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Glucagon-like peptide 1 (GLP-1).

Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH.

Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30. Review.


Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

Reimann F, Diakogiannaki E, Moss CE, Gribble FM.

Peptides. 2019 Nov 19:170206. doi: 10.1016/j.peptides.2019.170206. [Epub ahead of print] Review.


Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis: a mechanism targeted by Roux-en-Y gastric bypass surgery but not by preoperative very-low-calorie diet.

Wallenius V, Elias E, Elebring E, Haisma B, Casselbrant A, Larraufie P, Spak E, Reimann F, le Roux CW, Docherty NG, Gribble FM, Fändriks L.

Gut. 2019 Nov 21. pii: gutjnl-2019-319372. doi: 10.1136/gutjnl-2019-319372. [Epub ahead of print]


Effects of long-acting GIP, xenin and oxyntomodulin peptide analogues on alpha-cell transdifferentiation in insulin-deficient diabetic GluCreERT2;ROSA26-eYFP mice.

Sarnobat D, Moffett RC, Gault VA, Tanday N, Reimann F, Gribble FM, Flatt PR, Irwin N.

Peptides. 2019 Nov 16:170205. doi: 10.1016/j.peptides.2019.170205. [Epub ahead of print] Review.


The glucose-dependent insulinotropic polypeptide signaling axis in the central nervous system.

Adriaenssens AE, Gribble FM, Reimann F.

Peptides. 2019 Nov 4:170194. doi: 10.1016/j.peptides.2019.170194. [Epub ahead of print] Review.


Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

Billing LJ, Larraufie P, Lewis J, Leiter A, Li J, Lam B, Yeo GS, Goldspink DA, Kay RG, Gribble FM, Reimann F.

Mol Metab. 2019 Nov;29:158-169. doi: 10.1016/j.molmet.2019.09.001. Epub 2019 Sep 7.


Characterisation of proguanylin expressing cells in the intestine - evidence for constitutive luminal secretion.

Dye FS, Larraufie P, Kay R, Darwish T, Rievaj J, Goldspink DA, Meek CL, Middleton SJ, Hardwick RH, Roberts GP, Percival-Alwyn JL, Vaughan T, Ferraro F, Challis BG, O'Rahilly S, Groves M, Gribble FM, Reimann F.

Sci Rep. 2019 Oct 30;9(1):15574. doi: 10.1038/s41598-019-52049-0.


Synaptic Inputs to the Mouse Dorsal Vagal Complex and Its Resident Preproglucagon Neurons.

Holt MK, Pomeranz LE, Beier KT, Reimann F, Gribble FM, Rinaman L.

J Neurosci. 2019 Dec 4;39(49):9767-9781. doi: 10.1523/JNEUROSCI.2145-19.2019. Epub 2019 Oct 30.


A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1.

Thiebaud N, Gribble F, Reimann F, Trapp S, Fadool DA.

Sci Rep. 2019 Oct 29;9(1):15542. doi: 10.1038/s41598-019-51880-9.


Ghrelin does not directly stimulate secretion of glucagon-like peptide-1.

Jepsen SL, Vestergaard ET, Larraufie P, Gribble FM, Reimann F, Jørgensen JOL, Holst JJ, Kuhre RE.

J Clin Endocrinol Metab. 2019 Oct 14. pii: dgz046. doi: 10.1210/clinem/dgz046. [Epub ahead of print]


Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.

Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448.


Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice.

Jepsen SL, Grunddal KV, Wewer Albrechtsen NJ, Engelstoft MS, Gabe MBN, Jensen EP, Ørskov C, Poulsen SS, Rosenkilde MM, Pedersen J, Gribble FM, Reimann F, Deacon CF, Schwartz TW, Christ AD, Martin RE, Holst JJ.

Am J Physiol Endocrinol Metab. 2019 Dec 1;317(6):E1081-E1093. doi: 10.1152/ajpendo.00239.2019. Epub 2019 Sep 10.


Glucose-Dependent Insulinotropic Polypeptide Receptor-Expressing Cells in the Hypothalamus Regulate Food Intake.

Adriaenssens AE, Biggs EK, Darwish T, Tadross J, Sukthankar T, Girish M, Polex-Wolf J, Lam BY, Zvetkova I, Pan W, Chiarugi D, Yeo GSH, Blouet C, Gribble FM, Reimann F.

Cell Metab. 2019 Nov 5;30(5):987-996.e6. doi: 10.1016/j.cmet.2019.07.013. Epub 2019 Aug 22.


Glucose stimulates somatostatin secretion in pancreatic δ-cells by cAMP-dependent intracellular Ca2+ release.

Denwood G, Tarasov A, Salehi A, Vergari E, Ramracheya R, Takahashi H, Nikolaev VO, Seino S, Gribble F, Reimann F, Rorsman P, Zhang Q.

J Gen Physiol. 2019 Sep 2;151(9):1094-1115. doi: 10.1085/jgp.201912351. Epub 2019 Jul 29.


Abcc5 Knockout Mice Have Lower Fat Mass and Increased Levels of Circulating GLP-1.

Cyranka M, Veprik A, McKay EJ, van Loon N, Thijsse A, Cotter L, Hare N, Saibudeen A, Lingam S, Pires E, Larraufie P, Reimann F, Gribble F, Stewart M, Bentley E, Lear P, McCullagh J, Cantley J, Cox RD, de Wet H.

Obesity (Silver Spring). 2019 Aug;27(8):1292-1304. doi: 10.1002/oby.22521.


No direct effect of SGLT2 activity on glucagon secretion.

Kuhre RE, Ghiasi SM, Adriaenssens AE, Wewer Albrechtsen NJ, Andersen DB, Aivazidis A, Chen L, Mandrup-Poulsen T, Ørskov C, Gribble FM, Reimann F, Wierup N, Tyrberg B, Holst JJ.

Diabetologia. 2019 Jun;62(6):1011-1023. doi: 10.1007/s00125-019-4849-6. Epub 2019 Mar 22.


Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

Lu VB, Rievaj J, O'Flaherty EA, Smith CA, Pais R, Pattison LA, Tolhurst G, Leiter AB, Bulmer DC, Gribble FM, Reimann F.

Nat Commun. 2019 Mar 4;10(1):1029. doi: 10.1038/s41467-019-09045-9.


Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.

Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ.

Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y.


Function and mechanisms of enteroendocrine cells and gut hormones in metabolism.

Gribble FM, Reimann F.

Nat Rev Endocrinol. 2019 Apr;15(4):226-237. doi: 10.1038/s41574-019-0168-8. Review.


Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

Roberts GP, Larraufie P, Richards P, Kay RG, Galvin SG, Miedzybrodzka EL, Leiter A, Li HJ, Glass LL, Ma MKL, Lam B, Yeo GSH, Scharfmann R, Chiarugi D, Hardwick RH, Reimann F, Gribble FM.

Diabetes. 2019 May;68(5):1062-1072. doi: 10.2337/db18-0883. Epub 2019 Feb 7.


Acipimox Acutely Increases GLP-1 Concentrations in Overweight Subjects and Hypopituitary Patients.

Vestergaard ET, Hjelholt AJ, Kuhre RE, Møller N, Larraufie P, Gribble FM, Reimann F, Jessen N, Holst JJ, Jørgensen JOL.

J Clin Endocrinol Metab. 2019 Jul 1;104(7):2581-2592. doi: 10.1210/jc.2018-02503.


Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery.

Larraufie P, Roberts GP, McGavigan AK, Kay RG, Li J, Leiter A, Melvin A, Biggs EK, Ravn P, Davy K, Hornigold DC, Yeo GSH, Hardwick RH, Reimann F, Gribble FM.

Cell Rep. 2019 Feb 5;26(6):1399-1408.e6. doi: 10.1016/j.celrep.2019.01.047.


PYY plays a key role in the resolution of diabetes following bariatric surgery in humans.

Guida C, Stephen SD, Watson M, Dempster N, Larraufie P, Marjot T, Cargill T, Rickers L, Pavlides M, Tomlinson J, Cobbold JFL, Zhao CM, Chen D, Gribble F, Reimann F, Gillies R, Sgromo B, Rorsman P, Ryan JD, Ramracheya RD.

EBioMedicine. 2019 Feb;40:67-76. doi: 10.1016/j.ebiom.2018.12.040. Epub 2019 Jan 11.


GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S.

Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016. Epub 2019 Jan 10.


Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion.

Vergari E, Knudsen JG, Ramracheya R, Salehi A, Zhang Q, Adam J, Asterholm IW, Benrick A, Briant LJB, Chibalina MV, Gribble FM, Hamilton A, Hastoy B, Reimann F, Rorsman NJG, Spiliotis II, Tarasov A, Wu Y, Ashcroft FM, Rorsman P.

Nat Commun. 2019 Jan 11;10(1):139. doi: 10.1038/s41467-018-08193-8.


Immunosuppression overcomes insulin- and vector-specific immune responses that limit efficacy of AAV2/8-mediated insulin gene therapy in NOD mice.

Recino A, Gan SU, Sia KC, Sawyer Y, Trendell J, Kay R, Gribble FM, Reimann F, Foale R, Notaridou M, Holmes N, Lever A, Lee KO, Nathwani A, Cooke A, Calne R, Wallberg M.

Gene Ther. 2019 Feb;26(1-2):40-56. doi: 10.1038/s41434-018-0052-5. Epub 2018 Dec 4.


Trophoblast organoids as a model for maternal-fetal interactions during human placentation.

Turco MY, Gardner L, Kay RG, Hamilton RS, Prater M, Hollinshead MS, McWhinnie A, Esposito L, Fernando R, Skelton H, Reimann F, Gribble FM, Sharkey A, Marsh SGE, O'Rahilly S, Hemberger M, Burton GJ, Moffett A.

Nature. 2018 Dec;564(7735):263-267. doi: 10.1038/s41586-018-0753-3. Epub 2018 Nov 28.


The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW.

Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5.


Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.

Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S.

Diabetes. 2019 Jan;68(1):21-33. doi: 10.2337/db18-0729. Epub 2018 Oct 2.


Models and Tools for Studying Enteroendocrine Cells.

Goldspink DA, Reimann F, Gribble FM.

Endocrinology. 2018 Dec 1;159(12):3874-3884. doi: 10.1210/en.2018-00672. Review.


Distribution and Stimulus Secretion Coupling of Enteroendocrine Cells along the Intestinal Tract.

Adriaenssens AE, Reimann F, Gribble FM.

Compr Physiol. 2018 Sep 14;8(4):1603-1638. doi: 10.1002/cphy.c170047. Review.


Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan P, Kay RG, Brouwers B, Herranz-Pérez V, Jura M, Larraufie P, Jerber J, Pembroke J, Bartels T, White A, Gribble FM, Reimann F, Farooqi IS, O'Rahilly S, Merkle FT.

Mol Metab. 2018 Nov;17:82-97. doi: 10.1016/j.molmet.2018.08.006. Epub 2018 Aug 21.


Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells.

Billing LJ, Smith CA, Larraufie P, Goldspink DA, Galvin S, Kay RG, Howe JD, Walker R, Pruna M, Glass L, Pais R, Gribble FM, Reimann F.

Mol Metab. 2018 Oct;16:65-75. doi: 10.1016/j.molmet.2018.07.011. Epub 2018 Jul 30.


Assessment and Management of Anti-Insulin Autoantibodies in Varying Presentations of Insulin Autoimmune Syndrome.

Church D, Cardoso L, Kay RG, Williams CL, Freudenthal B, Clarke C, Harris J, Moorthy M, Karra E, Gribble FM, Reimann F, Burling K, Williams AJK, Munir A, Jones TH, Führer D, Moeller LC, Cohen M, Khoo B, Halsall D, Semple RK.

J Clin Endocrinol Metab. 2018 Oct 1;103(10):3845-3855. doi: 10.1210/jc.2018-00972.


Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Beumer J, Artegiani B, Post Y, Reimann F, Gribble F, Nguyen TN, Zeng H, Van den Born M, Van Es JH, Clevers H.

Nat Cell Biol. 2018 Aug;20(8):909-916. doi: 10.1038/s41556-018-0143-y. Epub 2018 Jul 23.


Peptidomic analysis of endogenous plasma peptides from patients with pancreatic neuroendocrine tumours.

Kay RG, Challis BG, Casey RT, Roberts GP, Meek CL, Reimann F, Gribble FM.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1414-1424. doi: 10.1002/rcm.8183.


Free Fatty Acid Receptors in Enteroendocrine Cells.

Lu VB, Gribble FM, Reimann F.

Endocrinology. 2018 Jul 1;159(7):2826-2835. doi: 10.1210/en.2018-00261. Review.


Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

Kuhre RE, Wewer Albrechtsen NJ, Larsen O, Jepsen SL, Balk-Møller E, Andersen DB, Deacon CF, Schoonjans K, Reimann F, Gribble FM, Albrechtsen R, Hartmann B, Rosenkilde MM, Holst JJ.

Mol Metab. 2018 May;11:84-95. doi: 10.1016/j.molmet.2018.03.007. Epub 2018 Mar 17.


Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.

Roberts GP, Kay RG, Howard J, Hardwick RH, Reimann F, Gribble FM.

Surg Obes Relat Dis. 2018 May;14(5):562-568. doi: 10.1016/j.soard.2018.01.039. Epub 2018 Feb 3.


Hierarchical neural architecture underlying thirst regulation.

Augustine V, Gokce SK, Lee S, Wang B, Davidson TJ, Reimann F, Gribble F, Deisseroth K, Lois C, Oka Y.

Nature. 2018 Mar 8;555(7695):204-209. doi: 10.1038/nature25488. Epub 2018 Feb 28.


Rapid sensing of l-leucine by human and murine hypothalamic neurons: Neurochemical and mechanistic insights.

Heeley N, Kirwan P, Darwish T, Arnaud M, Evans ML, Merkle FT, Reimann F, Gribble FM, Blouet C.

Mol Metab. 2018 Apr;10:14-27. doi: 10.1016/j.molmet.2018.01.021. Epub 2018 Feb 7.


Targeted intestinal delivery of incretin secretagogues-towards new diabetes and obesity therapies.

Gribble FM, Meek CL, Reimann F.

Peptides. 2018 Feb;100:68-74. doi: 10.1016/j.peptides.2017.11.008. Review.


Microbial regulation of the L cell transcriptome.

Arora T, Akrami R, Pais R, Bergqvist L, Johansson BR, Schwartz TW, Reimann F, Gribble FM, Bäckhed F.

Sci Rep. 2018 Jan 19;8(1):1207. doi: 10.1038/s41598-017-18079-2.


SCFAs strongly stimulate PYY production in human enteroendocrine cells.

Larraufie P, Martin-Gallausiaux C, Lapaque N, Dore J, Gribble FM, Reimann F, Blottiere HM.

Sci Rep. 2018 Jan 8;8(1):74. doi: 10.1038/s41598-017-18259-0.


Mechanistic insights into the detection of free fatty and bile acids by ileal glucagon-like peptide-1 secreting cells.

Goldspink DA, Lu VB, Billing LJ, Larraufie P, Tolhurst G, Gribble FM, Reimann F.

Mol Metab. 2018 Jan;7:90-101. doi: 10.1016/j.molmet.2017.11.005. Epub 2017 Nov 11.


Development and characterisation of a novel glucagon like peptide-1 receptor antibody.

Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, Baker DJ, Hornigold DC, Ravn P, Reimann F, Gribble FM.

Diabetologia. 2018 Mar;61(3):711-721. doi: 10.1007/s00125-017-4491-0. Epub 2017 Nov 9.


Single-cell RNA-sequencing reveals a distinct population of proglucagon-expressing cells specific to the mouse upper small intestine.

Glass LL, Calero-Nieto FJ, Jawaid W, Larraufie P, Kay RG, Göttgens B, Reimann F, Gribble FM.

Mol Metab. 2017 Oct;6(10):1296-1303. doi: 10.1016/j.molmet.2017.07.014. Epub 2017 Aug 1.


Roux-en-Y Gastric Bypass Surgery in the Management of Familial Partial Lipodystrophy Type 1.

Melvin A, Adams C, Flanagan C, Gaff L, Gratton B, Gribble F, Roberts G, Semple RK, O'Rahilly S, Rubino F, Stears A, Savage DB.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3616-3620. doi: 10.1210/jc.2017-01235.


Optogenetic Analysis of Depolarization-Dependent Glucagonlike Peptide-1 Release.

Chimerel C, Riccio C, Murison K, Gribble FM, Reimann F.

Endocrinology. 2017 Oct 1;158(10):3426-3434. doi: 10.1210/en.2017-00434.


Chylomicrons stimulate incretin secretion in mouse and human cells.

Psichas A, Larraufie PF, Goldspink DA, Gribble FM, Reimann F.

Diabetologia. 2017 Dec;60(12):2475-2485. doi: 10.1007/s00125-017-4420-2. Epub 2017 Sep 2.

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