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Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication.

Merlino F, Tomassi S, Yousif AM, Messere A, Marinelli L, Grieco P, Novellino E, Cosconati S, Di Maro S.

Org Lett. 2019 Aug 16;21(16):6378-6382. doi: 10.1021/acs.orglett.9b02283. Epub 2019 Jul 30.


Synthesis and Pharmacological Evaluation of a Novel Peptide Based on Anemonia sulcata BDS-I Toxin as a New KV3.4 Inhibitor Exerting a Neuroprotective Effect Against Amyloid-β Peptide.

Ciccone R, Piccialli I, Grieco P, Merlino F, Annunziato L, Pannaccione A.

Front Chem. 2019 Jul 9;7:479. doi: 10.3389/fchem.2019.00479. eCollection 2019.


Urotensin II receptor expression in patients with ulcerative colitis: a pilot study.

Gravina AG, Dallio M, Tuccillo C, Martorano M, Abenavoli L, Luzza F, Stiuso P, Lama S, Grieco P, Merlino F, Caraglia M, Loguercio C, Federico A.

Minerva Gastroenterol Dietol. 2019 Jul 9. doi: 10.23736/S1121-421X.19.02602-3. [Epub ahead of print]


Total hip arthroplasty in Parkinson's disease patients: a propensity score-matched analysis with minimum 2-year surveillance.

Shah NV, Solow M, Lavian JD, Bloom LR, Grieco PW, Stroud SG, Abraham R, Naziri Q, Paulino CB, Maheshwari AV, Diebo BG.

Hip Int. 2019 Jul 3:1120700019862247. doi: 10.1177/1120700019862247. [Epub ahead of print]


The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.

Buommino E, Carotenuto A, Antignano I, Bellavita R, Casciaro B, Loffredo MR, Merlino F, Novellino E, Mangoni ML, Nocera FP, Brancaccio D, Punzi P, Roversi D, Ingenito R, Bianchi E, Grieco P.

ChemMedChem. 2019 Jul 3;14(13):1283-1290. doi: 10.1002/cmdc.201900221. Epub 2019 Jun 3.


Improved synthesis on solid phase of dithiocarbamic cRGD-derivative and 99m Tc-radiolabelling.

Caporale A, Bolzati C, Incisivo GM, Salvarese N, Grieco P, Ruvo M.

J Pept Sci. 2019 Feb;25(2):e3140. doi: 10.1002/psc.3140.


Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects.

Liu C, Wu P, Zhu H, Grieco P, Yu R, Gao X, Wu G, Wang D, Xu H, Qi W.

Molecules. 2019 Jan 18;24(2). pii: E337. doi: 10.3390/molecules24020337.


Short PlGF-derived peptides bind VEGFR-1 and VEGFR-2 in vitro and on the surface of endothelial cells.

Caporale A, Martin AD, Capasso D, Focà G, Sandomenico A, D'Andrea LD, Grieco P, Ruvo M, Doti N.

J Pept Sci. 2019 May;25(5):e3146. doi: 10.1002/psc.3146. Epub 2019 Jan 16.


Vertebral Osteomyelitis: A Comparison of Associated Outcomes in Early Versus Delayed Surgical Treatment.

Segreto FA, Beyer GA, Grieco P, Horn SR, Bortz CA, Jalai CM, Passias PG, Paulino CB, Diebo BG.

Int J Spine Surg. 2018 Dec 21;12(6):703-712. doi: 10.14444/5088. eCollection 2018 Dec.


Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides.

Merlino F, Billard É, Yousif AM, Di Maro S, Brancaccio D, Abate L, Carotenuto A, Bellavita R, d'Emmanuele di Villa Bianca R, Santicioli P, Marinelli L, Novellino E, Hébert TE, Lubell WD, Chatenet D, Grieco P.

J Med Chem. 2019 Feb 14;62(3):1455-1467. doi: 10.1021/acs.jmedchem.8b01601. Epub 2019 Jan 23.


Natural and synthetic peptides in the cardiovascular diseases: An update on diagnostic and therapeutic potentials.

Grieco P, Gomez-Monterrey I.

Arch Biochem Biophys. 2019 Feb 15;662:15-32. doi: 10.1016/ Epub 2018 Nov 24. Review.


Strategic Patient Discharge: the Case of Long-Term Care Hospitals.

Eliason PJ, Grieco P, McDevitt RC, Roberts JW.

Am Econ Rev. 2018 Nov;108(11):3232-65.


Investigation on side-product formation during the synthesis of a lactoferrin-derived lactam-bridged cyclic peptide.

Scala MC, Spensiero A, Pepe G, Bertamino A, Carotenuto A, Grieco P, Novellino E, Gomez-Monterrey IM, Campiglia P, Sala M.

Amino Acids. 2018 Oct;50(10):1367-1375. doi: 10.1007/s00726-018-2612-9. Epub 2018 Jul 4.


Bilateral Spontaneous Quadriceps Tendon Ruptures after Staged Bilateral Total Knee Arthroplasties: A Case Report.

Coste M, Newman JM, Shah NV, Eldib AM, Grieco PW, Maheshwari AV.

J Long Term Eff Med Implants. 2018;28(1):63-71. doi: 10.1615/JLongTermEffMedImplants.2018025731.


The Effects of Meniscal Geometry on Susceptibility for Meniscal and ACL Injury in Non-Arthritic Knees: A Retrospective Case-Control Study.

Tejani A, Naziri Q, Grieco PW, Pivec R, Greene D, Kapadia BV, Chatterjee D, Urban WP.

J Long Term Eff Med Implants. 2018;28(1):31-36. doi: 10.1615/JLongTermEffMedImplants.2017020736.


Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors.

Merlino F, Zhou Y, Cai M, Carotenuto A, Yousif AM, Brancaccio D, Di Maro S, Zappavigna S, Limatola A, Novellino E, Grieco P, Hruby VJ.

J Med Chem. 2018 May 10;61(9):4263-4269. doi: 10.1021/acs.jmedchem.8b00488. Epub 2018 Apr 25.


New alternate bearing surfaces in total hip arthroplasty: A review of the current literature.

Grieco PW, Pascal S, Newman JM, Shah NV, Stroud SG, Sheth NP, Maheshwari AV.

J Clin Orthop Trauma. 2018 Jan-Mar;9(1):7-16. doi: 10.1016/j.jcot.2017.10.013. Epub 2017 Oct 27. Review.


The Amphibian Antimicrobial Peptide Temporin B Inhibits In Vitro Herpes Simplex Virus 1 Infection.

Marcocci ME, Amatore D, Villa S, Casciaro B, Aimola P, Franci G, Grieco P, Galdiero M, Palamara AT, Mangoni ML, Nencioni L.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02367-17. doi: 10.1128/AAC.02367-17. Print 2018 May.


Complications in Patients Undergoing Spinal Fusion After THA.

Diebo BG, Beyer GA, Grieco PW, Liu S, Day LM, Abraham R, Naziri Q, Passias PG, Maheshwari AV, Paulino CB.

Clin Orthop Relat Res. 2018 Feb;476(2):412-417. doi: 10.1007/s11999.0000000000000009.


Semiochemicals to enhance herbivory by Diorhabda carinulata aggregations in saltcedar (Tamarix spp.) infestations.

Gaffke AM, Sing SE, Dudley TL, Bean DW, Russak JA, Mafra-Neto A, Grieco PA, Peterson RK, Weaver DK.

Pest Manag Sci. 2018 Jun;74(6):1494-1503. doi: 10.1002/ps.4848. Epub 2018 Feb 23.


Adult Reconstruction Studies Presented at AAOS and AAHKS 2011-2015 Annual Meetings. Is There a Difference in Future Publication?

Naziri Q, Mixa PJ, Murray DP, Grieco PW, Illical EM, Maheshwari AV, Khanuja HS.

J Arthroplasty. 2018 May;33(5):1594-1597. doi: 10.1016/j.arth.2017.11.058. Epub 2017 Dec 6. Review.


Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration.

Yousif AM, Ingangi V, Merlino F, Brancaccio D, Minopoli M, Bellavita R, Novellino E, Carriero MV, Carotenuto A, Grieco P.

Eur J Med Chem. 2018 Jan 1;143:348-360. doi: 10.1016/j.ejmech.2017.11.030. Epub 2017 Dec 1.


Glycine-replaced derivatives of [Pro3,DLeu9]TL, a temporin L analogue: Evaluation of antimicrobial, cytotoxic and hemolytic activities.

Merlino F, Carotenuto A, Casciaro B, Martora F, Loffredo MR, Di Grazia A, Yousif AM, Brancaccio D, Palomba L, Novellino E, Galdiero M, Iovene MR, Mangoni ML, Grieco P.

Eur J Med Chem. 2017 Oct 20;139:750-761. doi: 10.1016/j.ejmech.2017.08.040. Epub 2017 Aug 21.


Melanocortin receptor agonists MCR1-5 protect photoreceptors from high-glucose damage and restore antioxidant enzymes in primary retinal cell culture.

Maisto R, Gesualdo C, Trotta MC, Grieco P, Testa F, Simonelli F, Barcia JM, D'Amico M, Di Filippo C, Rossi S.

J Cell Mol Med. 2017 May;21(5):968-974. doi: 10.1111/jcmm.13036. Epub 2016 Dec 20.


Multiple beneficial effects of melanocortin MC4 receptor agonists in experimental neurodegenerative disorders: Therapeutic perspectives.

Giuliani D, Ottani A, Neri L, Zaffe D, Grieco P, Jochem J, Cavallini GM, Catania A, Guarini S.

Prog Neurobiol. 2017 Jan;148:40-56. doi: 10.1016/j.pneurobio.2016.11.004. Epub 2016 Dec 1. Review.


Regenerate bone stimulation following limb lengthening: a meta-analysis.

Jauregui JJ, Ventimiglia AV, Grieco PW, Frumberg DB, Herzenberg JE.

BMC Musculoskelet Disord. 2016 Sep 29;17(1):407.


Proteomic comparison of near-isogenic barley (Hordeum vulgare L.) germplasm differing in the allelic state of a major senescence QTL identifies numerous proteins involved in plant pathogen defense.

Mason KE, Hilmer JK, Maaty WS, Reeves BD, Grieco PA, Bothner B, Fischer AM.

Plant Physiol Biochem. 2016 Dec;109:114-127. doi: 10.1016/j.plaphy.2016.09.008. Epub 2016 Sep 14.


Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization.

Genua M, Ingangi V, Fonteyne P, Piontini A, Yousif AM, Merlino F, Grieco P, Malesci A, Carriero MV, Danese S.

Inflamm Bowel Dis. 2016 Oct;22(10):2390-401. doi: 10.1097/MIB.0000000000000896.


Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase.

Sala M, Spensiero A, Esposito F, Scala MC, Vernieri E, Bertamino A, Manfra M, Carotenuto A, Grieco P, Novellino E, Cadeddu M, Tramontano E, Schols D, Campiglia P, Gomez-Monterrey IM.

Front Microbiol. 2016 Jun 10;7:845. doi: 10.3389/fmicb.2016.00845. eCollection 2016.


Urotensin-II Receptor: A Double Identity Receptor Involved in Vasoconstriction and in the Development of Digestive Tract Cancers and other Tumors.

Federico A, Zappavigna S, Dallio M, Misso G, Merlino F, Loguercio C, Novellino E, Grieco P, Caraglia M.

Curr Cancer Drug Targets. 2017;17(2):109-121. doi: 10.2174/1568009616666160621101248. Review.


The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells.

Ingangi V, Bifulco K, Yousif AM, Ragone C, Motti ML, Rea D, Minopoli M, Botti G, Scognamiglio G, Fazioli F, Gallo M, De Chiara A, Arra C, Grieco P, Carriero MV.

Oncotarget. 2016 Aug 23;7(34):54474-54487. doi: 10.18632/oncotarget.9976.


Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity.

Merlino F, Yousif AM, Billard É, Dufour-Gallant J, Turcotte S, Grieco P, Chatenet D, Lubell WD.

J Med Chem. 2016 May 26;59(10):4740-52. doi: 10.1021/acs.jmedchem.6b00108. Epub 2016 May 17.


Nanocarriers Conjugated with Cell Penetrating Peptides: New Trojan Horses by Modern Ulysses.

Zappavigna S, Misso G, Falanga A, Perillo E, Novellino E, Galdiero M, Grieco P, Caraglia M, Galdiero S.

Curr Pharm Biotechnol. 2016;17(8):700-22. Review.


Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9.

Merlino F, Brancaccio D, Yousif AM, Piras L, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Carotenuto A, Grieco P.

ChemMedChem. 2016 Aug 19;11(16):1856-64. doi: 10.1002/cmdc.201500607. Epub 2016 Apr 9.


Activation of Melanocortin Receptors MC 1 and MC 5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy.

Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D'Amico M, Di Filippo C.

Mediators Inflamm. 2016;2016:7368389. doi: 10.1155/2016/7368389. Epub 2016 Jan 12.


Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells.

Durso M, Gaglione M, Piras L, Mercurio ME, Terreri S, Olivieri M, Marinelli L, Novellino E, Incoronato M, Grieco P, Orsini G, Tonon G, Messere A, Cimmino A.

Eur J Med Chem. 2016 Mar 23;111:15-25. doi: 10.1016/j.ejmech.2016.01.047. Epub 2016 Jan 27.


Screening Platform toward New Anti-HIV Aptamers Set on Molecular Docking and Fluorescence Quenching Techniques.

Oliviero G, Stornaiuolo M, D'Atri V, Nici F, Yousif AM, D'Errico S, Piccialli G, Mayol L, Novellino E, Marinelli L, Grieco P, Carotenuto A, Noppen S, Liekens S, Balzarini J, Borbone N.

Anal Chem. 2016 Feb 16;88(4):2327-34. doi: 10.1021/acs.analchem.5b04268. Epub 2016 Feb 5.


Targeting "Undruggable" Proteins: Design of Synthetic Cyclopeptides.

Russo A, Aiello C, Grieco P, Marasco D.

Curr Med Chem. 2016;23(8):748-62. Review.


Discovery of Novel Potent and Selective Agonists at the Melanocortin-3 Receptor.

Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P.

J Med Chem. 2015 Dec 24;58(24):9773-8. doi: 10.1021/acs.jmedchem.5b01285. Epub 2015 Dec 16.


A novel technique for guided bone regeneration using platelet-rich plasma and osteogenic progenitor cells: Literature-based rationale and case report.

Kwon T, Grieco PC, Levin L, Intini G.

Quintessence Int. 2016 Mar;47(3):233-40. doi: 10.3290/j.qi.a34975. Review.


Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.

De Cobelli O, Buonerba C, Terracciano D, Bottero D, Lucarelli G, Bove P, Altieri V, Coman I, Perdonà S, Facchini G, Berretta M, Di Lorenzo G, Grieco P, Novellino E, Franco R, Caraglia M, Manini C, Mirone V, De Placido S, Sonpavde G, Ferro M.

Future Oncol. 2015 Nov;11(22):3091-8. doi: 10.2217/fon.15.249. Epub 2015 Sep 18.


Cyclization of the urokinase receptor-derived ser-arg-ser-arg-tyr Peptide generates a potent inhibitor of trans-endothelial migration of monocytes.

Yousif AM, Minopoli M, Bifulco K, Ingangi V, Di Carluccio G, Merlino F, Motti ML, Grieco P, Carriero MV.

PLoS One. 2015 May 4;10(5):e0126172. doi: 10.1371/journal.pone.0126172. eCollection 2015.


The renaissance era of peptides in drug discovery at the 14th Naples workshop on bioactive peptides.

Morelli G, Saviano M, Grieco P.

J Pept Sci. 2015 May;21(5):321-2. doi: 10.1002/psc.2783. Epub 2015 Apr 10. No abstract available.


Antimicrobial peptides as an opportunity against bacterial diseases.

Galdiero S, Falanga A, Berisio R, Grieco P, Morelli G, Galdiero M.

Curr Med Chem. 2015;22(14):1665-77. Review.


An investigation into the origin of the biased agonism associated with the urotensin II receptor activation.

Brancaccio D, Merlino F, Limatola A, Yousif AM, Gomez-Monterrey I, Campiglia P, Novellino E, Grieco P, Carotenuto A.

J Pept Sci. 2015 May;21(5):392-9. doi: 10.1002/psc.2740. Epub 2015 Feb 19.


Biomechanical evaluation of varying the number of loops in a repair of a physiological model of Achilles tendon rupture.

Grieco PW, Frumberg DB, Weinberg M, Pivec R, Naziri Q, Uribe JA.

Foot Ankle Int. 2015 Apr;36(4):444-9. doi: 10.1177/1071100714559270. Epub 2014 Nov 7.


Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury.

Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC, Getting SJ.

Biochem Pharmacol. 2014 Nov 15;92(2):336-47. doi: 10.1016/j.bcp.2014.08.019. Epub 2014 Aug 28.


A new therapeutic approach to erectile dysfunction: urotensin-II receptor high affinity agonist ligands.

di Villa Bianca Rd, Mitidieri E, Donnarumma E, Fusco F, Longo N, Rosa GD, Novellino E, Grieco P, Mirone V, Cirino G, Sorrentino R.

Asian J Androl. 2015 Jan-Feb;17(1):81-5. doi: 10.4103/1008-682X.133322.


Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor.

Carotenuto A, Auriemma L, Merlino F, Yousif AM, Marasco D, Limatola A, Campiglia P, Gomez-Monterrey I, Santicioli P, Meini S, Maggi CA, Novellino E, Grieco P.

J Med Chem. 2014 Jul 24;57(14):5965-74. doi: 10.1021/jm500218x. Epub 2014 Jul 10.


Conversion of S-phenylsulfonylcysteine residues to mixed disulfides at pH 4.0: utility in protein thiol blocking and in protein-S-nitrosothiol detection.

Reeves BD, Joshi N, Campanello GC, Hilmer JK, Chetia L, Vance JA, Reinschmidt JN, Miller CG, Giedroc DP, Dratz EA, Singel DJ, Grieco PA.

Org Biomol Chem. 2014 Oct 28;12(40):7942-56. doi: 10.1039/c4ob00995a. Epub 2014 Jul 2.

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