Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 188

1.

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice.

Rubio C, Puerto M, García-Rodríquez JJ, Lu VB, García-Martínez I, Alén R, Sanmartín-Salinas P, Toledo-Lobo MV, Saiz J, Ruperez J, Barbas C, Menchén L, Gribble FM, Reimann F, Guijarro LG, Carrascosa JM, Valverde ÁM.

Mol Metab. 2020 Feb 6;35:100954. doi: 10.1016/j.molmet.2020.01.018. [Epub ahead of print]

2.

Essential Role of Syntaxin-Binding Protein-1 in the Regulation of Glucagon-Like Peptide-1 Secretion.

Campbell JR, Martchenko A, Sweeney ME, Maalouf MF, Psichas A, Gribble FM, Reimann F, Brubaker PL.

Endocrinology. 2020 May 1;161(5). pii: bqaa039. doi: 10.1210/endocr/bqaa039.

PMID:
32141504
3.

Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2020 Feb;578(7796):E24. doi: 10.1038/s41586-020-2031-4.

PMID:
32051582
4.

L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.

Lund ML, Sorrentino G, Egerod KL, Kroone C, Mortensen B, Knop FK, Reimann F, Gribble FM, Drucker DJ, de Koning EJP, Schoonjans K, Bäckhed F, Schwartz TW, Petersen N.

Diabetes. 2020 Apr;69(4):614-623. doi: 10.2337/db19-0764. Epub 2020 Feb 10.

PMID:
32041793
5.

Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine.

Modvig IM, Andersen DB, Grunddal KV, Kuhre RE, Martinussen C, Christiansen CB, Ørskov C, Larraufie P, Kay RG, Reimann F, Gribble FM, Hartmann B, Bojsen-Møller KN, Madsbad S, Wewer Albrechtsen NJ, Holst JJ.

Int J Obes (Lond). 2020 Feb 3. doi: 10.1038/s41366-020-0541-7. [Epub ahead of print]

PMID:
32015474
6.

The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1.

Biancolin AD, Martchenko A, Mitova E, Gurges P, Michalchyshyn E, Chalmers JA, Doria A, Mychaleckyj JC, Adriaenssens AE, Reimann F, Gribble FM, Gil-Lozano M, Cox BJ, Brubaker PL.

Mol Metab. 2020 Jan;31:124-137. doi: 10.1016/j.molmet.2019.11.004. Epub 2019 Nov 21.

7.

Development and validation of an LC-MS/MS method for detection and quantification of in vivo derived metabolites of [Pyr1]apelin-13 in humans.

Nyimanu D, Kay RG, Sulentic P, Kuc RE, Ambery P, Jermutus L, Reimann F, Gribble FM, Cheriyan J, Maguire JJ, Davenport AP.

Sci Rep. 2019 Dec 27;9(1):19934. doi: 10.1038/s41598-019-56157-9.

8.

GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25. Erratum in: Nature. 2020 Feb 13;:.

PMID:
31875646
9.

Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

Reimann F, Diakogiannaki E, Moss CE, Gribble FM.

Peptides. 2020 Mar;125:170206. doi: 10.1016/j.peptides.2019.170206. Epub 2019 Nov 19. Review.

PMID:
31756367
10.

Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet.

Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fändriks L.

Gut. 2019 Nov 21. pii: gutjnl-2019-319372. doi: 10.1136/gutjnl-2019-319372. [Epub ahead of print]

11.

Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice.

Sarnobat D, Moffett RC, Gault VA, Tanday N, Reimann F, Gribble FM, Flatt PR, Irwin N.

Peptides. 2020 Mar;125:170205. doi: 10.1016/j.peptides.2019.170205. Epub 2019 Nov 16. Review.

PMID:
31738969
12.

The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.

Adriaenssens AE, Gribble FM, Reimann F.

Peptides. 2020 Mar;125:170194. doi: 10.1016/j.peptides.2019.170194. Epub 2019 Nov 4. Review.

PMID:
31697967
13.

Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F.

Mol Metab. 2019 Nov;29:158-169. doi: 10.1016/j.molmet.2019.09.001. Epub 2019 Sep 7.

14.

Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.

Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O'Rahilly S, Groves M, Gribble FM, Reimann F.

Sci Rep. 2019 Oct 30;9(1):15574. doi: 10.1038/s41598-019-52049-0.

15.

Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons.

Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L.

J Neurosci. 2019 Dec 4;39(49):9767-9781. doi: 10.1523/JNEUROSCI.2145-19.2019. Epub 2019 Oct 30.

16.

Ghrelin Does Not Directly Stimulate Secretion of Glucagon-like Peptide-1.

Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE.

J Clin Endocrinol Metab. 2020 Jan 1;105(1). pii: dgz046. doi: 10.1210/clinem/dgz046.

PMID:
31608930
17.

Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.

Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448.

18.

Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice.

Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1081-E1093. doi: 10.1152/ajpendo.00239.2019. Epub 2019 Sep 10.

PMID:
31503512
19.

Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.

Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F.

Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22.

20.

No direct effect of SGLT2 activity on glucagon secretion.

Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.

Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22.

PMID:
30903205
21.

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F.

Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9.

22.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.

Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ.

Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y.

23.

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.

Gribble FM, Reimann F.

Nat Rev Endocrinol. 2019 Apr;15(4):226-237. doi: 10.1038/s41574-019-0168-8. Review.

PMID:
30760847
24.

Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7.

25.

Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581-2592. doi: 10.1210/jc.2018-02503.

PMID:
30726969
26.

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM.

Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047.

27.

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.

28.

Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P.

Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8.

29.

Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice.

Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M.

Gene Ther. 2019 Feb;26(1-2):40-56. doi: 10.1038/s41434-018-0052-5. Epub 2018 Dec 4.

30.

Trophoblast organoids as a model for maternal-fetal interactions during human placentation.

Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O'Rahilly S, Hemberger M, Burton GJ, Moffett A.

Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018-0753-3. Epub 2018 Nov 28.

PMID:
30487605
31.

Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.

Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S.

Diabetes. 2019 Jan;68(1):21-33. doi: 10.2337/db18-0729. Epub 2018 Oct 2.

32.

Models and Tools for Studying Enteroendocrine Cells.

Goldspink DA, Reimann F, Gribble FM.

Endocrinology. 2018 Dec 1;159(12):3874-3884. doi: 10.1210/en.2018-00672. Review.

33.

Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.

Adriaenssens AE, Reimann F, Gribble FM.

Compr Physiol. 2018 Sep 14;8(4):1603-1638. doi: 10.1002/cphy.c170047. Review.

PMID:
30215862
34.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.

Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21.

35.

Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.

Mol Metab. 2018 Oct;16:65-75. doi: 10.1016/j.molmet.2018.07.011. Epub 2018 Jul 30.

36.

Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.

Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. doi: 10.1210/jc.2018-00972.

37.

Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours.

Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1414-1424. doi: 10.1002/rcm.8183.

38.

Free Fatty Acid Receptors in Enteroendocrine Cells.

Lu VB, Gribble FM, Reimann F.

Endocrinology. 2018 Jul 1;159(7):2826-2835. doi: 10.1210/en.2018-00261. Review.

PMID:
29688303
39.

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.

40.

Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.

Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM.

Surg Obes Relat Dis. 2018 May;14(5):562-568. doi: 10.1016/j.soard.2018.01.039. Epub 2018 Feb 3.

41.

Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7.

42.

Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies.

Gribble FM, Meek CL, Reimann F.

Peptides. 2018 Feb;100:68-74. doi: 10.1016/j.peptides.2017.11.008. Review.

43.

Microbial regulation of the L cell transcriptome.

Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F.

Sci Rep. 2018 Jan 19;8(1):1207. doi: 10.1038/s41598-017-18079-2.

44.

SCFAs strongly stimulate PYY production in human enteroendocrine cells.

Larraufie P, Martin-Gallausiaux C, Lapaque N, Dore J, Gribble FM, Reimann F, Blottiere HM.

Sci Rep. 2018 Jan 8;8(1):74. doi: 10.1038/s41598-017-18259-0.

45.

Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells.

Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F.

Mol Metab. 2018 Jan;7:90-101. doi: 10.1016/j.molmet.2017.11.005. Epub 2017 Nov 11.

46.

Development and characterisation of a novel glucagon like peptide-1 receptor antibody.

Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM.

Diabetologia. 2018 Mar;61(3):711-721. doi: 10.1007/s00125-017-4491-0. Epub 2017 Nov 9.

47.

Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM.

Mol Metab. 2017 Oct;6(10):1296-1303. doi: 10.1016/j.molmet.2017.07.014. Epub 2017 Aug 1.

48.

Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.

Chimerel C, Riccio C, Murison K, Gribble FM, Reimann F.

Endocrinology. 2017 Oct 1;158(10):3426-3434. doi: 10.1210/en.2017-00434.

49.

Chylomicrons stimulate incretin secretion in mouse and human cells.

Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F.

Diabetologia. 2017 Dec;60(12):2475-2485. doi: 10.1007/s00125-017-4420-2. Epub 2017 Sep 2.

50.

Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.

Kay RG, Galvin S, Larraufie P, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2017 Dec 15;31(23):1963-1973. doi: 10.1002/rcm.7978.

Supplemental Content

Loading ...
Support Center