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Items: 1 to 50 of 107

1.

First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors.

Li Y, Gardner JJ, Fortney KR, Leus IV, Bonifay V, Zgurskaya HI, Pletnev AA, Zhang S, Zhang ZY, Gribble GW, Spinola SM, Duerfeldt AS.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1836-1841. doi: 10.1016/j.bmcl.2019.05.003. Epub 2019 May 6.

PMID:
31104993
2.

A Modified ToxT Inhibitor Reduces Vibrio cholerae Virulence in Vivo.

Woodbrey AK, Onyango EO, Kovacikova G, Kull FJ, Gribble GW.

Biochemistry. 2018 Sep 25;57(38):5609-5615. doi: 10.1021/acs.biochem.8b00667. Epub 2018 Sep 12.

3.

Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.

Fu L, Lin QX, Onyango EO, Liby KT, Sporn MB, Gribble GW.

Org Biomol Chem. 2017 Jul 19;15(28):6001-6005. doi: 10.1039/c7ob01420a.

PMID:
28678272
4.

A new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT.

Woodbrey AK, Onyango EO, Pellegrini M, Kovacikova G, Taylor RK, Gribble GW, Kull FJ.

Sci Rep. 2017 Mar 23;7:45011. doi: 10.1038/srep45011.

5.

Synthesis of a Masked 2,3-Diaminoindole.

Mannes PZ, Onyango EO, Gribble GW.

J Org Chem. 2016 Dec 16;81(24):12478-12481. Epub 2016 Dec 1.

PMID:
27978742
6.

Photo-degradation of 2,4-dinitroanisole (DNAN): An emerging munitions compound.

Taylor S, Walsh ME, Becher JB, Ringelberg DB, Mannes PZ, Gribble GW.

Chemosphere. 2017 Jan;167:193-203. doi: 10.1016/j.chemosphere.2016.09.142. Epub 2016 Oct 6.

PMID:
27721130
7.

Correction to "Triple Benzannulation of Naphthalene via a 1,3,6-Naphthotriyne Synthetic Equivalent. Synthesis of Dibenz[a,c]anthracene".

Mannes PZ, Onyango EO, Gribble GW.

J Org Chem. 2015 Dec 18;80(24):12746. doi: 10.1021/acs.joc.5b02627. Epub 2015 Nov 24. No abstract available.

PMID:
26600209
8.

Triple Benzannulation of Naphthalene via a 1,3,6-Naphthotriyne Synthetic Equivalent. Synthesis of Dibenz[a,c]anthracene.

Mannes PZ, Onyango EO, Gribble GW.

J Org Chem. 2015 Nov 6;80(21):11189-92. doi: 10.1021/acs.joc.5b01972. Epub 2015 Oct 20. Erratum in: J Org Chem. 2015 Dec 18;80(24):12746.

PMID:
26452053
9.

Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.

Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT.

Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024. Epub 2015 Jul 31.

PMID:
26238177
10.

Biological Activity of Recently Discovered Halogenated Marine Natural Products.

Gribble GW.

Mar Drugs. 2015 Jun 30;13(7):4044-136. doi: 10.3390/md13074044. Review.

11.

Syntheses of 1-Bromo-8-methylnaphthalene and 1-Bromo-5-methylnaphthalene.

Onyango EO, Kelley AR, Qian DC, Gribble GW.

J Org Chem. 2015 Jun 5;80(11):5970-2. doi: 10.1021/acs.joc.5b00730. Epub 2015 May 11.

PMID:
25923236
12.

An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives.

Fu L, Lin QX, Liby KT, Sporn MB, Gribble GW.

Org Biomol Chem. 2014 Jul 28;12(28):5192-200. doi: 10.1039/c4ob00679h.

PMID:
24915424
13.

Methyl 1-benzyl-5-methyl-2,4-diphenyl-1H-pyrrole-3-carboxyl-ate.

Lopchuk JM, Gribble GW, Jasinski JP.

Acta Crystallogr Sect E Struct Rep Online. 2014 Feb 22;70(Pt 3):o338-9. doi: 10.1107/S1600536814003316. eCollection 2014 Mar 1.

14.

Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).

Onyango EO, Fu L, Cao M, Liby KT, Sporn MB, Gribble GW.

Bioorg Med Chem Lett. 2014 Jan 15;24(2):532-4. doi: 10.1016/j.bmcl.2013.12.034. Epub 2013 Dec 15.

PMID:
24388806
15.

Synthesis of a dicyano abietane, a key intermediate for the anti-inflammatory agent TBE-31.

Onyango EO, Fu L, Gribble GW.

Org Lett. 2014 Jan 3;16(1):322-4. doi: 10.1021/ol403289y. Epub 2013 Dec 4.

PMID:
24303944
16.

Bruceolline J: 2-hy-droxy-3,3-dimethyl-2,3-di-hydro-cyclo-penta-[b]indol-1(4H)-one.

Lopchuk JM, Gribble GW, Millikan SP, Jasinski JP.

Acta Crystallogr Sect E Struct Rep Online. 2013 Jul 31;69(Pt 8):o1351-2. doi: 10.1107/S1600536813020527. eCollection 2013.

17.

What controls regiochemistry in 1,3-dipolar cycloadditions of m√ľnchnones with nitrostyrenes?

Lopchuk JM, Hughes RP, Gribble GW.

Org Lett. 2013 Oct 18;15(20):5218-21. doi: 10.1021/ol402385v. Epub 2013 Sep 27.

PMID:
24073889
18.

Bruceolline D: 3,3-dimethyl-1H,4H-cyclo-penta-[b]indol-2(3H)-one.

Lopchuk JM, Gribble GW, Jasinski JP.

Acta Crystallogr Sect E Struct Rep Online. 2013 Jun 8;69(Pt 7):o1043. doi: 10.1107/S1600536813014955. eCollection 2013.

19.

A short, protecting group-free total synthesis of bruceollines D, E, and J.

Lopchuk JM, Green IL, Badenock JC, Gribble GW.

Org Lett. 2013 Sep 6;15(17):4485-7. doi: 10.1021/ol402042f. Epub 2013 Aug 12.

PMID:
23937106
20.

Efficient and scalable synthesis of bardoxolone methyl (cddo-methyl ester).

Fu L, Gribble GW.

Org Lett. 2013 Apr 5;15(7):1622-5. doi: 10.1021/ol400399x. Epub 2013 Mar 26.

PMID:
23530743
21.

Occurrence of halogenated alkaloids.

Gribble GW.

Alkaloids Chem Biol. 2012;71:1-165. Review.

PMID:
23189746
22.

3,3-Dimethyl-1,2,3,4-tetra-hydro-cyclo-penta-[b]indole-1,2-dione (bruceolline E).

Jordon JA, Badenock JC, Gribble GW, Jasinski JP, Golen JA.

Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o364-5. doi: 10.1107/S1600536812000517. Epub 2012 Jan 11.

23.

Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.

Honda T, Yoshizawa H, Sundararajan C, David E, Lajoie MJ, Favaloro FG Jr, Janosik T, Su X, Honda Y, Roebuck BD, Gribble GW.

J Med Chem. 2011 Mar 24;54(6):1762-78. doi: 10.1021/jm101445p. Epub 2011 Mar 1.

24.

New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress.

Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW.

J Nat Prod. 2011 Mar 25;74(3):537-45. doi: 10.1021/np100826q. Epub 2011 Feb 10. Review.

25.

Design of anti-parasitic and anti-fungal hydroxy-naphthoquinones that are less susceptible to drug resistance.

Hughes LM, Lanteri CA, O'Neil MT, Johnson JD, Gribble GW, Trumpower BL.

Mol Biochem Parasitol. 2011 May;177(1):12-9. doi: 10.1016/j.molbiopara.2011.01.002. Epub 2011 Jan 18.

26.

Enantioseparation and absolute configuration of the atropisomers of a naturally produced hexahalogenated 1,1'-dimethyl-2,2'-bipyrrole.

Rosenfelder N, Ostrowicz P, Fu L, Gribble GW, Tittlemier SA, Frey W, Vetter W.

J Chromatogr A. 2010 Mar 26;1217(13):2050-5. doi: 10.1016/j.chroma.2010.01.083. Epub 2010 Feb 4.

PMID:
20176363
27.

4-Phenyl-sulfon-yl-2-(p-tolyl-sulfon-yl)-1H,8H-pyrrolo-[2,3-b]indole.

Badenock JC, Jordan JA, Pelkey ET, Gribble GW, Jasinski JP.

Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 9;66(Pt 11):o2757-8. doi: 10.1107/S1600536810039425.

28.

Outlook.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:377-8. doi: 10.1007/978-3-211-99323-1_8. No abstract available.

PMID:
19953390
29.

Significance.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:375-6. doi: 10.1007/978-3-211-99323-1_7. No abstract available.

PMID:
19953389
30.

Natural function.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:369-74. doi: 10.1007/978-3-211-99323-1_6. No abstract available.

PMID:
19953388
31.

Biodegradation.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:367-8. doi: 10.1007/978-3-211-99323-1_5. No abstract available.

PMID:
19953387
32.

Biohalogenation.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:349-65. doi: 10.1007/978-3-211-99323-1_4. No abstract available.

PMID:
19953386
33.

Occurrence.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:9-348. doi: 10.1007/978-3-211-99323-1_3. No abstract available.

PMID:
19953385
34.

Origins.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:3-8. doi: 10.1007/978-3-211-99323-1_2. No abstract available.

PMID:
19953384
35.

Introduction.

Gribble GW.

Fortschr Chem Org Naturst. 2010;91:1. doi: 10.1007/978-3-211-99323-1_1. No abstract available.

PMID:
19953383
36.

Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones.

Hughes LM, Covian R, Gribble GW, Trumpower BL.

Biochim Biophys Acta. 2010 Jan;1797(1):38-43. doi: 10.1016/j.bbabio.2009.07.010. Epub 2009 Aug 4.

37.

A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.

Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB.

Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123.

38.

Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.

Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB.

Clin Cancer Res. 2008 Jul 15;14(14):4556-63. doi: 10.1158/1078-0432.CCR-08-0040.

39.

The rexinoid LG100268 and the synthetic triterpenoid CDDO-methyl amide are more potent than erlotinib for prevention of mouse lung carcinogenesis.

Liby K, Black CC, Royce DB, Williams CR, Risingsong R, Yore MM, Liu X, Honda T, Gribble GW, Lamph WW, Sporn TA, Dmitrovsky E, Sporn MB.

Mol Cancer Ther. 2008 May;7(5):1251-7. doi: 10.1158/1535-7163.MCT-08-0023.

40.

Isolation and structure determination of the cembranoid eunicin from a new genus of octocoral, Pseudoplexaura.

Sponholtz WR, Bianco MA, Gribble GW.

Nat Prod Res. 2008 Mar 20;22(5):440-7. doi: 10.1080/14786410701591788.

PMID:
18404564
41.

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex.

To C, Kulkarni S, Pawson T, Honda T, Gribble GW, Sporn MB, Wrana JL, Di Guglielmo GM.

J Biol Chem. 2008 Apr 25;283(17):11700-13. doi: 10.1074/jbc.M704064200. Epub 2008 Feb 18.

42.

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice.

Dinkova-Kostova AT, Jenkins SN, Wehage SL, Huso DL, Benedict AL, Stephenson KK, Fahey JW, Liu H, Liby KT, Honda T, Gribble GW, Sporn MB, Talalay P.

Biochem Biophys Res Commun. 2008 Mar 21;367(4):859-65. doi: 10.1016/j.bbrc.2008.01.026. Epub 2008 Jan 17.

PMID:
18206646
43.

Anthropogenic persistent organic pollutants-lessons to learn from halogenated natural products.

Vetter W, Gribble GW.

Environ Toxicol Chem. 2007 Nov;26(11):2249-52. No abstract available.

PMID:
17941728
44.

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB.

Mol Cancer Ther. 2007 Jul;6(7):2113-9.

45.

Parameters determining the relative efficacy of hydroxy-naphthoquinone inhibitors of the cytochrome bc1 complex.

Kessl JJ, Moskalev NV, Gribble GW, Nasr M, Meshnick SR, Trumpower BL.

Biochim Biophys Acta. 2007 Apr;1767(4):319-26. Epub 2007 Feb 27.

46.

Novel tricyclic compounds having acetylene groups at C-8a and cyano enones in rings A and C: highly potent anti-inflammatory and cytoprotective agents.

Honda T, Sundararajan C, Yoshizawa H, Su X, Honda Y, Liby KT, Sporn MB, Gribble GW.

J Med Chem. 2007 Apr 19;50(8):1731-4. Epub 2007 Mar 17.

47.

The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice.

Liby K, Royce DB, Williams CR, Risingsong R, Yore MM, Honda T, Gribble GW, Dmitrovsky E, Sporn TA, Sporn MB.

Cancer Res. 2007 Mar 15;67(6):2414-9.

48.

The synthetic triterpenoid TP-222 inhibits RANKL stimulation of osteoclastogenesis and matrix metalloproteinase-9 expression.

Fava RA, Elliott S, Raymond L, Mollmark J, Hays E, Honda T, Gribble GW, Sporn MB, Vincenti MP.

J Rheumatol. 2007 May;34(5):1058-68. Epub 2007 Mar 15.

PMID:
17361985
49.

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW.

Mol Cancer Ther. 2007 Jan;6(1):154-62.

50.

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