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Items: 1 to 50 of 85

1.

The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.

van Bemmel JG, Galupa R, Gard C, Servant N, Picard C, Davies J, Szempruch AJ, Zhan Y, Żylicz JJ, Nora EP, Lameiras S, de Wit E, Gentien D, Baulande S, Giorgetti L, Guttman M, Hughes JR, Higgs DR, Gribnau J, Heard E.

Nat Genet. 2019 Jun;51(6):1024-1034. doi: 10.1038/s41588-019-0412-0. Epub 2019 May 27.

PMID:
31133748
2.

A novel approach to differentiate rat embryonic stem cells in vitro reveals a role for RNF12 in activation of X chromosome inactivation.

Magaraki A, Loda A, Gontan C, Merzouk S, Sleddens-Linkels E, Meek S, Baarends WM, Burdon T, Gribnau J.

Sci Rep. 2019 Apr 15;9(1):6068. doi: 10.1038/s41598-019-42246-2.

3.

Gestational jet lag predisposes to later-life skeletal and cardiac disease.

Chaves I, van der Eerden B, Boers R, Boers J, Streng AA, Ridwan Y, Schreuders-Koedam M, Vermeulen M, van der Pluijm I, Essers J, Gribnau J, Reiss IKM, van der Horst GTJ.

Chronobiol Int. 2019 May;36(5):657-671. doi: 10.1080/07420528.2019.1579734. Epub 2019 Feb 22.

PMID:
30793958
4.

Current State of Renal Regenerative Therapies.

Shankar AS, Hoorn EJ, Gribnau J, Baan CC, Hoogduijn MJ.

Transplantation. 2019 Feb;103(2):250-261. doi: 10.1097/TP.0000000000002547. Review.

PMID:
30489479
5.

REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice.

Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS, Rentmeester E, Demmers J, Gribnau J.

Nat Commun. 2018 Nov 12;9(1):4752. doi: 10.1038/s41467-018-07060-w.

6.

Identifying cystogenic paracrine signaling molecules in cyst fluid of patients with polycystic kidney disease.

Kenter AT, van Rossum-Fikkert SE, Salih M, Verhagen PCMS, van Leenders GJLH, Demmers JAA, Jansen G, Gribnau J, Zietse R, Hoorn EJ.

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F204-F213. doi: 10.1152/ajprenal.00470.2018. Epub 2018 Nov 7.

PMID:
30403162
7.

Simultaneous RNA-DNA FISH in Mouse Preimplantation Embryos.

Magaraki A, Loda A, Gribnau J, Baarends WM.

Methods Mol Biol. 2018;1861:131-147. doi: 10.1007/978-1-4939-8766-5_11.

PMID:
30218365
8.

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion.

Adrianse RL, Smith K, Gatbonton-Schwager T, Sripathy SP, Lao U, Foss EJ, Boers RG, Boers JB, Gribnau J, Bedalov A.

Epigenetics Chromatin. 2018 Aug 31;11(1):50. doi: 10.1186/s13072-018-0219-8.

9.

Allele-specific control of replication timing and genome organization during development.

Rivera-Mulia JC, Dimond A, Vera D, Trevilla-Garcia C, Sasaki T, Zimmerman J, Dupont C, Gribnau J, Fraser P, Gilbert DM.

Genome Res. 2018 Jun;28(6):800-811. doi: 10.1101/gr.232561.117. Epub 2018 May 7.

10.

Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder.

Frints SGM, Ozanturk A, Rodríguez Criado G, Grasshoff U, de Hoon B, Field M, Manouvrier-Hanu S, E Hickey S, Kammoun M, Gripp KW, Bauer C, Schroeder C, Toutain A, Mihalic Mosher T, Kelly BJ, White P, Dufke A, Rentmeester E, Moon S, Koboldt DC, van Roozendaal KEP, Hu H, Haas SA, Ropers HH, Murray L, Haan E, Shaw M, Carroll R, Friend K, Liebelt J, Hobson L, De Rademaeker M, Geraedts J, Fryns JP, Vermeesch J, Raynaud M, Riess O, Gribnau J, Katsanis N, Devriendt K, Bauer P, Gecz J, Golzio C, Gontan C, Kalscheuer VM.

Mol Psychiatry. 2018 May 4. doi: 10.1038/s41380-018-0065-x. [Epub ahead of print]

PMID:
29728705
11.

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.

Lazzarano S, Kučka M, Castro JPL, Naumann R, Medina P, Fletcher MNC, Wombacher R, Gribnau J, Hochepied T, Van Montagu M, Libert C, Chan YF.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3680-3685. doi: 10.1073/pnas.1717474115. Epub 2018 Mar 21.

12.

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

de Vrij FM, Bouwkamp CG, Gunhanlar N, Shpak G, Lendemeijer B, Baghdadi M, Gopalakrishna S, Ghazvini M, Li TM, Quadri M, Olgiati S, Breedveld GJ, Coesmans M, Mientjes E, de Wit T, Verheijen FW, Beverloo HB, Cohen D, Kok RM, Bakker PR, Nijburg A, Spijker AT, Haffmans PMJ, Hoencamp E, Bergink V; GROUP Study Consortium, Vorstman JA, Wu T, Olde Loohuis LM, Amin N, Langen CD, Hofman A, Hoogendijk WJ, van Duijn CM, Ikram MA, Vernooij MW, Tiemeier H, Uitterlinden AG, Elgersma Y, Distel B, Gribnau J, White T, Bonifati V, Kushner SA.

Mol Psychiatry. 2019 May;24(5):757-771. doi: 10.1038/s41380-017-0004-2. Epub 2018 Jan 4.

13.

Genome-wide DNA methylation profiling using the methylation-dependent restriction enzyme LpnPI.

Boers R, Boers J, de Hoon B, Kockx C, Ozgur Z, Molijn A, van IJcken W, Laven J, Gribnau J.

Genome Res. 2018 Jan;28(1):88-99. doi: 10.1101/gr.222885.117. Epub 2017 Dec 8.

14.

Genetic and epigenetic features direct differential efficiency of Xist-mediated silencing at X-chromosomal and autosomal locations.

Loda A, Brandsma JH, Vassilev I, Servant N, Loos F, Amirnasr A, Splinter E, Barillot E, Poot RA, Heard E, Gribnau J.

Nat Commun. 2017 Sep 25;8(1):690. doi: 10.1038/s41467-017-00528-1.

15.

X chromosome inactivation in a female carrier of a 1.28 Mb deletion encompassing the human X inactivation centre.

de Hoon B, Splinter E, Eussen B, Douben JCW, Rentmeester E, van de Heijning M, Laven JSE, de Klein JEMM, Liebelt J, Gribnau J.

Philos Trans R Soc Lond B Biol Sci. 2017 Nov 5;372(1733). pii: 20160359. doi: 10.1098/rstb.2016.0359.

16.

An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum.

Higuera GA, Iaffaldano G, Bedar M, Shpak G, Broersen R, Munshi ST, Dupont C, Gribnau J, de Vrij FMS, Kushner SA, De Zeeuw CI.

Sci Rep. 2017 Aug 18;7(1):8863. doi: 10.1038/s41598-017-09348-1.

17.

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells.

Gunhanlar N, Shpak G, van der Kroeg M, Gouty-Colomer LA, Munshi ST, Lendemeijer B, Ghazvini M, Dupont C, Hoogendijk WJG, Gribnau J, de Vrij FMS, Kushner SA.

Mol Psychiatry. 2018 May;23(5):1336-1344. doi: 10.1038/mp.2017.56. Epub 2017 Apr 18.

18.

Silencing markers are retained on pericentric heterochromatin during murine primordial germ cell development.

Magaraki A, van der Heijden G, Sleddens-Linkels E, Magarakis L, van Cappellen WA, Peters AHFM, Gribnau J, Baarends WM, Eijpe M.

Epigenetics Chromatin. 2017 Mar 11;10:11. doi: 10.1186/s13072-017-0119-3. eCollection 2017.

19.

X chromosome inactivation: silencing, topology and reactivation.

Robert Finestra T, Gribnau J.

Curr Opin Cell Biol. 2017 Jun;46:54-61. doi: 10.1016/j.ceb.2017.01.007. Epub 2017 Feb 23. Review.

PMID:
28236732
20.

Characterization of Histone Modifications Associated with Inactive X-Chromosome in Trophoblast Stem Cells, eXtra-Embryonic Endoderm Cells and in In Vitro Derived Undifferentiated and Differentiated Epiblast Like Stem Cells.

Dupont C, Maduro C, Den Braanker H, Boers R, Kurek D, Gribnau J.

PLoS One. 2016 Dec 15;11(12):e0167154. doi: 10.1371/journal.pone.0167154. eCollection 2016.

21.

FGF treatment of host embryos injected with ES cells increases rates of chimaerism.

Dupont C, Loos F, Kong-A-San J, Gribnau J.

Transgenic Res. 2017 Apr;26(2):237-246. doi: 10.1007/s11248-016-9997-6. Epub 2016 Nov 21.

22.

Round Spermatid Injection Rescues Female Lethality of a Paternally Inherited Xist Deletion in Mouse.

Federici F, Magaraki A, Wassenaar E, van Veen-Buurman CJ, van de Werken C, Baart EB, Laven JS, Grootegoed JA, Gribnau J, Baarends WM.

PLoS Genet. 2016 Oct 7;12(10):e1006358. doi: 10.1371/journal.pgen.1006358. eCollection 2016 Oct.

23.

Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.

Loos F, Maduro C, Loda A, Lehmann J, Kremers GJ, Ten Berge D, Grootegoed JA, Gribnau J.

Mol Cell Biol. 2016 Oct 13;36(21):2656-2667. doi: 10.1128/MCB.00183-16. Print 2016 Nov 1.

24.

Genomes of Ellobius species provide insight into the evolutionary dynamics of mammalian sex chromosomes.

Mulugeta E, Wassenaar E, Sleddens-Linkels E, van IJcken WF, Heard E, Grootegoed JA, Just W, Gribnau J, Baarends WM.

Genome Res. 2016 Sep;26(9):1202-10. doi: 10.1101/gr.201665.115. Epub 2016 Aug 10.

25.

New Xist-Interacting Proteins in X-Chromosome Inactivation.

Mira-Bontenbal H, Gribnau J.

Curr Biol. 2016 May 23;26(10):1383. doi: 10.1016/j.cub.2016.05.009. No abstract available.

26.

New Xist-Interacting Proteins in X-Chromosome Inactivation.

Mira-Bontenbal H, Gribnau J.

Curr Biol. 2016 Apr 25;26(8):R338-42. doi: 10.1016/j.cub.2016.03.022. Review.

27.

Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks H, Kerstens HH, Barakat TS, Splinter E, Dirks RA, van Mierlo G, Joshi O, Wang SY, Babak T, Albers CA, Kalkan T, Smith A, Jouneau A, de Laat W, Gribnau J, Stunnenberg HG.

Genome Biol. 2016 Feb 5;17:22. doi: 10.1186/s13059-016-0885-4. No abstract available.

28.

Fitting the Puzzle Pieces: the Bigger Picture of XCI.

Maduro C, de Hoon B, Gribnau J.

Trends Biochem Sci. 2016 Feb;41(2):138-147. doi: 10.1016/j.tibs.2015.12.003. Epub 2016 Jan 13. Review.

PMID:
26796628
29.

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Marks H, Kerstens HH, Barakat TS, Splinter E, Dirks RA, van Mierlo G, Joshi O, Wang SY, Babak T, Albers CA, Kalkan T, Smith A, Jouneau A, de Laat W, Gribnau J, Stunnenberg HG.

Genome Biol. 2015 Aug 3;16:149. doi: 10.1186/s13059-015-0698-x. Erratum in: Genome Biol. 2016;17:22.

30.

Buccal swab as a reliable predictor for X inactivation ratio in inaccessible tissues.

de Hoon B, Monkhorst K, Riegman P, Laven JS, Gribnau J.

J Med Genet. 2015 Nov;52(11):784-90. doi: 10.1136/jmedgenet-2015-103194. Epub 2015 Jul 28.

31.

Cis- and trans-regulation in X inactivation.

van Bemmel JG, Mira-Bontenbal H, Gribnau J.

Chromosoma. 2016 Mar;125(1):41-50. doi: 10.1007/s00412-015-0525-x. Epub 2015 Jul 22. Review.

32.

Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.

Fernandes TG, Duarte ST, Ghazvini M, Gaspar C, Santos DC, Porteira AR, Rodrigues GM, Haupt S, Rombo DM, Armstrong J, Sebastião AM, Gribnau J, Garcia-Cazorla À, Brüstle O, Henrique D, Cabral JM, Diogo MM.

Biotechnol J. 2015 Oct;10(10):1578-88. doi: 10.1002/biot.201400751. Epub 2015 Jun 30.

PMID:
26123315
33.

Chromatin-Mediated Reversible Silencing of Sense-Antisense Gene Pairs in Embryonic Stem Cells Is Consolidated upon Differentiation.

Loos F, Loda A, van Wijk L, Grootegoed JA, Gribnau J.

Mol Cell Biol. 2015 Jul;35(14):2436-47. doi: 10.1128/MCB.00029-15. Epub 2015 May 11.

34.

Stable X chromosome reactivation in female human induced pluripotent stem cells.

Barakat TS, Ghazvini M, de Hoon B, Li T, Eussen B, Douben H, van der Linden R, van der Stap N, Boter M, Laven JS, Galjaard RJ, Grootegoed JA, de Klein A, Gribnau J.

Stem Cell Reports. 2015 Feb 10;4(2):199-208. doi: 10.1016/j.stemcr.2014.12.012. Epub 2015 Jan 29.

35.

Epigenetic characterization of the FMR1 promoter in induced pluripotent stem cells from human fibroblasts carrying an unmethylated full mutation.

de Esch CE, Ghazvini M, Loos F, Schelling-Kazaryan N, Widagdo W, Munshi ST, van der Wal E, Douben H, Gunhanlar N, Kushner SA, Pijnappel WW, de Vrij FM, Geijsen N, Gribnau J, Willemsen R.

Stem Cell Reports. 2014 Oct 14;3(4):548-55. doi: 10.1016/j.stemcr.2014.07.013. Epub 2014 Sep 11.

36.

Generation of knockout alleles by RFLP based BAC targeting of polymorphic embryonic stem cells.

Barakat TS, Gribnau J.

Methods Mol Biol. 2015;1227:143-80. doi: 10.1007/978-1-4939-1652-8_7.

PMID:
25239745
38.

The trans-activator RNF12 and cis-acting elements effectuate X chromosome inactivation independent of X-pairing.

Barakat TS, Loos F, van Staveren S, Myronova E, Ghazvini M, Grootegoed JA, Gribnau J.

Mol Cell. 2014 Mar 20;53(6):965-78. doi: 10.1016/j.molcel.2014.02.006. Epub 2014 Mar 6.

39.

Structural and numerical changes of chromosome X in patients with esophageal atresia.

Brosens E, de Jong EM, Barakat TS, Eussen BH, D'haene B, De Baere E, Verdin H, Poddighe PJ, Galjaard RJ, Gribnau J, Brooks AS, Tibboel D, de Klein A.

Eur J Hum Genet. 2014 Sep;22(9):1077-84. doi: 10.1038/ejhg.2013.295. Epub 2014 Jan 8.

40.

Different flavors of X-chromosome inactivation in mammals.

Dupont C, Gribnau J.

Curr Opin Cell Biol. 2013 Jun;25(3):314-21. doi: 10.1016/j.ceb.2013.03.001. Epub 2013 Apr 8. Review.

PMID:
23578369
41.

The pluripotency factor-bound intron 1 of Xist is dispensable for X chromosome inactivation and reactivation in vitro and in vivo.

Minkovsky A, Barakat TS, Sellami N, Chin MH, Gunhanlar N, Gribnau J, Plath K.

Cell Rep. 2013 Mar 28;3(3):905-18. doi: 10.1016/j.celrep.2013.02.018. Epub 2013 Mar 21.

42.

X chromosome inactivation in the cycle of life.

Barakat TS, Gribnau J.

Development. 2012 Jun;139(12):2085-9. doi: 10.1242/dev.069328. Review.

43.

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation.

Gontan C, Achame EM, Demmers J, Barakat TS, Rentmeester E, van IJcken W, Grootegoed JA, Gribnau J.

Nature. 2012 Apr 29;485(7398):386-90. doi: 10.1038/nature11070.

PMID:
22596162
44.

RNF12 controls embryonic stem cell fate and morphogenesis in zebrafish embryos by targeting Smad7 for degradation.

Zhang L, Huang H, Zhou F, Schimmel J, Pardo CG, Zhang T, Barakat TS, Sheppard KA, Mickanin C, Porter JA, Vertegaal AC, van Dam H, Gribnau J, Lu CX, ten Dijke P.

Mol Cell. 2012 Jun 8;46(5):650-61. doi: 10.1016/j.molcel.2012.04.003. Epub 2012 May 3. Erratum in: Mol Cell. 2012 Jul 27;47(2):330.

45.

Spatial partitioning of the regulatory landscape of the X-inactivation centre.

Nora EP, Lajoie BR, Schulz EG, Giorgetti L, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J, Heard E.

Nature. 2012 Apr 11;485(7398):381-5. doi: 10.1038/nature11049.

46.

Origin and evolution of X chromosome inactivation.

Gribnau J, Grootegoed JA.

Curr Opin Cell Biol. 2012 Jun;24(3):397-404. doi: 10.1016/j.ceb.2012.02.004. Epub 2012 Mar 14. Review.

PMID:
22425180
47.

Impact of intertumoral heterogeneity on predicting chemotherapy response of BRCA1-deficient mammary tumors.

Rottenberg S, Vollebergh MA, de Hoon B, de Ronde J, Schouten PC, Kersbergen A, Zander SA, Pajic M, Jaspers JE, Jonkers M, Lodén M, Sol W, van der Burg E, Wesseling J, Gillet JP, Gottesman MM, Gribnau J, Wessels L, Linn SC, Jonkers J, Borst P.

Cancer Res. 2012 May 1;72(9):2350-61. doi: 10.1158/0008-5472.CAN-11-4201. Epub 2012 Mar 6.

48.

Precise BAC targeting of genetically polymorphic mouse ES cells.

Barakat TS, Rentmeester E, Sleutels F, Grootegoed JA, Gribnau J.

Nucleic Acids Res. 2011 Oct;39(18):e121. doi: 10.1093/nar/gkr550. Epub 2011 Jul 7.

49.

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.

Splinter E, de Wit E, Nora EP, Klous P, van de Werken HJ, Zhu Y, Kaaij LJ, van Ijcken W, Gribnau J, Heard E, de Laat W.

Genes Dev. 2011 Jul 1;25(13):1371-83. doi: 10.1101/gad.633311. Epub 2011 Jun 20.

50.

Xist regulation and function explored.

Pontier DB, Gribnau J.

Hum Genet. 2011 Aug;130(2):223-36. doi: 10.1007/s00439-011-1008-7. Epub 2011 May 28. Review.

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