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Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells.

Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, Grey ST, Tang Q, Roep B, Ricordi C, Naji A, Orlando G, Anderson DG, Poznansky M, Ludwig B, Tomei A, Greiner DL, Graham M, Carpenter M, Migliaccio G, D'Amour K, Hering B, Piemonti L, Berney T, Rickels M, Kay T, Adams A.

Transplantation. 2018 Aug;102(8):1223-1229. doi: 10.1097/TP.0000000000002217.


Oxygen-permeable microwell device maintains islet mass and integrity during shipping.

Rojas-Canales DM, Waibel M, Forget A, Penko D, Nitschke J, Harding FJ, Delalat B, Blencowe A, Loudovaris T, Grey ST, Thomas HE, Kay TWH, Drogemuller CJ, Voelcker NH, Coates PT.

Endocr Connect. 2018 Mar;7(3):490-503. doi: 10.1530/EC-17-0349. Epub 2018 Feb 26.


Equipping the islet graft for self defence: targeting nuclear factor κB and implications for tolerance.

Zammit NW, Grey ST.

Curr Opin Organ Transplant. 2018 Feb;23(1):97-105. doi: 10.1097/MOT.0000000000000482.


Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.

Chou A, Froio D, Nagrial AM, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ; Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M.

Gut. 2017 Oct 28. pii: gutjnl-2017-315144. doi: 10.1136/gutjnl-2017-315144. [Epub ahead of print]


The 2017 Transplantation Awards: Recognizing a Landmark Clinical Trial and a Basic Science Discovery With Far-Reaching Implications.

Grey ST, Issa F.

Transplantation. 2017 Nov;101(11):2655-2656. doi: 10.1097/TP.0000000000001949. No abstract available.


A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.


Inhibition of Y1 receptor signaling improves islet transplant outcome.

Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H.

Nat Commun. 2017 Sep 8;8(1):490. doi: 10.1038/s41467-017-00624-2.


MicroRNA-125a and -b inhibit A20 and MAVS to promote inflammation and impair antiviral response in COPD.

Hsu AC, Dua K, Starkey MR, Haw TJ, Nair PM, Nichol K, Zammit N, Grey ST, Baines KJ, Foster PS, Hansbro PM, Wark PA.

JCI Insight. 2017 Apr 6;2(7):e90443. doi: 10.1172/jci.insight.90443.


Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Del Monte-Nieto G, Conway JR, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NL, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV; Australian Pancreatic Cancer Genome Initiative (APGI), Evans TR, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8504. doi: 10.1126/scitranslmed.aai8504.


Transcriptome Profiling of IL-17A Preactivated Mesenchymal Stem Cells: A Comparative Study to Unmodified and IFN-γ Modified Mesenchymal Stem Cells.

Sivanathan KN, Rojas-Canales D, Grey ST, Gronthos S, Coates PT.

Stem Cells Int. 2017;2017:1025820. doi: 10.1155/2017/1025820. Epub 2017 Feb 15.


Local Sphingosine Kinase 1 Activity Improves Islet Transplantation.

Rojas-Canales D, Penko D, Myo Min KK, Parham KA, Peiris H, Haberberger RV, Pitson SM, Drogemuller C, Keating DJ, Grey ST, Coates PT, Bonder CS, Jessup CF.

Diabetes. 2017 May;66(5):1301-1311. doi: 10.2337/db16-0837. Epub 2017 Feb 7.


Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.

Villanueva JE, Walters SN, Saito M, Malle EK, Zammit NW, Watson KA, Brink R, La Gruta NL, Alexander SI, Grey ST.

Diabetologia. 2017 Apr;60(4):679-689. doi: 10.1007/s00125-016-4198-7. Epub 2017 Jan 6.


Immunodepletion and Hypoxia Preconditioning of Mouse Compact Bone Cells as a Novel Protocol to Isolate Highly Immunosuppressive Mesenchymal Stem Cells.

Sivanathan KN, Gronthos S, Grey ST, Rojas-Canales D, Coates PT.

Stem Cells Dev. 2017 Apr 1;26(7):512-527. doi: 10.1089/scd.2016.0180. Epub 2017 Mar 2.


Awards in Transplantation Science Recognize the Best Articles Published in Transplantation.

Grey ST, Issa F, Tullius SG.

Transplantation. 2017 Jan;101(1):10-12. doi: 10.1097/TP.0000000000001580. No abstract available.


Finding a New Home for Islet Cell Transplants.

Coates PT, Grey ST.

Transplantation. 2016 Jul;100(7):1398-9. doi: 10.1097/TP.0000000000001161. No abstract available.


PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113. Epub 2016 Apr 4.


Fattening Up Allograft Rejection.

Grey ST.

Transplantation. 2016 May;100(5):979-80. doi: 10.1097/TP.0000000000001142. No abstract available.


Antigen-encoding bone marrow terminates islet-directed memory CD8+ T-cell responses to alleviate islet transplant rejection.

Coleman MA, Jessup CF, Bridge JA, Overgaard NH, Penko D, Walters S, Borg DJ, Galea R, Forbes JM, Thomas R, Coates PT, Grey ST, Wells JW, Steptoe RJ.

Diabetes. 2016 May;65(5):1328-1340. doi: 10.2337/db15-1418. Epub 2016 Mar 9.


Awards in Transplantation Science Recognize the Best Manuscripts Published in Transplantation.

Tullius SG, Grey ST, Issa F.

Transplantation. 2016 Feb;100(2):249-50. doi: 10.1097/TP.0000000000001104. No abstract available.


Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.


Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST.

J Exp Med. 2015 Jul 27;212(8):1239-54. doi: 10.1084/jem.20150218. Epub 2015 Jun 29.


Interleukin-17A-Induced Human Mesenchymal Stem Cells Are Superior Modulators of Immunological Function.

Sivanathan KN, Rojas-Canales DM, Hope CM, Krishnan R, Carroll RP, Gronthos S, Grey ST, Coates PT.

Stem Cells. 2015 Sep;33(9):2850-63. doi: 10.1002/stem.2075. Epub 2015 Jun 23.


Telling the tiger by its stripes: mapping the genomics of kidney graft tolerance in real time.

Roden DL, Grey ST.

Kidney Int. 2015 May;87(5):875-7. doi: 10.1038/ki.2015.66.


TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.

Villanueva JE, Malle EK, Gardam S, Silveira PA, Zammit NW, Walters SN, Brink R, Grey ST.

Eur J Immunol. 2015 Jun;45(6):1820-31. doi: 10.1002/eji.201445416. Epub 2015 May 26.


Emerging roles for A20 in islet biology and pathology.

Zammit NW, Grey ST.

Adv Exp Med Biol. 2014;809:141-62. Review.


Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing.

Scott C, Bonner J, Min D, Boughton P, Stokes R, Cha KM, Walters SN, Maslowski K, Sierro F, Grey ST, Twigg S, McLennan S, Gunton JE.

Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C349-57. doi: 10.1152/ajpcell.00306.2013. Epub 2014 Jul 2.


IGF2: an endocrine hormone to improve islet transplant survival.

Hughes A, Rojas-Canales D, Drogemuller C, Voelcker NH, Grey ST, Coates PT.

J Endocrinol. 2014 May;221(2):R41-8. Review.


A role for intrathymic B cells in the generation of natural regulatory T cells.

Walters SN, Webster KE, Daley S, Grey ST.

J Immunol. 2014 Jul 1;193(1):170-6. doi: 10.4049/jimmunol.1302519. Epub 2014 May 28.


BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice.

Mariño E, Walters SN, Villanueva JE, Richards JL, Mackay CR, Grey ST.

Eur J Immunol. 2014 Apr;44(4):983-93. doi: 10.1002/eji.201344186. Epub 2014 Feb 16.


Sulindac activates NF-κB signaling in colon cancer cells.

Mladenova D, Pangon L, Currey N, Ng I, Musgrove EA, Grey ST, Kohonen-Corish MR.

Cell Commun Signal. 2013 Oct 1;11:73. doi: 10.1186/1478-811X-11-73.


Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets.

Walters SN, Luzuriaga J, Chan JY, Grey ST, Laybutt DR.

J Mol Endocrinol. 2013 Sep 6;51(2):225-32. doi: 10.1530/JME-13-0016. Print 2013 Oct.


B-lymphocyte therapy for Type 2 diabetes: the 'B' side of diabetic medication?

Grey ST.

Immunotherapy. 2013 Jul;5(7):669-72. doi: 10.2217/imt.13.52. No abstract available.


Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.

Stolp J, Mariño E, Batten M, Sierro F, Cox SL, Grey ST, Silveira PA.

J Immunol. 2013 Jul 1;191(1):97-109. doi: 10.4049/jimmunol.1203252. Epub 2013 Jun 5.


Multicenter Australian trial of islet transplantation: improving accessibility and outcomes.

O'Connell PJ, Holmes-Walker DJ, Goodman D, Hawthorne WJ, Loudovaris T, Gunton JE, Thomas HE, Grey ST, Drogemuller CJ, Ward GM, Torpy DJ, Coates PT, Kay TW; Australian Islet Transplant Consortium.

Am J Transplant. 2013 Jul;13(7):1850-8. doi: 10.1111/ajt.12250. Epub 2013 May 13.


Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.

Tan BM, Zammit NW, Yam AO, Slattery R, Walters SN, Malle E, Grey ST.

Diabetologia. 2013 Mar;56(3):520-32. doi: 10.1007/s00125-012-2784-x. Epub 2012 Dec 20.


Low-dose rapamycin unmasks the protective potential of targeting intragraft NF-κB for islet transplants.

Zammit NW, Tan BM, Walters SN, Liuwantara D, Villanueva JE, Malle EK, Grey ST.

Cell Transplant. 2013;22(12):2355-66. doi: 10.3727/096368912X658737. Epub 2012 Oct 31.


A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis.

Cantley J, Walters SN, Jung MH, Weinberg A, Cowley MJ, Whitworth TP, Kaplan W, Hawthorne WJ, O'Connell PJ, Weir G, Grey ST.

Cell Transplant. 2013;22(11):2147-59. doi: 10.3727/096368912X658728. Epub 2012 Oct 31.


B-cell cross-presentation of autologous antigen precipitates diabetes.

Mariño E, Tan B, Binge L, Mackay CR, Grey ST.

Diabetes. 2012 Nov;61(11):2893-905. doi: 10.2337/db12-0006. Epub 2012 Jul 24. Erratum in: Diabetes. 2013 Feb;62(2):662.


Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling.

Gunton JE, Sisavanh M, Stokes RA, Satin J, Satin LS, Zhang M, Liu SM, Cai W, Cheng K, Cooney GJ, Laybutt DR, So T, Molero JC, Grey ST, Andres DA, Rolph MS, Mackay CR.

PLoS One. 2012;7(6):e39462. doi: 10.1371/journal.pone.0039462. Epub 2012 Jun 28.


IL-2/IL-2Ab complexes induce regulatory T cell expansion and protect against proteinuric CKD.

Polhill T, Zhang GY, Hu M, Sawyer A, Zhou JJ, Saito M, Webster KE, Wang Y, Wang Y, Grey ST, Sprent J, Harris DC, Alexander SI, Wang YM.

J Am Soc Nephrol. 2012 Aug;23(8):1303-8. doi: 10.1681/ASN.2011111130. Epub 2012 Jun 7.


B cells as effectors and regulators of autoimmunity.

Mariño E, Grey ST.

Autoimmunity. 2012 Aug;45(5):377-87. doi: 10.3109/08916934.2012.665527. Review.


Human islets express a marked proinflammatory molecular signature prior to transplantation.

Cowley MJ, Weinberg A, Zammit NW, Walters SN, Hawthorne WJ, Loudovaris T, Thomas H, Kay T, Gunton JE, Alexander SI, Kaplan W, Chapman J, O'Connell PJ, Grey ST.

Cell Transplant. 2012;21(9):2063-78. doi: 10.3727/096368911X627372. Epub 2012 Mar 8.


Expression of pro- and antiapoptotic molecules of the Bcl-2 family in human islets postisolation.

Campbell PD, Weinberg A, Chee J, Mariana L, Ayala R, Hawthorne WJ, O'Connell PJ, Loudovaris T, Cowley MJ, Kay TW, Grey ST, Thomas HE.

Cell Transplant. 2012;21(1):49-60. doi: 10.3727/096368911X566262. Epub 2011 Apr 29.


B cell-directed therapies in type 1 diabetes.

Mariño E, Silveira PA, Stolp J, Grey ST.

Trends Immunol. 2011 Jun;32(6):287-94. doi: 10.1016/ Epub 2011 Apr 29. Review.


Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes.

Forbes JM, Söderlund J, Yap FY, Knip M, Andrikopoulos S, Ilonen J, Simell O, Veijola R, Sourris KC, Coughlan MT, Forsblom C, Slattery R, Grey ST, Wessman M, Yamamoto H, Bierhaus A, Cooper ME, Groop PH.

Diabetologia. 2011 May;54(5):1032-42. doi: 10.1007/s00125-011-2058-z. Epub 2011 Feb 6. Erratum in: Diabetologia. 2011 Jun;54(6):1586-7.


The hypoxia response pathway and β-cell function.

Cantley J, Grey ST, Maxwell PH, Withers DJ.

Diabetes Obes Metab. 2010 Oct;12 Suppl 2:159-67. doi: 10.1111/j.1463-1326.2010.01276.x. Review.


Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets.

Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE.

J Clin Invest. 2010 Jun;120(6):2171-83. doi: 10.1172/JCI35846. Epub 2010 May 3.


Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model.

Zmuda EJ, Viapiano M, Grey ST, Hadley G, Garcia-Ocaña A, Hai T.

Diabetologia. 2010 Jul;53(7):1438-50. doi: 10.1007/s00125-010-1696-x. Epub 2010 Mar 28.


CD4(+)CD25(+) T-cells control autoimmunity in the absence of B-cells.

Mariño E, Villanueva J, Walters S, Liuwantara D, Mackay F, Grey ST.

Diabetes. 2009 Jul;58(7):1568-77. doi: 10.2337/db08-1504. Epub 2009 Mar 31.


In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression.

Webster KE, Walters S, Kohler RE, Mrkvan T, Boyman O, Surh CD, Grey ST, Sprent J.

J Exp Med. 2009 Apr 13;206(4):751-60. doi: 10.1084/jem.20082824. Epub 2009 Mar 30.

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