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Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.

Gribble FM, Reimann F.

Nat Rev Endocrinol. 2019 Feb 13. doi: 10.1038/s41574-019-0168-8. [Epub ahead of print] Review.


Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 Feb 7. pii: db180883. doi: 10.2337/db18-0883. [Epub ahead of print]


Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL.

J Clin Endocrinol Metab. 2019 Feb 6. doi: 10.1210/jc.2018-02503. [Epub ahead of print]


Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM.

Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047.


GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Jan 2. pii: S1550-4131(18)30753-8. doi: 10.1016/j.cmet.2018.12.016. [Epub ahead of print]


Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P.

Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8.


Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice.

Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M.

Gene Ther. 2018 Dec 4. doi: 10.1038/s41434-018-0052-5. [Epub ahead of print]


Trophoblast organoids as a model for maternal-fetal interactions during human placentation.

Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O'Rahilly S, Hemberger M, Burton GJ, Moffett A.

Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018-0753-3. Epub 2018 Nov 28.


Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.

Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S.

Diabetes. 2019 Jan;68(1):21-33. doi: 10.2337/db18-0729. Epub 2018 Oct 2.


Models and Tools for Studying Enteroendocrine Cells.

Goldspink DA, Reimann F, Gribble FM.

Endocrinology. 2018 Dec 1;159(12):3874-3884. doi: 10.1210/en.2018-00672.


Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.

Adriaenssens AE, Reimann F, Gribble FM.

Compr Physiol. 2018 Sep 14;8(4):1603-1638. doi: 10.1002/cphy.c170047.


Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.

Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21.


Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.

Mol Metab. 2018 Oct;16:65-75. doi: 10.1016/j.molmet.2018.07.011. Epub 2018 Jul 30.


Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.

Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. doi: 10.1210/jc.2018-00972.


Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours.

Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1414-1424. doi: 10.1002/rcm.8183.


Free Fatty Acid Receptors in Enteroendocrine Cells.

Lu VB, Gribble FM, Reimann F.

Endocrinology. 2018 Jul 1;159(7):2826-2835. doi: 10.1210/en.2018-00261. Review.


Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.


Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.

Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM.

Surg Obes Relat Dis. 2018 May;14(5):562-568. doi: 10.1016/j.soard.2018.01.039. Epub 2018 Feb 3.


Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7.


Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies.

Gribble FM, Meek CL, Reimann F.

Peptides. 2018 Feb;100:68-74. doi: 10.1016/j.peptides.2017.11.008. Review.


Microbial regulation of the L cell transcriptome.

Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F.

Sci Rep. 2018 Jan 19;8(1):1207. doi: 10.1038/s41598-017-18079-2.


SCFAs strongly stimulate PYY production in human enteroendocrine cells.

Larraufie P, Martin-Gallausiaux C, Lapaque N, Dore J, Gribble FM, Reimann F, Blottiere HM.

Sci Rep. 2018 Jan 8;8(1):74. doi: 10.1038/s41598-017-18259-0.


Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells.

Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F.

Mol Metab. 2018 Jan;7:90-101. doi: 10.1016/j.molmet.2017.11.005. Epub 2017 Nov 11.


Development and characterisation of a novel glucagon like peptide-1 receptor antibody.

Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM.

Diabetologia. 2018 Mar;61(3):711-721. doi: 10.1007/s00125-017-4491-0. Epub 2017 Nov 9.


Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM.

Mol Metab. 2017 Oct;6(10):1296-1303. doi: 10.1016/j.molmet.2017.07.014. Epub 2017 Aug 1.


Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.

Chimerel C, Riccio C, Murison K, Gribble FM, Reimann F.

Endocrinology. 2017 Oct 1;158(10):3426-3434. doi: 10.1210/en.2017-00434.


Chylomicrons stimulate incretin secretion in mouse and human cells.

Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F.

Diabetologia. 2017 Dec;60(12):2475-2485. doi: 10.1007/s00125-017-4420-2. Epub 2017 Sep 2.


Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.

Kay RG, Galvin S, Larraufie P, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):1963-1973. doi: 10.1002/rcm.7978.


Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity.

Worthington JJ, Reimann F, Gribble FM.

Mucosal Immunol. 2018 Jan;11(1):3-20. doi: 10.1038/mi.2017.73. Epub 2017 Aug 30. Review.


Serotonergic modulation of the activity of GLP-1 producing neurons in the nucleus of the solitary tract in mouse.

Holt MK, Llewellyn-Smith IJ, Reimann F, Gribble FM, Trapp S.

Mol Metab. 2017 Jun 7;6(8):909-921. doi: 10.1016/j.molmet.2017.06.002. eCollection 2017 Aug.


Pregnane glycosides from Cynanchum menarandrense.

Tsoukalas M, Psichas A, Reimann F, Gribble FM, Lobstein A, Urbain A.

Steroids. 2017 Sep;125:27-32. doi: 10.1016/j.steroids.2017.06.005. Epub 2017 Jun 19.


The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1.

Wheeler SE, Stacey HM, Nahaei Y, Hale SJ, Hardy AB, Reimann F, Gribble FM, Larraufie P, Gaisano HY, Brubaker PL.

Diabetes. 2017 Sep;66(9):2327-2338. doi: 10.2337/db16-1403. Epub 2017 Jun 8.


Mixed Primary Cultures of Murine Small Intestine Intended for the Study of Gut Hormone Secretion and Live Cell Imaging of Enteroendocrine Cells.

Psichas A, Tolhurst G, Brighton CA, Gribble FM, Reimann F.

J Vis Exp. 2017 Apr 20;(122). doi: 10.3791/55687.


Signalling in the gut endocrine axis.

Gribble FM, Reimann F.

Physiol Behav. 2017 Jul 1;176:183-188. doi: 10.1016/j.physbeh.2017.02.039. Epub 2017 Feb 28. Review.


Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight.

Anderberg RH, Richard JE, Eerola K, López-Ferreras L, Banke E, Hansson C, Nissbrandt H, Berqquist F, Gribble FM, Reimann F, Wernstedt Asterholm I, Lamy CM, Skibicka KP.

Diabetes. 2017 Apr;66(4):1062-1073. doi: 10.2337/db16-0755. Epub 2017 Jan 5.


Scaling it down: new in vitro tools to get the balance right.

Biggs EK, Gribble FM, Reimann F.

Biochem J. 2017 Jan 1;474(1):47-50. doi: 10.1042/BCJ20160874. Review.


Gut Hormone Regulation and Secretion via FFA1 and FFA4.

Gribble FM, Diakogiannaki E, Reimann F.

Handb Exp Pharmacol. 2017;236:181-203. doi: 10.1007/164_2016_46. Review.


GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

Ekberg JH, Hauge M, Kristensen LV, Madsen AN, Engelstoft MS, Husted AS, Sichlau R, Egerod KL, Timshel P, Kowalski TJ, Gribble FM, Reiman F, Hansen HS, Howard AD, Holst B, Schwartz TW.

Endocrinology. 2016 Dec;157(12):4561-4569. Epub 2016 Oct 25.


Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

Adriaenssens AE, Svendsen B, Lam BY, Yeo GS, Holst JJ, Reimann F, Gribble FM.

Diabetologia. 2016 Oct;59(10):2156-65. doi: 10.1007/s00125-016-4033-1. Epub 2016 Jul 7.


Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion.

Reimann F, Gribble FM.

J Diabetes Investig. 2016 Apr;7 Suppl 1:13-9. doi: 10.1111/jdi.12478. Epub 2016 Mar 14. Review.


Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca2+ influx in response to IL-6.

Anesten F, Holt MK, Schéle E, Pálsdóttir V, Reimann F, Gribble FM, Safari C, Skibicka KP, Trapp S, Jansson JO.

Am J Physiol Regul Integr Comp Physiol. 2016 Jul 1;311(1):R115-23. doi: 10.1152/ajpregu.00383.2015. Epub 2016 Apr 20.


Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Sayers SR, Reimann F, Gribble FM, Parker H, Zac-Varghese S, Bloom SR, Foretz M, Viollet B, Rutter GA.

PLoS One. 2016 Mar 24;11(3):e0149549. doi: 10.1371/journal.pone.0149549. eCollection 2016.


Stimulation of incretin secreting cells.

Pais R, Gribble FM, Reimann F.

Ther Adv Endocrinol Metab. 2016 Feb;7(1):24-42. doi: 10.1177/2042018815618177. Review.


Peptide production and secretion in GLUTag, NCI-H716, and STC-1 cells: a comparison to native L-cells.

Kuhre RE, Wewer Albrechtsen NJ, Deacon CF, Balk-Møller E, Rehfeld JF, Reimann F, Gribble FM, Holst JJ.

J Mol Endocrinol. 2016 Apr;56(3):201-11. doi: 10.1530/JME-15-0293. Epub 2016 Jan 27.


G protein-coupled receptors as new therapeutic targets for type 2 diabetes.

Reimann F, Gribble FM.

Diabetologia. 2016 Feb;59(2):229-33. doi: 10.1007/s00125-015-3825-z. Epub 2015 Dec 12. Review.


Galanin inhibits GLP-1 and GIP secretion via the GAL1 receptor in enteroendocrine L and K cells.

Psichas A, Glass LL, Sharp SJ, Reimann F, Gribble FM.

Br J Pharmacol. 2016 Mar;173(5):888-98. doi: 10.1111/bph.13407. Epub 2016 Feb 8.


Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain.

Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S.

Mol Metab. 2015 Aug 5;4(10):718-31. doi: 10.1016/j.molmet.2015.07.008. eCollection 2015 Oct.


GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness.

Svendsen B, Pais R, Engelstoft MS, Milev NB, Richards P, Christiansen CB, Egerod KL, Jensen SM, Habib AM, Gribble FM, Schwartz TW, Reimann F, Holst JJ.

J Endocrinol. 2016 Jan;228(1):39-48. doi: 10.1530/JOE-15-0247. Epub 2015 Oct 19.


Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium.

Gribble FM, Reimann F.

Annu Rev Physiol. 2016;78:277-99. doi: 10.1146/annurev-physiol-021115-105439. Epub 2015 Oct 6. Review.


Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells.

Soedling H, Hodson DJ, Adrianssens AE, Gribble FM, Reimann F, Trapp S, Rutter GA.

Mol Metab. 2015 Jun 25;4(9):619-30. doi: 10.1016/j.molmet.2015.06.007. eCollection 2015 Sep.

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