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A K+/Na+ co-binding state: Simultaneous versus competitive binding of K+ and Na+ to glutamate transporters.

Wang J, Zielewicz L, Grewer C.

J Biol Chem. 2019 Jun 24. pii: jbc.RA119.009421. doi: 10.1074/jbc.RA119.009421. [Epub ahead of print]


Transient Kinetics Reveal Mechanism and Voltage Dependence of Inhibitor and Substrate Binding to Glutamate Transporters.

Zielewicz L, Wang J, Ndaru E, Grewer CT.

ACS Chem Biol. 2019 May 17;14(5):1002-1010. doi: 10.1021/acschembio.9b00194. Epub 2019 May 6.


Novel alanine serine cysteine transporter 2 (ASCT2) inhibitors based on sulfonamide and sulfonic acid ester scaffolds.

Ndaru E, Garibsingh RA, Shi Y, Wallace E, Zakrepine P, Wang J, Schlessinger A, Grewer C.

J Gen Physiol. 2019 Mar 4;151(3):357-368. doi: 10.1085/jgp.201812276. Epub 2019 Feb 4.


A Quantitative Model for BicD2/Cargo Interactions.

Noell CR, Loftus KM, Cui H, Grewer C, Kizer M, Debler EW, Solmaz SR.

Biochemistry. 2018 Nov 20;57(46):6538-6550. doi: 10.1021/acs.biochem.8b00987. Epub 2018 Nov 5.


Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2.

Garibsingh RA, Otte NJ, Ndaru E, Colas C, Grewer C, Holst J, Schlessinger A.

Front Chem. 2018 Jul 24;6:279. doi: 10.3389/fchem.2018.00279. eCollection 2018.


Energy Landscape of the Substrate Translocation Equilibrium of Plasma-Membrane Glutamate Transporters.

Wang J, Albers T, Grewer C.

J Phys Chem B. 2018 Jan 11;122(1):28-39. doi: 10.1021/acs.jpcb.7b09059. Epub 2017 Dec 22.


Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2.

Singh K, Tanui R, Gameiro A, Eisenberg G, Colas C, Schlessinger A, Grewer C.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):398-402. doi: 10.1016/j.bmcl.2016.12.063. Epub 2016 Dec 27.


Protonation-Driven Membrane Insertion of a pH-Low Insertion Peptide.

Hanz SZ, Shu NS, Qian J, Christman N, Kranz P, An M, Grewer C, Qiang W.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12376-81. doi: 10.1002/anie.201605203. Epub 2016 Aug 31.


Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2(SNAT2) by Chemical Modification.

Chen C, Wang J, Cai R, Yuan Y, Guo Z, Grewer C, Zhang Z.

PLoS One. 2016 Jun 29;11(6):e0158319. doi: 10.1371/journal.pone.0158319. eCollection 2016.


Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides.

Delgado DA, Doherty K, Cheng Q, Kim H, Xu D, Dong H, Grewer C, Qiang W.

J Biol Chem. 2016 Jun 3;291(23):12233-44. doi: 10.1074/jbc.M116.720656. Epub 2016 Apr 7.


Electrogenic Steps Associated with Substrate Binding to the Neuronal Glutamate Transporter EAAC1.

Tanui R, Tao Z, Silverstein N, Kanner B, Grewer C.

J Biol Chem. 2016 May 27;291(22):11852-64. doi: 10.1074/jbc.M116.722470. Epub 2016 Apr 4.


Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening.

Colas C, Grewer C, Otte NJ, Gameiro A, Albers T, Singh K, Shere H, Bonomi M, Holst J, Schlessinger A.

PLoS Comput Biol. 2015 Oct 7;11(10):e1004477. doi: 10.1371/journal.pcbi.1004477. eCollection 2015 Oct.


How do glutamate transporters function as transporters and ion channels?

Grewer C, Gameiro A.

Biophys J. 2014 Aug 5;107(3):546-547. doi: 10.1016/j.bpj.2014.06.027. No abstract available.


Shedding light on conformational dynamics of na(+)-coupled transporters.

Grewer C.

Biophys J. 2014 Apr 15;106(8):1549-50. doi: 10.1016/j.bpj.2014.02.029. No abstract available.


SLC1 glutamate transporters.

Grewer C, Gameiro A, Rauen T.

Pflugers Arch. 2014 Jan;466(1):3-24. doi: 10.1007/s00424-013-1397-7. Epub 2013 Nov 19. Review.


Sequence selective recognition of double-stranded RNA at physiologically relevant conditions using PNA-peptide conjugates.

Muse O, Zengeya T, Mwaura J, Hnedzko D, McGee DW, Grewer CT, Rozners E.

ACS Chem Biol. 2013 Aug 16;8(8):1683-6. doi: 10.1021/cb400144x. Epub 2013 Jun 12.


Voltage-dependent processes in the electroneutral amino acid exchanger ASCT2.

Zander CB, Albers T, Grewer C.

J Gen Physiol. 2013 Jun;141(6):659-72. doi: 10.1085/jgp.201210948. Epub 2013 May 13.


Electrophysiological characterization of membrane transport proteins.

Grewer C, Gameiro A, Mager T, Fendler K.

Annu Rev Biophys. 2013;42:95-120. doi: 10.1146/annurev-biophys-083012-130312. Epub 2013 Feb 28. Review.


Protonation state of a conserved acidic amino acid involved in Na(+) binding to the glutamate transporter EAAC1.

Mwaura J, Tao Z, James H, Albers T, Schwartz A, Grewer C.

ACS Chem Neurosci. 2012 Dec 19;3(12):1073-83. doi: 10.1021/cn300163p. Epub 2012 Oct 19.


Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter.

Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A.

J Biol Chem. 2012 Aug 3;287(32):26921-31. doi: 10.1074/jbc.M112.364059. Epub 2012 Jun 15.


Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained glutamate analogue (+)-HIP-B.

Callender R, Gameiro A, Pinto A, De Micheli C, Grewer C.

Biochemistry. 2012 Jul 10;51(27):5486-95. Epub 2012 Jun 27.


Defining substrate and blocker activity of alanine-serine-cysteine transporter 2 (ASCT2) Ligands with Novel Serine Analogs.

Albers T, Marsiglia W, Thomas T, Gameiro A, Grewer C.

Mol Pharmacol. 2012 Mar;81(3):356-65. doi: 10.1124/mol.111.075648. Epub 2011 Nov 23.


A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transporters.

Rosental N, Gameiro A, Grewer C, Kanner BI.

J Biol Chem. 2011 Dec 2;286(48):41381-90. doi: 10.1074/jbc.M111.291021. Epub 2011 Oct 7.


The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.

Gameiro A, Braams S, Rauen T, Grewer C.

Biophys J. 2011 Jun 8;100(11):2623-32. doi: 10.1016/j.bpj.2011.04.034.


Hetero-oligomerization of neuronal glutamate transporters.

Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C.

J Biol Chem. 2011 Feb 4;286(5):3935-43. doi: 10.1074/jbc.M110.187492. Epub 2010 Dec 2.


Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.

Tao Z, Rosental N, Kanner BI, Gameiro A, Mwaura J, Grewer C.

J Biol Chem. 2010 Jun 4;285(23):17725-33. doi: 10.1074/jbc.M110.121798. Epub 2010 Apr 8.


A conserved Na(+) binding site of the sodium-coupled neutral amino acid transporter 2 (SNAT2).

Zhang Z, Albers T, Fiumera HL, Gameiro A, Grewer C.

J Biol Chem. 2009 Sep 11;284(37):25314-23. doi: 10.1074/jbc.M109.038422. Epub 2009 Jul 9.


Thallium ions can replace both sodium and potassium ions in the glutamate transporter excitatory amino acid carrier 1.

Tao Z, Gameiro A, Grewer C.

Biochemistry. 2008 Dec 2;47(48):12923-30. doi: 10.1021/bi8017174.


Glutamate forward and reverse transport: from molecular mechanism to transporter-mediated release after ischemia.

Grewer C, Gameiro A, Zhang Z, Tao Z, Braams S, Rauen T.

IUBMB Life. 2008 Sep;60(9):609-19. doi: 10.1002/iub.98. Review.


Highly conserved asparagine 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2.

Zhang Z, Gameiro A, Grewer C.

J Biol Chem. 2008 May 2;283(18):12284-92. doi: 10.1074/jbc.M706774200. Epub 2008 Mar 4.


Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function.

Erreger K, Grewer C, Javitch JA, Galli A.

J Neurosci. 2008 Jan 23;28(4):976-89. doi: 10.1523/JNEUROSCI.2796-07.2008.


Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1.

Zhang Z, Tao Z, Gameiro A, Barcelona S, Braams S, Rauen T, Grewer C.

Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18025-30. Epub 2007 Nov 8.


Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1.

Mim C, Tao Z, Grewer C.

Biochemistry. 2007 Aug 7;46(31):9007-18. Epub 2007 Jul 13.


Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative.

Zhang Z, Papageorgiou G, Corrie JE, Grewer C.

Biochemistry. 2007 Mar 27;46(12):3872-80. Epub 2007 Feb 21.


Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other.

Grewer C, Balani P, Weidenfeller C, Bartusel T, Tao Z, Rauen T.

Biochemistry. 2005 Sep 6;44(35):11913-23.


Rapid substrate-induced charge movements of the GABA transporter GAT1.

Bicho A, Grewer C.

Biophys J. 2005 Jul;89(1):211-31. Epub 2005 Apr 22. Erratum in: Biophys J. 2006 Jan 15;90(2):709.


Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.

Maier W, Corrie JE, Papageorgiou G, Laube B, Grewer C.

J Neurosci Methods. 2005 Mar 15;142(1):1-9.


Molecular dynamics simulation links conformation of a pore-flanking region to hyperekplexia-related dysfunction of the inhibitory glycine receptor.

Breitinger HG, Lanig H, Vohwinkel C, Grewer C, Breitinger U, Clark T, Becker CM.

Chem Biol. 2004 Oct;11(10):1339-50.


New inhibitors for the neutral amino acid transporter ASCT2 reveal its Na+-dependent anion leak.

Grewer C, Grabsch E.

J Physiol. 2004 Jun 15;557(Pt 3):747-59. Epub 2004 Apr 23.


Cloning, transport properties, and differential localization of two splice variants of GLT-1 in the rat CNS: implications for CNS glutamate homeostasis.

Sullivan R, Rauen T, Fischer F, Wiessner M, Grewer C, Bicho A, Pow DV.

Glia. 2004 Jan 15;45(2):155-69.


Toward the development of new photolabile protecting groups that can rapidly release bioactive compounds upon photolysis with visible light.

Banerjee A, Grewer C, Ramakrishnan L, Jäger J, Gameiro A, Breitinger HG, Gee KR, Carpenter BK, Hess GP.

J Org Chem. 2003 Oct 31;68(22):8361-7.


Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?

Grewer C, Watzke N, Rauen T, Bicho A.

J Biol Chem. 2003 Jan 24;278(4):2585-92. Epub 2002 Nov 4.

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