ATVBAHA.114.305185. Epub 2015 Mar 26.


Regulation of signal transduction by reactive oxygen species in the cardiovascular system.

Brown DI, Griendling KK.

Circ Res. 2015 Jan 30;116(3):531-49. doi: 10.1161/CIRCRESAHA.116.303584. Review.


Nuclear factor (erythroid-derived 2)-like 2, the brake in oxidative stress that nicotinamide adenine dinucleotide phosphate-oxidase-4 needs to protect the heart.

Abrahao TB, Griendling KK.

Hypertension. 2015 Mar;65(3):499-501. doi: 10.1161/HYPERTENSIONAHA.114.04347. Epub 2014 Dec 22. No abstract available.


Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization.

Datla SR, McGrail DJ, Vukelic S, Huff LP, Lyle AN, Pounkova L, Lee M, Seidel-Rogol B, Khalil MK, Hilenski LL, Terada LS, Dawson MR, Lassègue B, Griendling KK.

Am J Physiol Heart Circ Physiol. 2014 Oct 1;307(7):H945-57. doi: 10.1152/ajpheart.00918.2013. Epub 2014 Jul 25.


RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013. Epub 2014 May 28.


Polymerase δ-interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.

Amanso AM, Lassègue B, Joseph G, Landázuri N, Long JS, Weiss D, Taylor WR, Griendling KK.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1548-55. doi: 10.1161/ATVBAHA.114.303873. Epub 2014 May 22.


Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice.

Kim CW, Kumar S, Son DJ, Jang IH, Griendling KK, Jo H.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1412-21. doi: 10.1161/ATVBAHA.113.303134. Epub 2014 May 8.


Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK.

PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014.


NADPH oxidases: progress and opportunities.

San Martin A, Griendling KK.

Antioxid Redox Signal. 2014 Jun 10;20(17):2692-4. doi: 10.1089/ars.2014.5947.


Angiotensin II, from vasoconstrictor to growth factor: a paradigm shift.

Vukelic S, Griendling KK.

Circ Res. 2014 Feb 28;114(5):754-7. doi: 10.1161/CIRCRESAHA.114.303045. No abstract available.


Hydrogen peroxide regulates osteopontin expression through activation of transcriptional and translational pathways.

Lyle AN, Remus EW, Fan AE, Lassègue B, Walter GA, Kiyosue A, Griendling KK, Taylor WR.

J Biol Chem. 2014 Jan 3;289(1):275-85. doi: 10.1074/jbc.M113.489641. Epub 2013 Nov 18.


Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation.

Martin-Garrido A, Williams HC, Lee M, Seidel-Rogol B, Ci X, Dong JT, Lassègue B, Martín AS, Griendling KK.

PLoS One. 2013 Nov 13;8(11):e79657. doi: 10.1371/journal.pone.0079657. eCollection 2013.


Nox2-induced production of mitochondrial superoxide in angiotensin II-mediated endothelial oxidative stress and hypertension.

Dikalov SI, Nazarewicz RR, Bikineyeva A, Hilenski L, Lassègue B, Griendling KK, Harrison DG, Dikalova AE.

Antioxid Redox Signal. 2014 Jan 10;20(2):281-94. doi: 10.1089/ars.2012.4918. Epub 2013 Oct 30.


Polymerase delta interacting protein 2 sustains vascular structure and function.

Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132.


The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice.

Koga M, Engberding N, Dikalova AE, Chang KH, Seidel-Rogol B, Long JS, Lassègue B, Jo H, Griendling KK.

Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H747-55. doi: 10.1152/ajpheart.00825.2012. Epub 2013 Jun 28.


Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system.

Lassègue B, San Martín A, Griendling KK.

Circ Res. 2012 May 11;110(10):1364-90. doi: 10.1161/CIRCRESAHA.111.243972. Review.


Increased expression of Nox1 in neointimal smooth muscle cells promotes activation of matrix metalloproteinase-9.

Xu S, Shriver AS, Jagadeesha DK, Chamseddine AH, Szőcs K, Weintraub NL, Griendling KK, Bhalla RC, Miller FJ Jr.

J Vasc Res. 2012;49(3):242-8. doi: 10.1159/000332958. Epub 2012 Mar 15.


Differential roles of NADPH oxidases in vascular physiology and pathophysiology.

Amanso AM, Griendling KK.

Front Biosci (Schol Ed). 2012 Jan 1;4:1044-64. Review.


Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK.

Hitomi H, Mehta PK, Taniyama Y, Lassègue B, Seidel-Rogol B, San Martin A, Griendling KK.

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1415-22. doi: 10.1152/ajpcell.00017.2011. Epub 2011 Sep 7.


Platelet-derived growth factor (PDGF) regulates Slingshot phosphatase activity via Nox1-dependent auto-dephosphorylation of serine 834 in vascular smooth muscle cells.

Maheswaranathan M, Gole HK, Fernandez I, Lassègue B, Griendling KK, San Martín A.

J Biol Chem. 2011 Oct 14;286(41):35430-7. doi: 10.1074/jbc.M111.268284. Epub 2011 Aug 20.


Mechanical stretch augments insulin-induced vascular smooth muscle cell proliferation by insulin-like growth factor-1 receptor.

Liu G, Hitomi H, Hosomi N, Lei B, Nakano D, Deguchi K, Mori H, Masaki T, Ma H, Griendling KK, Nishiyama A.

Exp Cell Res. 2011 Oct 15;317(17):2420-8. doi: 10.1016/j.yexcr.2011.07.016. Epub 2011 Aug 9.


Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.

Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ.

Free Radic Biol Med. 2011 Oct 1;51(7):1271-88. doi: 10.1016/j.freeradbiomed.2011.06.011. Epub 2011 Jun 14. Review.


Career development of physician scientists: a survey of leaders in academic medicine.

Shea JA, Stern DT, Klotman PE, Clayton CP, O'Hara JL, Feldman MD, Griendling KK, Moss M, Straus SE, Jagsi R.

Am J Med. 2011 Aug;124(8):779-87. doi: 10.1016/j.amjmed.2011.04.004. No abstract available.


Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets.

Drummond GR, Selemidis S, Griendling KK, Sobey CG.

Nat Rev Drug Discov. 2011 Jun;10(6):453-71. doi: 10.1038/nrd3403. Review.

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