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Items: 1 to 50 of 90


Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla S, Dhakshnamoorthy J, Folco HD, Balachandran V, Xiao H, Sun LL, Wheeler D, Zofall M, Grewal SIS.

Cell. 2020 Jan 9;180(1):150-164.e15. doi: 10.1016/j.cell.2019.12.004. Epub 2019 Dec 26.


Cohesin Impedes Heterochromatin Assembly in Fission Yeast Cells Lacking Pds5.

Folco HD, McCue A, Balachandran V, Grewal SIS.

Genetics. 2019 Sep;213(1):127-141. doi: 10.1534/genetics.119.302256. Epub 2019 Jul 5.


CPF Recruitment to Non-canonical Transcription Termination Sites Triggers Heterochromatin Assembly and Gene Silencing.

Vo TV, Dhakshnamoorthy J, Larkin M, Zofall M, Thillainadesan G, Balachandran V, Holla S, Wheeler D, Grewal SIS.

Cell Rep. 2019 Jul 2;28(1):267-281.e5. doi: 10.1016/j.celrep.2019.05.107.


A conserved dimer interface connects ERH and YTH family proteins to promote gene silencing.

Xie G, Vo TV, Thillainadesan G, Holla S, Zhang B, Jiang Y, Lv M, Xu Z, Wang C, Balachandran V, Shi Y, Li F, Grewal SIS.

Nat Commun. 2019 Jan 16;10(1):251. doi: 10.1038/s41467-018-08273-9.


Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control.

Gallagher PS, Larkin M, Thillainadesan G, Dhakshnamoorthy J, Balachandran V, Xiao H, Wellman C, Chatterjee R, Wheeler D, Grewal SIS.

Nat Struct Mol Biol. 2018 May;25(5):372-383. doi: 10.1038/s41594-018-0056-2. Epub 2018 Apr 23.


Shushing histone turnover: It's FUN protecting epigenome-genome.

Taneja N, Grewal SIS.

Cell Cycle. 2017 Oct 2;16(19):1731-1732. doi: 10.1080/15384101.2017.1360651. Epub 2017 Aug 14. No abstract available.


Shelterin components mediate genome reorganization in response to replication stress.

Mizuguchi T, Taneja N, Matsuda E, Belton JM, FitzGerald P, Dekker J, Grewal SIS.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):5479-5484. doi: 10.1073/pnas.1705527114. Epub 2017 May 10.


SNF2 Family Protein Fft3 Suppresses Nucleosome Turnover to Promote Epigenetic Inheritance and Proper Replication.

Taneja N, Zofall M, Balachandran V, Thillainadesan G, Sugiyama T, Wheeler D, Zhou M, Grewal SI.

Mol Cell. 2017 Apr 6;66(1):50-62.e6. doi: 10.1016/j.molcel.2017.02.006. Epub 2017 Mar 16.


Untimely expression of gametogenic genes in vegetative cells causes uniparental disomy.

Folco HD, Chalamcharla VR, Sugiyama T, Thillainadesan G, Zofall M, Balachandran V, Dhakshnamoorthy J, Mizuguchi T, Grewal SI.

Nature. 2017 Mar 2;543(7643):126-130. doi: 10.1038/nature21372. Epub 2017 Feb 15.


Taz1-Shelterin Promotes Facultative Heterochromatin Assembly at Chromosome-Internal Sites Containing Late Replication Origins.

Zofall M, Smith DR, Mizuguchi T, Dhakshnamoorthy J, Grewal SIS.

Mol Cell. 2016 Jun 16;62(6):862-874. doi: 10.1016/j.molcel.2016.04.034. Epub 2016 Jun 2.


Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.

Sugiyama T, Thillainadesan G, Chalamcharla VR, Meng Z, Balachandran V, Dhakshnamoorthy J, Zhou M, Grewal SIS.

Mol Cell. 2016 Mar 3;61(5):747-759. doi: 10.1016/j.molcel.2016.01.029.


Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing.

Chalamcharla VR, Folco HD, Dhakshnamoorthy J, Grewal SI.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15548-55. doi: 10.1073/pnas.1522127112. Epub 2015 Dec 2.


Single-Nucleotide-Specific Targeting of the Tf1 Retrotransposon Promoted by the DNA-Binding Protein Sap1 of Schizosaccharomyces pombe.

Hickey A, Esnault C, Majumdar A, Chatterjee AG, Iben JR, McQueen PG, Yang AX, Mizuguchi T, Grewal SI, Levin HL.

Genetics. 2015 Nov;201(3):905-24. doi: 10.1534/genetics.115.181602. Epub 2015 Sep 9.


Chromosome domain architecture and dynamic organization of the fission yeast genome.

Mizuguchi T, Barrowman J, Grewal SI.

FEBS Lett. 2015 Oct 7;589(20 Pt A):2975-86. doi: 10.1016/j.febslet.2015.06.008. Epub 2015 Jun 19. Review.


The CENP-A N-tail confers epigenetic stability to centromeres via the CENP-T branch of the CCAN in fission yeast.

Folco HD, Campbell CS, May KM, Espinoza CA, Oegema K, Hardwick KG, Grewal SIS, Desai A.

Curr Biol. 2015 Feb 2;25(3):348-356. doi: 10.1016/j.cub.2014.11.060. Epub 2015 Jan 22.


Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe.

Mizuguchi T, Fudenberg G, Mehta S, Belton JM, Taneja N, Folco HD, FitzGerald P, Dekker J, Mirny L, Barrowman J, Grewal SIS.

Nature. 2014 Dec 18;516(7531):432-435. doi: 10.1038/nature13833. Epub 2014 Oct 12.


Yeast X-chromosome-associated protein 5 (Xap5) functions with H2A.Z to suppress aberrant transcripts.

Anver S, Roguev A, Zofall M, Krogan NJ, Grewal SI, Harmer SL.

EMBO Rep. 2014 Aug;15(8):894-902. doi: 10.15252/embr.201438902. Epub 2014 Jun 23.


Mtr4-like protein coordinates nuclear RNA processing for heterochromatin assembly and for telomere maintenance.

Lee NN, Chalamcharla VR, Reyes-Turcu F, Mehta S, Zofall M, Balachandran V, Dhakshnamoorthy J, Taneja N, Yamanaka S, Zhou M, Grewal SI.

Cell. 2013 Nov 21;155(5):1061-74. doi: 10.1016/j.cell.2013.10.027. Epub 2013 Nov 7.


Integration profiling of gene function with dense maps of transposon integration.

Guo Y, Park JM, Cui B, Humes E, Gangadharan S, Hung S, FitzGerald PC, Hoe KL, Grewal SI, Craig NL, Levin HL.

Genetics. 2013 Oct;195(2):599-609. doi: 10.1534/genetics.113.152744. Epub 2013 Jul 26.


HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin.

Aygün O, Mehta S, Grewal SI.

Nat Struct Mol Biol. 2013 May;20(5):547-54. doi: 10.1038/nsmb.2565. Epub 2013 Apr 21.


RNAi triggered by specialized machinery silences developmental genes and retrotransposons.

Yamanaka S, Mehta S, Reyes-Turcu FE, Zhuang F, Fuchs RT, Rong Y, Robb GB, Grewal SI.

Nature. 2013 Jan 24;493(7433):557-60. doi: 10.1038/nature11716. Epub 2012 Nov 14.


Hrp3 controls nucleosome positioning to suppress non-coding transcription in eu- and heterochromatin.

Shim YS, Choi Y, Kang K, Cho K, Oh S, Lee J, Grewal SI, Lee D.

EMBO J. 2012 Nov 28;31(23):4375-87. doi: 10.1038/emboj.2012.267. Epub 2012 Sep 18.


CENP-B cooperates with Set1 in bidirectional transcriptional silencing and genome organization of retrotransposons.

Lorenz DR, Mikheyeva IV, Johansen P, Meyer L, Berg A, Grewal SI, Cam HP.

Mol Cell Biol. 2012 Oct;32(20):4215-25. Epub 2012 Aug 20.


Different means, same end-heterochromatin formation by RNAi and RNAi-independent RNA processing factors in fission yeast.

Reyes-Turcu FE, Grewal SI.

Curr Opin Genet Dev. 2012 Apr;22(2):156-63. doi: 10.1016/j.gde.2011.12.004. Epub 2012 Jan 11. Review.


RNA elimination machinery targeting meiotic mRNAs promotes facultative heterochromatin formation.

Zofall M, Yamanaka S, Reyes-Turcu FE, Zhang K, Rubin C, Grewal SI.

Science. 2012 Jan 6;335(6064):96-100. doi: 10.1126/science.1211651. Epub 2011 Dec 1.


A homolog of male sex-determining factor SRY cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination.

Matsuda E, Sugioka-Sugiyama R, Mizuguchi T, Mehta S, Cui B, Grewal SI.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18754-9. doi: 10.1073/pnas.1109988108. Epub 2011 Oct 31.


Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin.

Reyes-Turcu FE, Zhang K, Zofall M, Chen E, Grewal SI.

Nat Struct Mol Biol. 2011 Sep 4;18(10):1132-8. doi: 10.1038/nsmb.2122.


Assembly and functions of heterochromatin in the fission yeast genome.

Aygün O, Grewal SI.

Cold Spring Harb Symp Quant Biol. 2010;75:259-67. doi: 10.1101/sqb.2010.75.055. Epub 2011 Apr 18.


Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Zhang K, Fischer T, Porter RL, Dhakshnamoorthy J, Zofall M, Zhou M, Veenstra T, Grewal SI.

Science. 2011 Mar 25;331(6024):1624-7. doi: 10.1126/science.1198712.


Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci.

Yamane K, Mizuguchi T, Cui B, Zofall M, Noma K, Grewal SI.

Mol Cell. 2011 Jan 7;41(1):56-66. doi: 10.1016/j.molcel.2010.12.009.


The prevalence and regulation of antisense transcripts in Schizosaccharomyces pombe.

Ni T, Tu K, Wang Z, Song S, Wu H, Xie B, Scott KC, Grewal SI, Gao Y, Zhu J.

PLoS One. 2010 Dec 20;5(12):e15271. doi: 10.1371/journal.pone.0015271.


RNAi-dependent formation of heterochromatin and its diverse functions.

Grewal SI.

Curr Opin Genet Dev. 2010 Apr;20(2):134-41. doi: 10.1016/j.gde.2010.02.003. Epub 2010 Mar 6. Review.


Centromeric localization of dispersed Pol III genes in fission yeast.

Iwasaki O, Tanaka A, Tanizawa H, Grewal SI, Noma K.

Mol Biol Cell. 2010 Jan 15;21(2):254-65. doi: 10.1091/mbc.E09-09-0790. Epub 2009 Nov 12.


Histone H2A.Z cooperates with RNAi and heterochromatin factors to suppress antisense RNAs.

Zofall M, Fischer T, Zhang K, Zhou M, Cui B, Veenstra TD, Grewal SI.

Nature. 2009 Sep 17;461(7262):419-22. doi: 10.1038/nature08321. Epub 2009 Aug 19.


Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast.

Fischer T, Cui B, Dhakshnamoorthy J, Zhou M, Rubin C, Zofall M, Veenstra TD, Grewal SI.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8998-9003. doi: 10.1073/pnas.0813063106. Epub 2009 May 14.


Transcriptional scaffolds for heterochromatin assembly.

Cam HP, Chen ES, Grewal SI.

Cell. 2009 Feb 20;136(4):610-4. doi: 10.1016/j.cell.2009.02.004.


Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.

Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ.

Science. 2008 Oct 17;322(5900):405-10. doi: 10.1126/science.1162609. Epub 2008 Sep 25.


Fission yeast chromatin assembly factor 1 assists in the replication-coupled maintenance of heterochromatin.

Dohke K, Miyazaki S, Tanaka K, Urano T, Grewal SI, Murakami Y.

Genes Cells. 2008 Oct;13(10):1027-43. doi: 10.1111/j.1365-2443.2008.01225.x. Epub 2008 Aug 29.


Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators.

Leem YE, Ripmaster TL, Kelly FD, Ebina H, Heincelman ME, Zhang K, Grewal SI, Hoffman CS, Levin HL.

Mol Cell. 2008 Apr 11;30(1):98-107. doi: 10.1016/j.molcel.2008.02.016.


Roles of the Clr4 methyltransferase complex in nucleation, spreading and maintenance of heterochromatin.

Zhang K, Mosch K, Fischle W, Grewal SI.

Nat Struct Mol Biol. 2008 Apr;15(4):381-8. doi: 10.1038/nsmb.1406. Epub 2008 Mar 16.


Cell cycle control of centromeric repeat transcription and heterochromatin assembly.

Chen ES, Zhang K, Nicolas E, Cam HP, Zofall M, Grewal SI.

Nature. 2008 Feb 7;451(7179):734-7. doi: 10.1038/nature06561. Epub 2008 Jan 23.


Host genome surveillance for retrotransposons by transposon-derived proteins.

Cam HP, Noma K, Ebina H, Levin HL, Grewal SI.

Nature. 2008 Jan 24;451(7177):431-6. Epub 2007 Dec 19.


A discrete class of intergenic DNA dictates meiotic DNA break hotspots in fission yeast.

Cromie GA, Hyppa RW, Cam HP, Farah JA, Grewal SI, Smith GR.

PLoS Genet. 2007 Aug;3(8):e141. Epub 2007 Jul 10.


Transcription and RNA interference in the formation of heterochromatin.

Grewal SI, Elgin SC.

Nature. 2007 May 24;447(7143):399-406. Review.


Distinct roles of HDAC complexes in promoter silencing, antisense suppression and DNA damage protection.

Nicolas E, Yamada T, Cam HP, Fitzgerald PC, Kobayashi R, Grewal SI.

Nat Struct Mol Biol. 2007 May;14(5):372-80. Epub 2007 Apr 22.


RNAi-mediated heterochromatin assembly in fission yeast.

Zofall M, Grewal SI.

Cold Spring Harb Symp Quant Biol. 2006;71:487-96. Review.


Ribonuclease activity of Dis3 is required for mitotic progression and provides a possible link between heterochromatin and kinetochore function.

Murakami H, Goto DB, Toda T, Chen ES, Grewal SI, Martienssen RA, Yanagida M.

PLoS One. 2007 Mar 21;2(3):e317.


SHREC, an effector complex for heterochromatic transcriptional silencing.

Sugiyama T, Cam HP, Sugiyama R, Noma K, Zofall M, Kobayashi R, Grewal SI.

Cell. 2007 Feb 9;128(3):491-504. Erratum in: Cell. 2007 Jun 15;129(6):1227.


Heterochromatin revisited.

Grewal SI, Jia S.

Nat Rev Genet. 2007 Jan;8(1):35-46. Review.


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