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Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's Disease.

Li C, Grider JR, Murthy KS, Bohl J, Rivet E, Wieghard N, Kuemmerle JF.

Inflamm Bowel Dis. 2020 Feb 7. pii: izaa015. doi: 10.1093/ibd/izaa015. [Epub ahead of print]


Expression and function of umami receptors T1R1/T1R3 in gastric smooth muscle.

Crowe MS, Wang H, Blakeney BA, Mahavadi S, Singh K, Murthy KS, Grider JR.

Neurogastroenterol Motil. 2020 Feb;32(2):e13737. doi: 10.1111/nmo.13737. Epub 2019 Nov 12.


Expression patterns of L-amino acid receptors in the murine STC-1 enteroendocrine cell line.

Wang H, Murthy KS, Grider JR.

Cell Tissue Res. 2019 Dec;378(3):471-483. doi: 10.1007/s00441-019-03074-y. Epub 2019 Aug 13.


Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization.

Mahavadi S, Nalli AD, Wang H, Kendig DM, Crowe MS, Lyall V, Grider JR, Murthy KS.

PLoS One. 2018 Dec 20;13(12):e0209359. doi: 10.1371/journal.pone.0209359. eCollection 2018. Retraction in: PLoS One. 2019 Nov 7;14(11):e0225159.


Branched Short-Chain Fatty Acid Isovaleric Acid Causes Colonic Smooth Muscle Relaxation via cAMP/PKA Pathway.

Blakeney BA, Crowe MS, Mahavadi S, Murthy KS, Grider JR.

Dig Dis Sci. 2019 May;64(5):1171-1181. doi: 10.1007/s10620-018-5417-5. Epub 2018 Dec 17.


Identification of expression and function of the glucagon-like peptide-1 receptor in colonic smooth muscle.

May AT, Crowe MS, Blakeney BA, Mahavadi S, Wang H, Grider JR, Murthy KS.

Peptides. 2019 Feb;112:48-55. doi: 10.1016/j.peptides.2018.11.007. Epub 2018 Nov 30.


Muscarinic m2 receptor-mediated actin polymerization via PI3 kinase γ and integrin-linked kinase in gastric smooth muscle.

Mahavadi S, Grider JR, Murthy KS.

Neurogastroenterol Motil. 2019 Feb;31(2):e13495. doi: 10.1111/nmo.13495. Epub 2018 Nov 4.


Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells.

Qian J, Mummalaneni S, Larsen J, Grider JR, Spielman AI, Özdener MH, Lyall V.

PLoS One. 2018 Mar 7;13(3):e0194089. doi: 10.1371/journal.pone.0194089. eCollection 2018.


Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).

Qian J, Mummalaneni S, Grider JR, Damaj MI, Lyall V.

PLoS One. 2018 Jan 2;13(1):e0190465. doi: 10.1371/journal.pone.0190465. eCollection 2018.


Matrix Metalloprotease-1 and Elastase Are Novel Uterotonic Agents Acting Through Protease-Activated Receptor 1.

Walsh SW, Nugent WH, Solotskaya AV, Anderson CD, Grider JR, Strauss JF 3rd.

Reprod Sci. 2018 Jul;25(7):1058-1066. doi: 10.1177/1933719117732162. Epub 2017 Sep 27.


Augmentation of cGMP/PKG pathway and colonic motility by hydrogen sulfide.

Nalli AD, Bhattacharya S, Wang H, Kendig DM, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G330-G341. doi: 10.1152/ajpgi.00161.2017. Epub 2017 Jul 13.


Diabetes-induced oxidative stress mediates upregulation of RhoA/Rho kinase pathway and hypercontractility of gastric smooth muscle.

Mahavadi S, Sriwai W, Manion O, Grider JR, Murthy KS.

PLoS One. 2017 Jul 5;12(7):e0178574. doi: 10.1371/journal.pone.0178574. eCollection 2017.


Nicotine-Induced Effects on Nicotinic Acetylcholine Receptors (nAChRs), Ca2+ and Brain-Derived Neurotrophic Factor (BDNF) in STC-1 Cells.

Qian J, Mummalaneni SK, Alkahtani RM, Mahavadi S, Murthy KS, Grider JR, Lyall V.

PLoS One. 2016 Nov 15;11(11):e0166565. doi: 10.1371/journal.pone.0166565. eCollection 2016.


Enhanced Sensitivity of α3β4 Nicotinic Receptors in Enteric Neurons after Long-Term Morphine: Implication for Opioid-Induced Constipation.

Gade AR, Kang M, Khan F, Grider JR, Damaj MI, Dewey WL, Akbarali HI.

J Pharmacol Exp Ther. 2016 Jun;357(3):520-8. doi: 10.1124/jpet.116.233304. Epub 2016 Apr 11.


Spatiotemporal Mapping of Motility in Ex Vivo Preparations of the Intestines.

Kendig DM, Hurst NR, Grider JR.

J Vis Exp. 2016 Jan 27;(107):e53263. doi: 10.3791/53263.


Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis.

Kumar DP, Asgharpour A, Mirshahi F, Park SH, Liu S, Imai Y, Nadler JL, Grider JR, Murthy KS, Sanyal AJ.

J Biol Chem. 2016 Mar 25;291(13):6626-40. doi: 10.1074/jbc.M115.699504. Epub 2016 Jan 12.


Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO.

J Neurosci. 2015 Aug 19;35(33):11543-58. doi: 10.1523/JNEUROSCI.5267-14.2015.


Serotonin and colonic motility.

Kendig DM, Grider JR.

Neurogastroenterol Motil. 2015 Jul;27(7):899-905. doi: 10.1111/nmo.12617. Review.


Stimulation of synthesis and release of brain-derived neurotropic factor from intestinal smooth muscle cells by substance P and pituitary adenylate cyclase-activating peptide.

Al-Qudah M, Alkahtani R, Akbarali HI, Murthy KS, Grider JR.

Neurogastroenterol Motil. 2015 Aug;27(8):1162-74. doi: 10.1111/nmo.12604. Epub 2015 Jun 18.


Noncanonical STAT3 activation regulates excess TGF-β1 and collagen I expression in muscle of stricturing Crohn's disease.

Li C, Iness A, Yoon J, Grider JR, Murthy KS, Kellum JM, Kuemmerle JF.

J Immunol. 2015 Apr 1;194(7):3422-31. doi: 10.4049/jimmunol.1401779. Epub 2015 Mar 4.


Inhibition of NMDAR reduces bladder hypertrophy and improves bladder function in cyclophosphamide induced cystitis.

Liu M, Shen S, Kendig DM, Mahavadi S, Murthy KS, Grider JR, Qiao LY.

J Urol. 2015 May;193(5):1676-83. doi: 10.1016/j.juro.2014.12.092. Epub 2015 Jan 6.


Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells.

Nalli AD, Rajagopal S, Mahavadi S, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C485-95. doi: 10.1152/ajpcell.00280.2014. Epub 2015 Jan 7.


Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation.

Rajagopal S, Nalli AD, Kumar DP, Bhattacharya S, Hu W, Mahavadi S, Grider JR, Murthy KS.

J Pharmacol Exp Ther. 2015 Mar;352(3):509-18. doi: 10.1124/jpet.114.221929. Epub 2014 Dec 30.


Suppression of the PI3K pathway in vivo reduces cystitis-induced bladder hypertrophy and restores bladder capacity examined by magnetic resonance imaging.

Qiao Z, Xia C, Shen S, Corwin FD, Liu M, Guan R, Grider JR, Qiao LY.

PLoS One. 2014 Dec 8;9(12):e114536. doi: 10.1371/journal.pone.0114536. eCollection 2014.


Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S.

Bala V, Rajagopal S, Kumar DP, Nalli AD, Mahavadi S, Sanyal AJ, Grider JR, Murthy KS.

Front Physiol. 2014 Nov 3;5:420. doi: 10.3389/fphys.2014.00420. eCollection 2014.


Activation of the umami taste receptor (T1R1/T1R3) initiates the peristaltic reflex and pellet propulsion in the distal colon.

Kendig DM, Hurst NR, Bradley ZL, Mahavadi S, Kuemmerle JF, Lyall V, DeSimone J, Murthy KS, Grider JR.

Am J Physiol Gastrointest Liver Physiol. 2014 Dec 1;307(11):G1100-7. doi: 10.1152/ajpgi.00251.2014. Epub 2014 Oct 16.


The short chain fatty acids, butyrate and propionate, have differential effects on the motility of the guinea pig colon.

Hurst NR, Kendig DM, Murthy KS, Grider JR.

Neurogastroenterol Motil. 2014 Nov;26(11):1586-96. doi: 10.1111/nmo.12425. Epub 2014 Sep 16. Erratum in: Neurogastroenterol Motil. 2015 Sep;27(9):1345-7.


Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.

Mahavadi S, Nalli AD, Kumar DP, Hu W, Kuemmerle JF, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C402-11. doi: 10.1152/ajpcell.00123.2014. Epub 2014 Jun 18.


Regulation of Gβγi-dependent PLC-β3 activity in smooth muscle: inhibitory phosphorylation of PLC-β3 by PKA and PKG and stimulatory phosphorylation of Gαi-GTPase-activating protein RGS2 by PKG.

Nalli AD, Kumar DP, Al-Shboul O, Mahavadi S, Kuemmerle JF, Grider JR, Murthy KS.

Cell Biochem Biophys. 2014 Nov;70(2):867-80. doi: 10.1007/s12013-014-9992-6.


Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-κB/AMP-activated kinase/myosin light chain kinase pathway.

Nalli AD, Kumar DP, Mahavadi S, Al-Shboul O, Alkahtani R, Kuemmerle JF, Grider JR, Murthy KS.

J Pharmacol Exp Ther. 2014 Jul;350(1):89-98. doi: 10.1124/jpet.113.212522. Epub 2014 Apr 25.


Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation.

Al-Shboul O, Nalli AD, Kumar DP, Zhou R, Mahavadi S, Kuemmerle JF, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2014 Jun 15;306(12):C1129-41. doi: 10.1152/ajpcell.00021.2014. Epub 2014 Apr 16.


Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinase.

Mahavadi S, Sriwai W, Huang J, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G535-45. doi: 10.1152/ajpgi.00397.2013. Epub 2014 Jan 9.


Role of various kinases in muscarinic M3 receptor-mediated contraction of longitudinal muscle of rat colon.

Anderson CD Jr, Kendig DM, Al-Qudah M, Mahavadi S, Murthy KS, Grider JR.

J Smooth Muscle Res. 2014;50:103-19. doi: 10.1540/jsmr.50.103.


Brain-derived neurotrophic factor enhances cholinergic contraction of longitudinal muscle of rabbit intestine via activation of phospholipase C.

Al-Qudah M, Anderson CD, Mahavadi S, Bradley ZL, Akbarali HI, Murthy KS, Grider JR.

Am J Physiol Gastrointest Liver Physiol. 2014 Feb 15;306(4):G328-37. doi: 10.1152/ajpgi.00203.2013. Epub 2013 Dec 19.


Increased PDE5 activity and decreased Rho kinase and PKC activities in colonic muscle from caveolin-1-/- mice impair the peristaltic reflex and propulsion.

Mahavadi S, Bhattacharya S, Kumar DP, Clay C, Ross G, Akbarali HI, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G964-74. doi: 10.1152/ajpgi.00165.2013. Epub 2013 Oct 24.


Increased activation of latent TGF-β1 by αVβ3 in human Crohn's disease and fibrosis in TNBS colitis can be prevented by cilengitide.

Li C, Flynn RS, Grider JR, Murthy KS, Kellum JM, Akbari H, Kuemmerle JF.

Inflamm Bowel Dis. 2013 Dec;19(13):2829-39. doi: 10.1097/MIB.0b013e3182a8452e.


An in-vitro preparation of isolated enteric neurons and glia from the myenteric plexus of the adult mouse.

Smith TH, Ngwainmbi J, Grider JR, Dewey WL, Akbarali HI.

J Vis Exp. 2013 Aug 7;(78). doi: 10.3791/50688.


Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA.

Sriwai W, Mahavadi S, Al-Shboul O, Grider JR, Murthy KS.

PLoS One. 2013 Jun 18;8(6):e66743. doi: 10.1371/journal.pone.0066743. Print 2013.


Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO.

Dev Biol. 2013 Sep 1;381(1):28-37. doi: 10.1016/j.ydbio.2013.06.021. Epub 2013 Jun 24.


Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-induced colitis in mice.

Alkahtani R, Mahavadi S, Al-Shboul O, Alsharari S, Grider JR, Murthy KS.

Inflammation. 2013 Dec;36(6):1304-15. doi: 10.1007/s10753-013-9669-0.


Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1.

Bhattacharya S, Mahavadi S, Al-Shboul O, Rajagopal S, Grider JR, Murthy KS.

Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C334-47. doi: 10.1152/ajpcell.00334.2012. Epub 2013 Jun 19.


Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle.

Al-Shboul O, Mahavadi S, Sriwai W, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G314-24. doi: 10.1152/ajpgi.00457.2012. Epub 2013 Jun 13.


TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.

Ren Z, Rhyu MR, Phan TH, Mummalaneni S, Murthy KS, Grider JR, DeSimone JA, Lyall V.

Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G106-17. doi: 10.1152/ajpgi.00053.2013. Epub 2013 May 2.


Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle.

Ahmed R, Mahavadi S, Al-Shboul O, Bhattacharya S, Grider JR, Murthy KS.

Regul Pept. 2013 Jun 10;184:96-103. doi: 10.1016/j.regpep.2013.03.028. Epub 2013 Mar 27.


Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC₂, in gastrointestinal smooth muscle.

Mahavadi S, Bhattacharya S, Kim J, Fayed S, Al-Shboul O, Grider JR, Murthy KS.

Peptides. 2013 May;43:137-45. doi: 10.1016/j.peptides.2013.03.008. Epub 2013 Mar 15.


Electrophysiological characteristics of enteric neurons isolated from the immortomouse.

Hawkins EG, Dewey WL, Anitha M, Srinivasan S, Grider JR, Akbarali HI.

Dig Dis Sci. 2013 Jun;58(6):1516-27. doi: 10.1007/s10620-013-2557-5. Epub 2013 Jan 31.


Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway.

Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS.

Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35. doi: 10.1152/ajpgi.00388.2012. Epub 2012 Dec 28.


The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice.

Alemi F, Poole DP, Chiu J, Schoonjans K, Cattaruzza F, Grider JR, Bunnett NW, Corvera CU.

Gastroenterology. 2013 Jan;144(1):145-54. doi: 10.1053/j.gastro.2012.09.055. Epub 2012 Oct 3.


Morphine decreases enteric neuron excitability via inhibition of sodium channels.

Smith TH, Grider JR, Dewey WL, Akbarali HI.

PLoS One. 2012;7(9):e45251. doi: 10.1371/journal.pone.0045251. Epub 2012 Sep 21. Erratum in: PLoS One. 2013;8(5). doi: 10.1371/annotation/c2d0d839-3fea-4dfd-ad78-4e4fb1271b20.


Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.

Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS, Sanyal AJ.

Biochem Biophys Res Commun. 2012 Oct 26;427(3):600-5. doi: 10.1016/j.bbrc.2012.09.104. Epub 2012 Sep 27.

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