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Items: 1 to 50 of 135

1.

Compatibility of RUNX1/ETO fusion protein modules driving CD34+ human progenitor cell expansion.

Chen-Wichmann L, Shvartsman M, Preiss C, Hockings C, Windisch R, Redondo Monte E, Leubolt G, Spiekermann K, Lausen J, Brendel C, Grez M, Greif PA, Wichmann C.

Oncogene. 2019 Jan;38(2):261-272. doi: 10.1038/s41388-018-0441-7. Epub 2018 Aug 9.

PMID:
30093631
2.

Targeting HSP90 dimerization via the C terminus is effective in imatinib-resistant CML and lacks the heat shock response.

Bhatia S, Diedrich D, Frieg B, Ahlert H, Stein S, Bopp B, Lang F, Zang T, Kröger T, Ernst T, Kögler G, Krieg A, Lüdeke S, Kunkel H, Rodrigues Moita AJ, Kassack MU, Marquardt V, Opitz FV, Oldenburg M, Remke M, Babor F, Grez M, Hochhaus A, Borkhardt A, Groth G, Nagel-Steger L, Jose J, Kurz T, Gohlke H, Hansen FK, Hauer J.

Blood. 2018 Jul 19;132(3):307-320. doi: 10.1182/blood-2017-10-810986. Epub 2018 May 3.

3.

Non-Clinical Efficacy and Safety Studies on G1XCGD, a Lentiviral Vector for Ex Vivo Gene Therapy of X-Linked Chronic Granulomatous Disease.

Brendel C, Rothe M, Santilli G, Charrier S, Stein S, Kunkel H, Abriss D, Müller-Kuller U, Gaspar B, Modlich U, Galy A, Schambach A, Thrasher AJ, Grez M.

Hum Gene Ther Clin Dev. 2018 Jun;29(2):69-79. doi: 10.1089/humc.2017.245. Epub 2018 Apr 17.

PMID:
29664709
4.

Contribution of the use of basic telemedicine tools to the care of children and adolescents with juvenile idiopathic arthritis at the Puerto Montt Hospital, Chile.

Strickler AS, Palma J, Charris R, Candia T, Grez M, González B, King A, Rivera V.

Rev Chil Pediatr. 2018 Feb;89(1):59-66. doi: 10.4067/S0370-41062018000100059. English, Spanish.

5.

A small, portable RNA device for the control of exon skipping in mammalian cells.

Vogel M, Weigand JE, Kluge B, Grez M, Suess B.

Nucleic Acids Res. 2018 May 4;46(8):e48. doi: 10.1093/nar/gky062.

6.

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer.

Weber H, Valbuena JR, Barbhuiya MA, Stein S, Kunkel H, García P, Bizama C, Riquelme I, Espinoza JA, Kurtz SE, Tyner JW, Calderon JF, Corvalán AH, Grez M, Pandey A, Leal-Rojas P, Roa JC.

Oncotarget. 2017 Apr 18;8(16):26169-26184. doi: 10.18632/oncotarget.15410.

7.

Role of Personality Functioning in the Quality of Life of Patients with Depression.

Crempien C, Grez M, Valdés C, López MJ, de la Parra G, Krause M.

J Nerv Ment Dis. 2017 Sep;205(9):705-713. doi: 10.1097/NMD.0000000000000676.

PMID:
28350562
8.

Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.

Schanda J, Lee CW, Wohlan K, Müller-Kuller U, Kunkel H, Coco IQ, Stein S, Metz A, Koch J, Lausen J, Platzbecker U, Medyouf H, Gohlke H, Heuser M, Eder M, Grez M, Scherr M, Wichmann C.

Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2. No abstract available.

9.

UPF1 regulates myeloid cell functions and S100A9 expression by the hnRNP E2/miRNA-328 balance.

Saul MJ, Stein S, Grez M, Jakobsson PJ, Steinhilber D, Suess B.

Sci Rep. 2016 Aug 30;6:31995. doi: 10.1038/srep31995.

10.

Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level.

Coutandin D, Osterburg C, Srivastav RK, Sumyk M, Kehrloesser S, Gebel J, Tuppi M, Hannewald J, Schäfer B, Salah E, Mathea S, Müller-Kuller U, Doutch J, Grez M, Knapp S, Dötsch V.

Elife. 2016 Mar 14;5. pii: e13909. doi: 10.7554/eLife.13909.

11.

MiR144/451 Expression Is Repressed by RUNX1 During Megakaryopoiesis and Disturbed by RUNX1/ETO.

Kohrs N, Kolodziej S, Kuvardina ON, Herglotz J, Yillah J, Herkt S, Piechatzek A, Salinas Riester G, Lingner T, Wichmann C, Bonig H, Seifried E, Platzbecker U, Medyouf H, Grez M, Lausen J.

PLoS Genet. 2016 Mar 18;12(3):e1005946. doi: 10.1371/journal.pgen.1005946. eCollection 2016 Mar.

12.

Hyperinflammation in patients with chronic granulomatous disease leads to impairment of hematopoietic stem cell functions.

Weisser M, Demel UM, Stein S, Chen-Wichmann L, Touzot F, Santilli G, Sujer S, Brendel C, Siler U, Cavazzana M, Thrasher AJ, Reichenbach J, Essers MAG, Schwäble J, Grez M.

J Allergy Clin Immunol. 2016 Jul;138(1):219-228.e9. doi: 10.1016/j.jaci.2015.11.028. Epub 2016 Feb 4.

PMID:
26853280
13.

A new level of regulation in gluconeogenesis: metabolic state modulates the intracellular localization of aldolase B and its interaction with liver fructose-1,6-bisphosphatase.

Droppelmann CA, Sáez DE, Asenjo JL, Yáñez AJ, García-Rocha M, Concha II, Grez M, Guinovart JJ, Slebe JC.

Biochem J. 2015 Dec 1;472(2):225-37. doi: 10.1042/BJ20150269. Epub 2015 Sep 28.

PMID:
26417114
14.

Rapamycin and WYE-354 suppress human gallbladder cancer xenografts in mice.

Weber H, Leal P, Stein S, Kunkel H, García P, Bizama C, Espinoza JA, Riquelme I, Nervi B, Araya JC, Grez M, Roa JC.

Oncotarget. 2015 Oct 13;6(31):31877-88. doi: 10.18632/oncotarget.5047.

15.

TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T.

Biomaterials. 2015 Nov;69:191-200. doi: 10.1016/j.biomaterials.2015.07.057. Epub 2015 Aug 3.

PMID:
26295532
16.

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies.

Giordano FA, Appelt JU, Link B, Gerdes S, Lehrer C, Scholz S, Paruzynski A, Roeder I, Wenz F, Glimm H, von Kalle C, Grez M, Schmidt M, Laufs S.

Mol Ther Methods Clin Dev. 2015 Apr 1;2:14061. doi: 10.1038/mtm.2014.61. eCollection 2015.

17.

Successful Combination of Sequential Gene Therapy and Rescue Allo-HSCT in Two Children with X-CGD - Importance of Timing.

Siler U, Paruzynski A, Holtgreve-Grez H, Kuzmenko E, Koehl U, Renner ED, Alhan C, de Loosdrecht AA, Schwäble J, Pfluger T, Tchinda J, Schmugge M, Jauch A, Naundorf S, Kühlcke K, Notheis G, Güngor T, Kalle CV, Schmidt M, Grez M, Seger R, Reichenbach J.

Curr Gene Ther. 2015;15(4):416-27.

PMID:
25981636
18.

Advantages and applications of CAR-expressing natural killer cells.

Glienke W, Esser R, Priesner C, Suerth JD, Schambach A, Wels WS, Grez M, Kloess S, Arseniev L, Koehl U.

Front Pharmacol. 2015 Feb 12;6:21. doi: 10.3389/fphar.2015.00021. eCollection 2015. Review.

19.

A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.

Müller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M.

Nucleic Acids Res. 2015 Feb 18;43(3):1577-92. doi: 10.1093/nar/gkv019. Epub 2015 Jan 20.

20.

CD105 is a surface marker for receptor-targeted gene transfer into human long-term repopulating hematopoietic stem cells.

Kays SK, Kaufmann KB, Abel T, Brendel C, Bonig H, Grez M, Buchholz CJ, Kneissl S.

Stem Cells Dev. 2015 Mar 15;24(6):714-23. doi: 10.1089/scd.2014.0455. Epub 2015 Jan 20.

21.

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells.

Hennig D, Müller S, Wichmann C, Drube S, Pietschmann K, Pelzl L, Grez M, Bug G, Heinzel T, Krämer OH.

Br J Cancer. 2015 Jan 20;112(2):329-37. doi: 10.1038/bjc.2014.589. Epub 2014 Dec 16.

22.

[Domestic violence in Chile].

León T, Grez M, Prato JA, Torres R, Ruiz S.

Rev Med Chil. 2014 Aug;142(8):1014-22. doi: 10.4067/S0034-98872014000800009. Review. Spanish.

23.

Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor.

Schönfeld K, Sahm C, Zhang C, Naundorf S, Brendel C, Odendahl M, Nowakowska P, Bönig H, Köhl U, Kloess S, Köhler S, Holtgreve-Grez H, Jauch A, Schmidt M, Schubert R, Kühlcke K, Seifried E, Klingemann HG, Rieger MA, Tonn T, Grez M, Wels WS.

Mol Ther. 2015 Feb;23(2):330-8. doi: 10.1038/mt.2014.219. Epub 2014 Nov 6.

24.

Conditional control of mammalian gene expression by tetracycline-dependent hammerhead ribozymes.

Beilstein K, Wittmann A, Grez M, Suess B.

ACS Synth Biol. 2015 May 15;4(5):526-34. doi: 10.1021/sb500270h. Epub 2014 Oct 27.

PMID:
25265236
25.

Gene therapy for chronic granulomatous disease: current status and future perspectives.

Kaufmann KB, Chiriaco M, Siler U, Finocchi A, Reichenbach J, Stein S, Grez M.

Curr Gene Ther. 2014;14(6):447-60. Review.

PMID:
25245086
26.

CD133-targeted gene transfer into long-term repopulating hematopoietic stem cells.

Brendel C, Goebel B, Daniela A, Brugman M, Kneissl S, Schwäble J, Kaufmann KB, Müller-Kuller U, Kunkel H, Chen-Wichmann L, Abel T, Serve H, Bystrykh L, Buchholz CJ, Grez M.

Mol Ther. 2015 Jan;23(1):63-70. doi: 10.1038/mt.2014.173. Epub 2014 Sep 5. Erratum in: Mol Ther. 2015 Apr;23(4):790.

27.

Activating c-KIT mutations confer oncogenic cooperativity and rescue RUNX1/ETO-induced DNA damage and apoptosis in human primary CD34+ hematopoietic progenitors.

Wichmann C, Quagliano-Lo Coco I, Yildiz Ö, Chen-Wichmann L, Weber H, Syzonenko T, Döring C, Brendel C, Ponnusamy K, Kinner A, Brandts C, Henschler R, Grez M.

Leukemia. 2015 Feb;29(2):279-89. doi: 10.1038/leu.2014.179. Epub 2014 Jun 4.

28.

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

Chiriaco M, Farinelli G, Capo V, Zonari E, Scaramuzza S, Di Matteo G, Sergi LS, Migliavacca M, Hernandez RJ, Bombelli F, Giorda E, Kajaste-Rudnitski A, Trono D, Grez M, Rossi P, Finocchi A, Naldini L, Gentner B, Aiuti A.

Mol Ther. 2014 Aug;22(8):1472-1483. doi: 10.1038/mt.2014.87. Epub 2014 May 29.

29.

Generation of X-CGD cells for vector evaluation from healthy donor CD34(+) HSCs by shRNA-mediated knock down of gp91(phox).

Brendel C, Kaufmann KB, Krattenmacher A, Pahujani S, Grez M.

Mol Ther Methods Clin Dev. 2014 Aug 27;1:14037. doi: 10.1038/mtm.2014.37. eCollection 2014.

30.

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis.

Schiffmann S, Weigert A, Männich J, Eberle M, Birod K, Häussler A, Ferreiros N, Schreiber Y, Kunkel H, Grez M, Weichand B, Brüne B, Pfeilschifter W, Nüsing R, Niederberger E, Grösch S, Scholich K, Geisslinger G.

Biochem Pharmacol. 2014 Feb 15;87(4):625-35. doi: 10.1016/j.bcp.2013.12.006. Epub 2013 Dec 16.

PMID:
24355567
31.

Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells.

Faridi F, Ponnusamy K, Quagliano-Lo Coco I, Chen-Wichmann L, Grez M, Henschler R, Wichmann C.

Front Genet. 2013 Nov 28;4:254. doi: 10.3389/fgene.2013.00254. Review.

32.

Prostacyclin mediates neuropathic pain through interleukin 1β-expressing resident macrophages.

Schuh CD, Pierre S, Weigert A, Weichand B, Altenrath K, Schreiber Y, Ferreiros N, Zhang DD, Suo J, Treutlein EM, Henke M, Kunkel H, Grez M, Nüsing R, Brüne B, Geisslinger G, Scholich K.

Pain. 2014 Mar;155(3):545-55. doi: 10.1016/j.pain.2013.12.006. Epub 2013 Dec 11.

PMID:
24333781
33.

A bispecific transmembrane antibody simultaneously targeting intra- and extracellular epitopes of the epidermal growth factor receptor inhibits receptor activation and tumor cell growth.

Müller N, Hartmann C, Genssler S, Koch J, Kinner A, Grez M, Wels WS.

Int J Cancer. 2014 Jun 1;134(11):2547-59. doi: 10.1002/ijc.28585. Epub 2013 Nov 18.

34.

Gene therapy on the move.

Kaufmann KB, Büning H, Galy A, Schambach A, Grez M.

EMBO Mol Med. 2013 Nov;5(11):1642-61. doi: 10.1002/emmm.201202287. Epub 2013 Sep 17. Review.

35.

Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppression.

Kuçi Z, Seiberth J, Latifi-Pupovci H, Wehner S, Stein S, Grez M, Bönig H, Köhl U, Klingebiel T, Bader P, Kuçi S.

Haematologica. 2013 Oct;98(10):1609-16. doi: 10.3324/haematol.2013.092700. Epub 2013 Aug 23.

36.

From determinants of RUNX1/ETO tetramerization to small-molecule protein-protein interaction inhibitors targeting acute myeloid leukemia.

Metz A, Schanda J, Grez M, Wichmann C, Gohlke H.

J Chem Inf Model. 2013 Sep 23;53(9):2197-202. doi: 10.1021/ci400332e. Epub 2013 Sep 12.

PMID:
23957251
37.

Interference with RUNX1/ETO leukemogenic function by cell-penetrating peptides targeting the NHR2 oligomerization domain.

Bartel Y, Grez M, Wichmann C.

Biomed Res Int. 2013;2013:297692. doi: 10.1155/2013/297692. Epub 2013 Jun 25.

38.

From bench to bedside: preclinical evaluation of a self-inactivating gammaretroviral vector for the gene therapy of X-linked chronic granulomatous disease.

Stein S, Scholz S, Schwäble J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Müller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG Jr, Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kühlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M.

Hum Gene Ther Clin Dev. 2013 Jun;24(2):86-98. doi: 10.1089/humc.2013.019.

39.

Human miR223 promoter as a novel myelo-specific promoter for chronic granulomatous disease gene therapy.

Brendel C, Hänseler W, Wohlgensinger V, Bianchi M, Tokmak S, Chen-Wichmann L, Kuzmenko E, Cesarovic N, Nicholls F, Reichenbach J, Seger R, Grez M, Siler U.

Hum Gene Ther Methods. 2013 Jun;24(3):151-9. doi: 10.1089/hgtb.2012.157. Epub 2013 May 2.

40.

Transient Expression of an LEDGF/p75 Chimera Retargets Lentivector Integration and Functionally Rescues in a Model for X-CGD.

Vets S, De Rijck J, Brendel C, Grez M, Bushman F, Debyser Z, Gijsbers R.

Mol Ther Nucleic Acids. 2013 Mar 5;2:e77. doi: 10.1038/mtna.2013.4.

41.

A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T.

Stem Cells. 2013 Mar;31(3):488-99. doi: 10.1002/stem.1316.

42.

Alpharetroviral vector-mediated gene therapy for X-CGD: functional correction and lack of aberrant splicing.

Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwäble J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M.

Mol Ther. 2013 Mar;21(3):648-61. doi: 10.1038/mt.2012.249. Epub 2012 Dec 4.

43.

Histone arginine methylation keeps RUNX1 target genes in an intermediate state.

Herglotz J, Kuvardina ON, Kolodziej S, Kumar A, Hussong H, Grez M, Lausen J.

Oncogene. 2013 May 16;32(20):2565-75. doi: 10.1038/onc.2012.274. Epub 2012 Jul 9.

PMID:
22777353
44.

Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.

Eißmann M, Melzer IM, Fernández SB, Michel G, Hrabě de Angelis M, Hoefler G, Finkenwirth P, Jauch A, Schoell B, Grez M, Schmidt M, Bartholomae CC, Newrzela S, Haetscher N, Rieger MA, Zachskorn C, Mittelbronn M, Zörnig M.

Oncogene. 2013 May 16;32(20):2586-91. doi: 10.1038/onc.2012.263. Epub 2012 Jul 2.

PMID:
22751129
45.

Safer, silencing-resistant lentiviral vectors: optimization of the ubiquitous chromatin-opening element through elimination of aberrant splicing.

Knight S, Zhang F, Mueller-Kuller U, Bokhoven M, Gupta A, Broughton T, Sha S, Antoniou MN, Brendel C, Grez M, Thrasher AJ, Collins M, Takeuchi Y.

J Virol. 2012 Sep;86(17):9088-95. doi: 10.1128/JVI.00485-12. Epub 2012 Jun 13.

46.

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.

Reddy PN, Sargin B, Choudhary C, Stein S, Grez M, Müller-Tidow C, Berdel WE, Serve H, Brandts CH; Study Alliance Leukemia (SAL).

Blood. 2012 Aug 23;120(8):1691-702. Epub 2012 Apr 19.

PMID:
22517899
47.

Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus.

Nagel J, Gross B, Meggendorfer M, Preiss C, Grez M, Brack-Werner R, Dietzel S.

Chromosoma. 2012 Aug;121(4):353-67. doi: 10.1007/s00412-012-0366-9. Epub 2012 Mar 14.

48.

Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decay.

Ochs MJ, Sorg BL, Pufahl L, Grez M, Suess B, Steinhilber D.

PLoS One. 2012;7(2):e31363. doi: 10.1371/journal.pone.0031363. Epub 2012 Feb 21.

49.

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A.

Mol Ther. 2012 May;20(5):1022-32. doi: 10.1038/mt.2011.309. Epub 2012 Feb 14.

50.

Physiological regulation of transgene expression by a lentiviral vector containing the A2UCOE linked to a myeloid promoter.

Brendel C, Müller-Kuller U, Schultze-Strasser S, Stein S, Chen-Wichmann L, Krattenmacher A, Kunkel H, Dillmann A, Antoniou MN, Grez M.

Gene Ther. 2012 Oct;19(10):1018-29. doi: 10.1038/gt.2011.167. Epub 2011 Nov 10.

PMID:
22071971

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